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The map label for this gene is yhcA [H]

Identifier: 229917899

GI number: 229917899

Start: 2113152

End: 2114648

Strand: Reverse

Name: yhcA [H]

Synonym: EAT1b_2177

Alternate gene names: 229917899

Gene position: 2114648-2113152 (Counterclockwise)

Preceding gene: 229917907

Following gene: 229917898

Centisome position: 70.49

GC content: 50.63

Gene sequence:

>1497_bases
ATGAAACCAGAATTCCAAAAGAAACCGCCTTACGTTATGCTGGCGGTCCTCTTTGCGGGTGCGTTTATCGCATTTTTAAA
CAACTCATTACTCAACGTCGCGCTCCCATCGATCATGGTCGACCTCGAGATTGCAGACTACTCGACCGTTCAATGGCTCG
CGACAGGCTTTATGCTCGTGACAGGTGTACTCGTCCCGGCATCCGCCTATTTGATCACTCGTTTTTCTAACCGAAGCTTG
TTCATCACCTCGATGAGTATCTTCGCCATCGGTACGGCGATCGCGGCCTTCTCGCCAAACTTTGGCTGGTTGTTGAGCGG
TCGGATGATTCAAGCCGTCGGAGCCTCGACAATGGGACCACTCTTGATGAACGTCATGCTCGTCAGCTTCCCTCGTGAAA
AACGGGGAATGGCGATGGGAATCTTCGGGCTCGTCATGATCTCGGCACCTGCGATTGGACCGACACTCTCGGGTTATATC
GTCGAGTACTATGACTGGCGCGTCTTATTCGAAATGATTTTACCGCTCGCCATCATCGGTCTCGCGCTCGCTGTTTGGAA
AGCGGAGAACGTCATGGTCCAAAACAAAGACCAATCTCTCGATTACTTGTCACTCGTCTTATCGACACTCGGATTTGGTG
GAATTTTGTACGGTGTCAGCTCAGCAAGCTCGGACGGCTGGGATAACCCAATCGTCTTGGCGACGATGATTGTCGGTGCC
ATCTCATTGATCGCCTTCATCTACCGCCAGCTTCATATGGAAAAACCATTACTCGACTTGCGTGCTTACAAACATCCGAT
GTTCGCACTCGCGTCAGTCATTGCGATGGTCAATGCGGTCGCCATGTTCTCCGGTATGATTTTGACACCGGCTTACGTCC
AAAGCGTACGTGGCATCTCGCCACTCGATTCAGGGCTCATGCTTCTCCCTGGTGCGATCATCATGGGAATCATGTCGCCA
ATCACGGGTAAACTGTTTGACCGATTCGGGCCAAAATTATTGGCAATTACCGGATTGACCATCACCGCCGTATCGACGTA
CATGCTCGCTCACGTCCAACTTGACTCGACGTACACGTATATCGTCTTAACGTACACATTGCGTATGTTCGGGATGTCGA
TGGTCATGATGCCGATCATGACAAATGGACTCAACCAGTTACCGACTCGCCTCAATCCGCACGGAACGGCCATCAACAAC
ACGGCCCAACAAGTATCTGGTGCGATTGGTACGGCAGTCCTCGTCACTATCATGAACTCGGTGACACGCACGGAAGCTGA
ATCATTGATGACCGGAATTGATCCTGCGACACTCACTGAGAGCTCGATGGGTGCCATCACTCAGCAAGCCCTCTTGTCTG
GGATTCAATATTCGTTCTATGTCGCACTCGGGATGAACCTCTTGGCACTCGTTTTAGCATTTTTCGTGAAACGCGTGGAT
GTACGGAAGTTCGATGACAATGTAGAAGCTATTGAAGAATTGAAACAAGCGAATTAA

Upstream 100 bases:

>100_bases
AATAGTACAAAAAGGTTGCTTTATTTATACAACGGGTATAAAATCATTTCATCGACACTTACCAACACATAACTATTTAG
AAAATAAAGGAGCCATCCAT

Downstream 100 bases:

>100_bases
TAGGAAAAGCCGTTCTGAATGAATTGATTCAGAGCGGCTTTTTTAATTTCTCATTCCCTACATAAATAAATCTGAAATTA
AAATTTAATCCTAATATGGT

Product: drug resistance transporter EmrB/QacA subfamily

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKPEFQKKPPYVMLAVLFAGAFIAFLNNSLLNVALPSIMVDLEIADYSTVQWLATGFMLVTGVLVPASAYLITRFSNRSL
FITSMSIFAIGTAIAAFSPNFGWLLSGRMIQAVGASTMGPLLMNVMLVSFPREKRGMAMGIFGLVMISAPAIGPTLSGYI
VEYYDWRVLFEMILPLAIIGLALAVWKAENVMVQNKDQSLDYLSLVLSTLGFGGILYGVSSASSDGWDNPIVLATMIVGA
ISLIAFIYRQLHMEKPLLDLRAYKHPMFALASVIAMVNAVAMFSGMILTPAYVQSVRGISPLDSGLMLLPGAIIMGIMSP
ITGKLFDRFGPKLLAITGLTITAVSTYMLAHVQLDSTYTYIVLTYTLRMFGMSMVMMPIMTNGLNQLPTRLNPHGTAINN
TAQQVSGAIGTAVLVTIMNSVTRTEAESLMTGIDPATLTESSMGAITQQALLSGIQYSFYVALGMNLLALVLAFFVKRVD
VRKFDDNVEAIEELKQAN

Sequences:

>Translated_498_residues
MKPEFQKKPPYVMLAVLFAGAFIAFLNNSLLNVALPSIMVDLEIADYSTVQWLATGFMLVTGVLVPASAYLITRFSNRSL
FITSMSIFAIGTAIAAFSPNFGWLLSGRMIQAVGASTMGPLLMNVMLVSFPREKRGMAMGIFGLVMISAPAIGPTLSGYI
VEYYDWRVLFEMILPLAIIGLALAVWKAENVMVQNKDQSLDYLSLVLSTLGFGGILYGVSSASSDGWDNPIVLATMIVGA
ISLIAFIYRQLHMEKPLLDLRAYKHPMFALASVIAMVNAVAMFSGMILTPAYVQSVRGISPLDSGLMLLPGAIIMGIMSP
ITGKLFDRFGPKLLAITGLTITAVSTYMLAHVQLDSTYTYIVLTYTLRMFGMSMVMMPIMTNGLNQLPTRLNPHGTAINN
TAQQVSGAIGTAVLVTIMNSVTRTEAESLMTGIDPATLTESSMGAITQQALLSGIQYSFYVALGMNLLALVLAFFVKRVD
VRKFDDNVEAIEELKQAN
>Mature_498_residues
MKPEFQKKPPYVMLAVLFAGAFIAFLNNSLLNVALPSIMVDLEIADYSTVQWLATGFMLVTGVLVPASAYLITRFSNRSL
FITSMSIFAIGTAIAAFSPNFGWLLSGRMIQAVGASTMGPLLMNVMLVSFPREKRGMAMGIFGLVMISAPAIGPTLSGYI
VEYYDWRVLFEMILPLAIIGLALAVWKAENVMVQNKDQSLDYLSLVLSTLGFGGILYGVSSASSDGWDNPIVLATMIVGA
ISLIAFIYRQLHMEKPLLDLRAYKHPMFALASVIAMVNAVAMFSGMILTPAYVQSVRGISPLDSGLMLLPGAIIMGIMSP
ITGKLFDRFGPKLLAITGLTITAVSTYMLAHVQLDSTYTYIVLTYTLRMFGMSMVMMPIMTNGLNQLPTRLNPHGTAINN
TAQQVSGAIGTAVLVTIMNSVTRTEAESLMTGIDPATLTESSMGAITQQALLSGIQYSFYVALGMNLLALVLAFFVKRVD
VRKFDDNVEAIEELKQAN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=416, Percent_Identity=25.2403846153846, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789042, Length=499, Percent_Identity=23.6472945891784, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081983, Length=396, Percent_Identity=26.7676767676768, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790195, Length=435, Percent_Identity=25.5172413793103, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788392, Length=399, Percent_Identity=25.8145363408521, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323735, Length=334, Percent_Identity=24.8502994011976, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=247, Percent_Identity=24.6963562753036, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=537, Percent_Identity=21.0428305400372, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53946; Mature: 53946

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPEFQKKPPYVMLAVLFAGAFIAFLNNSLLNVALPSIMVDLEIADYSTVQWLATGFMLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHH
TGVLVPASAYLITRFSNRSLFITSMSIFAIGTAIAAFSPNFGWLLSGRMIQAVGASTMGP
HHHHHHHHHHHEEEECCCEEEEEHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHH
LLMNVMLVSFPREKRGMAMGIFGLVMISAPAIGPTLSGYIVEYYDWRVLFEMILPLAIIG
HHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHH
LALAVWKAENVMVQNKDQSLDYLSLVLSTLGFGGILYGVSSASSDGWDNPIVLATMIVGA
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ISLIAFIYRQLHMEKPLLDLRAYKHPMFALASVIAMVNAVAMFSGMILTPAYVQSVRGIS
HHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHHCCCC
PLDSGLMLLPGAIIMGIMSPITGKLFDRFGPKLLAITGLTITAVSTYMLAHVQLDSTYTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHEEEECCCHHH
IVLTYTLRMFGMSMVMMPIMTNGLNQLPTRLNPHGTAINNTAQQVSGAIGTAVLVTIMNS
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VTRTEAESLMTGIDPATLTESSMGAITQQALLSGIQYSFYVALGMNLLALVLAFFVKRVD
HHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKFDDNVEAIEELKQAN
HHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKPEFQKKPPYVMLAVLFAGAFIAFLNNSLLNVALPSIMVDLEIADYSTVQWLATGFMLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHH
TGVLVPASAYLITRFSNRSLFITSMSIFAIGTAIAAFSPNFGWLLSGRMIQAVGASTMGP
HHHHHHHHHHHEEEECCCEEEEEHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHH
LLMNVMLVSFPREKRGMAMGIFGLVMISAPAIGPTLSGYIVEYYDWRVLFEMILPLAIIG
HHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHH
LALAVWKAENVMVQNKDQSLDYLSLVLSTLGFGGILYGVSSASSDGWDNPIVLATMIVGA
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ISLIAFIYRQLHMEKPLLDLRAYKHPMFALASVIAMVNAVAMFSGMILTPAYVQSVRGIS
HHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHHCCCC
PLDSGLMLLPGAIIMGIMSPITGKLFDRFGPKLLAITGLTITAVSTYMLAHVQLDSTYTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHEEEECCCHHH
IVLTYTLRMFGMSMVMMPIMTNGLNQLPTRLNPHGTAINNTAQQVSGAIGTAVLVTIMNS
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VTRTEAESLMTGIDPATLTESSMGAITQQALLSGIQYSFYVALGMNLLALVLAFFVKRVD
HHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKFDDNVEAIEELKQAN
HHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]