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The map label for this gene is kinC [H]

Identifier: 23099135

GI number: 23099135

Start: 1720313

End: 1721407

Strand: Direct

Name: kinC [H]

Synonym: OB1680

Alternate gene names: 23099135

Gene position: 1720313-1721407 (Clockwise)

Preceding gene: 23099133

Following gene: 23099136

Centisome position: 47.38

GC content: 31.87

Gene sequence:

>1095_bases
ATGAAAAATAAAAAAGATAACTATGTAACAGAGCGGAACTCGAAAACTCCTGAAAGTCTTAAAAATATACAGCATGCGAC
AGACTTGCCTGACGAAATTATAAATTGGATAGATAAGAAAAGTGATGGAATCTTTGTTTTATTAGATATAGTAGGAGAAA
TTTTATATATCACAGAATCTATTAAACGAATTTTAGGTTTTTCTCCATCAAAAGTTGTAGGATTGAATTGGGATGAGATG
GTTTCCAGTAAAGATGTAGAACTTGCTAGAAGAAAAGCGGAGCTAACTGATAAAACATTGAGAAAATTCAATCTAAATGT
TCTTAATAACGATGGAAATTATGTTCCGTTAACTTGTGAATTCGAATATTATCGAACTGTTGATAAACAAATTTATGTAT
TAGTTTATTTGAAAGACCTTACAGTAAAAAAGGAATTAGAAGATATGATGGTTCGTTCAGAAAAAATGAATGTAGCAGGC
CAATTAGCTGCAGGCATTGCGCATGAAATTAGAAATCCACTAACATCATTAAAGGGTTTTTTACAATTACTTCAAGCAGG
GGTCAACCATAAAGAAGAATACTTCAAGATAATGATAGAAGAAATAGAAAAGATAGAATCGATAACCTCGGAATTATTAT
TTATTTCGAAACCACTAACAGATAACCGCACGGATGAGATTATAAGTGATATGATTAATGACGTTATTATGTTATTAAGT
CCACAAGCAAAACAAAAAAACATCAGAATTGTTAAGTTAGGTGTATGTAACCAAACTATTGTTTGCGATCGTTCGCAAAT
TAAACAAGTACTCATTAATTTAGTAAAAAATGCAATTGAAGCCATGGACAACGGTGGGGAAATAATCATAACCAGTGAAG
ACGTAGAGGATAATGTTATTGTATCGGTTATTGATGAGGGTATTGGTATTCCTGAAGGGATACTGCACAAACTAGGAGAA
CCATTTTTCACTACAAAACAAACTGGTACAGGCTTAGGCTTATTAATCACAAAGCAAATCTTAGAAGCACATAACGCTAA
TTTCGAAGTATCTAATAACCATGATAAAGGAAGTACTTTTAAACTGGTATTCTGA

Upstream 100 bases:

>100_bases
GTTTCATTATAATGTCAATTTATCTTAATAACAAGTATCATATTTCAATCGTCATAATCATACATATTATGTAAAAGGTA
ATTCTGGAAGGAGCACAGTT

Downstream 100 bases:

>100_bases
TAAATTATGATATTCTTAATTATACTAATATAAGATTTTGTTATAGGGTTACATAACTAATTCGAATATAGTTTTCAAGG
TTTTATAATTGTTTTATTGT

Product: sporulation kinase C

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKNKKDNYVTERNSKTPESLKNIQHATDLPDEIINWIDKKSDGIFVLLDIVGEILYITESIKRILGFSPSKVVGLNWDEM
VSSKDVELARRKAELTDKTLRKFNLNVLNNDGNYVPLTCEFEYYRTVDKQIYVLVYLKDLTVKKELEDMMVRSEKMNVAG
QLAAGIAHEIRNPLTSLKGFLQLLQAGVNHKEEYFKIMIEEIEKIESITSELLFISKPLTDNRTDEIISDMINDVIMLLS
PQAKQKNIRIVKLGVCNQTIVCDRSQIKQVLINLVKNAIEAMDNGGEIIITSEDVEDNVIVSVIDEGIGIPEGILHKLGE
PFFTTKQTGTGLGLLITKQILEAHNANFEVSNNHDKGSTFKLVF

Sequences:

>Translated_364_residues
MKNKKDNYVTERNSKTPESLKNIQHATDLPDEIINWIDKKSDGIFVLLDIVGEILYITESIKRILGFSPSKVVGLNWDEM
VSSKDVELARRKAELTDKTLRKFNLNVLNNDGNYVPLTCEFEYYRTVDKQIYVLVYLKDLTVKKELEDMMVRSEKMNVAG
QLAAGIAHEIRNPLTSLKGFLQLLQAGVNHKEEYFKIMIEEIEKIESITSELLFISKPLTDNRTDEIISDMINDVIMLLS
PQAKQKNIRIVKLGVCNQTIVCDRSQIKQVLINLVKNAIEAMDNGGEIIITSEDVEDNVIVSVIDEGIGIPEGILHKLGE
PFFTTKQTGTGLGLLITKQILEAHNANFEVSNNHDKGSTFKLVF
>Mature_364_residues
MKNKKDNYVTERNSKTPESLKNIQHATDLPDEIINWIDKKSDGIFVLLDIVGEILYITESIKRILGFSPSKVVGLNWDEM
VSSKDVELARRKAELTDKTLRKFNLNVLNNDGNYVPLTCEFEYYRTVDKQIYVLVYLKDLTVKKELEDMMVRSEKMNVAG
QLAAGIAHEIRNPLTSLKGFLQLLQAGVNHKEEYFKIMIEEIEKIESITSELLFISKPLTDNRTDEIISDMINDVIMLLS
PQAKQKNIRIVKLGVCNQTIVCDRSQIKQVLINLVKNAIEAMDNGGEIIITSEDVEDNVIVSVIDEGIGIPEGILHKLGE
PFFTTKQTGTGLGLLITKQILEAHNANFEVSNNHDKGSTFKLVF

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=32.2448979591837, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=36.7521367521368, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790300, Length=315, Percent_Identity=26.984126984127, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=26.0700389105058, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786600, Length=379, Percent_Identity=24.802110817942, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081816, Length=213, Percent_Identity=27.6995305164319, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788393, Length=204, Percent_Identity=28.921568627451, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=228, Percent_Identity=21.4912280701754, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=26.0162601626016, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=262, Percent_Identity=25.5725190839695, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=28.3653846153846, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=278, Percent_Identity=24.1007194244604, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=24.3346007604563, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41170; Mature: 41170

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKKDNYVTERNSKTPESLKNIQHATDLPDEIINWIDKKSDGIFVLLDIVGEILYITES
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
IKRILGFSPSKVVGLNWDEMVSSKDVELARRKAELTDKTLRKFNLNVLNNDGNYVPLTCE
HHHHHCCCCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEE
FEYYRTVDKQIYVLVYLKDLTVKKELEDMMVRSEKMNVAGQLAAGIAHEIRNPLTSLKGF
HHHHHHHCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLLQAGVNHKEEYFKIMIEEIEKIESITSELLFISKPLTDNRTDEIISDMINDVIMLLS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
PQAKQKNIRIVKLGVCNQTIVCDRSQIKQVLINLVKNAIEAMDNGGEIIITSEDVEDNVI
CCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCE
VSVIDEGIGIPEGILHKLGEPFFTTKQTGTGLGLLITKQILEAHNANFEVSNNHDKGSTF
EEEHHCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEE
KLVF
EEEC
>Mature Secondary Structure
MKNKKDNYVTERNSKTPESLKNIQHATDLPDEIINWIDKKSDGIFVLLDIVGEILYITES
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
IKRILGFSPSKVVGLNWDEMVSSKDVELARRKAELTDKTLRKFNLNVLNNDGNYVPLTCE
HHHHHCCCCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEE
FEYYRTVDKQIYVLVYLKDLTVKKELEDMMVRSEKMNVAGQLAAGIAHEIRNPLTSLKGF
HHHHHHHCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLLQAGVNHKEEYFKIMIEEIEKIESITSELLFISKPLTDNRTDEIISDMINDVIMLLS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
PQAKQKNIRIVKLGVCNQTIVCDRSQIKQVLINLVKNAIEAMDNGGEIIITSEDVEDNVI
CCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCE
VSVIDEGIGIPEGILHKLGEPFFTTKQTGTGLGLLITKQILEAHNANFEVSNNHDKGSTF
EEEHHCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEE
KLVF
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]