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The map label for this gene is obgE

Identifier: 23099497

GI number: 23099497

Start: 2070450

End: 2071730

Strand: Reverse

Name: obgE

Synonym: OB2042

Alternate gene names: 23099497

Gene position: 2071730-2070450 (Counterclockwise)

Preceding gene: 23099498

Following gene: 23099496

Centisome position: 57.06

GC content: 37.63

Gene sequence:

>1281_bases
ATGTTTGTCGATCAAGTAAGTGTATATGTAAAAGCTGGGGATGGAGGTAATGGCCTTGTAGCATATCGTAGAGAGAAATA
TGTTCCTAAAGGCGGCCCGGCTGGTGGAGACGGCGGTAATGGTTCAAATGTTGTATTTAAAGTAGATGAAGGATTAAATA
CATTAATGGAATTTCGTTATAACCGTCATTTTAAAGGTAAGCGTGGAGAAAATGGAATGAGCAAAACACAGCATGGGAGA
AATGCTGATCCATTAGTAATTCCTGTACCCCCTGGTACGACTGTTATTGATGAAGATACAGGAGAAGTAATTGCTGATCT
TACAAAACACGAACAAGAAGCTGTTATTGTTAAAGGTGGTCGAGGAGGTCGTGGTAATACACGATTTGCAACACCTAGAA
ATCCTGCACCAGATATGGCAGAGAACGGTGAACCAGGTCAAGAAAGAAATATAAAGGTAGAATTGAAATTAATTGCGGAT
GTAGGTCTTGTAGGCTTCCCAAGTGTTGGTAAGTCAACTTTACTGTCTGTGGTTAGTGCCGCAAAGCCGAAGATTGCTGA
TTATCATTTTACAACATTATCACCAAACTTAGGTGTTGTTGACACTCAGGATTCGCGGAGTTTTGTTTTGGCAGACTTGC
CAGGTTTAATTGAAGGGGCATCACAAGGAATAGGCCTAGGGCATCAATTTTTAAGACATATTGAACGAACAAGAGTTATT
CTACACGTTATCGATATGGCAGGAACAGAAGGTAGAGATCCATATGAAGATTATAAAAAGATTAATCAAGAATTAAGCGA
TTATGATGAAAAACTTATGGATCGTCCGCAAATTATTGCAGCGAATAAAATGGACATGCCAAATGCACAAGAAAATCTCA
TTCAGTTTAAAAATGAGTTAGAAGACGATATACCTGTGTATGAAATATCTGCTTTAACGAAGGATGGGTTAAGAGACCTT
TTATTTGCTATAGCTGATAAACTAGAAACAATTCCAAAGTATGAAAAAGAATTAGAAGAAACAGACGATACTGTTGTTTA
CAGATATCAAAAAGAAGAAGATCCTTTCCATATTACAAGAGATCCAGATGGTGCATTTGTATTATATGGACAACGTATAG
AGAAATTATTTAAGATGACTGATTTTCAACATGATGAAGCCGTACAACGCTTTGCTAGACAACTACGTGGAATGGGTGTA
GATAAAGCTTTACGTGAAAAAGGAGCCCAAGACGGGGATGTTGTCAGATTGCTTGAGTATGAATTTGAATTTATAGAGTA
A

Upstream 100 bases:

>100_bases
ACGTTTTGCAAAGTAATTTAGGAAATGTACAAATCGAACGATTTAATGACCGGTTGCAATTCGTATTCTCGCTAATTAGA
GAATAATGAGGTGAAATAAA

Downstream 100 bases:

>100_bases
CTATGATGCAACAGTAGCTGCAAGGGGGAAGTAAAGTGACAAGTATAGGGTATTTAGGACCAAAAGGAACATTTACTAAA
ATGGCAGTAGATTCAGTCTT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MFVDQVSVYVKAGDGGNGLVAYRREKYVPKGGPAGGDGGNGSNVVFKVDEGLNTLMEFRYNRHFKGKRGENGMSKTQHGR
NADPLVIPVPPGTTVIDEDTGEVIADLTKHEQEAVIVKGGRGGRGNTRFATPRNPAPDMAENGEPGQERNIKVELKLIAD
VGLVGFPSVGKSTLLSVVSAAKPKIADYHFTTLSPNLGVVDTQDSRSFVLADLPGLIEGASQGIGLGHQFLRHIERTRVI
LHVIDMAGTEGRDPYEDYKKINQELSDYDEKLMDRPQIIAANKMDMPNAQENLIQFKNELEDDIPVYEISALTKDGLRDL
LFAIADKLETIPKYEKELEETDDTVVYRYQKEEDPFHITRDPDGAFVLYGQRIEKLFKMTDFQHDEAVQRFARQLRGMGV
DKALREKGAQDGDVVRLLEYEFEFIE

Sequences:

>Translated_426_residues
MFVDQVSVYVKAGDGGNGLVAYRREKYVPKGGPAGGDGGNGSNVVFKVDEGLNTLMEFRYNRHFKGKRGENGMSKTQHGR
NADPLVIPVPPGTTVIDEDTGEVIADLTKHEQEAVIVKGGRGGRGNTRFATPRNPAPDMAENGEPGQERNIKVELKLIAD
VGLVGFPSVGKSTLLSVVSAAKPKIADYHFTTLSPNLGVVDTQDSRSFVLADLPGLIEGASQGIGLGHQFLRHIERTRVI
LHVIDMAGTEGRDPYEDYKKINQELSDYDEKLMDRPQIIAANKMDMPNAQENLIQFKNELEDDIPVYEISALTKDGLRDL
LFAIADKLETIPKYEKELEETDDTVVYRYQKEEDPFHITRDPDGAFVLYGQRIEKLFKMTDFQHDEAVQRFARQLRGMGV
DKALREKGAQDGDVVRLLEYEFEFIE
>Mature_426_residues
MFVDQVSVYVKAGDGGNGLVAYRREKYVPKGGPAGGDGGNGSNVVFKVDEGLNTLMEFRYNRHFKGKRGENGMSKTQHGR
NADPLVIPVPPGTTVIDEDTGEVIADLTKHEQEAVIVKGGRGGRGNTRFATPRNPAPDMAENGEPGQERNIKVELKLIAD
VGLVGFPSVGKSTLLSVVSAAKPKIADYHFTTLSPNLGVVDTQDSRSFVLADLPGLIEGASQGIGLGHQFLRHIERTRVI
LHVIDMAGTEGRDPYEDYKKINQELSDYDEKLMDRPQIIAANKMDMPNAQENLIQFKNELEDDIPVYEISALTKDGLRDL
LFAIADKLETIPKYEKELEETDDTVVYRYQKEEDPFHITRDPDGAFVLYGQRIEKLFKMTDFQHDEAVQRFARQLRGMGV
DKALREKGAQDGDVVRLLEYEFEFIE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=323, Percent_Identity=42.1052631578947, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI111955139, Length=356, Percent_Identity=36.7977528089888, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI111955063, Length=248, Percent_Identity=37.0967741935484, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=39.3700787401575, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4557537, Length=87, Percent_Identity=44.8275862068966, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=32.3529411764706, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789574, Length=359, Percent_Identity=45.4038997214485, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=36.231884057971, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790615, Length=186, Percent_Identity=30.1075268817204, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=321, Percent_Identity=39.5638629283489, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=32.3624595469256, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=175, Percent_Identity=30.2857142857143, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=87, Percent_Identity=47.1264367816092, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=146, Percent_Identity=33.5616438356164, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=164, Percent_Identity=40.8536585365854, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321612, Length=92, Percent_Identity=43.4782608695652, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319281, Length=87, Percent_Identity=45.9770114942529, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129375, Length=324, Percent_Identity=39.5061728395062, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24585318, Length=309, Percent_Identity=38.1877022653722, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356473, Length=87, Percent_Identity=44.8275862068966, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17981711, Length=146, Percent_Identity=34.9315068493151, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640873, Length=191, Percent_Identity=31.413612565445, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640877, Length=191, Percent_Identity=31.413612565445, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640875, Length=191, Percent_Identity=31.413612565445, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_OCEIH (Q8EPQ0)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692963.1
- HSSP:   P20964
- ProteinModelPortal:   Q8EPQ0
- GeneID:   1015034
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2042
- NMPDR:   fig|221109.1.peg.2040
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12297
- BioCyc:   OIHE221109:OB2042-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 47444; Mature: 47444

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDQVSVYVKAGDGGNGLVAYRREKYVPKGGPAGGDGGNGSNVVFKVDEGLNTLMEFRY
CCCCEEEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
NRHFKGKRGENGMSKTQHGRNADPLVIPVPPGTTVIDEDTGEVIADLTKHEQEAVIVKGG
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEECC
RGGRGNTRFATPRNPAPDMAENGEPGQERNIKVELKLIADVGLVGFPSVGKSTLLSVVSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKPKIADYHFTTLSPNLGVVDTQDSRSFVLADLPGLIEGASQGIGLGHQFLRHIERTRVI
CCCCCCCEEEEEECCCCCEEECCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
LHVIDMAGTEGRDPYEDYKKINQELSDYDEKLMDRPQIIAANKMDMPNAQENLIQFKNEL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
EDDIPVYEISALTKDGLRDLLFAIADKLETIPKYEKELEETDDTVVYRYQKEEDPFHITR
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
DPDGAFVLYGQRIEKLFKMTDFQHDEAVQRFARQLRGMGVDKALREKGAQDGDVVRLLEY
CCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEH
EFEFIE
HHHHCC
>Mature Secondary Structure
MFVDQVSVYVKAGDGGNGLVAYRREKYVPKGGPAGGDGGNGSNVVFKVDEGLNTLMEFRY
CCCCEEEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
NRHFKGKRGENGMSKTQHGRNADPLVIPVPPGTTVIDEDTGEVIADLTKHEQEAVIVKGG
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEECC
RGGRGNTRFATPRNPAPDMAENGEPGQERNIKVELKLIADVGLVGFPSVGKSTLLSVVSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKPKIADYHFTTLSPNLGVVDTQDSRSFVLADLPGLIEGASQGIGLGHQFLRHIERTRVI
CCCCCCCEEEEEECCCCCEEECCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
LHVIDMAGTEGRDPYEDYKKINQELSDYDEKLMDRPQIIAANKMDMPNAQENLIQFKNEL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
EDDIPVYEISALTKDGLRDLLFAIADKLETIPKYEKELEETDDTVVYRYQKEEDPFHITR
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
DPDGAFVLYGQRIEKLFKMTDFQHDEAVQRFARQLRGMGVDKALREKGAQDGDVVRLLEY
CCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEH
EFEFIE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376