Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 229917812

GI number: 229917812

Start: 2043911

End: 2044894

Strand: Reverse

Name: qor [C]

Synonym: EAT1b_2090

Alternate gene names: 229917812

Gene position: 2044894-2043911 (Counterclockwise)

Preceding gene: 229917814

Following gene: 229917811

Centisome position: 68.17

GC content: 54.27

Gene sequence:

>984_bases
ATGAAAGCTTTATTACTACACGAACCGAACACATGGCAAACGATGCGAATCGAAGAAGTTGATACACCGACGCTTCGTTC
CGGTGAGGTATTGATTGAAGGAGAATATGCAGGGCTCAACCCCGTCGACTATAAAACGGCGACCAACGGCAAACCCGAAT
GGTCATACCCTCACGTCCTCGGGCTTGATGTCGCGGGTACGATTTCCGCTGTCGCGGATGACGTGACGAATGTACAAGTC
GGTGACCGTGTCCTCTACCACAGCAACTGGAATGAATGGGGTGGTTTCGCCGAGTTCACTCGTGCCAAGGCGCACATGGT
CGTCCCGATTCCAGAATCCATCTCGTTCGCTGATGCGGTCGCTTTACCGACAGCTGGATTCACAGCGTACCAAGCCATCT
TTGAAAAACTTCCGATGAATGCGATCGACACGATCCTCATTCACGCGGGTGCCGGTGGTGTCGGTGGCTTTGCCATTCAG
CTGGCGAAGTATCTCGGAAAGCGTGTCATCACGACCGCTTCAGCGCGCAACCATGACTGGGTCAAACAGCTCGGAGCTGA
CGAGGCCATCGATTACAATACGGAAGACTGGCAACAACGAGTGATGGAACTGACGAGTGGTCACGGTGTCAATGCCGTCA
TCGATCCCGTCGGTCGTGAGACGGCGACCGCTTCCCTCGAAGTCATCGCCTATAACGGACATATCGCCCATATCGCCGGA
GCCCCTGACATGAGTGTCATCAAACCGTTCACACGTGTCATCTCCTACCATGAGGTCGCCCTCAATGCGATTCATCATCA
ACAGGACCGCGTGAGCGAGGCGAACATCGTCCGCATCGGCACGCACATGCTCGAACTGCTTGCAGCGGGCGAGATTCAAC
CGATGATTCAAGAGACGATTCCGTTCGCGGACATCCCGAAGAAGTTGGTCGAACTCTCAGACCGACACGTCGTCGGGAAG
ATTGTTGCCAACCTAAAAGCATAA

Upstream 100 bases:

>100_bases
TTTTGTATTCGTTATCTTCAGTATAAAAGGCAGTAAATCATAAGACAAATAACGTTTAAAGGATATATCGATAAATAAAT
TTATAAGGAGTGGATAGTTG

Downstream 100 bases:

>100_bases
TCACAAAAGTCATGCCAATTATAAATTGACATTGATAATCATTTTCAATTAGTCTGTTGTTGAGGTGATGACAATGAAAC
TATTGATTGGGTACGTGAGC

Product: alcohol dehydrogenase zinc-binding domain protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKALLLHEPNTWQTMRIEEVDTPTLRSGEVLIEGEYAGLNPVDYKTATNGKPEWSYPHVLGLDVAGTISAVADDVTNVQV
GDRVLYHSNWNEWGGFAEFTRAKAHMVVPIPESISFADAVALPTAGFTAYQAIFEKLPMNAIDTILIHAGAGGVGGFAIQ
LAKYLGKRVITTASARNHDWVKQLGADEAIDYNTEDWQQRVMELTSGHGVNAVIDPVGRETATASLEVIAYNGHIAHIAG
APDMSVIKPFTRVISYHEVALNAIHHQQDRVSEANIVRIGTHMLELLAAGEIQPMIQETIPFADIPKKLVELSDRHVVGK
IVANLKA

Sequences:

>Translated_327_residues
MKALLLHEPNTWQTMRIEEVDTPTLRSGEVLIEGEYAGLNPVDYKTATNGKPEWSYPHVLGLDVAGTISAVADDVTNVQV
GDRVLYHSNWNEWGGFAEFTRAKAHMVVPIPESISFADAVALPTAGFTAYQAIFEKLPMNAIDTILIHAGAGGVGGFAIQ
LAKYLGKRVITTASARNHDWVKQLGADEAIDYNTEDWQQRVMELTSGHGVNAVIDPVGRETATASLEVIAYNGHIAHIAG
APDMSVIKPFTRVISYHEVALNAIHHQQDRVSEANIVRIGTHMLELLAAGEIQPMIQETIPFADIPKKLVELSDRHVVGK
IVANLKA
>Mature_327_residues
MKALLLHEPNTWQTMRIEEVDTPTLRSGEVLIEGEYAGLNPVDYKTATNGKPEWSYPHVLGLDVAGTISAVADDVTNVQV
GDRVLYHSNWNEWGGFAEFTRAKAHMVVPIPESISFADAVALPTAGFTAYQAIFEKLPMNAIDTILIHAGAGGVGGFAIQ
LAKYLGKRVITTASARNHDWVKQLGADEAIDYNTEDWQQRVMELTSGHGVNAVIDPVGRETATASLEVIAYNGHIAHIAG
APDMSVIKPFTRVISYHEVALNAIHHQQDRVSEANIVRIGTHMLELLAAGEIQPMIQETIPFADIPKKLVELSDRHVVGK
IVANLKA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=238, Percent_Identity=27.3109243697479, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI13236495, Length=238, Percent_Identity=27.3109243697479, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI22538446, Length=335, Percent_Identity=24.1791044776119, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI22538444, Length=335, Percent_Identity=24.1791044776119, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI194239676, Length=204, Percent_Identity=29.9019607843137, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI47519420, Length=333, Percent_Identity=26.7267267267267, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI18379349, Length=284, Percent_Identity=26.056338028169, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI24308257, Length=348, Percent_Identity=24.4252873563218, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI41872631, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI28557745, Length=232, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1790485, Length=206, Percent_Identity=33.0097087378641, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789651, Length=262, Percent_Identity=28.6259541984733, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510941, Length=229, Percent_Identity=25.764192139738, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=300, Percent_Identity=27.6666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71987554, Length=359, Percent_Identity=26.4623955431755, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319520, Length=344, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581345, Length=278, Percent_Identity=24.8201438848921, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19920632, Length=235, Percent_Identity=24.6808510638298, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330659, Length=235, Percent_Identity=24.6808510638298, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35638; Mature: 35638

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLLHEPNTWQTMRIEEVDTPTLRSGEVLIEGEYAGLNPVDYKTATNGKPEWSYPHVL
CCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
GLDVAGTISAVADDVTNVQVGDRVLYHSNWNEWGGFAEFTRAKAHMVVPIPESISFADAV
ECCCHHHHHHHHHHHCCEEECCEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHH
ALPTAGFTAYQAIFEKLPMNAIDTILIHAGAGGVGGFAIQLAKYLGKRVITTASARNHDW
HCCCCCHHHHHHHHHHCCCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCCHHH
VKQLGADEAIDYNTEDWQQRVMELTSGHGVNAVIDPVGRETATASLEVIAYNGHIAHIAG
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEECCEEEEEEC
APDMSVIKPFTRVISYHEVALNAIHHQQDRVSEANIVRIGTHMLELLAAGEIQPMIQETI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCHHHHHHC
PFADIPKKLVELSDRHVVGKIVANLKA
CHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKALLLHEPNTWQTMRIEEVDTPTLRSGEVLIEGEYAGLNPVDYKTATNGKPEWSYPHVL
CCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
GLDVAGTISAVADDVTNVQVGDRVLYHSNWNEWGGFAEFTRAKAHMVVPIPESISFADAV
ECCCHHHHHHHHHHHCCEEECCEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHH
ALPTAGFTAYQAIFEKLPMNAIDTILIHAGAGGVGGFAIQLAKYLGKRVITTASARNHDW
HCCCCCHHHHHHHHHHCCCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCCHHH
VKQLGADEAIDYNTEDWQQRVMELTSGHGVNAVIDPVGRETATASLEVIAYNGHIAHIAG
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEECCEEEEEEC
APDMSVIKPFTRVISYHEVALNAIHHQQDRVSEANIVRIGTHMLELLAAGEIQPMIQETI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCHHHHHHC
PFADIPKKLVELSDRHVVGKIVANLKA
CHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA