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The map label for this gene is ag45 [H]

Identifier: 23099485

GI number: 23099485

Start: 2059567

End: 2060862

Strand: Reverse

Name: ag45 [H]

Synonym: OB2030

Alternate gene names: 23099485

Gene position: 2060862-2059567 (Counterclockwise)

Preceding gene: 23099487

Following gene: 23099483

Centisome position: 56.76

GC content: 33.1

Gene sequence:

>1296_bases
ATGGAAATAACTCTTACAGCAATTATATTTATCGTAAGCTATATATTTATTATGACGGAGAAAATTAATCGGGCAATTAT
TGCACTTGCAGGAGGAACACTTTTAATATTAACAGGGGTTTATACGATAGATGAGGTATTTACGCAATATATTGATTGGA
ATACAATTGCCTTATTGTTTTCGATGATGGTTCTTATTTCAATCACTGAAAAAACAGGACTGTTCACTTTTATAGCAATT
CGTTTTGCTCAAAAAGTAAAAGGTAATCAGGTAGCTTTACTGATTGGTTCTGGGATTTTAACGGCTATTGGATCGGCTTT
TCTAGATAATGTAACAACTGTACTAATTTTTGTACCGATAATGATTCAAATAACGAAATTATTAAAACTACCTTTGTTTC
CCTACTTATTAATGATTATTTTTAGTTCAAATATAGGGGGTTCAGCAACCTTAATTGGTGATCCTCCGAATATAATGATT
GGACAGGCTGTAGATCATTTCACATTCCTCTCATTTTTACAGCATACAGCTCCAGTAGCAATAATCATGTTTGTTATTCA
GTTAGTATTATTGTTAGTCCTATTTCGTAAGCCTTTAAAGAATGCAAGACCAGAAGTCGAGAAAATAGTGAAATTAGATG
CAAAGGAAAAATTATTAATCTCACCTTTATTATATAAGTCGGTAAGTGTTTTATTGCTTACCATAATGGGTTTTATCCTG
CATTCCATCGTACATGTCTCCATGACTGCAATTGCATTATCAGGAGCAATACTTCTATTACTACTAACGGAGAAGGATTT
ACATACGGAGCACGTTTTTTCTAAAGTCGAGTGGGTAACATTATTTTTCTTTATTGGTTTATTTACCATTGTTGGTGGTT
TAGAACAAGTTGGTATAATTGATGAACTCGCAAGATTACTTGTTGCAACAACTGAAGGAGACTACGTAACGACTACAATT
CTTATATTATGGATGTCTGGTATATTCTCTGGATTTATTGATAATATTCCATTTGTCGCAGCAATGATTCCAGTAATTCA
AGAATTTGAATCTTATGGAATGATATATTTAGACCCAATATGGTGGGCGTTAGCAATAGGTGCTTGTTTAGGAGGTAATG
CAACCTTAATTGGTGCTTCGGCAAATGTTGTTGTTGCGGGGATGGCAGAGAGTGCAGGTGAAAAAATTTCCTTTCTTCGT
TTTATGAAATTTGGAATGATCATTGTATTTTTATCTTTGATTGTTTCATCCATATATATTTACTTCCGATATCTATTACC
ATATACCAACATGTAG

Upstream 100 bases:

>100_bases
TGACAACTTGTATCTCGGAAGTCGATTTCTCTTTATATTGCTAGCGATTTTAAGGTAGTTATGGACGATAATACATATTT
GGAACGAGAGGATAAAATAT

Downstream 100 bases:

>100_bases
GAGCTTCATAAATTTGATGTCAACGGATATAAAGAGCTATGAGACTTCTTTCAGTGAACGATATGTAGGATAAATAAGTA
AAGAACGACCAATAAAGTTG

Product: hypothetical protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MEITLTAIIFIVSYIFIMTEKINRAIIALAGGTLLILTGVYTIDEVFTQYIDWNTIALLFSMMVLISITEKTGLFTFIAI
RFAQKVKGNQVALLIGSGILTAIGSAFLDNVTTVLIFVPIMIQITKLLKLPLFPYLLMIIFSSNIGGSATLIGDPPNIMI
GQAVDHFTFLSFLQHTAPVAIIMFVIQLVLLLVLFRKPLKNARPEVEKIVKLDAKEKLLISPLLYKSVSVLLLTIMGFIL
HSIVHVSMTAIALSGAILLLLLTEKDLHTEHVFSKVEWVTLFFFIGLFTIVGGLEQVGIIDELARLLVATTEGDYVTTTI
LILWMSGIFSGFIDNIPFVAAMIPVIQEFESYGMIYLDPIWWALAIGACLGGNATLIGASANVVVAGMAESAGEKISFLR
FMKFGMIIVFLSLIVSSIYIYFRYLLPYTNM

Sequences:

>Translated_431_residues
MEITLTAIIFIVSYIFIMTEKINRAIIALAGGTLLILTGVYTIDEVFTQYIDWNTIALLFSMMVLISITEKTGLFTFIAI
RFAQKVKGNQVALLIGSGILTAIGSAFLDNVTTVLIFVPIMIQITKLLKLPLFPYLLMIIFSSNIGGSATLIGDPPNIMI
GQAVDHFTFLSFLQHTAPVAIIMFVIQLVLLLVLFRKPLKNARPEVEKIVKLDAKEKLLISPLLYKSVSVLLLTIMGFIL
HSIVHVSMTAIALSGAILLLLLTEKDLHTEHVFSKVEWVTLFFFIGLFTIVGGLEQVGIIDELARLLVATTEGDYVTTTI
LILWMSGIFSGFIDNIPFVAAMIPVIQEFESYGMIYLDPIWWALAIGACLGGNATLIGASANVVVAGMAESAGEKISFLR
FMKFGMIIVFLSLIVSSIYIYFRYLLPYTNM
>Mature_431_residues
MEITLTAIIFIVSYIFIMTEKINRAIIALAGGTLLILTGVYTIDEVFTQYIDWNTIALLFSMMVLISITEKTGLFTFIAI
RFAQKVKGNQVALLIGSGILTAIGSAFLDNVTTVLIFVPIMIQITKLLKLPLFPYLLMIIFSSNIGGSATLIGDPPNIMI
GQAVDHFTFLSFLQHTAPVAIIMFVIQLVLLLVLFRKPLKNARPEVEKIVKLDAKEKLLISPLLYKSVSVLLLTIMGFIL
HSIVHVSMTAIALSGAILLLLLTEKDLHTEHVFSKVEWVTLFFFIGLFTIVGGLEQVGIIDELARLLVATTEGDYVTTTI
LILWMSGIFSGFIDNIPFVAAMIPVIQEFESYGMIYLDPIWWALAIGACLGGNATLIGASANVVVAGMAESAGEKISFLR
FMKFGMIIVFLSLIVSSIYIYFRYLLPYTNM

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=450, Percent_Identity=32.6666666666667, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574683, Length=488, Percent_Identity=32.7868852459016, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574681, Length=488, Percent_Identity=32.7868852459016, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574685, Length=488, Percent_Identity=32.7868852459016, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574678, Length=488, Percent_Identity=32.7868852459016, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19920704, Length=494, Percent_Identity=32.5910931174089, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581759, Length=488, Percent_Identity=32.7868852459016, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI221472711, Length=482, Percent_Identity=31.1203319502075, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581764, Length=482, Percent_Identity=31.1203319502075, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI45550608, Length=474, Percent_Identity=30.8016877637131, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI85724998, Length=431, Percent_Identity=27.8422273781903, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI62484377, Length=431, Percent_Identity=27.8422273781903, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24656008, Length=445, Percent_Identity=27.1910112359551, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 47560; Mature: 47560

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLTAIIFIVSYIFIMTEKINRAIIALAGGTLLILTGVYTIDEVFTQYIDWNTIALLF
CCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHHHHHHHHHCHHHHHHHH
SMMVLISITEKTGLFTFIAIRFAQKVKGNQVALLIGSGILTAIGSAFLDNVTTVLIFVPI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
MIQITKLLKLPLFPYLLMIIFSSNIGGSATLIGDPPNIMIGQAVDHFTFLSFLQHTAPVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHH
IIMFVIQLVLLLVLFRKPLKNARPEVEKIVKLDAKEKLLISPLLYKSVSVLLLTIMGFIL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HSIVHVSMTAIALSGAILLLLLTEKDLHTEHVFSKVEWVTLFFFIGLFTIVGGLEQVGII
HHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHH
DELARLLVATTEGDYVTTTILILWMSGIFSGFIDNIPFVAAMIPVIQEFESYGMIYLDPI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECHH
WWALAIGACLGGNATLIGASANVVVAGMAESAGEKISFLRFMKFGMIIVFLSLIVSSIYI
HHHHHHHHHCCCCEEEEECCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFRYLLPYTNM
HHHHHHCCCCC
>Mature Secondary Structure
MEITLTAIIFIVSYIFIMTEKINRAIIALAGGTLLILTGVYTIDEVFTQYIDWNTIALLF
CCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHHHHHHHHHCHHHHHHHH
SMMVLISITEKTGLFTFIAIRFAQKVKGNQVALLIGSGILTAIGSAFLDNVTTVLIFVPI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
MIQITKLLKLPLFPYLLMIIFSSNIGGSATLIGDPPNIMIGQAVDHFTFLSFLQHTAPVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHH
IIMFVIQLVLLLVLFRKPLKNARPEVEKIVKLDAKEKLLISPLLYKSVSVLLLTIMGFIL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HSIVHVSMTAIALSGAILLLLLTEKDLHTEHVFSKVEWVTLFFFIGLFTIVGGLEQVGII
HHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHH
DELARLLVATTEGDYVTTTILILWMSGIFSGFIDNIPFVAAMIPVIQEFESYGMIYLDPI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECHH
WWALAIGACLGGNATLIGASANVVVAGMAESAGEKISFLRFMKFGMIIVFLSLIVSSIYI
HHHHHHHHHCCCCEEEEECCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFRYLLPYTNM
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]