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The map label for this gene is panF [H]

Identifier: 23097956

GI number: 23097956

Start: 535128

End: 536564

Strand: Direct

Name: panF [H]

Synonym: OB0501

Alternate gene names: 23097956

Gene position: 535128-536564 (Clockwise)

Preceding gene: 23097955

Following gene: 23097957

Centisome position: 14.74

GC content: 35.98

Gene sequence:

>1437_bases
ATGAATTGGGAAGCAGTTATACCATTATTCCTATTAATTTTTATCATTTTTTTAGTTGGAATGTGGTCAAGTAAATTTGT
GCGGAATACAGATTCATTTGTTCAAGAATATTTTCTTGGGGGCAGGAGCTTAGGTGGGTTCATATTAGCGATGACGCTTG
TAACTACTTATGGAAGTGCAAGTAGTTTTCTTAGTGGTCCAGGAACTGCTTATAATGAAGGATTAGGTTGGGTTCTTTTA
TCCATGACTCAATTAGCTACAGGTTATTTTGTGTTAATGGTATTAGGTAAACGATTTGCGATTGTTACTCGAAAATACAA
AGCAGTAACTATTGTAGATTTTTTAAAAGAAAGATATCAATCCAAATGGGTCGTTTTATTATCTTCATTTAGTATACTGA
TATTCTTATTTTCTGCAATGTCTGCACAATGGATAGGTGGAGGTAGGTTAATTCAGTCGCTTACTGGTATGTCTTACCTT
TCTGCATTATTTATATTTTCTGCTGCAGTACTTATCTATGTGATTGTAGGGGGATTCCGAGCAGTTGCAATTACAGATGG
AATTCAAGGAATTATTATGTTTTTAGGTACATTAATATTGCTAATTGCTGTAATTGTTGCAGGTGGAGGAGTTCCACAAA
TTATGGAAGACTTACGTGCAGAAAATATGAATCTTATAACACCTTTTGGCGCGGATGGTGGATTAACACCTGCATTTGTA
TCTTCCTTTTGGATATTAGTCGGTGTGGGAGTTATTGCCCTACCACAAATTGCAGTAAGAGCAATGTCATATAAAAACTC
GCGATCACTTCATAGAGCCATTATTATTAGTACGATTGTAGTTGGATTTATAATGTTAAATATGCACTTAATTGGCGTGC
TCGGTAGACCAGTAATGCCTGGAATTGAAGTAGGTGATACCGTTATGCCATTACTTGCTCAAGAAGTGCTACCTGGCTGG
CTAGCTGGAATTGTATTGGCAGCACCTATGGCAGCTATCATGACAACCGTTAATTCATTATTGTTAATGGTTAGTTCCAC
GATTATAAAGGATGTATATTTAAATTATATTGAAAAAGAAGCTACAGATAAAAAAGTGCGTGGTTTGAGCATGGGGGTGA
CTGCCCTTATCGGAGTTATTGTTATAGTTATGTCGCTACAACCACCTGATCTAATTATCTGGTTAAATCTATTCTCGATG
GGTGGCTTAGAAGCAGCTTTTATTTGGCCGATTGTATTGGGGTTATATTGGAACCGAGGCAATAAATATGGCGCAATAGC
TTCCATGATAACAGGTGTGTCTAGTTATATTATTTTTGAAAGTTTCTTTCCACAACCATTCGGAATGCATTCTGTTGTAA
CGTCGATAACTATTGCTTTAATAGCTTATATCATTGGAAGTTTATCTAAACAACATCCAGTATCACAAATGAGTTAA

Upstream 100 bases:

>100_bases
ATAGCAGTTAAATTCTTTTTTAAAGATATACCACTTGATGATACAGAGGAAAATTAATCTTAATACCGGGTCAATGGGTT
AGAGTGAGGAGAAAAATGTA

Downstream 100 bases:

>100_bases
ATAGTAGTTTCTATATTACTTTTAAATCTTACTTTTAAGTATCTCTCAAAAACGAGCGATACTTTTTTTATTGCTTAGGA
AACTATACAATTTGAATGCT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MNWEAVIPLFLLIFIIFLVGMWSSKFVRNTDSFVQEYFLGGRSLGGFILAMTLVTTYGSASSFLSGPGTAYNEGLGWVLL
SMTQLATGYFVLMVLGKRFAIVTRKYKAVTIVDFLKERYQSKWVVLLSSFSILIFLFSAMSAQWIGGGRLIQSLTGMSYL
SALFIFSAAVLIYVIVGGFRAVAITDGIQGIIMFLGTLILLIAVIVAGGGVPQIMEDLRAENMNLITPFGADGGLTPAFV
SSFWILVGVGVIALPQIAVRAMSYKNSRSLHRAIIISTIVVGFIMLNMHLIGVLGRPVMPGIEVGDTVMPLLAQEVLPGW
LAGIVLAAPMAAIMTTVNSLLLMVSSTIIKDVYLNYIEKEATDKKVRGLSMGVTALIGVIVIVMSLQPPDLIIWLNLFSM
GGLEAAFIWPIVLGLYWNRGNKYGAIASMITGVSSYIIFESFFPQPFGMHSVVTSITIALIAYIIGSLSKQHPVSQMS

Sequences:

>Translated_478_residues
MNWEAVIPLFLLIFIIFLVGMWSSKFVRNTDSFVQEYFLGGRSLGGFILAMTLVTTYGSASSFLSGPGTAYNEGLGWVLL
SMTQLATGYFVLMVLGKRFAIVTRKYKAVTIVDFLKERYQSKWVVLLSSFSILIFLFSAMSAQWIGGGRLIQSLTGMSYL
SALFIFSAAVLIYVIVGGFRAVAITDGIQGIIMFLGTLILLIAVIVAGGGVPQIMEDLRAENMNLITPFGADGGLTPAFV
SSFWILVGVGVIALPQIAVRAMSYKNSRSLHRAIIISTIVVGFIMLNMHLIGVLGRPVMPGIEVGDTVMPLLAQEVLPGW
LAGIVLAAPMAAIMTTVNSLLLMVSSTIIKDVYLNYIEKEATDKKVRGLSMGVTALIGVIVIVMSLQPPDLIIWLNLFSM
GGLEAAFIWPIVLGLYWNRGNKYGAIASMITGVSSYIIFESFFPQPFGMHSVVTSITIALIAYIIGSLSKQHPVSQMS
>Mature_478_residues
MNWEAVIPLFLLIFIIFLVGMWSSKFVRNTDSFVQEYFLGGRSLGGFILAMTLVTTYGSASSFLSGPGTAYNEGLGWVLL
SMTQLATGYFVLMVLGKRFAIVTRKYKAVTIVDFLKERYQSKWVVLLSSFSILIFLFSAMSAQWIGGGRLIQSLTGMSYL
SALFIFSAAVLIYVIVGGFRAVAITDGIQGIIMFLGTLILLIAVIVAGGGVPQIMEDLRAENMNLITPFGADGGLTPAFV
SSFWILVGVGVIALPQIAVRAMSYKNSRSLHRAIIISTIVVGFIMLNMHLIGVLGRPVMPGIEVGDTVMPLLAQEVLPGW
LAGIVLAAPMAAIMTTVNSLLLMVSSTIIKDVYLNYIEKEATDKKVRGLSMGVTALIGVIVIVMSLQPPDLIIWLNLFSM
GGLEAAFIWPIVLGLYWNRGNKYGAIASMITGVSSYIIFESFFPQPFGMHSVVTSITIALIAYIIGSLSKQHPVSQMS

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=492, Percent_Identity=26.4227642276423, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI17941285, Length=462, Percent_Identity=22.7272727272727, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI14140236, Length=392, Percent_Identity=23.469387755102, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4507031, Length=477, Percent_Identity=25.9958071278826, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4507033, Length=392, Percent_Identity=22.7040816326531, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082237, Length=468, Percent_Identity=47.008547008547, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1787251, Length=487, Percent_Identity=26.8993839835729, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790503, Length=446, Percent_Identity=25.1121076233184, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790113, Length=440, Percent_Identity=24.3181818181818, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539284, Length=468, Percent_Identity=23.2905982905983, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651739, Length=381, Percent_Identity=22.8346456692913, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648033, Length=464, Percent_Identity=21.9827586206897, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356865, Length=464, Percent_Identity=21.9827586206897, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51813; Mature: 51813

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWEAVIPLFLLIFIIFLVGMWSSKFVRNTDSFVQEYFLGGRSLGGFILAMTLVTTYGSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
SSFLSGPGTAYNEGLGWVLLSMTQLATGYFVLMVLGKRFAIVTRKYKAVTIVDFLKERYQ
HHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKWVVLLSSFSILIFLFSAMSAQWIGGGRLIQSLTGMSYLSALFIFSAAVLIYVIVGGFR
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVAITDGIQGIIMFLGTLILLIAVIVAGGGVPQIMEDLRAENMNLITPFGADGGLTPAFV
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
SSFWILVGVGVIALPQIAVRAMSYKNSRSLHRAIIISTIVVGFIMLNMHLIGVLGRPVMP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GIEVGDTVMPLLAQEVLPGWLAGIVLAAPMAAIMTTVNSLLLMVSSTIIKDVYLNYIEKE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATDKKVRGLSMGVTALIGVIVIVMSLQPPDLIIWLNLFSMGGLEAAFIWPIVLGLYWNRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHCCC
NKYGAIASMITGVSSYIIFESFFPQPFGMHSVVTSITIALIAYIIGSLSKQHPVSQMS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNWEAVIPLFLLIFIIFLVGMWSSKFVRNTDSFVQEYFLGGRSLGGFILAMTLVTTYGSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
SSFLSGPGTAYNEGLGWVLLSMTQLATGYFVLMVLGKRFAIVTRKYKAVTIVDFLKERYQ
HHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKWVVLLSSFSILIFLFSAMSAQWIGGGRLIQSLTGMSYLSALFIFSAAVLIYVIVGGFR
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVAITDGIQGIIMFLGTLILLIAVIVAGGGVPQIMEDLRAENMNLITPFGADGGLTPAFV
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
SSFWILVGVGVIALPQIAVRAMSYKNSRSLHRAIIISTIVVGFIMLNMHLIGVLGRPVMP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GIEVGDTVMPLLAQEVLPGWLAGIVLAAPMAAIMTTVNSLLLMVSSTIIKDVYLNYIEKE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATDKKVRGLSMGVTALIGVIVIVMSLQPPDLIIWLNLFSMGGLEAAFIWPIVLGLYWNRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHCCC
NKYGAIASMITGVSSYIIFESFFPQPFGMHSVVTSITIALIAYIIGSLSKQHPVSQMS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]