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The map label for this gene is mutL [H]

Identifier: 23099087

GI number: 23099087

Start: 1673425

End: 1675317

Strand: Direct

Name: mutL [H]

Synonym: OB1632

Alternate gene names: 23099087

Gene position: 1673425-1675317 (Clockwise)

Preceding gene: 23099086

Following gene: 23099088

Centisome position: 46.09

GC content: 38.51

Gene sequence:

>1893_bases
ATGCCAATTATTCAAATGCCAGATGCACTCGCAAATAAAATCGCAGCTGGTGAAGTAGTGGAAAGGCCAGCTTCAGTGGT
TAAAGAGCTATTAGAAAACAGTATAGATGCAGGTGCAACATGGATAAGAGTAGAAATAAAAGAAGCAGGACTGGAAGAAA
TTCGTATTACAGATAATGGCGCTGGAATGGAAGAGGATGATGTAGAAAGAGCTTTTCTGCGACATGCAACGAGTAAAATT
AAGAATGAATCCGATTTGTTCCATGTAAAAACACTTGGTTTTCGCGGAGAGGCTTTAGCAAGTATTGCGTCTGTCAGTAA
ATTATCGGCCCAAACCTCCCAAGGAGATCAAGCAGGTACTCTCTTGCAGTTAGAGGGTGGAAGTGTTAAACATCGTGGGA
AAAGCGATGCAAGGCAAGGGACAGATATTACAGTCAGTGAATTATTCTATAACACACCTGCACGATTAAAATATATGAAG
AGCCTGCATACAGAATTAGGTCATATTTCTGATGTTTTAAATAGAATGGCATTAGCACATCCTGAGGTTCGGATAGAAGC
TTTGCATAATGACAAAGGACTTATTAAAACAAATGGGAACGGAGATATTCTTCAGGTAATTTCGCAAGTGTACGGGATGA
GTGTGGCAAAACAAATGCTGCCAGTTGATGTTAAAACGCTCGATTATAGAGTGCACGGTTATATCGCTAAACCAGAAGTG
ACAAGGGCTTCTCGTAATTATATGTCAACCATTATTAACGGACGTTTTATACGAAATATCGGATTAAATAAAGCAATATT
ACAAGGCTACCATACATTATTGCCTATTGGACGATCGCCGATTGTCGTACTCAATATCGAGATGGATCCGATTCTTGTGG
ATGTGAATGTACACCCTGCCAAACTAGAAGTTCGATTCAGTAAGGATAAAGAGCTTTTTACATCCATTGAAAGTATGATT
CGAGATCGGTTTAGAGAGATTACACTTATTCCTAAGGTAGAGAAACAACCGGTGCAGAGGCAAAAATCAGAACAATCCTC
TTTTCGATTTGATTCAAATAATCGTGAAAAACAACCCATTAACTCTGATTTTTCCCAGGATTCGCGCTCTATCATACGTG
ATCAAACAGAAAAATTTGATCTGCCTGAAACTCGAGATAAAATGATCAATCGTGAAATAGAGCAACACGCCAATTTAGTT
GATAACGATGAATCAGAGGTAACTGAAAAAGTATCGGTGGATATGTCAACATCTTCATTTGAAGCAGCACATGCTCCAAA
TCGAGAAGAGCAAACGAATACCATTGATAAACGTGTTCCGATGATGTATCCAATTGGACAATTGCAAGGAACTTATATTC
TTGCTCAAAATGAAAATGGGTTATTTATGGTTGATCAGCATGCAGCTCAGGAACGTGTGAAATACGAATTCTTTCGTAAT
AAATTAGGGAAACCGATGAACGAATCTCAGGAATTATTGATACCAATGACATTTGATTTCGCTAAGCAAGAATCATTGTT
CATTGAAAATCATAAAGAAGATCTCGAACAAGTTGGATTATTTTTTGAGGCTTTTGGCAATCAAACGTATGTCATCCGTT
CGCATCCTACCTGGTTCCCAAAAGGATTTGAGGAGGAAGTTATCCGTGAGATGGTGGATCAAGTGATGAATGAATCCAAA
ATAAGCGTAGAGGGTATTCGAGAAGAAGCAGCTATTCTGATGTCTTGTAAACGCTCGATAAAAGCGAATCATTATTTAAC
TTCGGATGAGATGTACCAACTTCTTGAAGATTTAAGAAATACAACGGATCCTTTTACTTGCCCACACGGAAGGCCGATTA
TCGTTCATTTTTCGACGTATGAATTGGAGAAGATGTTTAAACGTGTAATGTAG

Upstream 100 bases:

>100_bases
TTAAAGAATGTTAATGTTCTGGATTTAACACCGTTAGAAGCAATGAATGAATTGTATCGCCTACAAAAAGGATTAAAGCA
ATATTAGAGAGGGTGATATC

Downstream 100 bases:

>100_bases
CAGTATAAACTTACTCTTTTATGTCAAACCTAGGAACATTAAATTAATACATAGGTTAACATTTGGAGTGAGTGACATGG
AAAATCAACGGTTAATTAAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MPIIQMPDALANKIAAGEVVERPASVVKELLENSIDAGATWIRVEIKEAGLEEIRITDNGAGMEEDDVERAFLRHATSKI
KNESDLFHVKTLGFRGEALASIASVSKLSAQTSQGDQAGTLLQLEGGSVKHRGKSDARQGTDITVSELFYNTPARLKYMK
SLHTELGHISDVLNRMALAHPEVRIEALHNDKGLIKTNGNGDILQVISQVYGMSVAKQMLPVDVKTLDYRVHGYIAKPEV
TRASRNYMSTIINGRFIRNIGLNKAILQGYHTLLPIGRSPIVVLNIEMDPILVDVNVHPAKLEVRFSKDKELFTSIESMI
RDRFREITLIPKVEKQPVQRQKSEQSSFRFDSNNREKQPINSDFSQDSRSIIRDQTEKFDLPETRDKMINREIEQHANLV
DNDESEVTEKVSVDMSTSSFEAAHAPNREEQTNTIDKRVPMMYPIGQLQGTYILAQNENGLFMVDQHAAQERVKYEFFRN
KLGKPMNESQELLIPMTFDFAKQESLFIENHKEDLEQVGLFFEAFGNQTYVIRSHPTWFPKGFEEEVIREMVDQVMNESK
ISVEGIREEAAILMSCKRSIKANHYLTSDEMYQLLEDLRNTTDPFTCPHGRPIIVHFSTYELEKMFKRVM

Sequences:

>Translated_630_residues
MPIIQMPDALANKIAAGEVVERPASVVKELLENSIDAGATWIRVEIKEAGLEEIRITDNGAGMEEDDVERAFLRHATSKI
KNESDLFHVKTLGFRGEALASIASVSKLSAQTSQGDQAGTLLQLEGGSVKHRGKSDARQGTDITVSELFYNTPARLKYMK
SLHTELGHISDVLNRMALAHPEVRIEALHNDKGLIKTNGNGDILQVISQVYGMSVAKQMLPVDVKTLDYRVHGYIAKPEV
TRASRNYMSTIINGRFIRNIGLNKAILQGYHTLLPIGRSPIVVLNIEMDPILVDVNVHPAKLEVRFSKDKELFTSIESMI
RDRFREITLIPKVEKQPVQRQKSEQSSFRFDSNNREKQPINSDFSQDSRSIIRDQTEKFDLPETRDKMINREIEQHANLV
DNDESEVTEKVSVDMSTSSFEAAHAPNREEQTNTIDKRVPMMYPIGQLQGTYILAQNENGLFMVDQHAAQERVKYEFFRN
KLGKPMNESQELLIPMTFDFAKQESLFIENHKEDLEQVGLFFEAFGNQTYVIRSHPTWFPKGFEEEVIREMVDQVMNESK
ISVEGIREEAAILMSCKRSIKANHYLTSDEMYQLLEDLRNTTDPFTCPHGRPIIVHFSTYELEKMFKRVM
>Mature_629_residues
PIIQMPDALANKIAAGEVVERPASVVKELLENSIDAGATWIRVEIKEAGLEEIRITDNGAGMEEDDVERAFLRHATSKIK
NESDLFHVKTLGFRGEALASIASVSKLSAQTSQGDQAGTLLQLEGGSVKHRGKSDARQGTDITVSELFYNTPARLKYMKS
LHTELGHISDVLNRMALAHPEVRIEALHNDKGLIKTNGNGDILQVISQVYGMSVAKQMLPVDVKTLDYRVHGYIAKPEVT
RASRNYMSTIINGRFIRNIGLNKAILQGYHTLLPIGRSPIVVLNIEMDPILVDVNVHPAKLEVRFSKDKELFTSIESMIR
DRFREITLIPKVEKQPVQRQKSEQSSFRFDSNNREKQPINSDFSQDSRSIIRDQTEKFDLPETRDKMINREIEQHANLVD
NDESEVTEKVSVDMSTSSFEAAHAPNREEQTNTIDKRVPMMYPIGQLQGTYILAQNENGLFMVDQHAAQERVKYEFFRNK
LGKPMNESQELLIPMTFDFAKQESLFIENHKEDLEQVGLFFEAFGNQTYVIRSHPTWFPKGFEEEVIREMVDQVMNESKI
SVEGIREEAAILMSCKRSIKANHYLTSDEMYQLLEDLRNTTDPFTCPHGRPIIVHFSTYELEKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=33.5365853658537, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI310128478, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=334, Percent_Identity=28.1437125748503, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI189458898, Length=333, Percent_Identity=28.8288288288288, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI189458896, Length=191, Percent_Identity=35.0785340314136, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI91992162, Length=436, Percent_Identity=25.2293577981651, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI91992160, Length=436, Percent_Identity=25.2293577981651, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI310128480, Length=324, Percent_Identity=26.2345679012346, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=29.0598290598291, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1790612, Length=354, Percent_Identity=40.6779661016949, Blast_Score=227, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=35.9133126934984, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=354, Percent_Identity=27.683615819209, Blast_Score=129, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=320, Percent_Identity=33.75, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=380, Percent_Identity=29.2105263157895, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6325093, Length=263, Percent_Identity=27.7566539923954, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=358, Percent_Identity=24.0223463687151, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=34.2507645259939, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI17136970, Length=341, Percent_Identity=29.0322580645161, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71735; Mature: 71603

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIQMPDALANKIAAGEVVERPASVVKELLENSIDAGATWIRVEIKEAGLEEIRITDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
AGMEEDDVERAFLRHATSKIKNESDLFHVKTLGFRGEALASIASVSKLSAQTSQGDQAGT
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LLQLEGGSVKHRGKSDARQGTDITVSELFYNTPARLKYMKSLHTELGHISDVLNRMALAH
EEEECCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEVRIEALHNDKGLIKTNGNGDILQVISQVYGMSVAKQMLPVDVKTLDYRVHGYIAKPEV
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCH
TRASRNYMSTIINGRFIRNIGLNKAILQGYHTLLPIGRSPIVVLNIEMDPILVDVNVHPA
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCE
KLEVRFSKDKELFTSIESMIRDRFREITLIPKVEKQPVQRQKSEQSSFRFDSNNREKQPI
EEEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
NSDFSQDSRSIIRDQTEKFDLPETRDKMINREIEQHANLVDNDESEVTEKVSVDMSTSSF
CCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCCC
EAAHAPNREEQTNTIDKRVPMMYPIGQLQGTYILAQNENGLFMVDQHAAQERVKYEFFRN
HHHCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHH
KLGKPMNESQELLIPMTFDFAKQESLFIENHKEDLEQVGLFFEAFGNQTYVIRSHPTWFP
HCCCCCCCCCCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCC
KGFEEEVIREMVDQVMNESKISVEGIREEAAILMSCKRSIKANHYLTSDEMYQLLEDLRN
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHC
TTDPFTCPHGRPIIVHFSTYELEKMFKRVM
CCCCCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
PIIQMPDALANKIAAGEVVERPASVVKELLENSIDAGATWIRVEIKEAGLEEIRITDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
AGMEEDDVERAFLRHATSKIKNESDLFHVKTLGFRGEALASIASVSKLSAQTSQGDQAGT
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LLQLEGGSVKHRGKSDARQGTDITVSELFYNTPARLKYMKSLHTELGHISDVLNRMALAH
EEEECCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEVRIEALHNDKGLIKTNGNGDILQVISQVYGMSVAKQMLPVDVKTLDYRVHGYIAKPEV
CCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCH
TRASRNYMSTIINGRFIRNIGLNKAILQGYHTLLPIGRSPIVVLNIEMDPILVDVNVHPA
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCE
KLEVRFSKDKELFTSIESMIRDRFREITLIPKVEKQPVQRQKSEQSSFRFDSNNREKQPI
EEEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
NSDFSQDSRSIIRDQTEKFDLPETRDKMINREIEQHANLVDNDESEVTEKVSVDMSTSSF
CCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCCC
EAAHAPNREEQTNTIDKRVPMMYPIGQLQGTYILAQNENGLFMVDQHAAQERVKYEFFRN
HHHCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHH
KLGKPMNESQELLIPMTFDFAKQESLFIENHKEDLEQVGLFFEAFGNQTYVIRSHPTWFP
HCCCCCCCCCCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCC
KGFEEEVIREMVDQVMNESKISVEGIREEAAILMSCKRSIKANHYLTSDEMYQLLEDLRN
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHC
TTDPFTCPHGRPIIVHFSTYELEKMFKRVM
CCCCCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA