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The map label for this gene is malR [H]

Identifier: 23100012

GI number: 23100012

Start: 2613129

End: 2614145

Strand: Reverse

Name: malR [H]

Synonym: OB2557

Alternate gene names: 23100012

Gene position: 2614145-2613129 (Counterclockwise)

Preceding gene: 23100013

Following gene: 23100011

Centisome position: 72.0

GC content: 33.43

Gene sequence:

>1017_bases
ATGGTTACGATAAAAGATATTGCCAAAGCGACAGGTGTATCCCCATCAACAGTTTCAAGAGTAATTGCTGATAATTCACG
TATTAGTGAAGAAACAAAGGCAAAGGTAAGAAAAGCGATGGAGGATTTAGGTTATTTTCCTAATATGACTGCACGTAATT
TAGCAGTTAAATCAACAAAAACAATTGGGGTGATATTACCTTCTTCTGCAGATAAATCATTACAAAACCCATTTTTCTCA
GAAATATTACGAGGAATTGGATCTGTTACACATAAACTTCAATATTCTATGATGCTTTCCTCTGGTCAAACAGAAGAAGA
GATTTATGCTGAAGTACAAAGAATTGTATTAGGGAGTTATGTAGACGGAATTATATTGTTATATTCTCGTTTGAATGATC
GGGTAACTCAATTCCTAGTGGAAAAAGGCTTCCCATTTGTAATTGTAGGTAAACCTCAAGAGCTTAATGATAGAATCACA
TATGTAGATAATGATAACATTCAGGCTGGAGAAGATATCACTTCCCATTTAATTGAGACTGGTCACAATCGAATCGCTTT
TATTGGTGGCGCAAAAGATTTAGTCGTTACTATAGATCGTATGCAAGGTTATACTAATGCACTTAAAAAAGCGGATATAC
CAATATTAGAAGAGTATCTAATTCATACAGAGTTTTTAAAATCTGGTGGAAAAGAAGCAGTGGAAAAAATTCTTCGTTTA
CCTGAGAGACCTGATGCAGTCGTAGTAAGTGATGATTTAATTAGTATTGGTGTAATTGGAATGTTAGAAGAGTCGGGATT
AAGTGTACCAGAGGATATTTCCTTAGTAAGTTTTAATAACGCTTATCTTTCAGAAATAATTCATCCTGCTTTAACAACGA
TAGATATTCAAATCTATAAACTTGGCGTAGAATCAGCAAAGGCTATTATCGAAAAAAAAATTGGGATAGATGATCCGAAA
CGAATCATTATTCCGCATTATATTATCTATCGAGATTCTGTAAAAAGAAATTCATAA

Upstream 100 bases:

>100_bases
AACGTTATCTCATATCAGGGTTAGCAGCAGGTGGAACAAAAGGGTAGAATAGAGTAATATACGAAGTATATGTTGTAAAT
AACAGCTAGAAGGTGAAAGA

Downstream 100 bases:

>100_bases
AAGAATAGTTGAAAGAAGGGGGGTGTATGCACTCTCCATTTTTTTCGCAGTACTGGGGAGTAATATCCCATTTTAAGACA
ATGCGTATTAAGGAAAGAAG

Product: transcriptional regulator

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MVTIKDIAKATGVSPSTVSRVIADNSRISEETKAKVRKAMEDLGYFPNMTARNLAVKSTKTIGVILPSSADKSLQNPFFS
EILRGIGSVTHKLQYSMMLSSGQTEEEIYAEVQRIVLGSYVDGIILLYSRLNDRVTQFLVEKGFPFVIVGKPQELNDRIT
YVDNDNIQAGEDITSHLIETGHNRIAFIGGAKDLVVTIDRMQGYTNALKKADIPILEEYLIHTEFLKSGGKEAVEKILRL
PERPDAVVVSDDLISIGVIGMLEESGLSVPEDISLVSFNNAYLSEIIHPALTTIDIQIYKLGVESAKAIIEKKIGIDDPK
RIIIPHYIIYRDSVKRNS

Sequences:

>Translated_338_residues
MVTIKDIAKATGVSPSTVSRVIADNSRISEETKAKVRKAMEDLGYFPNMTARNLAVKSTKTIGVILPSSADKSLQNPFFS
EILRGIGSVTHKLQYSMMLSSGQTEEEIYAEVQRIVLGSYVDGIILLYSRLNDRVTQFLVEKGFPFVIVGKPQELNDRIT
YVDNDNIQAGEDITSHLIETGHNRIAFIGGAKDLVVTIDRMQGYTNALKKADIPILEEYLIHTEFLKSGGKEAVEKILRL
PERPDAVVVSDDLISIGVIGMLEESGLSVPEDISLVSFNNAYLSEIIHPALTTIDIQIYKLGVESAKAIIEKKIGIDDPK
RIIIPHYIIYRDSVKRNS
>Mature_338_residues
MVTIKDIAKATGVSPSTVSRVIADNSRISEETKAKVRKAMEDLGYFPNMTARNLAVKSTKTIGVILPSSADKSLQNPFFS
EILRGIGSVTHKLQYSMMLSSGQTEEEIYAEVQRIVLGSYVDGIILLYSRLNDRVTQFLVEKGFPFVIVGKPQELNDRIT
YVDNDNIQAGEDITSHLIETGHNRIAFIGGAKDLVVTIDRMQGYTNALKKADIPILEEYLIHTEFLKSGGKEAVEKILRL
PERPDAVVVSDDLISIGVIGMLEESGLSVPEDISLVSFNNAYLSEIIHPALTTIDIQIYKLGVESAKAIIEKKIGIDDPK
RIIIPHYIIYRDSVKRNS

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=314, Percent_Identity=30.2547770700637, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790194, Length=300, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=29.483282674772, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1787948, Length=336, Percent_Identity=29.1666666666667, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789068, Length=303, Percent_Identity=30.03300330033, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789202, Length=306, Percent_Identity=28.4313725490196, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787906, Length=339, Percent_Identity=28.6135693215339, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI48994940, Length=314, Percent_Identity=27.7070063694268, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788474, Length=324, Percent_Identity=25, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790715, Length=333, Percent_Identity=27.027027027027, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789456, Length=344, Percent_Identity=26.453488372093, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790689, Length=330, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786268, Length=291, Percent_Identity=22.3367697594502, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37437; Mature: 37437

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIKDIAKATGVSPSTVSRVIADNSRISEETKAKVRKAMEDLGYFPNMTARNLAVKSTK
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
TIGVILPSSADKSLQNPFFSEILRGIGSVTHKLQYSMMLSSGQTEEEIYAEVQRIVLGSY
EEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VDGIILLYSRLNDRVTQFLVEKGFPFVIVGKPQELNDRITYVDNDNIQAGEDITSHLIET
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHC
GHNRIAFIGGAKDLVVTIDRMQGYTNALKKADIPILEEYLIHTEFLKSGGKEAVEKILRL
CCCEEEEEECCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
PERPDAVVVSDDLISIGVIGMLEESGLSVPEDISLVSFNNAYLSEIIHPALTTIDIQIYK
CCCCCEEEEECCHHHHHHHEEEHHCCCCCCCCCEEEEECHHHHHHHHHHHHHEEEEEEEE
LGVESAKAIIEKKIGIDDPKRIIIPHYIIYRDSVKRNS
ECHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCCC
>Mature Secondary Structure
MVTIKDIAKATGVSPSTVSRVIADNSRISEETKAKVRKAMEDLGYFPNMTARNLAVKSTK
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
TIGVILPSSADKSLQNPFFSEILRGIGSVTHKLQYSMMLSSGQTEEEIYAEVQRIVLGSY
EEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VDGIILLYSRLNDRVTQFLVEKGFPFVIVGKPQELNDRITYVDNDNIQAGEDITSHLIET
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHC
GHNRIAFIGGAKDLVVTIDRMQGYTNALKKADIPILEEYLIHTEFLKSGGKEAVEKILRL
CCCEEEEEECCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
PERPDAVVVSDDLISIGVIGMLEESGLSVPEDISLVSFNNAYLSEIIHPALTTIDIQIYK
CCCCCEEEEECCHHHHHHHEEEHHCCCCCCCCCEEEEECHHHHHHHHHHHHHEEEEEEEE
LGVESAKAIIEKKIGIDDPKRIIIPHYIIYRDSVKRNS
ECHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]