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The map label for this gene is ymfI [H]

Identifier: 23099073

GI number: 23099073

Start: 1658162

End: 1658878

Strand: Direct

Name: ymfI [H]

Synonym: OB1618

Alternate gene names: 23099073

Gene position: 1658162-1658878 (Clockwise)

Preceding gene: 23099072

Following gene: 23099074

Centisome position: 45.67

GC content: 36.54

Gene sequence:

>717_bases
ATGAGGGGAAATGTACTAGTTATTGGTGCAAGTGGAGAAATCGGTATTGCTATTGCTCGTAAACTTGCTAAAGAAGGATA
TTCGTTATTATTACATTACCATCAAAATGTTGAACCTATACTACAATTACAGCTTGAATTGGATGAAGATGCTATTCTAG
GTTTTTATCAGGCTGATTTAAGCACAAGTAATGGGATACATCATTTAATACATCAATTGGATTTTGATATTGATGGTATT
GTGTTTGCTGGTGGAAATGCACATTTTGATTTATTTCAAGATAGCTTAGAGGAAGAAATGGATGACATGTTACAACTGCA
TATAAAAGCTCCTTGGATGATTACGAAGCATGTATTACCAAATATGATTCGAAAAAATAAAGGCCATATTGTGTTTATCA
CTTCTATCTGGGGAGACCGCGGTGCAAGTAACGAAGTGATGTACTCTTCCGTAAAAGGTGCTCAAAACAGTTTTGTACGG
GCTTTAGCTAAGGAGGTATCCCTAAGTGGTATCTCGGTAAATGGAGTCAGTCCTGGTTTTATACAGACGAAGATGAATGC
ACATTTATCAGCGGAAGAAGTTCATTCCATTATTGATGAAATACCTCTTAACCGTGCTGGTTTACCTGAAGAAGTGGCAA
ATACGGTACACTTTTTGATGAGTGATCAATCTAGCTACATTCGTGGTGAAATTATAGAAGTTAATGGAGCATGGTAA

Upstream 100 bases:

>100_bases
ACAACAATTAACGGTGGATGATGCAAATAAATTTTTAAGTGAGTGGATTAAGGAAGAACGATTAGCAACTTGTACTATTT
CTGCAGAATAAGGTGAGAAT

Downstream 100 bases:

>100_bases
AAATATACTTTTTTATGAATATTTTCGGTTGAAACCTCAAATAATAAGTTTGATTCTACGAATATGAGGAGGAAATCGAA
ATGTCTGTTTTAGATAATTT

Product: 3-oxoacyl-[acyl-carrier-protein] reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRGNVLVIGASGEIGIAIARKLAKEGYSLLLHYHQNVEPILQLQLELDEDAILGFYQADLSTSNGIHHLIHQLDFDIDGI
VFAGGNAHFDLFQDSLEEEMDDMLQLHIKAPWMITKHVLPNMIRKNKGHIVFITSIWGDRGASNEVMYSSVKGAQNSFVR
ALAKEVSLSGISVNGVSPGFIQTKMNAHLSAEEVHSIIDEIPLNRAGLPEEVANTVHFLMSDQSSYIRGEIIEVNGAW

Sequences:

>Translated_238_residues
MRGNVLVIGASGEIGIAIARKLAKEGYSLLLHYHQNVEPILQLQLELDEDAILGFYQADLSTSNGIHHLIHQLDFDIDGI
VFAGGNAHFDLFQDSLEEEMDDMLQLHIKAPWMITKHVLPNMIRKNKGHIVFITSIWGDRGASNEVMYSSVKGAQNSFVR
ALAKEVSLSGISVNGVSPGFIQTKMNAHLSAEEVHSIIDEIPLNRAGLPEEVANTVHFLMSDQSSYIRGEIIEVNGAW
>Mature_238_residues
MRGNVLVIGASGEIGIAIARKLAKEGYSLLLHYHQNVEPILQLQLELDEDAILGFYQADLSTSNGIHHLIHQLDFDIDGI
VFAGGNAHFDLFQDSLEEEMDDMLQLHIKAPWMITKHVLPNMIRKNKGHIVFITSIWGDRGASNEVMYSSVKGAQNSFVR
ALAKEVSLSGISVNGVSPGFIQTKMNAHLSAEEVHSIIDEIPLNRAGLPEEVANTVHFLMSDQSSYIRGEIIEVNGAW

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=31.9148936170213, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=29.8387096774194, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI15277342, Length=243, Percent_Identity=27.9835390946502, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI66933014, Length=187, Percent_Identity=24.0641711229947, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=27.9835390946502, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=141, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7705925, Length=159, Percent_Identity=28.9308176100629, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI210032110, Length=217, Percent_Identity=27.1889400921659, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=232, Percent_Identity=31.4655172413793, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=31.8367346938775, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=241, Percent_Identity=31.9502074688797, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=23.4817813765182, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=27.1604938271605, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=26.5560165975104, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=24.0816326530612, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=25.6198347107438, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787905, Length=154, Percent_Identity=28.5714285714286, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=30.2040816326531, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=30.4, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=28.2157676348548, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.1497975708502, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=144, Percent_Identity=29.8611111111111, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=107, Percent_Identity=37.3831775700935, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=27.7551020408163, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508651, Length=245, Percent_Identity=24.8979591836735, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=255, Percent_Identity=27.843137254902, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=256, Percent_Identity=27.734375, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=26.5151515151515, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=31.4741035856574, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24643142, Length=237, Percent_Identity=29.535864978903, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639444, Length=237, Percent_Identity=27.8481012658228, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=28.3524904214559, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=244, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=27.710843373494, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=27.5590551181102, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358495, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644337, Length=118, Percent_Identity=34.7457627118644, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26296; Mature: 26296

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGNVLVIGASGEIGIAIARKLAKEGYSLLLHYHQNVEPILQLQLELDEDAILGFYQADL
CCCCEEEEECCCCCHHHHHHHHHHCCHHEEEECCCCCCEEEEEEEECCCCCEEEEEEECC
STSNGIHHLIHQLDFDIDGIVFAGGNAHFDLFQDSLEEEMDDMLQLHIKAPWMITKHVLP
CCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NMIRKNKGHIVFITSIWGDRGASNEVMYSSVKGAQNSFVRALAKEVSLSGISVNGVSPGF
HHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCCE
IQTKMNAHLSAEEVHSIIDEIPLNRAGLPEEVANTVHFLMSDQSSYIRGEIIEVNGAW
EEEHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
>Mature Secondary Structure
MRGNVLVIGASGEIGIAIARKLAKEGYSLLLHYHQNVEPILQLQLELDEDAILGFYQADL
CCCCEEEEECCCCCHHHHHHHHHHCCHHEEEECCCCCCEEEEEEEECCCCCEEEEEEECC
STSNGIHHLIHQLDFDIDGIVFAGGNAHFDLFQDSLEEEMDDMLQLHIKAPWMITKHVLP
CCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NMIRKNKGHIVFITSIWGDRGASNEVMYSSVKGAQNSFVRALAKEVSLSGISVNGVSPGF
HHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCCE
IQTKMNAHLSAEEVHSIIDEIPLNRAGLPEEVANTVHFLMSDQSSYIRGEIIEVNGAW
EEEHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]