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The map label for this gene is ribB [H]

Identifier: 229597120

GI number: 229597120

Start: 1123940

End: 1125031

Strand: Direct

Name: ribB [H]

Synonym: NMCC_1139

Alternate gene names: 229597120

Gene position: 1123940-1125031 (Clockwise)

Preceding gene: 161870099

Following gene: 161870105

Centisome position: 52.19

GC content: 58.52

Gene sequence:

>1092_bases
ATGTCCCATATCTCCCCCATCCCCGAAATCCTAGCCGACATCAAAGCCGGCAAAATGGTCATCATCACCGATGCCGAAGA
CCGAGAAAACGAAGGCGACCTGCTGATGGCGGCGCAATTCGTCACGCCCGAAGCCATCAACTTCATGATCAAACACGCGC
GCGGCTTGGTCTGCCTGCCGATGGACGGCGAAATGGTCGAAAAACTCGGGCTGCCGATGATGACCCAAAAAAACGGCGCG
CAATACGGCACCAACTTTACCGTCTCCATCGAAGCCGCACACGGCATTACCACCGGCATTTCCGCCGCCGACCGCGCCCT
GACTATTCAAACCGCCGTTTCCCCGACCGCCAAACCCGAAGACATCGTCCAACCCGGTCATATCTTTCCGCTTCGCGCCC
AAAAAGGCGGCGTACTCGTCCGCGCCGGACACACCGAAGCCGGCGTCGACCTGGCGCAAATGAACGGGCTGATTCCTGCC
GCCGTTATTTGCGAAATCATCAACGACGACGGCACGATGGCGCGTATGCCCGAACTGATGAAGTTTGCCGAAGAACACAA
GCTCAAAATCGGCACCATTACCGACCTCATCGAATACCGCAGCCGTACCGAAAGCCTGCTCGAAGACATGGGCAATGCGC
CTGTACAAACCCCGTGGGGCGAGTTCCAACAACACGTTTACGTCGACAAACTCTCCGGCGAAACCCACCTCGCCCTCGTC
AAAGGCACGCCCGCCGCCGACACCGAAACCCTCGTCCGCGTCCACGAACCCTTCAGCGTGATGGACTTCATCCAAGCCAA
TCCGCGCCATTCATGGTCGCTGCCCAAAGCCCTTGAGCGCATCCAACAAGCCGAAAGCGGCGTCGTCATCCTCTTACACC
GCGCCGAAGACGGCGCATCCCTGCTCGACCGCACCCTGCCCAAAGGTGCAAACCAAGCCTACAAATGGGACAGCAAAAGC
TACGGCATCGGCGCACAAATCCTCGTCGGCCTCAACGTCAAAAAACTGCGCGTCCTCGGGCAGCCCTCATCTTTCACCGG
CCTGACCGGCTTCGGTTTGGAAGTCGTCGGCTTTGAAGAAGCGGAAAAATAA

Upstream 100 bases:

>100_bases
GAAAAAAGCCCGTAAAATCGAACAGGCGGCAAAAATGCCCGCCTTTTGGCTCGATACCGAACACACCGCCCGCCCGTCCG
AACACACAGGAAAACACACC

Downstream 100 bases:

>100_bases
TATAGTAAATTCAAATACTTTATATTTGCTTTATTTATTGCATTATTTCCGTGCAAACGAAAACCCGGTCTGTTGGGTTG
GATTTTGTTTTTGCAAATTT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSHISPIPEILADIKAGKMVIITDAEDRENEGDLLMAAQFVTPEAINFMIKHARGLVCLPMDGEMVEKLGLPMMTQKNGA
QYGTNFTVSIEAAHGITTGISAADRALTIQTAVSPTAKPEDIVQPGHIFPLRAQKGGVLVRAGHTEAGVDLAQMNGLIPA
AVICEIINDDGTMARMPELMKFAEEHKLKIGTITDLIEYRSRTESLLEDMGNAPVQTPWGEFQQHVYVDKLSGETHLALV
KGTPAADTETLVRVHEPFSVMDFIQANPRHSWSLPKALERIQQAESGVVILLHRAEDGASLLDRTLPKGANQAYKWDSKS
YGIGAQILVGLNVKKLRVLGQPSSFTGLTGFGLEVVGFEEAEK

Sequences:

>Translated_363_residues
MSHISPIPEILADIKAGKMVIITDAEDRENEGDLLMAAQFVTPEAINFMIKHARGLVCLPMDGEMVEKLGLPMMTQKNGA
QYGTNFTVSIEAAHGITTGISAADRALTIQTAVSPTAKPEDIVQPGHIFPLRAQKGGVLVRAGHTEAGVDLAQMNGLIPA
AVICEIINDDGTMARMPELMKFAEEHKLKIGTITDLIEYRSRTESLLEDMGNAPVQTPWGEFQQHVYVDKLSGETHLALV
KGTPAADTETLVRVHEPFSVMDFIQANPRHSWSLPKALERIQQAESGVVILLHRAEDGASLLDRTLPKGANQAYKWDSKS
YGIGAQILVGLNVKKLRVLGQPSSFTGLTGFGLEVVGFEEAEK
>Mature_362_residues
SHISPIPEILADIKAGKMVIITDAEDRENEGDLLMAAQFVTPEAINFMIKHARGLVCLPMDGEMVEKLGLPMMTQKNGAQ
YGTNFTVSIEAAHGITTGISAADRALTIQTAVSPTAKPEDIVQPGHIFPLRAQKGGVLVRAGHTEAGVDLAQMNGLIPAA
VICEIINDDGTMARMPELMKFAEEHKLKIGTITDLIEYRSRTESLLEDMGNAPVQTPWGEFQQHVYVDKLSGETHLALVK
GTPAADTETLVRVHEPFSVMDFIQANPRHSWSLPKALERIQQAESGVVILLHRAEDGASLLDRTLPKGANQAYKWDSKSY
GIGAQILVGLNVKKLRVLGQPSSFTGLTGFGLEVVGFEEAEK

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=194, Percent_Identity=51.0309278350515, Blast_Score=218, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=41.6666666666667, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 39367; Mature: 39236

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHISPIPEILADIKAGKMVIITDAEDRENEGDLLMAAQFVTPEAINFMIKHARGLVCLP
CCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEC
MDGEMVEKLGLPMMTQKNGAQYGTNFTVSIEAAHGITTGISAADRALTIQTAVSPTAKPE
CCHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHH
DIVQPGHIFPLRAQKGGVLVRAGHTEAGVDLAQMNGLIPAAVICEIINDDGTMARMPELM
HHCCCCCEEEEEECCCCEEEEECCCHHCCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
KFAEEHKLKIGTITDLIEYRSRTESLLEDMGNAPVQTPWGEFQQHVYVDKLSGETHLALV
HHHHHHCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCEEEEEE
KGTPAADTETLVRVHEPFSVMDFIQANPRHSWSLPKALERIQQAESGVVILLHRAEDGAS
ECCCCCCCHHHEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHH
LLDRTLPKGANQAYKWDSKSYGIGAQILVGLNVKKLRVLGQPSSFTGLTGFGLEVVGFEE
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCEEEEECCC
AEK
CCC
>Mature Secondary Structure 
SHISPIPEILADIKAGKMVIITDAEDRENEGDLLMAAQFVTPEAINFMIKHARGLVCLP
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEC
MDGEMVEKLGLPMMTQKNGAQYGTNFTVSIEAAHGITTGISAADRALTIQTAVSPTAKPE
CCHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHH
DIVQPGHIFPLRAQKGGVLVRAGHTEAGVDLAQMNGLIPAAVICEIINDDGTMARMPELM
HHCCCCCEEEEEECCCCEEEEECCCHHCCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
KFAEEHKLKIGTITDLIEYRSRTESLLEDMGNAPVQTPWGEFQQHVYVDKLSGETHLALV
HHHHHHCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCEEEEEE
KGTPAADTETLVRVHEPFSVMDFIQANPRHSWSLPKALERIQQAESGVVILLHRAEDGAS
ECCCCCCCHHHEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHH
LLDRTLPKGANQAYKWDSKSYGIGAQILVGLNVKKLRVLGQPSSFTGLTGFGLEVVGFEE
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCEEEEECCC
AEK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]