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The map label for this gene is ctpB [H]

Identifier: 23099945

GI number: 23099945

Start: 2548145

End: 2549611

Strand: Reverse

Name: ctpB [H]

Synonym: OB2490

Alternate gene names: 23099945

Gene position: 2549611-2548145 (Counterclockwise)

Preceding gene: 23099946

Following gene: 23099944

Centisome position: 70.23

GC content: 36.2

Gene sequence:

>1467_bases
ATGAAGCTTAGTAAGAAACAAATAGTGCTTATACTTGTGGGCGCTTTGCTATTAGGTTTTGCAGGTGCATATGGAGGATT
TCAACTAGCACAAGATAATAATCAACAATCATCACAATCTTCTGTTGAAAATTCTTCGACGAATGAAGATGACAGTAATG
GACAGTCTGAGTTGACCGGAGATTTAAGTAAAGTCTCTCAAGCCTATGATATTATTAAAGAAAATTACTTAGAAGATGTA
GAAGATAAACAATTAGTCGAAGGTGCAATCGAAGGAATGTTGGCAACTCTAGAGGACCAACATACATCTTATTTAGATGT
TGAGATGATGCAACAGTTTAATGAACAAATCGAATCCTCTTTTGAAGGAATTGGAGCAGAAGTTAGTATGGTGAATGGCA
ATGTCACTATTGTTTCTCCAATGAAAGGATCTCCAGCAGAAGAATCGGGTTTACGACCAAATGACCAAGTGTTAAAAGTA
GATGGAGAAAGTCTAGAAGGATTAAATTTAAATGAAGCTGTAGCACAAATTAGAGGTGAAAAGGGTTCAGAAGTTGTTCT
AGAGATACAAAGATCAGGTGTTACTGAACCATTTGAAGTAACAATTGTACGAGATACAATACCTGTAGAAACTGTATATA
GTGAAACAAAAGAAGTAGATGGTAAATTGACAGGAATTATCGAAATCACTAATTTCTCTGAAAAAACCGGAGATGAATTT
GATCAACAATTAACTGAACTAGAGAATCAAGGAATAGAAGGATTAGTTATTGATGTCCGTGGTAATCCAGGTGGGCTGTT
AAATGTAGCAGAAGATATTCTAAAACATTTAGTACCAAAAGATCTTCCAATCCTGCAAATTGAAGATGGAGAGGGACAAG
TAGAGGAAGTATATTCAGATTTAGAAGAGAAAAAAGAGTACCCTATTAGTGTTATGATTGACGAAGGAAGTGCGTCAGCT
TCTGAGATTCTTGCAGTTGCTATGAAGGATCTTGGGTATGATATAGTCGGTGAAACTAGTTACGGAAAAGGTACAGTTCA
ACAAGCTGTTCCAATGGGGGACGGAAGCTCTATTAAGTTAACCACATTAAAATGGCTTTCCCCTAAAGGTGAATGGATAA
ATGAAGAAGGTGTTGAGCCTACTATCGAGGAGAAACAACCAGAATATTATTATTCTATACCGATCCAAGTAGAAGAACCG
TTCTCTTTAGATGAGACTAGTGAGGAAATTGCTAATATGCAAGTAATGTTAACTGGATTAGGCTATGATACTGGCCGTAC
AGATGGATATTTTGATGAACAGACCGCAGAAGCAGTAAAAGATTTTCAAGCAGATAATGATTTAGAAGCTACTGGGGAAG
TAGATTCAGAAACTGGTGGATTAATTGAAACACAACTCGTTGAAAAGATTAGAAACGGTGAAGATGATCAACAACTGGAT
ACTTCATTAGAAGAATTGTATCAATAA

Upstream 100 bases:

>100_bases
TTAACATGGTATCCTTTTCTTATTGAAGTATTTTCATATCTGAATAAATATTAATATAGAAACAAGCGGGTGCTTGTACT
ATTAACTAAGAGGTGGAGAC

Downstream 100 bases:

>100_bases
ATTAAGACGCCATTTGTAAGGGTCTAGTCTTAAAGTGAGGACTTTTACCGTAAGATTGCTCACTTGGATAAATTCTGTTC
TTAAGATAAATCCACGAGTG

Product: carboxy-terminal processing protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKLSKKQIVLILVGALLLGFAGAYGGFQLAQDNNQQSSQSSVENSSTNEDDSNGQSELTGDLSKVSQAYDIIKENYLEDV
EDKQLVEGAIEGMLATLEDQHTSYLDVEMMQQFNEQIESSFEGIGAEVSMVNGNVTIVSPMKGSPAEESGLRPNDQVLKV
DGESLEGLNLNEAVAQIRGEKGSEVVLEIQRSGVTEPFEVTIVRDTIPVETVYSETKEVDGKLTGIIEITNFSEKTGDEF
DQQLTELENQGIEGLVIDVRGNPGGLLNVAEDILKHLVPKDLPILQIEDGEGQVEEVYSDLEEKKEYPISVMIDEGSASA
SEILAVAMKDLGYDIVGETSYGKGTVQQAVPMGDGSSIKLTTLKWLSPKGEWINEEGVEPTIEEKQPEYYYSIPIQVEEP
FSLDETSEEIANMQVMLTGLGYDTGRTDGYFDEQTAEAVKDFQADNDLEATGEVDSETGGLIETQLVEKIRNGEDDQQLD
TSLEELYQ

Sequences:

>Translated_488_residues
MKLSKKQIVLILVGALLLGFAGAYGGFQLAQDNNQQSSQSSVENSSTNEDDSNGQSELTGDLSKVSQAYDIIKENYLEDV
EDKQLVEGAIEGMLATLEDQHTSYLDVEMMQQFNEQIESSFEGIGAEVSMVNGNVTIVSPMKGSPAEESGLRPNDQVLKV
DGESLEGLNLNEAVAQIRGEKGSEVVLEIQRSGVTEPFEVTIVRDTIPVETVYSETKEVDGKLTGIIEITNFSEKTGDEF
DQQLTELENQGIEGLVIDVRGNPGGLLNVAEDILKHLVPKDLPILQIEDGEGQVEEVYSDLEEKKEYPISVMIDEGSASA
SEILAVAMKDLGYDIVGETSYGKGTVQQAVPMGDGSSIKLTTLKWLSPKGEWINEEGVEPTIEEKQPEYYYSIPIQVEEP
FSLDETSEEIANMQVMLTGLGYDTGRTDGYFDEQTAEAVKDFQADNDLEATGEVDSETGGLIETQLVEKIRNGEDDQQLD
TSLEELYQ
>Mature_488_residues
MKLSKKQIVLILVGALLLGFAGAYGGFQLAQDNNQQSSQSSVENSSTNEDDSNGQSELTGDLSKVSQAYDIIKENYLEDV
EDKQLVEGAIEGMLATLEDQHTSYLDVEMMQQFNEQIESSFEGIGAEVSMVNGNVTIVSPMKGSPAEESGLRPNDQVLKV
DGESLEGLNLNEAVAQIRGEKGSEVVLEIQRSGVTEPFEVTIVRDTIPVETVYSETKEVDGKLTGIIEITNFSEKTGDEF
DQQLTELENQGIEGLVIDVRGNPGGLLNVAEDILKHLVPKDLPILQIEDGEGQVEEVYSDLEEKKEYPISVMIDEGSASA
SEILAVAMKDLGYDIVGETSYGKGTVQQAVPMGDGSSIKLTTLKWLSPKGEWINEEGVEPTIEEKQPEYYYSIPIQVEEP
FSLDETSEEIANMQVMLTGLGYDTGRTDGYFDEQTAEAVKDFQADNDLEATGEVDSETGGLIETQLVEKIRNGEDDQQLD
TSLEELYQ

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=262, Percent_Identity=38.1679389312977, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 53406; Mature: 53406

Theoretical pI: Translated: 3.72; Mature: 3.72

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSKKQIVLILVGALLLGFAGAYGGFQLAQDNNQQSSQSSVENSSTNEDDSNGQSELTG
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
DLSKVSQAYDIIKENYLEDVEDKQLVEGAIEGMLATLEDQHTSYLDVEMMQQFNEQIESS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHH
FEGIGAEVSMVNGNVTIVSPMKGSPAEESGLRPNDQVLKVDGESLEGLNLNEAVAQIRGE
HHCCCCEEEEECCCEEEEECCCCCCCHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCC
KGSEVVLEIQRSGVTEPFEVTIVRDTIPVETVYSETKEVDGKLTGIIEITNFSEKTGDEF
CCCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHH
DQQLTELENQGIEGLVIDVRGNPGGLLNVAEDILKHLVPKDLPILQIEDGEGQVEEVYSD
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LEEKKEYPISVMIDEGSASASEILAVAMKDLGYDIVGETSYGKGTVQQAVPMGDGSSIKL
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCEEEE
TTLKWLSPKGEWINEEGVEPTIEEKQPEYYYSIPIQVEEPFSLDETSEEIANMQVMLTGL
EEEEEECCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCHHHHHHHCEEEEEEEC
GYDTGRTDGYFDEQTAEAVKDFQADNDLEATGEVDSETGGLIETQLVEKIRNGEDDQQLD
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
TSLEELYQ
HHHHHHCC
>Mature Secondary Structure
MKLSKKQIVLILVGALLLGFAGAYGGFQLAQDNNQQSSQSSVENSSTNEDDSNGQSELTG
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
DLSKVSQAYDIIKENYLEDVEDKQLVEGAIEGMLATLEDQHTSYLDVEMMQQFNEQIESS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHH
FEGIGAEVSMVNGNVTIVSPMKGSPAEESGLRPNDQVLKVDGESLEGLNLNEAVAQIRGE
HHCCCCEEEEECCCEEEEECCCCCCCHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCC
KGSEVVLEIQRSGVTEPFEVTIVRDTIPVETVYSETKEVDGKLTGIIEITNFSEKTGDEF
CCCEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHH
DQQLTELENQGIEGLVIDVRGNPGGLLNVAEDILKHLVPKDLPILQIEDGEGQVEEVYSD
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LEEKKEYPISVMIDEGSASASEILAVAMKDLGYDIVGETSYGKGTVQQAVPMGDGSSIKL
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCEEEE
TTLKWLSPKGEWINEEGVEPTIEEKQPEYYYSIPIQVEEPFSLDETSEEIANMQVMLTGL
EEEEEECCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCHHHHHHHCEEEEEEEC
GYDTGRTDGYFDEQTAEAVKDFQADNDLEATGEVDSETGGLIETQLVEKIRNGEDDQQLD
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
TSLEELYQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]