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The map label for this gene is tkt [H]

Identifier: 23099127

GI number: 23099127

Start: 1712669

End: 1714669

Strand: Direct

Name: tkt [H]

Synonym: OB1672

Alternate gene names: 23099127

Gene position: 1712669-1714669 (Clockwise)

Preceding gene: 23099126

Following gene: 23099128

Centisome position: 47.17

GC content: 39.08

Gene sequence:

>2001_bases
ATGTCAGGCAAGGTAGAACAATTATCAATAAATACAATTCGTACTTTATCTATTGACGCAATTGAAAATGCGAACTCAGG
ACACCCTGGTTTACCAATGGGTGCAGCGCCAATGGCGTACACATTATGGACAGACTTTATGAATCATCATCCAAAAAACT
CTAAATGGTTTAACCGTGATCGCTTTGTATTATCAGCGGGACACGGATCAATGTTACTATATAGTTTATTGCACCTTTCT
GGATACGATGTATCTATTGAAGACCTTAAAGGATTTCGTCAGTGGGATTCCAAAACTCCTGGACATCCGGAAGTACATCA
TACCGATGGTGTAGAAGCAACTACTGGACCTTTAGGACAAGGTATTGCGATGTCAGTGGGTATGGCTATGGCAGAAGCTC
ATTTAGGCGCAACGTTTAATAAAGATAAATATTCTGTAGTGGATCACTATACGTATGCCTTAGTAAGTGACGGTGATTTA
ATGGAAGGGATTTCTCATGAATCCGCTTCTTTAGCAGGTCACTTAGGTCTAGGTAAACTTATTGCTCTATATGATTCTAA
TGATATTTCATTAGATGGAGATCTAGATCGTTCTTTCTCAGAGGAAACGGAAAAACGTTTTGAAGCTTATGGTTGGCAAG
TATTGCGAGTGGAAGATGGAAACGATGTAAATGCTATTCGTGAAGCAATTAAAGAAGCTCAACGTAATACGAAGCAACCA
ACACTTATTGAAGTGAAGACAATTATAGGTTATGGTTCTCCAAATAAATCAGCTTCTGCTGCTTCGCATGGTGCGCCACT
AGGTGAAGATGAAATAATATTAACAAAAGAATATTATGAGTGGGAACATGAACCATTCCATGTACCAGATGAAGTATATG
CTGATTTCCAAGAAAAAATCGTTAACGATGGTGAAAAGAAAGAAGCTGCTTGGAATCAACTGGTTGAAGAATATAAAAAA
TCTTATCCAGAATTAGGAGAGCAATTCGATTTAGCAATCAAAGGTCAACTTCCAGAAGGTTGGGAAAAAGAACTTCCAAT
ATATGAGCCTGGAAGCAGCATTGCAACTCGTGCATCTTCAGGTGAAGTGTTAAATGCAGTAGCTAAAGCAGTTCCTAACT
TCTTTGGTGGAAGTGCAGATCTAGCTGGATCTAACAAAACAACCATAAAAGAAGAAGGCGACTTTACAAAAGAAGATTAT
TCTGGACGTAATGTATGGTTTGGCGTACGTGAACACGCTATGGGAGCGGCATTAAATGGAATGGCCTTGCATGGAGGTTT
ACAAGTATTTGCTGGAACGTTCTTCGTGTTTAGTGATTACCTTCGCCCTGCTGTTCGTTTAGCAGCAATTATGAATATGC
CAGTAAACTTTGTGTTTACTCATGATTCTATTGCGGTTGGTGAAGATGGTCCGACTCATGAACCAATTGAACAATTAGCA
TCTTTAAGAGCAGTTCCAAACTTATCACTTATTCGTCCTGCGGATGCGAATGAAGTACAAGCTGCATGGAGACTAGCTCT
TGAATCTGAACATCAGCCAACAGCGCTTGTTCTTACTCGTCAAAACTTACCAACACTAGAAGGTACGAAGGAAAATGCGT
ACGAAGGTGTGAAAAAAGGTGCCTATGTAATTAGTAAATCTGAGAAAGAAACTCCAGATGCACTATTACTAGCTACTGGT
TCAGAAGTTCAATTAGCAGTGCGTGCACAAGAAACATTAAAAGAAAAAGGTATCGATGTTCAAGTCGTTAGCATGCCTTC
ATGGGATCGTTTTGAAGCTCAAGAGGATGCATACAAGAATGAAGTACTACCAAAAGAAGTGAAAGCTAGAGTAGGAATCG
AAATGGCTGCTTCATTTGGATGGGAACGTTATGTAGGTCTTGATGGCAAAGTAATCGGTATTAATCGCTTTGGTGCATCT
GCAAAAGGTGATAAAGTTATTGAAGAGTATGGATTCACAGTAGAAAATGTTGTAAAACATGTGGAAGACTTATTAAAATA
A

Upstream 100 bases:

>100_bases
GAAACAAAAAACATTAAATTCTATTAGTCATGCTTGTTGTCATGATAAATTCAATATAGAATGGATAAGTAAAGGCTTTA
TTTTGAAAGGGGTAGGCAAA

Downstream 100 bases:

>100_bases
TAGGTCCATATAGAAGAAAGGCGATTCCATTAAGGTTTCGTCTTTCTTTTTATATTTTTAGTTGGATTCGACAAAAGAAG
AAGTTATTTGCGAACTAATT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSGKVEQLSINTIRTLSIDAIENANSGHPGLPMGAAPMAYTLWTDFMNHHPKNSKWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVSIEDLKGFRQWDSKTPGHPEVHHTDGVEATTGPLGQGIAMSVGMAMAEAHLGATFNKDKYSVVDHYTYALVSDGDL
MEGISHESASLAGHLGLGKLIALYDSNDISLDGDLDRSFSEETEKRFEAYGWQVLRVEDGNDVNAIREAIKEAQRNTKQP
TLIEVKTIIGYGSPNKSASAASHGAPLGEDEIILTKEYYEWEHEPFHVPDEVYADFQEKIVNDGEKKEAAWNQLVEEYKK
SYPELGEQFDLAIKGQLPEGWEKELPIYEPGSSIATRASSGEVLNAVAKAVPNFFGGSADLAGSNKTTIKEEGDFTKEDY
SGRNVWFGVREHAMGAALNGMALHGGLQVFAGTFFVFSDYLRPAVRLAAIMNMPVNFVFTHDSIAVGEDGPTHEPIEQLA
SLRAVPNLSLIRPADANEVQAAWRLALESEHQPTALVLTRQNLPTLEGTKENAYEGVKKGAYVISKSEKETPDALLLATG
SEVQLAVRAQETLKEKGIDVQVVSMPSWDRFEAQEDAYKNEVLPKEVKARVGIEMAASFGWERYVGLDGKVIGINRFGAS
AKGDKVIEEYGFTVENVVKHVEDLLK

Sequences:

>Translated_666_residues
MSGKVEQLSINTIRTLSIDAIENANSGHPGLPMGAAPMAYTLWTDFMNHHPKNSKWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVSIEDLKGFRQWDSKTPGHPEVHHTDGVEATTGPLGQGIAMSVGMAMAEAHLGATFNKDKYSVVDHYTYALVSDGDL
MEGISHESASLAGHLGLGKLIALYDSNDISLDGDLDRSFSEETEKRFEAYGWQVLRVEDGNDVNAIREAIKEAQRNTKQP
TLIEVKTIIGYGSPNKSASAASHGAPLGEDEIILTKEYYEWEHEPFHVPDEVYADFQEKIVNDGEKKEAAWNQLVEEYKK
SYPELGEQFDLAIKGQLPEGWEKELPIYEPGSSIATRASSGEVLNAVAKAVPNFFGGSADLAGSNKTTIKEEGDFTKEDY
SGRNVWFGVREHAMGAALNGMALHGGLQVFAGTFFVFSDYLRPAVRLAAIMNMPVNFVFTHDSIAVGEDGPTHEPIEQLA
SLRAVPNLSLIRPADANEVQAAWRLALESEHQPTALVLTRQNLPTLEGTKENAYEGVKKGAYVISKSEKETPDALLLATG
SEVQLAVRAQETLKEKGIDVQVVSMPSWDRFEAQEDAYKNEVLPKEVKARVGIEMAASFGWERYVGLDGKVIGINRFGAS
AKGDKVIEEYGFTVENVVKHVEDLLK
>Mature_665_residues
SGKVEQLSINTIRTLSIDAIENANSGHPGLPMGAAPMAYTLWTDFMNHHPKNSKWFNRDRFVLSAGHGSMLLYSLLHLSG
YDVSIEDLKGFRQWDSKTPGHPEVHHTDGVEATTGPLGQGIAMSVGMAMAEAHLGATFNKDKYSVVDHYTYALVSDGDLM
EGISHESASLAGHLGLGKLIALYDSNDISLDGDLDRSFSEETEKRFEAYGWQVLRVEDGNDVNAIREAIKEAQRNTKQPT
LIEVKTIIGYGSPNKSASAASHGAPLGEDEIILTKEYYEWEHEPFHVPDEVYADFQEKIVNDGEKKEAAWNQLVEEYKKS
YPELGEQFDLAIKGQLPEGWEKELPIYEPGSSIATRASSGEVLNAVAKAVPNFFGGSADLAGSNKTTIKEEGDFTKEDYS
GRNVWFGVREHAMGAALNGMALHGGLQVFAGTFFVFSDYLRPAVRLAAIMNMPVNFVFTHDSIAVGEDGPTHEPIEQLAS
LRAVPNLSLIRPADANEVQAAWRLALESEHQPTALVLTRQNLPTLEGTKENAYEGVKKGAYVISKSEKETPDALLLATGS
EVQLAVRAQETLKEKGIDVQVVSMPSWDRFEAQEDAYKNEVLPKEVKARVGIEMAASFGWERYVGLDGKVIGINRFGASA
KGDKVIEEYGFTVENVVKHVEDLLK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=672, Percent_Identity=26.7857142857143, Blast_Score=166, Evalue=9e-41,
Organism=Homo sapiens, GI4507521, Length=672, Percent_Identity=26.7857142857143, Blast_Score=166, Evalue=9e-41,
Organism=Homo sapiens, GI133778974, Length=575, Percent_Identity=27.4782608695652, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI225637459, Length=592, Percent_Identity=22.8040540540541, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI225637463, Length=485, Percent_Identity=23.7113402061856, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI225637461, Length=485, Percent_Identity=23.7113402061856, Blast_Score=113, Evalue=8e-25,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=50.3030303030303, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=49.6229260935143, Blast_Score=653, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=663, Percent_Identity=25.7918552036199, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=48.3582089552239, Blast_Score=610, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=44.7251114413076, Blast_Score=572, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45551847, Length=590, Percent_Identity=27.9661016949153, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=590, Percent_Identity=27.9661016949153, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=28.2097649186257, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666278, Length=581, Percent_Identity=26.1617900172117, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73152; Mature: 73020

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKVEQLSINTIRTLSIDAIENANSGHPGLPMGAAPMAYTLWTDFMNHHPKNSKWFNRD
CCCCCEEEECCEEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVSIEDLKGFRQWDSKTPGHPEVHHTDGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GIAMSVGMAMAEAHLGATFNKDKYSVVDHYTYALVSDGDLMEGISHESASLAGHLGLGKL
CHHHHHHHHHHHHHHCCCCCCCCEEHHHHEEEEEEECCHHHHCCCCCHHHHHHCCCCCEE
IALYDSNDISLDGDLDRSFSEETEKRFEAYGWQVLRVEDGNDVNAIREAIKEAQRNTKQP
EEEECCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC
TLIEVKTIIGYGSPNKSASAASHGAPLGEDEIILTKEYYEWEHEPFHVPDEVYADFQEKI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VNDGEKKEAAWNQLVEEYKKSYPELGEQFDLAIKGQLPEGWEKELPIYEPGSSIATRASS
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCCCCCHHHHCCCC
GEVLNAVAKAVPNFFGGSADLAGSNKTTIKEEGDFTKEDYSGRNVWFGVREHAMGAALNG
CHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC
MALHGGLQVFAGTFFVFSDYLRPAVRLAAIMNMPVNFVFTHDSIAVGEDGPTHEPIEQLA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAVPNLSLIRPADANEVQAAWRLALESEHQPTALVLTRQNLPTLEGTKENAYEGVKKG
HHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCC
AYVISKSEKETPDALLLATGSEVQLAVRAQETLKEKGIDVQVVSMPSWDRFEAQEDAYKN
EEEEECCCCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
EVLPKEVKARVGIEMAASFGWERYVGLDGKVIGINRFGASAKGDKVIEEYGFTVENVVKH
CCCCHHHHHHHCHHHHHHCCCCEEECCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHH
VEDLLK
HHHHHC
>Mature Secondary Structure 
SGKVEQLSINTIRTLSIDAIENANSGHPGLPMGAAPMAYTLWTDFMNHHPKNSKWFNRD
CCCCEEEECCEEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVSIEDLKGFRQWDSKTPGHPEVHHTDGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GIAMSVGMAMAEAHLGATFNKDKYSVVDHYTYALVSDGDLMEGISHESASLAGHLGLGKL
CHHHHHHHHHHHHHHCCCCCCCCEEHHHHEEEEEEECCHHHHCCCCCHHHHHHCCCCCEE
IALYDSNDISLDGDLDRSFSEETEKRFEAYGWQVLRVEDGNDVNAIREAIKEAQRNTKQP
EEEECCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC
TLIEVKTIIGYGSPNKSASAASHGAPLGEDEIILTKEYYEWEHEPFHVPDEVYADFQEKI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VNDGEKKEAAWNQLVEEYKKSYPELGEQFDLAIKGQLPEGWEKELPIYEPGSSIATRASS
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCCCCCHHHHCCCC
GEVLNAVAKAVPNFFGGSADLAGSNKTTIKEEGDFTKEDYSGRNVWFGVREHAMGAALNG
CHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC
MALHGGLQVFAGTFFVFSDYLRPAVRLAAIMNMPVNFVFTHDSIAVGEDGPTHEPIEQLA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAVPNLSLIRPADANEVQAAWRLALESEHQPTALVLTRQNLPTLEGTKENAYEGVKKG
HHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCC
AYVISKSEKETPDALLLATGSEVQLAVRAQETLKEKGIDVQVVSMPSWDRFEAQEDAYKN
EEEEECCCCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
EVLPKEVKARVGIEMAASFGWERYVGLDGKVIGINRFGASAKGDKVIEEYGFTVENVVKH
CCCCHHHHHHHCHHHHHHCCCCEEECCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHH
VEDLLK
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]