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The map label for this gene is ectB

Identifier: 23097973

GI number: 23097973

Start: 551008

End: 552288

Strand: Direct

Name: ectB

Synonym: OB0518

Alternate gene names: 23097973

Gene position: 551008-552288 (Clockwise)

Preceding gene: 23097971

Following gene: 23097974

Centisome position: 15.18

GC content: 37.78

Gene sequence:

>1281_bases
ATGACAACGATTGTTGATAAAGCCCGGAATGATATGGCAGTATTTGAAGAAATGGAATCAGCGGTAAGAAGCTATAGTCG
CGGATGGCCAGTAGTATTTGAAAAAGCGAAAGGCTATAAGCTGTGGGATAAAAATGGAAATGAGTATATTGACTTCTTTG
CTGGGGCAGGTGCACTAAATTATGGCCATAATCCAAGTGAAATGCAAAAAGTCATGATTGATTATATACAAAATGATGGT
GTTATTCATAGTCTTGATATGGCTACGGCACCGCGTAAAAAATTCTTAGAGTCATTTAATGAAATAATTTTAAAACCACG
TAATATGGATTATAAAGTAATGTTCCCTGGTCCTACAGGTACGAATACGGTTGAAAGTGCTTTAAAAATTGCTCGTAAAG
TAACAGGACGAGATACGGTAATTGGTTTTACAAATGCGTTTCACGGAATGACAATCGGTTCCCTATCGGTTACAGGTAAT
TCCTTTAAACGTAATGGAGCTGGAATACCGTTAAATCATGCAATTTCTATGCCATTTGATCAATATGTAGATGAGCAAGA
TTCAATTGCATATATTGAACGTTTCCTAGAGGATTCTGGAAGTGGAGTAGCACTACCAGCTGCATTTATTCTAGAAACAG
TTCAAGGAGAAGGTGGAATTAACGCTGCCCGTCTTGAATGGGTGAAAAAAATAGAAGAAATTTGCAGAAAATGGGATATT
CTACTAATCATTGATGATGTCCAGGCAGGATGTGGAAGAACGGGTACATTCTTTAGCTTTGAAGAAGCAGGAATCAACCC
AGATATAGTTTGCCTGTCAAAATCAATTGGTGGAGTTGGGTTGCCAATGGCAATCACATTGATTAAACCTGAATTTGATC
AATGGGGACCTGGTGAACACAACGGTACATTCCGTGGAAATAACCTTGCATTTTTAGCAGCTACAGAAGCATTAAACAAT
TGGAAAACGGATGCATTCTCTCAAAATATTAAGAAAATGAGTTCTCTATTCCAAGAGAGAATGAAACGCATCGTAGAAAA
GTTTCCTGAATTAAATGCAGATTTAAGAGGTAGAGGCTTAATGCTTGGTATTGGGGTTCATGTAGATGGACTTGCAGGCG
AAATTTGCGCGGAAGCATTTTCTAGAGGTTTAATTCTTGAGACATCCGGAGCGAAGGATGAAGTTGTTAAATTCCTTCCG
CCATTAATTATTGATGAAGATGGTATTGAAAAAGGAATGGACATCTTAGAAGAAAGTATTCAAGCAGCACTAGAGAAATA
A

Upstream 100 bases:

>100_bases
TTAAAACAGATCATTTTCCAGCTAAAGATGAAGAACATGAAGAGGAACTACTTTTTAGAATAGGGCCAATGAGAAAAAAT
AAAAATAAAAGGATGATATA

Downstream 100 bases:

>100_bases
GGAGGAATTTTAATCATGATCGTAAAATCATTAGAAGACATTCAAGGTACAGAGGATCATCAAAAAGGGGAAACATGGGA
AAGCAGACGTTTTGTTTTAA

Product: diaminobutyrate--2-oxoglutarate aminotransferase

Products: NA

Alternate protein names: DABA aminotransferase; Diaminobutyrate--2-oxoglutarate aminotransferase; L-2,4-diaminobutyric acid transaminase

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTTIVDKARNDMAVFEEMESAVRSYSRGWPVVFEKAKGYKLWDKNGNEYIDFFAGAGALNYGHNPSEMQKVMIDYIQNDG
VIHSLDMATAPRKKFLESFNEIILKPRNMDYKVMFPGPTGTNTVESALKIARKVTGRDTVIGFTNAFHGMTIGSLSVTGN
SFKRNGAGIPLNHAISMPFDQYVDEQDSIAYIERFLEDSGSGVALPAAFILETVQGEGGINAARLEWVKKIEEICRKWDI
LLIIDDVQAGCGRTGTFFSFEEAGINPDIVCLSKSIGGVGLPMAITLIKPEFDQWGPGEHNGTFRGNNLAFLAATEALNN
WKTDAFSQNIKKMSSLFQERMKRIVEKFPELNADLRGRGLMLGIGVHVDGLAGEICAEAFSRGLILETSGAKDEVVKFLP
PLIIDEDGIEKGMDILEESIQAALEK

Sequences:

>Translated_426_residues
MTTIVDKARNDMAVFEEMESAVRSYSRGWPVVFEKAKGYKLWDKNGNEYIDFFAGAGALNYGHNPSEMQKVMIDYIQNDG
VIHSLDMATAPRKKFLESFNEIILKPRNMDYKVMFPGPTGTNTVESALKIARKVTGRDTVIGFTNAFHGMTIGSLSVTGN
SFKRNGAGIPLNHAISMPFDQYVDEQDSIAYIERFLEDSGSGVALPAAFILETVQGEGGINAARLEWVKKIEEICRKWDI
LLIIDDVQAGCGRTGTFFSFEEAGINPDIVCLSKSIGGVGLPMAITLIKPEFDQWGPGEHNGTFRGNNLAFLAATEALNN
WKTDAFSQNIKKMSSLFQERMKRIVEKFPELNADLRGRGLMLGIGVHVDGLAGEICAEAFSRGLILETSGAKDEVVKFLP
PLIIDEDGIEKGMDILEESIQAALEK
>Mature_425_residues
TTIVDKARNDMAVFEEMESAVRSYSRGWPVVFEKAKGYKLWDKNGNEYIDFFAGAGALNYGHNPSEMQKVMIDYIQNDGV
IHSLDMATAPRKKFLESFNEIILKPRNMDYKVMFPGPTGTNTVESALKIARKVTGRDTVIGFTNAFHGMTIGSLSVTGNS
FKRNGAGIPLNHAISMPFDQYVDEQDSIAYIERFLEDSGSGVALPAAFILETVQGEGGINAARLEWVKKIEEICRKWDIL
LIIDDVQAGCGRTGTFFSFEEAGINPDIVCLSKSIGGVGLPMAITLIKPEFDQWGPGEHNGTFRGNNLAFLAATEALNNW
KTDAFSQNIKKMSSLFQERMKRIVEKFPELNADLRGRGLMLGIGVHVDGLAGEICAEAFSRGLILETSGAKDEVVKFLPP
LIIDEDGIEKGMDILEESIQAALEK

Specific function: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=27.027027027027, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI284507298, Length=314, Percent_Identity=26.7515923566879, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13994255, Length=453, Percent_Identity=23.1788079470199, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=25.0580046403712, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI188536080, Length=431, Percent_Identity=22.0417633410673, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI38679950, Length=431, Percent_Identity=22.0417633410673, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI38679946, Length=431, Percent_Identity=22.0417633410673, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226442705, Length=431, Percent_Identity=24.5939675174014, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442709, Length=339, Percent_Identity=26.8436578171091, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=23.6714975845411, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=32.0843091334895, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=31.75, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789759, Length=424, Percent_Identity=27.3584905660377, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1788044, Length=398, Percent_Identity=29.3969849246231, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=28.0104712041885, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=27.511961722488, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786349, Length=340, Percent_Identity=26.1764705882353, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=27.8606965174129, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=285, Percent_Identity=27.0175438596491, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=27.6849642004773, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=453, Percent_Identity=23.841059602649, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=22.2737819025522, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=422, Percent_Identity=30.0947867298578, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=28.9855072463768, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=24.4623655913978, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357415, Length=431, Percent_Identity=26.4501160092807, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=23.972602739726, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=23.8532110091743, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356575, Length=448, Percent_Identity=23.2142857142857, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281366494, Length=431, Percent_Identity=22.5058004640371, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24667139, Length=431, Percent_Identity=22.5058004640371, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24667143, Length=431, Percent_Identity=22.5058004640371, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECTB_OCEIH (Q8ESU8)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691439.1
- ProteinModelPortal:   Q8ESU8
- SMR:   Q8ESU8
- GeneID:   1015788
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0518
- NMPDR:   fig|221109.1.peg.521
- HOGENOM:   HBG725944
- OMA:   VWEPGEH
- ProtClustDB:   PRK09264
- BioCyc:   OIHE221109:OB0518-MONOMER
- BRENDA:   2.6.1.76
- InterPro:   IPR005814
- InterPro:   IPR004637
- InterPro:   IPR012773
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF7
- TIGRFAMs:   TIGR00709
- TIGRFAMs:   TIGR02407

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.76

Molecular weight: Translated: 46943; Mature: 46812

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIVDKARNDMAVFEEMESAVRSYSRGWPVVFEKAKGYKLWDKNGNEYIDFFAGAGALN
CCCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCCEEEEEECCCCCC
YGHNPSEMQKVMIDYIQNDGVIHSLDMATAPRKKFLESFNEIILKPRNMDYKVMFPGPTG
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCC
TNTVESALKIARKVTGRDTVIGFTNAFHGMTIGSLSVTGNSFKRNGAGIPLNHAISMPFD
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCCHH
QYVDEQDSIAYIERFLEDSGSGVALPAAFILETVQGEGGINAARLEWVKKIEEICRKWDI
HHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCE
LLIIDDVQAGCGRTGTFFSFEEAGINPDIVCLSKSIGGVGLPMAITLIKPEFDQWGPGEH
EEEEECCCCCCCCCCCEEEEHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
NGTFRGNNLAFLAATEALNNWKTDAFSQNIKKMSSLFQERMKRIVEKFPELNADLRGRGL
CCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
MLGIGVHVDGLAGEICAEAFSRGLILETSGAKDEVVKFLPPLIIDEDGIEKGMDILEESI
EEEECEEECCHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCCEECCCCHHHHHHHHHHHH
QAALEK
HHHHCC
>Mature Secondary Structure 
TTIVDKARNDMAVFEEMESAVRSYSRGWPVVFEKAKGYKLWDKNGNEYIDFFAGAGALN
CCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCCEEEEEECCCCCC
YGHNPSEMQKVMIDYIQNDGVIHSLDMATAPRKKFLESFNEIILKPRNMDYKVMFPGPTG
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCC
TNTVESALKIARKVTGRDTVIGFTNAFHGMTIGSLSVTGNSFKRNGAGIPLNHAISMPFD
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCCHH
QYVDEQDSIAYIERFLEDSGSGVALPAAFILETVQGEGGINAARLEWVKKIEEICRKWDI
HHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCE
LLIIDDVQAGCGRTGTFFSFEEAGINPDIVCLSKSIGGVGLPMAITLIKPEFDQWGPGEH
EEEEECCCCCCCCCCCEEEEHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
NGTFRGNNLAFLAATEALNNWKTDAFSQNIKKMSSLFQERMKRIVEKFPELNADLRGRGL
CCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
MLGIGVHVDGLAGEICAEAFSRGLILETSGAKDEVVKFLPPLIIDEDGIEKGMDILEESI
EEEECEEECCHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCCEECCCCHHHHHHHHHHHH
QAALEK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376