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The map label for this gene is purC

Identifier: 23098197

GI number: 23098197

Start: 789966

End: 790679

Strand: Direct

Name: purC

Synonym: OB0742

Alternate gene names: 23098197

Gene position: 789966-790679 (Clockwise)

Preceding gene: 23098196

Following gene: 23098198

Centisome position: 21.76

GC content: 34.59

Gene sequence:

>714_bases
ATGAAAGCAGCACTTTTATATGAAGGTAAAGCGAAGAAAGTATATCAATCTTCTGAAGATGAACATCAATTAGTGCTCTC
CTATAAAAATGACGCAACAGCTTTTAATGGCGAGAAGAAAAGTCAATTTGAAGGGAAAGGGAGACTCAATAATGAGATCT
CCTCCCTTATCTTTCAACGTTTACATGAAGCAGGAATTAGCACACATTTTATAAAACGGTTAGATTCGACTCAACAAATT
GTTCAGAAAACTAGTATTATTCCTTTAGAAGTGGTAATTCGCAATCTTGCGACAGGTAGTATTACCAAGAGGTTAGGAAT
TAAAGAAAAGGTATCTTTTACCCCACCATTACTCGAATTGTTTTATAAAGATGATGCTTTAGGTGATCCGTTAATCAATG
ATGAGCATGCATTGCTATTAACGGATATAACGGAAACCGAATTAGCTGAAATAAAAGATAAAGCTAGAGAAGTAAATGCC
GCCCTACAAGAAATCTTTCAATCTATTGGAATTAAACTAGTAGATTTCAAACTGGAATTTGGAAGAAATAAAGATGGAGA
AATACTTCTTTCCGATGAAGTTTCTCCGGATACGTGCAGGTTATGGGATATTGAAACGAATGAAAAACTCGATAAAGATG
TATTTCGCCAAGGTACAGGAGACTTAATTACTGTATATCAAGAAATTTTAAATCGGTTGGAGGTTCATGTATGA

Upstream 100 bases:

>100_bases
GCAAGCAGAGATTGATGATTGTTTTGATTATACGTATCACTTGAAGAATGTCGATCAAATCTTTACAAAAATCGGTATTT
CCTAGGAGGCTCATATAGTT

Downstream 100 bases:

>100_bases
AAAAAGTAACGGTATATATCACATTAAAACCAGGAGTTTTGGATCCACAAGGAAAGGCAATTCAAGAATCACTTCAGTCC
TTAGGATATCAAGAGGTTGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKAALLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQRLHEAGISTHFIKRLDSTQQI
VQKTSIIPLEVVIRNLATGSITKRLGIKEKVSFTPPLLELFYKDDALGDPLINDEHALLLTDITETELAEIKDKAREVNA
ALQEIFQSIGIKLVDFKLEFGRNKDGEILLSDEVSPDTCRLWDIETNEKLDKDVFRQGTGDLITVYQEILNRLEVHV

Sequences:

>Translated_237_residues
MKAALLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQRLHEAGISTHFIKRLDSTQQI
VQKTSIIPLEVVIRNLATGSITKRLGIKEKVSFTPPLLELFYKDDALGDPLINDEHALLLTDITETELAEIKDKAREVNA
ALQEIFQSIGIKLVDFKLEFGRNKDGEILLSDEVSPDTCRLWDIETNEKLDKDVFRQGTGDLITVYQEILNRLEVHV
>Mature_237_residues
MKAALLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQRLHEAGISTHFIKRLDSTQQI
VQKTSIIPLEVVIRNLATGSITKRLGIKEKVSFTPPLLELFYKDDALGDPLINDEHALLLTDITETELAEIKDKAREVNA
ALQEIFQSIGIKLVDFKLEFGRNKDGEILLSDEVSPDTCRLWDIETNEKLDKDVFRQGTGDLITVYQEILNRLEVHV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=222, Percent_Identity=37.8378378378378, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI5453539, Length=222, Percent_Identity=37.8378378378378, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI119220559, Length=229, Percent_Identity=36.2445414847162, Blast_Score=124, Evalue=7e-29,
Organism=Escherichia coli, GI1788820, Length=236, Percent_Identity=45.3389830508475, Blast_Score=210, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=36.3636363636364, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI18860083, Length=221, Percent_Identity=34.3891402714932, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=34.2995169082126, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI160714955, Length=96, Percent_Identity=36.4583333333333, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_OCEIH (Q8ES99)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691663.1
- ProteinModelPortal:   Q8ES99
- SMR:   Q8ES99
- GeneID:   1016264
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0742
- NMPDR:   fig|221109.1.peg.750
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   OIHE221109:OB0742-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26875; Mature: 26875

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAALLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQR
CCCEEEECCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHH
LHEAGISTHFIKRLDSTQQIVQKTSIIPLEVVIRNLATGSITKRLGIKEKVSFTPPLLEL
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCHHCCCCHHHHHH
FYKDDALGDPLINDEHALLLTDITETELAEIKDKAREVNAALQEIFQSIGIKLVDFKLEF
HHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GRNKDGEILLSDEVSPDTCRLWDIETNEKLDKDVFRQGTGDLITVYQEILNRLEVHV
CCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAALLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQR
CCCEEEECCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHH
LHEAGISTHFIKRLDSTQQIVQKTSIIPLEVVIRNLATGSITKRLGIKEKVSFTPPLLEL
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCHHCCCCHHHHHH
FYKDDALGDPLINDEHALLLTDITETELAEIKDKAREVNAALQEIFQSIGIKLVDFKLEF
HHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GRNKDGEILLSDEVSPDTCRLWDIETNEKLDKDVFRQGTGDLITVYQEILNRLEVHV
CCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376