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The map label for this gene is manA [H]

Identifier: 229917607

GI number: 229917607

Start: 1848532

End: 1850319

Strand: Reverse

Name: manA [H]

Synonym: EAT1b_1882

Alternate gene names: 229917607

Gene position: 1850319-1848532 (Counterclockwise)

Preceding gene: 229917617

Following gene: 229917606

Centisome position: 61.68

GC content: 45.36

Gene sequence:

>1788_bases
ATGAGCGCTATTCTTTTAAAACCACACTATCAACACCGACTTTGGGGAGGGGAACGGCTGAAGCAATTTGGATTCGAATT
CAATGACCCTTCAATTGGTGAAGCCTGGACGGCTTCTGCATTAGAACAAGGCAGTTCAACCGTTGTTTCCGGACGTTACG
TTGGTCTTTCTTTGCGTGAACTCTATCAACAACATCCAGAGTTGTTTCAAGTTAAAGCGGACGTGTTTCCGCTACTGATT
AAATGGATTGATGCAAATGATGATTTGTCTATTCAAGTTCATCCTGATGATTCGTTAGCGGAACAACTCGAAAACGAATC
ATATGGAAAAAATGAATGTTGGTATATTCTCGATGCTCCAGCAAATGCTACACTCATTTACGGTCACTCCTATGCCACCT
CAGAAGACTTCAACAAAGCGCTTGAAACAGGCGATTTGGAACACGGCTTGATACGAAAATCGATTCATGCCGGTGATTTT
TTCTATGTCCCAGCTGGAACGGTCCATGCATTGACAAAAGGGGTATGCGTACTGGAAATTCAACAAAGTTCGGACACAAC
CTATCGTCTATACGATTACGAGCGACTGGATGTGACGACCGGTCGTCCACGTGAACTTCACGTAGAAAAGGGCATTCTCG
CTTCTTTCGTCCCTCACATTGGCTATAGTGAACCAATCCGTCAACTCGATCACTTTCGAACACGTTTGACGAAGAATCCA
TTCTTCTTCGTGGAAAAATGGCATGTTACAGCGAAAGAAAAGATTTCGACCGACACGTTCCGGTTACTATCTGTCGTGCA
AGGAACATTAATCATTGATGAGATGGAAGTACCTACGGGAGGTACACTCCTTCTCCCGGCCAATGAGTCGTTCTTGATTG
AGGGAGAAGCGATTTGTCTAGTGACTGGTGTTCCTTCCGATGAAAAACAAGCTGTCCGAATCGGGATTGATTTAGGAGGG
ACGAACACTCGGATTGCGGCTGTTTCACTCAAAGGTGAAGTACTGAAACAACTCACGTTTAACACGCAGCCTCAACTTCC
TTTCGAAGAGACACTAAAATCTATTGAGACTGCGATTAATCAATTCAATGTTGAATTCGATATCCAGCATGTTGGAATTG
TGGCTCCCGGTCCACTCGATTTGAAACAAGGGATGTTTTTAACGCCTCCAAACCTCCCGAATTGGCACAATCAAAAAATC
GTTGAGCCTTTAACACAGCGCCTCGGCTTTTCTGTCACCCTTGAAAACGATGCGAATGCAGCAGCTCTCGCAGAAGCTAA
ATTTGGAGCAGGAAAAGGATTCGATGCTGTTTTTTATGTAACAGTCAGCACTGGAATCGGTGGCGGTTATGTCTATAAAC
ATCAAATCATTCGAGGGGCGAACGGCAGTGCCGGTGAAATCGGAAATATGATTATCCGTTCGAACGGACCAGTTCACCCT
GTACTGAATCGAGGCTCTCTCGAATCACTGGCTAGTGGTACGGCACTCATGAATCGTGCAAGCGAAAAGGGATATACAAA
CGTCCCTTCGCTATTATCAGATGACGAGTACCGCCATCACTTCGTCGAGGAACTGGCTAGCGGACTAGCTAACATCATTC
ATACCGTCGATCCTGATGTGATTGTATTAGGAGGCGGCGTCATGATGTCGGCCTCATTATTTTGGAACGAATTACAACAA
GCAGTCTCGAATAAAATGTATCCACATGCTAGTGGAAAAACGCGTCTCTGCCTCACTCAATTGTCAGGAGATGCGGGTGT
GATCGGCGCTGCCTTTGTCGAAGCATAA

Upstream 100 bases:

>100_bases
TTTTATTATACACATGATTAATTTCATGTCTATACTTGATTTAAACTTTGTTTAGTTTTTAAATTCATAAGTGTATATCA
AATTAATAGGAGGACGGGAT

Downstream 100 bases:

>100_bases
TGAGGTTTGAAAAAAAAACGGACATTCATCGTGAATATCCGTTTTTTTGTATACAGAAATGTGAAATAAATCAAAATTAT
ACTTTGCGAATCATCTACAG

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSAILLKPHYQHRLWGGERLKQFGFEFNDPSIGEAWTASALEQGSSTVVSGRYVGLSLRELYQQHPELFQVKADVFPLLI
KWIDANDDLSIQVHPDDSLAEQLENESYGKNECWYILDAPANATLIYGHSYATSEDFNKALETGDLEHGLIRKSIHAGDF
FYVPAGTVHALTKGVCVLEIQQSSDTTYRLYDYERLDVTTGRPRELHVEKGILASFVPHIGYSEPIRQLDHFRTRLTKNP
FFFVEKWHVTAKEKISTDTFRLLSVVQGTLIIDEMEVPTGGTLLLPANESFLIEGEAICLVTGVPSDEKQAVRIGIDLGG
TNTRIAAVSLKGEVLKQLTFNTQPQLPFEETLKSIETAINQFNVEFDIQHVGIVAPGPLDLKQGMFLTPPNLPNWHNQKI
VEPLTQRLGFSVTLENDANAAALAEAKFGAGKGFDAVFYVTVSTGIGGGYVYKHQIIRGANGSAGEIGNMIIRSNGPVHP
VLNRGSLESLASGTALMNRASEKGYTNVPSLLSDDEYRHHFVEELASGLANIIHTVDPDVIVLGGGVMMSASLFWNELQQ
AVSNKMYPHASGKTRLCLTQLSGDAGVIGAAFVEA

Sequences:

>Translated_595_residues
MSAILLKPHYQHRLWGGERLKQFGFEFNDPSIGEAWTASALEQGSSTVVSGRYVGLSLRELYQQHPELFQVKADVFPLLI
KWIDANDDLSIQVHPDDSLAEQLENESYGKNECWYILDAPANATLIYGHSYATSEDFNKALETGDLEHGLIRKSIHAGDF
FYVPAGTVHALTKGVCVLEIQQSSDTTYRLYDYERLDVTTGRPRELHVEKGILASFVPHIGYSEPIRQLDHFRTRLTKNP
FFFVEKWHVTAKEKISTDTFRLLSVVQGTLIIDEMEVPTGGTLLLPANESFLIEGEAICLVTGVPSDEKQAVRIGIDLGG
TNTRIAAVSLKGEVLKQLTFNTQPQLPFEETLKSIETAINQFNVEFDIQHVGIVAPGPLDLKQGMFLTPPNLPNWHNQKI
VEPLTQRLGFSVTLENDANAAALAEAKFGAGKGFDAVFYVTVSTGIGGGYVYKHQIIRGANGSAGEIGNMIIRSNGPVHP
VLNRGSLESLASGTALMNRASEKGYTNVPSLLSDDEYRHHFVEELASGLANIIHTVDPDVIVLGGGVMMSASLFWNELQQ
AVSNKMYPHASGKTRLCLTQLSGDAGVIGAAFVEA
>Mature_594_residues
SAILLKPHYQHRLWGGERLKQFGFEFNDPSIGEAWTASALEQGSSTVVSGRYVGLSLRELYQQHPELFQVKADVFPLLIK
WIDANDDLSIQVHPDDSLAEQLENESYGKNECWYILDAPANATLIYGHSYATSEDFNKALETGDLEHGLIRKSIHAGDFF
YVPAGTVHALTKGVCVLEIQQSSDTTYRLYDYERLDVTTGRPRELHVEKGILASFVPHIGYSEPIRQLDHFRTRLTKNPF
FFVEKWHVTAKEKISTDTFRLLSVVQGTLIIDEMEVPTGGTLLLPANESFLIEGEAICLVTGVPSDEKQAVRIGIDLGGT
NTRIAAVSLKGEVLKQLTFNTQPQLPFEETLKSIETAINQFNVEFDIQHVGIVAPGPLDLKQGMFLTPPNLPNWHNQKIV
EPLTQRLGFSVTLENDANAAALAEAKFGAGKGFDAVFYVTVSTGIGGGYVYKHQIIRGANGSAGEIGNMIIRSNGPVHPV
LNRGSLESLASGTALMNRASEKGYTNVPSLLSDDEYRHHFVEELASGLANIIHTVDPDVIVLGGGVMMSASLFWNELQQA
VSNKMYPHASGKTRLCLTQLSGDAGVIGAAFVEA

Specific function: Unknown

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=263, Percent_Identity=31.1787072243346, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI298566315, Length=263, Percent_Identity=31.1787072243346, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4885285, Length=263, Percent_Identity=31.1787072243346, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI190014632, Length=263, Percent_Identity=31.1787072243346, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI87081733, Length=265, Percent_Identity=30.5660377358491, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787363, Length=258, Percent_Identity=26.7441860465116, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787878, Length=286, Percent_Identity=21.3286713286713, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786891, Length=211, Percent_Identity=28.9099526066351, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR014628
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 65311; Mature: 65179

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAILLKPHYQHRLWGGERLKQFGFEFNDPSIGEAWTASALEQGSSTVVSGRYVGLSLRE
CCEEEECCCHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEECEEECHHHHH
LYQQHPELFQVKADVFPLLIKWIDANDDLSIQVHPDDSLAEQLENESYGKNECWYILDAP
HHHHCCHHEEEHHHHHEEEHEEECCCCCEEEEECCCHHHHHHHCCCCCCCCCEEEEEECC
ANATLIYGHSYATSEDFNKALETGDLEHGLIRKSIHAGDFFYVPAGTVHALTKGVCVLEI
CCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCHHHHHHCCEEEEEE
QQSSDTTYRLYDYERLDVTTGRPRELHVEKGILASFVPHIGYSEPIRQLDHFRTRLTKNP
ECCCCCEEEEEEEEEEEECCCCCCEEEHHHCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
FFFVEKWHVTAKEKISTDTFRLLSVVQGTLIIDEMEVPTGGTLLLPANESFLIEGEAICL
EEEEEEEEECHHHHCCHHHHHHHHHHHCEEEEEEEECCCCCEEEEECCCCEEEECCEEEE
VTGVPSDEKQAVRIGIDLGGTNTRIAAVSLKGEVLKQLTFNTQPQLPFEETLKSIETAIN
EECCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QFNVEFDIQHVGIVAPGPLDLKQGMFLTPPNLPNWHNQKIVEPLTQRLGFSVTLENDANA
HCCEEEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCC
AALAEAKFGAGKGFDAVFYVTVSTGIGGGYVYKHQIIRGANGSAGEIGNMIIRSNGPVHP
EEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCC
VLNRGSLESLASGTALMNRASEKGYTNVPSLLSDDEYRHHFVEELASGLANIIHTVDPDV
CCCCCCHHHHHCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCE
IVLGGGVMMSASLFWNELQQAVSNKMYPHASGKTRLCLTQLSGDAGVIGAAFVEA
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEHHEECC
>Mature Secondary Structure 
SAILLKPHYQHRLWGGERLKQFGFEFNDPSIGEAWTASALEQGSSTVVSGRYVGLSLRE
CEEEECCCHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEECEEECHHHHH
LYQQHPELFQVKADVFPLLIKWIDANDDLSIQVHPDDSLAEQLENESYGKNECWYILDAP
HHHHCCHHEEEHHHHHEEEHEEECCCCCEEEEECCCHHHHHHHCCCCCCCCCEEEEEECC
ANATLIYGHSYATSEDFNKALETGDLEHGLIRKSIHAGDFFYVPAGTVHALTKGVCVLEI
CCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCHHHHHHCCEEEEEE
QQSSDTTYRLYDYERLDVTTGRPRELHVEKGILASFVPHIGYSEPIRQLDHFRTRLTKNP
ECCCCCEEEEEEEEEEEECCCCCCEEEHHHCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
FFFVEKWHVTAKEKISTDTFRLLSVVQGTLIIDEMEVPTGGTLLLPANESFLIEGEAICL
EEEEEEEEECHHHHCCHHHHHHHHHHHCEEEEEEEECCCCCEEEEECCCCEEEECCEEEE
VTGVPSDEKQAVRIGIDLGGTNTRIAAVSLKGEVLKQLTFNTQPQLPFEETLKSIETAIN
EECCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QFNVEFDIQHVGIVAPGPLDLKQGMFLTPPNLPNWHNQKIVEPLTQRLGFSVTLENDANA
HCCEEEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCC
AALAEAKFGAGKGFDAVFYVTVSTGIGGGYVYKHQIIRGANGSAGEIGNMIIRSNGPVHP
EEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCC
VLNRGSLESLASGTALMNRASEKGYTNVPSLLSDDEYRHHFVEELASGLANIIHTVDPDV
CCCCCCHHHHHCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCE
IVLGGGVMMSASLFWNELQQAVSNKMYPHASGKTRLCLTQLSGDAGVIGAAFVEA
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]