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The map label for this gene is ileS

Identifier: 23097817

GI number: 23097817

Start: 382966

End: 386034

Strand: Direct

Name: ileS

Synonym: OB0362

Alternate gene names: 23097817

Gene position: 382966-386034 (Clockwise)

Preceding gene: 23097816

Following gene: 23097818

Centisome position: 10.55

GC content: 38.35

Gene sequence:

>3069_bases
ATGGATCACGCACAACGTGAACGAAGCATGAGGGCGCATTGGAAAGAAAATCGAACGTTTCAACGCTCCATTGAAAACAG
AGAAGGTCAACAAACGTATGTATTTTATGAAGGGCCGCCAACGGCAAATGGAATGCCACATGCTGGTCATGCATTAGGCC
GTACGATTAAAGACTTTGTTGCTCGTTATAAAACAATGTCTGGTTATCAAGTATTACGTAAAGCAGGCTGGGACACACAT
GGTTTACCAGTAGAATTAGAAGTGGAAAAACAGCTTAATATCCGTGGGAAAGATGATATTGAGAAGTTTGGAGTAGAGAG
ATTTATTGAGAAATGTAAAGAAAGCGTCTTTGTTTATGAAAATGAATGGAAGGAATTCACGGACAAGCTTGGATATTGGG
TAGATATGGAAGATCCATACAAAACATTAAACAACCCATATATTGAGTCTGTTTGGAATATCCTTGCAACTATTCATGAT
GAAGATCTACTTTATAAAGGACATCGAGTAGTTCCATATTGCCCAAATTGCGAGACATCGTTAAGTTCCCATGAGGTGGC
ACAAGGCTATAAAGATGTGACAGATTTATCGGTAACTGCAAAATTCCGAATTAAAAATAAAGAAAATGAATATATTCTTG
GGTGGACAACAACTCCATGGACATTACCAGGAAATGTTGCGCTAGCAGTGAATCCAGAAATGACCTATGTAAAAGCGAAG
CAAGGTGAAGAAATCTATGTTGTTGCTAAATCATTAGCGAACACTGTTTTAGGTGAAGCTTACGAAGTGGTAGAAGAAGT
ATCGGGAGAAGATTTAGTTGGAATTAATTATGAGGCTCCATTTGACTTTATTTCTTTAGATAATGGTCATTACGTGATCG
GTGCAGACTTTGTTACCGATACAAGTGGTACCGGTATTGTCCATCTAAACCCAGCACATGGGGAAGATGACTATAACGCT
ATCCAGGCAAAAGGGATGGACTTTGTAAATGTAGTCGATTCTAAAGGAAGATATGAGGATGTAATCGCTCCGCTTGCAGG
ACAATTTGTGAAGGATAGCGATGTGGATATCATCAAAATGCTAGCAAAAGACGGAACTTTATACGAAAAGCAAAAATATG
AGCATAGCTACCCTCATTGCTGGAGATGTGATACACCATTGCTTTACTATGCGATGGAAGGTTGGTTTATTAAAACAACA
GCTGTAAAAGAAAGAATGCAGGAAAATAATCAAAGCGTAGAATGGTTCCCGAATCATATGCGTGATGGGCGTTTCGGAAA
CTTCCTTGATAATATGGTCGATTGGAATATTGGACGTAATCGCTATTGGGGAACACCGTTAAACGTATGGGTATGTGATG
ATTGTGATAAACAAAAATCGCCTCACTCGATCCAAGAGCTACGTGCTTTTGCAGATAGTGACGTACCAGAAGATATTGAA
TTGCATAAACCATATGTTGATAAAATTACATTCGACTGTGAATGTGGCGGTAAAATGCATCGTACAAAAGAAGTAATTGA
TGTTTGGTTCGACAGTGGATCGATGCCATTCGCACAATATCATCACCCGTTTGAAAACGATGAACTATTTAATAAACAAT
TCCCAGCAGATGTGGTTATTGAAGGAGTCGATCAGACACGCGGCTGGTTCTACAGTCTCCTAGCGGTATCTACACTGTTT
ACTGGTAAAACACCATACAAACGAGTATTATCTCTTGGGCATATTCTTGATGAGCATGGGCGAAAAATGTCAAAAAGTAA
AGGGAATGCTTTAAGTCCTGTGGAACTTATTGAAGAGTTTGGTGCAGATGCACTTCGTTGGGCACTTCTTGCTGATAGTT
CACCATGGAATAATAAGCGTTTCTCGAAAAAGACAGTAAGTCAGGCAAAATCAAAAGTCATTGATACGATATTAAATGTC
TATTCATTCTACTCTATGTATGCTGACATTGATAAATTTAATGTTGCAGAACATGCAACTGATGCTAAAACGACATTAGA
CAGTTGGATTCTATCCCGATTGAATTCGGTAATTAAAGAAGTAACAACAAGTCTTGATCAATATGATATTACTAAAGGTG
CTCGTTCCATTGCATTGTTTGTAGATGAATTAAGTAACTGGTATGTACGTCGTTCTAGACAGCGTTTTTGGAGCAGTGGC
ATGAATGAAGATAAAAAAGCTGCTTTCACTACATTACACGAAGTACTATCAAAACTTACGCAGTTAATGGCGCCATATAT
ACCATTTGTCGCAGATGATATATATACAAATCTGCAAGGGGATAGTGTTCATGTATCGGACTTCCCGAAAGTAGATGAAG
CTGCAATTGATGAGAAATTAGAAGCTGATATGCAAGGAGTACTTGAAGTCATTGAAGGAGCACGTTCACTCCGTAATGAA
GTAAACATTAAAACAAAGCAACCTCTTGCGGAGCTAGTGGTTGTTCCAAATGATGAACAACTTCAATCTGGGTTACAGGC
ATATACTTCCATTATCGAGGAAGAGATTAATGTGAAACAAGTTAGCTTTAAGAAAGACACTGCTGATTTCTTGGATACGG
AGATGAAACTTAACTTCCCGGTTGCTGGACCAAAACTAGGTAAACAAGTTGGTCAGGCAAAAGGAAAAGTAGAAAACTTT
ACGGAACAAGAAAAAGAAGCGTTCTTAGTGAACGGTACGATTAATGTTGAACTTCAAGATGGTAGTGAGGTCACTCTTGA
AAAAGAAGACATTATCGTAGAGAAAAAAGGACAAGAAGGATATCAATTATTTGAAGGCAATCGTTTTGTTCTTCTATTGG
ATACCAACTTGACAGAGAAGTTAAAGGAAGAAGGATTCGTAAGAGAGTTTATCCGTGCGGTACAAACATATCGTAAAGAA
CTTGATCTTCCAGTTGAACAGCGTGTGGATATATACGTGAATTCCGATGAAAATGCAGAGCGGATTCTATCAGAATTCGA
TGCTCTAATCCATGACGGATTAATCATTAACAGTGTTCAATTTGCAGAAAAAGAGGATATGAAGCAAGTAACAGTAAATG
ATACGGAAATGGGCTTGTCTATAGTATAA

Upstream 100 bases:

>100_bases
AAAACCGCTACGATGGTTTTTTATTTTTGTCTAATAATGGTAATACTCGATTCTACGTGGTGGATTCGAGTTTTTTTAAT
TTAGTGAAGAGGTGAATGGA

Downstream 100 bases:

>100_bases
GCAAAAAAGTAGGGGTGCGCCCCTGCTTTTTTGTTGTCTAGAAAATCAGAAAATTTTGGAGCTTTAGATAAACGTACGCT
TGTGCTTTTATTCTATTCCT

Product: isoleucyl-tRNA synthetase

Products: NA

Alternate protein names: Isoleucine--tRNA ligase 2; IleRS 2

Number of amino acids: Translated: 1022; Mature: 1022

Protein sequence:

>1022_residues
MDHAQRERSMRAHWKENRTFQRSIENREGQQTYVFYEGPPTANGMPHAGHALGRTIKDFVARYKTMSGYQVLRKAGWDTH
GLPVELEVEKQLNIRGKDDIEKFGVERFIEKCKESVFVYENEWKEFTDKLGYWVDMEDPYKTLNNPYIESVWNILATIHD
EDLLYKGHRVVPYCPNCETSLSSHEVAQGYKDVTDLSVTAKFRIKNKENEYILGWTTTPWTLPGNVALAVNPEMTYVKAK
QGEEIYVVAKSLANTVLGEAYEVVEEVSGEDLVGINYEAPFDFISLDNGHYVIGADFVTDTSGTGIVHLNPAHGEDDYNA
IQAKGMDFVNVVDSKGRYEDVIAPLAGQFVKDSDVDIIKMLAKDGTLYEKQKYEHSYPHCWRCDTPLLYYAMEGWFIKTT
AVKERMQENNQSVEWFPNHMRDGRFGNFLDNMVDWNIGRNRYWGTPLNVWVCDDCDKQKSPHSIQELRAFADSDVPEDIE
LHKPYVDKITFDCECGGKMHRTKEVIDVWFDSGSMPFAQYHHPFENDELFNKQFPADVVIEGVDQTRGWFYSLLAVSTLF
TGKTPYKRVLSLGHILDEHGRKMSKSKGNALSPVELIEEFGADALRWALLADSSPWNNKRFSKKTVSQAKSKVIDTILNV
YSFYSMYADIDKFNVAEHATDAKTTLDSWILSRLNSVIKEVTTSLDQYDITKGARSIALFVDELSNWYVRRSRQRFWSSG
MNEDKKAAFTTLHEVLSKLTQLMAPYIPFVADDIYTNLQGDSVHVSDFPKVDEAAIDEKLEADMQGVLEVIEGARSLRNE
VNIKTKQPLAELVVVPNDEQLQSGLQAYTSIIEEEINVKQVSFKKDTADFLDTEMKLNFPVAGPKLGKQVGQAKGKVENF
TEQEKEAFLVNGTINVELQDGSEVTLEKEDIIVEKKGQEGYQLFEGNRFVLLLDTNLTEKLKEEGFVREFIRAVQTYRKE
LDLPVEQRVDIYVNSDENAERILSEFDALIHDGLIINSVQFAEKEDMKQVTVNDTEMGLSIV

Sequences:

>Translated_1022_residues
MDHAQRERSMRAHWKENRTFQRSIENREGQQTYVFYEGPPTANGMPHAGHALGRTIKDFVARYKTMSGYQVLRKAGWDTH
GLPVELEVEKQLNIRGKDDIEKFGVERFIEKCKESVFVYENEWKEFTDKLGYWVDMEDPYKTLNNPYIESVWNILATIHD
EDLLYKGHRVVPYCPNCETSLSSHEVAQGYKDVTDLSVTAKFRIKNKENEYILGWTTTPWTLPGNVALAVNPEMTYVKAK
QGEEIYVVAKSLANTVLGEAYEVVEEVSGEDLVGINYEAPFDFISLDNGHYVIGADFVTDTSGTGIVHLNPAHGEDDYNA
IQAKGMDFVNVVDSKGRYEDVIAPLAGQFVKDSDVDIIKMLAKDGTLYEKQKYEHSYPHCWRCDTPLLYYAMEGWFIKTT
AVKERMQENNQSVEWFPNHMRDGRFGNFLDNMVDWNIGRNRYWGTPLNVWVCDDCDKQKSPHSIQELRAFADSDVPEDIE
LHKPYVDKITFDCECGGKMHRTKEVIDVWFDSGSMPFAQYHHPFENDELFNKQFPADVVIEGVDQTRGWFYSLLAVSTLF
TGKTPYKRVLSLGHILDEHGRKMSKSKGNALSPVELIEEFGADALRWALLADSSPWNNKRFSKKTVSQAKSKVIDTILNV
YSFYSMYADIDKFNVAEHATDAKTTLDSWILSRLNSVIKEVTTSLDQYDITKGARSIALFVDELSNWYVRRSRQRFWSSG
MNEDKKAAFTTLHEVLSKLTQLMAPYIPFVADDIYTNLQGDSVHVSDFPKVDEAAIDEKLEADMQGVLEVIEGARSLRNE
VNIKTKQPLAELVVVPNDEQLQSGLQAYTSIIEEEINVKQVSFKKDTADFLDTEMKLNFPVAGPKLGKQVGQAKGKVENF
TEQEKEAFLVNGTINVELQDGSEVTLEKEDIIVEKKGQEGYQLFEGNRFVLLLDTNLTEKLKEEGFVREFIRAVQTYRKE
LDLPVEQRVDIYVNSDENAERILSEFDALIHDGLIINSVQFAEKEDMKQVTVNDTEMGLSIV
>Mature_1022_residues
MDHAQRERSMRAHWKENRTFQRSIENREGQQTYVFYEGPPTANGMPHAGHALGRTIKDFVARYKTMSGYQVLRKAGWDTH
GLPVELEVEKQLNIRGKDDIEKFGVERFIEKCKESVFVYENEWKEFTDKLGYWVDMEDPYKTLNNPYIESVWNILATIHD
EDLLYKGHRVVPYCPNCETSLSSHEVAQGYKDVTDLSVTAKFRIKNKENEYILGWTTTPWTLPGNVALAVNPEMTYVKAK
QGEEIYVVAKSLANTVLGEAYEVVEEVSGEDLVGINYEAPFDFISLDNGHYVIGADFVTDTSGTGIVHLNPAHGEDDYNA
IQAKGMDFVNVVDSKGRYEDVIAPLAGQFVKDSDVDIIKMLAKDGTLYEKQKYEHSYPHCWRCDTPLLYYAMEGWFIKTT
AVKERMQENNQSVEWFPNHMRDGRFGNFLDNMVDWNIGRNRYWGTPLNVWVCDDCDKQKSPHSIQELRAFADSDVPEDIE
LHKPYVDKITFDCECGGKMHRTKEVIDVWFDSGSMPFAQYHHPFENDELFNKQFPADVVIEGVDQTRGWFYSLLAVSTLF
TGKTPYKRVLSLGHILDEHGRKMSKSKGNALSPVELIEEFGADALRWALLADSSPWNNKRFSKKTVSQAKSKVIDTILNV
YSFYSMYADIDKFNVAEHATDAKTTLDSWILSRLNSVIKEVTTSLDQYDITKGARSIALFVDELSNWYVRRSRQRFWSSG
MNEDKKAAFTTLHEVLSKLTQLMAPYIPFVADDIYTNLQGDSVHVSDFPKVDEAAIDEKLEADMQGVLEVIEGARSLRNE
VNIKTKQPLAELVVVPNDEQLQSGLQAYTSIIEEEINVKQVSFKKDTADFLDTEMKLNFPVAGPKLGKQVGQAKGKVENF
TEQEKEAFLVNGTINVELQDGSEVTLEKEDIIVEKKGQEGYQLFEGNRFVLLLDTNLTEKLKEEGFVREFIRAVQTYRKE
LDLPVEQRVDIYVNSDENAERILSEFDALIHDGLIINSVQFAEKEDMKQVTVNDTEMGLSIV

Specific function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activi

COG id: COG0060

COG function: function code J; Isoleucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily

Homologues:

Organism=Homo sapiens, GI94721239, Length=1046, Percent_Identity=35.9464627151052, Blast_Score=655, Evalue=0.0,
Organism=Homo sapiens, GI94721241, Length=1046, Percent_Identity=35.9464627151052, Blast_Score=655, Evalue=0.0,
Organism=Homo sapiens, GI46852147, Length=796, Percent_Identity=28.2663316582915, Blast_Score=283, Evalue=6e-76,
Organism=Homo sapiens, GI5454158, Length=865, Percent_Identity=22.1965317919075, Blast_Score=158, Evalue=3e-38,
Organism=Homo sapiens, GI268370295, Length=849, Percent_Identity=22.0259128386337, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI268370293, Length=857, Percent_Identity=22.0536756126021, Blast_Score=150, Evalue=7e-36,
Organism=Homo sapiens, GI268370297, Length=857, Percent_Identity=22.0536756126021, Blast_Score=150, Evalue=7e-36,
Organism=Escherichia coli, GI2367096, Length=785, Percent_Identity=29.4267515923567, Blast_Score=341, Evalue=2e-94,
Organism=Escherichia coli, GI1790708, Length=887, Percent_Identity=22.9988726042841, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1786861, Length=886, Percent_Identity=20.8803611738149, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17541896, Length=999, Percent_Identity=36.4364364364364, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980946, Length=876, Percent_Identity=28.0821917808219, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17510661, Length=872, Percent_Identity=23.9678899082569, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI72001587, Length=853, Percent_Identity=22.0398593200469, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319395, Length=1002, Percent_Identity=35.5289421157685, Blast_Score=637, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6325217, Length=788, Percent_Identity=26.0152284263959, Blast_Score=255, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6321531, Length=836, Percent_Identity=23.444976076555, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574730, Length=1003, Percent_Identity=33.6989032901296, Blast_Score=603, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24668547, Length=1003, Percent_Identity=33.6989032901296, Blast_Score=603, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24668543, Length=1003, Percent_Identity=33.6989032901296, Blast_Score=603, Evalue=1e-172,
Organism=Drosophila melanogaster, GI281366294, Length=784, Percent_Identity=27.9336734693878, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17864482, Length=868, Percent_Identity=23.3870967741935, Blast_Score=184, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24653289, Length=868, Percent_Identity=23.3870967741935, Blast_Score=184, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355675, Length=874, Percent_Identity=21.2814645308924, Blast_Score=144, Evalue=3e-34,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYI2_OCEIH (Q8ET99)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691283.1
- ProteinModelPortal:   Q8ET99
- SMR:   Q8ET99
- GeneID:   1015648
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0362
- NMPDR:   fig|221109.1.peg.367
- HOGENOM:   HBG577712
- OMA:   VEYEVEK
- ProtClustDB:   PRK06039
- BioCyc:   OIHE221109:OB0362-MONOMER
- BRENDA:   6.1.1.5
- GO:   GO:0005737
- HAMAP:   MF_02003
- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002301
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF9
- PRINTS:   PR00984
- TIGRFAMs:   TIGR00392

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit

EC number: =6.1.1.5

Molecular weight: Translated: 116801; Mature: 116801

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 585-585

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHAQRERSMRAHWKENRTFQRSIENREGQQTYVFYEGPPTANGMPHAGHALGRTIKDFV
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ARYKTMSGYQVLRKAGWDTHGLPVELEVEKQLNIRGKDDIEKFGVERFIEKCKESVFVYE
HHHHCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEH
NEWKEFTDKLGYWVDMEDPYKTLNNPYIESVWNILATIHDEDLLYKGHRVVPYCPNCETS
HHHHHHHHHCCEEEECCCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCC
LSSHEVAQGYKDVTDLSVTAKFRIKNKENEYILGWTTTPWTLPGNVALAVNPEMTYVKAK
CCHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCEECCCCEEEEECCCEEEEEEC
QGEEIYVVAKSLANTVLGEAYEVVEEVSGEDLVGINYEAPFDFISLDNGHYVIGADFVTD
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEECCCCEEEEECEEEC
TSGTGIVHLNPAHGEDDYNAIQAKGMDFVNVVDSKGRYEDVIAPLAGQFVKDSDVDIIKM
CCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAKDGTLYEKQKYEHSYPHCWRCDTPLLYYAMEGWFIKTTAVKERMQENNQSVEWFPNHM
HHCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHCCCCEEECCCCC
RDGRFGNFLDNMVDWNIGRNRYWGTPLNVWVCDDCDKQKSPHSIQELRAFADSDVPEDIE
CCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
LHKPYVDKITFDCECGGKMHRTKEVIDVWFDSGSMPFAQYHHPFENDELFNKQFPADVVI
CCCCHHHCEEEEECCCCCHHHHHHHHHHEECCCCCCHHHHCCCCCCCCHHCCCCCHHHEE
EGVDQTRGWFYSLLAVSTLFTGKTPYKRVLSLGHILDEHGRKMSKSKGNALSPVELIEEF
ECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GADALRWALLADSSPWNNKRFSKKTVSQAKSKVIDTILNVYSFYSMYADIDKFNVAEHAT
CCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHCC
DAKTTLDSWILSRLNSVIKEVTTSLDQYDITKGARSIALFVDELSNWYVRRSRQRFWSSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNEDKKAAFTTLHEVLSKLTQLMAPYIPFVADDIYTNLQGDSVHVSDFPKVDEAAIDEKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHH
EADMQGVLEVIEGARSLRNEVNIKTKQPLAELVVVPNDEQLQSGLQAYTSIIEEEINVKQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEE
VSFKKDTADFLDTEMKLNFPVAGPKLGKQVGQAKGKVENFTEQEKEAFLVNGTINVELQD
EECCCCHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEECEEEEEECC
GSEVTLEKEDIIVEKKGQEGYQLFEGNRFVLLLDTNLTEKLKEEGFVREFIRAVQTYRKE
CCEEEEECCCEEEECCCCCCCEEECCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHH
LDLPVEQRVDIYVNSDENAERILSEFDALIHDGLIINSVQFAEKEDMKQVTVNDTEMGLS
CCCCHHCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCHHHCHHCCCEEECCCCCCCCE
IV
EC
>Mature Secondary Structure
MDHAQRERSMRAHWKENRTFQRSIENREGQQTYVFYEGPPTANGMPHAGHALGRTIKDFV
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ARYKTMSGYQVLRKAGWDTHGLPVELEVEKQLNIRGKDDIEKFGVERFIEKCKESVFVYE
HHHHCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEH
NEWKEFTDKLGYWVDMEDPYKTLNNPYIESVWNILATIHDEDLLYKGHRVVPYCPNCETS
HHHHHHHHHCCEEEECCCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCC
LSSHEVAQGYKDVTDLSVTAKFRIKNKENEYILGWTTTPWTLPGNVALAVNPEMTYVKAK
CCHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCEECCCCEEEEECCCEEEEEEC
QGEEIYVVAKSLANTVLGEAYEVVEEVSGEDLVGINYEAPFDFISLDNGHYVIGADFVTD
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEECCCCEEEEECEEEC
TSGTGIVHLNPAHGEDDYNAIQAKGMDFVNVVDSKGRYEDVIAPLAGQFVKDSDVDIIKM
CCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAKDGTLYEKQKYEHSYPHCWRCDTPLLYYAMEGWFIKTTAVKERMQENNQSVEWFPNHM
HHCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHCCCCEEECCCCC
RDGRFGNFLDNMVDWNIGRNRYWGTPLNVWVCDDCDKQKSPHSIQELRAFADSDVPEDIE
CCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
LHKPYVDKITFDCECGGKMHRTKEVIDVWFDSGSMPFAQYHHPFENDELFNKQFPADVVI
CCCCHHHCEEEEECCCCCHHHHHHHHHHEECCCCCCHHHHCCCCCCCCHHCCCCCHHHEE
EGVDQTRGWFYSLLAVSTLFTGKTPYKRVLSLGHILDEHGRKMSKSKGNALSPVELIEEF
ECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GADALRWALLADSSPWNNKRFSKKTVSQAKSKVIDTILNVYSFYSMYADIDKFNVAEHAT
CCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHCC
DAKTTLDSWILSRLNSVIKEVTTSLDQYDITKGARSIALFVDELSNWYVRRSRQRFWSSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MNEDKKAAFTTLHEVLSKLTQLMAPYIPFVADDIYTNLQGDSVHVSDFPKVDEAAIDEKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHH
EADMQGVLEVIEGARSLRNEVNIKTKQPLAELVVVPNDEQLQSGLQAYTSIIEEEINVKQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEE
VSFKKDTADFLDTEMKLNFPVAGPKLGKQVGQAKGKVENFTEQEKEAFLVNGTINVELQD
EECCCCHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEECEEEEEECC
GSEVTLEKEDIIVEKKGQEGYQLFEGNRFVLLLDTNLTEKLKEEGFVREFIRAVQTYRKE
CCEEEEECCCEEEECCCCCCCEEECCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHH
LDLPVEQRVDIYVNSDENAERILSEFDALIHDGLIINSVQFAEKEDMKQVTVNDTEMGLS
CCCCHHCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCHHHCHHCCCEEECCCCCCCCE
IV
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376