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The map label for this gene is srrA [H]

Identifier: 229918113

GI number: 229918113

Start: 2343688

End: 2344377

Strand: Reverse

Name: srrA [H]

Synonym: EAT1b_2393

Alternate gene names: 229918113

Gene position: 2344377-2343688 (Counterclockwise)

Preceding gene: 229918114

Following gene: 229918112

Centisome position: 78.15

GC content: 50.29

Gene sequence:

>690_bases
ATGTCAGAATCAATGTTTCGTATCCTCGTGACCGACGACGAAGAACAAATGCGCGATTTGCTTGTATCAAATTTAGAAAA
AGAAGGGTATGAGACGGTCACCGCCTCAAACGGCCTTGAAGCGATTGAACGCTTGAAAGAAGAGACGTTCCATCTCGTCT
TACTTGACGTGATGATGCCAGAACTCGACGGATTGACGGCCTGCATGCGCATCCGTGAGTTCTCAAACGTACCCATCATC
CTGTTGACGGCACGCTCAGAAGAGCTCGACCGCATTCACGGCCTGAAAATCGGGGCAGACGATTACATCACAAAACCGTT
TAGCCCACGCGAATTACTCGCACGAATCGAAGCGACGCTCCGTCGTACGCACAGCTTCTCGAAAGAACAAGAGGCGACGT
TTGATGTCGGAATCCTCTCGATTGATATCGAAGGACGTGCCGTCAGTGTGAAAGGGAAGACCGTCAACTTGACACGAAAA
GAGTTTGATTTGCTCTACCTGTTCATCACGAACGACGAGAAAGTATTCTCTCGTGAGCAATTGCTCGATCAAATTTGGGG
GACCGAGTACCACGGGAACCTTCGCACGGTCGATACTCACATTAAGACGCTGCGCCTGAAACTCGGCGAGGCGGGCGGTT
ATATCCAGACCGTTTGGGGGATTGGCTACAAATTTGAGGCAAACGGATGA

Upstream 100 bases:

>100_bases
GAGCCGAATAAATCTGTTCTAATTCGAAGAGATAGGTATGATAGAAGTATGAGGGATTTATCACAACTCCCGTTAACCGT
TTTGCAAAGGAGAATGGCAT

Downstream 100 bases:

>100_bases
AACGATACACGATCAGGAAGCGGATTTGGATTACCATCTGGACAGCCAGCCTCTTCTCAGCGTTCGTGTTTCTCATCATG
ACGTTTTATCTGTACGACAA

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSESMFRILVTDDEEQMRDLLVSNLEKEGYETVTASNGLEAIERLKEETFHLVLLDVMMPELDGLTACMRIREFSNVPII
LLTARSEELDRIHGLKIGADDYITKPFSPRELLARIEATLRRTHSFSKEQEATFDVGILSIDIEGRAVSVKGKTVNLTRK
EFDLLYLFITNDEKVFSREQLLDQIWGTEYHGNLRTVDTHIKTLRLKLGEAGGYIQTVWGIGYKFEANG

Sequences:

>Translated_229_residues
MSESMFRILVTDDEEQMRDLLVSNLEKEGYETVTASNGLEAIERLKEETFHLVLLDVMMPELDGLTACMRIREFSNVPII
LLTARSEELDRIHGLKIGADDYITKPFSPRELLARIEATLRRTHSFSKEQEATFDVGILSIDIEGRAVSVKGKTVNLTRK
EFDLLYLFITNDEKVFSREQLLDQIWGTEYHGNLRTVDTHIKTLRLKLGEAGGYIQTVWGIGYKFEANG
>Mature_228_residues
SESMFRILVTDDEEQMRDLLVSNLEKEGYETVTASNGLEAIERLKEETFHLVLLDVMMPELDGLTACMRIREFSNVPIIL
LTARSEELDRIHGLKIGADDYITKPFSPRELLARIEATLRRTHSFSKEQEATFDVGILSIDIEGRAVSVKGKTVNLTRKE
FDLLYLFITNDEKVFSREQLLDQIWGTEYHGNLRTVDTHIKTLRLKLGEAGGYIQTVWGIGYKFEANG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=41.2017167381974, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=40.5172413793103, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=42.2222222222222, Blast_Score=173, Evalue=8e-45,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.9369369369369, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.4821428571429, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=38.3259911894273, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=37.0044052863436, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=35.5263157894737, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=34.5132743362832, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=35.2678571428571, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=33.9366515837104, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.3571428571429, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=32.4894514767932, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790437, Length=133, Percent_Identity=35.3383458646617, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790299, Length=145, Percent_Identity=29.6551724137931, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=35.2941176470588, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=30.1724137931034, Blast_Score=62, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=104, Percent_Identity=37.5, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26175; Mature: 26044

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESMFRILVTDDEEQMRDLLVSNLEKEGYETVTASNGLEAIERLKEETFHLVLLDVMMP
CCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
ELDGLTACMRIREFSNVPIILLTARSEELDRIHGLKIGADDYITKPFSPRELLARIEATL
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHH
RRTHSFSKEQEATFDVGILSIDIEGRAVSVKGKTVNLTRKEFDLLYLFITNDEKVFSREQ
HHHHCCCCCCCCEEEEEEEEEEECCEEEEEECCEEEEEEECEEEEEEEEECCHHHHHHHH
LLDQIWGTEYHGNLRTVDTHIKTLRLKLGEAGGYIQTVWGIGYKFEANG
HHHHHCCCCCCCCEEEHHHHHEEHEEEECCCCCEEEEEECCCEEEECCC
>Mature Secondary Structure 
SESMFRILVTDDEEQMRDLLVSNLEKEGYETVTASNGLEAIERLKEETFHLVLLDVMMP
CCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
ELDGLTACMRIREFSNVPIILLTARSEELDRIHGLKIGADDYITKPFSPRELLARIEATL
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHH
RRTHSFSKEQEATFDVGILSIDIEGRAVSVKGKTVNLTRKEFDLLYLFITNDEKVFSREQ
HHHHCCCCCCCCEEEEEEEEEEECCEEEEEECCEEEEEEECEEEEEEEEECCHHHHHHHH
LLDQIWGTEYHGNLRTVDTHIKTLRLKLGEAGGYIQTVWGIGYKFEANG
HHHHHCCCCCCCCEEEHHHHHEEHEEEECCCCCEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA