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The map label for this gene is mutS2

Identifier: 23099579

GI number: 23099579

Start: 2157583

End: 2159931

Strand: Reverse

Name: mutS2

Synonym: OB2124

Alternate gene names: 23099579

Gene position: 2159931-2157583 (Counterclockwise)

Preceding gene: 23099580

Following gene: 23099578

Centisome position: 59.49

GC content: 36.99

Gene sequence:

>2349_bases
ATGAATGAACGTGTATTACGTGTACTAGATTTCAAATCAGTAACTGAAATGTTAAAAGGACAAGCAGAAACAGCTTTAGG
TAAAGAAAGAGCAAAGATTACCAAGCCTCTTTCTTCTTTAGATAAAATAAATATGTTACAAGACGAAACAGATGAAGCTG
CAAAAATCATTAGGTTAAATCAAGCGATTCCTTTAGGAGGAATAACAGATATTAGGGCTAGTGTAAAACGTAGCTCGATA
GGTGGGATTCTTTCTACAGATGAATGTTTAGATGTTGCTAATACTTTATACGGAAGTAGAAATGTTAAAAATACAATTGA
AAATATGGAAGAGCTAGATATTCCTATTTTGAAAGAGCTAGTGGAACATATTACTCCTATACGTGAACTGGAACAGGCAA
TAAAAAGCTGTATCGATGATCATGGTCATATTATGGATGGAGCTTCTAGTCAATTAAGATCGATTCGTAGTTCCATTCGT
ACATTAGAGAGTAGGATTCGAGAAAAGCTAGAAAATTATACAAGAAGCAATAGTAAGATGCTCTCTGATGCAATTATAAC
TATAAGAAATGATCGCTATGTATTACCAGTAAAGCAAGAGTATCGTGGAGCTATTGGAGGGATTGTACATGATCAATCCG
CTTCTGGCCAAACACTGTTTATGGAACCAAAGGCAGTTGTTGACATCAACAACAGTCTTCATGAATCAAAGTCGAAAGAG
CAATTAGAAATTGAACGCATCTTAAAAGACTTGAGTAATCAGGTTGCTTCTTATGAACAGGATTTACTAGAAAATGTAAA
AGTATTAACAAATATTGATTTCATCTATGCTCGTGGGAAGTTAGCACAAGCAATGAAAGCATCACGTCCTAAAATGAACG
ATGAAGGATATATGAAGATGCAACAGGCTAGGCATCCAATGATCCCTATCGATGAAGTTGTAGCCAACGATATCGAATTT
GGCAGAGAGTATACCTCAATTGTTATTACTGGTCCTAATACAGGGGGGAAAACAGTAACCCTTAAATTAGTTGGACTTTG
TACATTAATGGCCCAATCAGGACTACAAGTTCCAGCACTAGATGGGTGTGAAATGCCAGTATTTGATGAAGTCTTTGCCG
ATATTGGTGACGAGCAATCAATTGAACAGAATTTAAGTACATTTTCTTCCCATATGACGAATATAGTCGATATTATGAAA
AAAATCACTGACCGTTCTCTTGTATTGTTTGATGAATTAGGATCAGGTACAGACCCGCAAGAAGGTGCTGCGTTAGCAAT
GGCAATATTGGATGAGGTAATCTCTAAGCAAGCACGTGTGATTGCGACAACACACTATCCTGAGTTAAAAGCATATGGTT
ATAATCGTGAACAAGTAGTGAATGCATCTGTTGAGTTTAACGTAGAGACTTTAAAGCCTACTTATCGCTTATTAATTGGT
GTGCCTGGACGGAGTAATGCATTCGATATTTCAACAAGGCTTGGCCTCGAACGAGCTACTATTGAAAGAGCCAAAAGCTT
AATCGGTGTAGATTCGAAGAGTGTGGAGAATATGATTGCCTCTTTAGAAAAGTCACATCTTGAGGCAGAACAGGATTATG
AACAAGCACATGATGTATTATTAGAATCAGAAAAACTTCGAAATGCATTAGAACATGAATGGAACCTTTTTGAACAGAAA
AAAGAAAAATTATATAAAAAAGCAGAAGAAAAAGCAGAGAAAGCGATTCAGAAGGCAAGAGAAGAAGCGGAGACTATTGT
TTCCGAAATGCGTCAGATGAAAGACTCTGCAGGGTTGAAGGAACATGAGTGGATCGAAGCAAGAAAAATGCTTGATGAAG
CTAAACCAAACTTAACCAAGAATGGTAATCAAAAACAAGTTGATCCGAAACCAGTGGAAGATAGACAACTTCAGCCAGGT
GATGAAATTAAATTACTAACGGTTAATCAAATGGGTGAAGTGTTAGAAAGAGTTAGTGATAAAGAATATTTAGTTCAGGT
TGGGATTATGAAAGTAAAAGTGAAACGAAAAGATCTGGAATTAATACGAAAACCAAAAAAGAAACAAGTGGATCCAGTAA
CTACAATCAAGGGTTCTAATTATCATGTTAGTACTGAACTGGATTTACGTGGTGAAAGATATGAAGATGCTATCCTCCGC
TTGGAGAAGTATGTAGATGATGTATTATTAGCAGGTTATCCAAAAGCATCGATCATACACGGTAAAGGAACGGGCGCCTT
ACGAAAAGGCGTACAAGAATTTGTAGGGAGACATCCACGGATAAAAGGTGCGCGACCTGGTGAATCAGGTGAAGGTGGTA
GTGGAGTAACTGTCATTCAATTAGGTTAA

Upstream 100 bases:

>100_bases
CAACTGTAATAAACAGTTGGACGAAAGAAGAGGTAGAGCGCTACTTTAACCGAGGTAAGTAAGTGCCCTTGGATGGACTT
AGCTAAAAGGGGTTTTTAAA

Downstream 100 bases:

>100_bases
TTTACTGTACTGAGACAAAACGAGCTTTTACTATTTCGTTAAACAAAATCACGTAAAGTTATAAGTTATCGTTTTGTCTC
AATTTTATTATACATAAGAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MNERVLRVLDFKSVTEMLKGQAETALGKERAKITKPLSSLDKINMLQDETDEAAKIIRLNQAIPLGGITDIRASVKRSSI
GGILSTDECLDVANTLYGSRNVKNTIENMEELDIPILKELVEHITPIRELEQAIKSCIDDHGHIMDGASSQLRSIRSSIR
TLESRIREKLENYTRSNSKMLSDAIITIRNDRYVLPVKQEYRGAIGGIVHDQSASGQTLFMEPKAVVDINNSLHESKSKE
QLEIERILKDLSNQVASYEQDLLENVKVLTNIDFIYARGKLAQAMKASRPKMNDEGYMKMQQARHPMIPIDEVVANDIEF
GREYTSIVITGPNTGGKTVTLKLVGLCTLMAQSGLQVPALDGCEMPVFDEVFADIGDEQSIEQNLSTFSSHMTNIVDIMK
KITDRSLVLFDELGSGTDPQEGAALAMAILDEVISKQARVIATTHYPELKAYGYNREQVVNASVEFNVETLKPTYRLLIG
VPGRSNAFDISTRLGLERATIERAKSLIGVDSKSVENMIASLEKSHLEAEQDYEQAHDVLLESEKLRNALEHEWNLFEQK
KEKLYKKAEEKAEKAIQKAREEAETIVSEMRQMKDSAGLKEHEWIEARKMLDEAKPNLTKNGNQKQVDPKPVEDRQLQPG
DEIKLLTVNQMGEVLERVSDKEYLVQVGIMKVKVKRKDLELIRKPKKKQVDPVTTIKGSNYHVSTELDLRGERYEDAILR
LEKYVDDVLLAGYPKASIIHGKGTGALRKGVQEFVGRHPRIKGARPGESGEGGSGVTVIQLG

Sequences:

>Translated_782_residues
MNERVLRVLDFKSVTEMLKGQAETALGKERAKITKPLSSLDKINMLQDETDEAAKIIRLNQAIPLGGITDIRASVKRSSI
GGILSTDECLDVANTLYGSRNVKNTIENMEELDIPILKELVEHITPIRELEQAIKSCIDDHGHIMDGASSQLRSIRSSIR
TLESRIREKLENYTRSNSKMLSDAIITIRNDRYVLPVKQEYRGAIGGIVHDQSASGQTLFMEPKAVVDINNSLHESKSKE
QLEIERILKDLSNQVASYEQDLLENVKVLTNIDFIYARGKLAQAMKASRPKMNDEGYMKMQQARHPMIPIDEVVANDIEF
GREYTSIVITGPNTGGKTVTLKLVGLCTLMAQSGLQVPALDGCEMPVFDEVFADIGDEQSIEQNLSTFSSHMTNIVDIMK
KITDRSLVLFDELGSGTDPQEGAALAMAILDEVISKQARVIATTHYPELKAYGYNREQVVNASVEFNVETLKPTYRLLIG
VPGRSNAFDISTRLGLERATIERAKSLIGVDSKSVENMIASLEKSHLEAEQDYEQAHDVLLESEKLRNALEHEWNLFEQK
KEKLYKKAEEKAEKAIQKAREEAETIVSEMRQMKDSAGLKEHEWIEARKMLDEAKPNLTKNGNQKQVDPKPVEDRQLQPG
DEIKLLTVNQMGEVLERVSDKEYLVQVGIMKVKVKRKDLELIRKPKKKQVDPVTTIKGSNYHVSTELDLRGERYEDAILR
LEKYVDDVLLAGYPKASIIHGKGTGALRKGVQEFVGRHPRIKGARPGESGEGGSGVTVIQLG
>Mature_782_residues
MNERVLRVLDFKSVTEMLKGQAETALGKERAKITKPLSSLDKINMLQDETDEAAKIIRLNQAIPLGGITDIRASVKRSSI
GGILSTDECLDVANTLYGSRNVKNTIENMEELDIPILKELVEHITPIRELEQAIKSCIDDHGHIMDGASSQLRSIRSSIR
TLESRIREKLENYTRSNSKMLSDAIITIRNDRYVLPVKQEYRGAIGGIVHDQSASGQTLFMEPKAVVDINNSLHESKSKE
QLEIERILKDLSNQVASYEQDLLENVKVLTNIDFIYARGKLAQAMKASRPKMNDEGYMKMQQARHPMIPIDEVVANDIEF
GREYTSIVITGPNTGGKTVTLKLVGLCTLMAQSGLQVPALDGCEMPVFDEVFADIGDEQSIEQNLSTFSSHMTNIVDIMK
KITDRSLVLFDELGSGTDPQEGAALAMAILDEVISKQARVIATTHYPELKAYGYNREQVVNASVEFNVETLKPTYRLLIG
VPGRSNAFDISTRLGLERATIERAKSLIGVDSKSVENMIASLEKSHLEAEQDYEQAHDVLLESEKLRNALEHEWNLFEQK
KEKLYKKAEEKAEKAIQKAREEAETIVSEMRQMKDSAGLKEHEWIEARKMLDEAKPNLTKNGNQKQVDPKPVEDRQLQPG
DEIKLLTVNQMGEVLERVSDKEYLVQVGIMKVKVKRKDLELIRKPKKKQVDPVTTIKGSNYHVSTELDLRGERYEDAILR
LEKYVDDVLLAGYPKASIIHGKGTGALRKGVQEFVGRHPRIKGARPGESGEGGSGVTVIQLG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=351, Percent_Identity=29.3447293447293, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI36949366, Length=419, Percent_Identity=24.582338902148, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4504191, Length=231, Percent_Identity=30.3030303030303, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI4557761, Length=324, Percent_Identity=28.0864197530864, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI26638666, Length=194, Percent_Identity=32.4742268041237, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4505253, Length=194, Percent_Identity=32.4742268041237, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI26638664, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI262231786, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1789089, Length=276, Percent_Identity=26.4492753623188, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=266, Percent_Identity=25.5639097744361, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=322, Percent_Identity=26.0869565217391, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508447, Length=269, Percent_Identity=26.0223048327138, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=363, Percent_Identity=22.8650137741047, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=295, Percent_Identity=27.4576271186441, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=498, Percent_Identity=24.6987951807229, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=271, Percent_Identity=29.520295202952, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321912, Length=254, Percent_Identity=26.3779527559055, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321109, Length=153, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320047, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664545, Length=287, Percent_Identity=27.5261324041812, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24584320, Length=169, Percent_Identity=34.9112426035503, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_OCEIH (Q8EPI1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693045.1
- HSSP:   Q56215
- ProteinModelPortal:   Q8EPI1
- SMR:   Q8EPI1
- GeneID:   1016274
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2124
- NMPDR:   fig|221109.1.peg.2122
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- BioCyc:   OIHE221109:OB2124-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 87510; Mature: 87510

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERVLRVLDFKSVTEMLKGQAETALGKERAKITKPLSSLDKINMLQDETDEAAKIIRLN
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
QAIPLGGITDIRASVKRSSIGGILSTDECLDVANTLYGSRNVKNTIENMEELDIPILKEL
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
VEHITPIRELEQAIKSCIDDHGHIMDGASSQLRSIRSSIRTLESRIREKLENYTRSNSKM
HHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LSDAIITIRNDRYVLPVKQEYRGAIGGIVHDQSASGQTLFMEPKAVVDINNSLHESKSKE
HHHHEEEEECCEEEEECHHHHCHHHCCCEECCCCCCCEEEECCCEEEECCHHHHHCCCHH
QLEIERILKDLSNQVASYEQDLLENVKVLTNIDFIYARGKLAQAMKASRPKMNDEGYMKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECHHHHHHHHHCCCCCCCCHHHHH
QQARHPMIPIDEVVANDIEFGREYTSIVITGPNTGGKTVTLKLVGLCTLMAQSGLQVPAL
HHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCCCC
DGCEMPVFDEVFADIGDEQSIEQNLSTFSSHMTNIVDIMKKITDRSLVLFDELGSGTDPQ
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
EGAALAMAILDEVISKQARVIATTHYPELKAYGYNREQVVNASVEFNVETLKPTYRLLIG
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEECEEEEEEHHHCCEEEEEEE
VPGRSNAFDISTRLGLERATIERAKSLIGVDSKSVENMIASLEKSHLEAEQDYEQAHDVL
CCCCCCCEEHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESEKLRNALEHEWNLFEQKKEKLYKKAEEKAEKAIQKAREEAETIVSEMRQMKDSAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EHEWIEARKMLDEAKPNLTKNGNQKQVDPKPVEDRQLQPGDEIKLLTVNQMGEVLERVSD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCC
KEYLVQVGIMKVKVKRKDLELIRKPKKKQVDPVTTIKGSNYHVSTELDLRGERYEDAILR
HHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHH
LEKYVDDVLLAGYPKASIIHGKGTGALRKGVQEFVGRHPRIKGARPGESGEGGSGVTVIQ
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
LG
EC
>Mature Secondary Structure
MNERVLRVLDFKSVTEMLKGQAETALGKERAKITKPLSSLDKINMLQDETDEAAKIIRLN
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
QAIPLGGITDIRASVKRSSIGGILSTDECLDVANTLYGSRNVKNTIENMEELDIPILKEL
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
VEHITPIRELEQAIKSCIDDHGHIMDGASSQLRSIRSSIRTLESRIREKLENYTRSNSKM
HHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LSDAIITIRNDRYVLPVKQEYRGAIGGIVHDQSASGQTLFMEPKAVVDINNSLHESKSKE
HHHHEEEEECCEEEEECHHHHCHHHCCCEECCCCCCCEEEECCCEEEECCHHHHHCCCHH
QLEIERILKDLSNQVASYEQDLLENVKVLTNIDFIYARGKLAQAMKASRPKMNDEGYMKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECHHHHHHHHHCCCCCCCCHHHHH
QQARHPMIPIDEVVANDIEFGREYTSIVITGPNTGGKTVTLKLVGLCTLMAQSGLQVPAL
HHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCCCC
DGCEMPVFDEVFADIGDEQSIEQNLSTFSSHMTNIVDIMKKITDRSLVLFDELGSGTDPQ
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
EGAALAMAILDEVISKQARVIATTHYPELKAYGYNREQVVNASVEFNVETLKPTYRLLIG
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEECEEEEEEHHHCCEEEEEEE
VPGRSNAFDISTRLGLERATIERAKSLIGVDSKSVENMIASLEKSHLEAEQDYEQAHDVL
CCCCCCCEEHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESEKLRNALEHEWNLFEQKKEKLYKKAEEKAEKAIQKAREEAETIVSEMRQMKDSAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EHEWIEARKMLDEAKPNLTKNGNQKQVDPKPVEDRQLQPGDEIKLLTVNQMGEVLERVSD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCC
KEYLVQVGIMKVKVKRKDLELIRKPKKKQVDPVTTIKGSNYHVSTELDLRGERYEDAILR
HHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHH
LEKYVDDVLLAGYPKASIIHGKGTGALRKGVQEFVGRHPRIKGARPGESGEGGSGVTVIQ
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
LG
EC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376