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The map label for this gene is fhs [H]

Identifier: 229576700

GI number: 229576700

Start: 2020274

End: 2021962

Strand: Direct

Name: fhs [H]

Synonym: BALH_1871

Alternate gene names: 229576700

Gene position: 2020274-2021962 (Clockwise)

Preceding gene: 118477545

Following gene: 118477547

Centisome position: 38.43

GC content: 38.48

Gene sequence:

>1689_bases
ATGACAACTACTACAACAGTTAAATCCGATATTGAAATCGCACAAGAAGCGAGTATGAAAAAGATTCAAGAAATTGCAGC
TGATTTAAATATTTTAGAAGATGAATTAGAGCCATACGGGCATTATAAAGGTAAGTTATCTCTTGATATTTTTAAGCGCT
TACAGAATGAGAAAGACGGTAAAGTTGTTTTAGTAACAGCAATTAACCCAACTCCAGCTGGAGAAGGTAAATCAACAGTA
ACAGTTGGTTTAGGTCAAGCTTTTAATAAAATTGGTAAGAAAACAGTAATTGCACTTCGCGAACCATCTCTTGGACCAAC
GATGGGGCTAAAAGGCGGAGCAGCAGGTGGTGGTTTTTCACAGGTTGTACCAATGGAAGACATTAACCTTCATTTTACTG
GAGATATCCATGCGATCACAACTGCTAATAACGCGTTAGCCGCGTTTATTGATAATCATATCCAACAAGGAAATACACTT
GGAATTGATACGCGTAAAATCGTTTGGAAACGTTGTGTTGACTTAAATGATCGTGCCCTTCGTAACGTAGTAATTGGTCT
TGGTGGACCGGTTCAAGGTGTACCACGTGAAGACGGTTTTGATATTACAGTAGCATCTGAAATTATGGCCGTATTCTGCC
TTGCAACAGATATTCAAGATTTAAAAGCACGTCTATCACGCATCGTAGTTGCTTATAATTTTGCAAATCAACCTGTAACG
GTTAAAGATTTAGGTGTAGAAGGTGCGTTAACATTATTATTAAAAGATGCATTAAAGCCAAACTTAGTGCAAACGTTAGA
AAATACACCAGCTATCATTCACGGCGGACCATTTGCGAATATCGCTCATGGTTGTAACAGTGTTATCGCTACAACAATGG
CAGCAAAATTAGGTGATTATGTTATTACAGAAGCTGGATTTGGTGCAGATTTAGGTGCTGAGAAGTTTTTAGATATTAAA
GCTCGTGCAGCTGGCATTAAACCAGAAGCAGTTGTTATTGTTGCGACGATTCGTGCGCTTAAAATGCATGGTGGCGTAGC
AAAAGATCAATTAAAAGAAGAAAATGTAGATGCATTAGCAAAAGGTATGGAGAACTTACAGAAGCACGTTGAAACAATTC
AAAGCTTCGGTGTGCCTTTCGTAATTGCAATTAATAAATTCATTACAGATACAGATGCAGAAGTTGCATACTTACAAGAA
TGGTGTAATGAGCGTGGCTATGCGGTATCCTTAACAGAAGTTTGGGAGAAAGGTGGCCAAGGCGGAGTTGACCTTGCTGA
AAAAGTGTTAAAAGAGATTGAAAAAGGTGAAAACAACTACGCACCACTTTATGAATTAGAATTACCATTAGAAGAGAAAA
TTCGTACAATTGCTCAAAAAGTGTACGGCGCAAAAGACATTGAATTTGCTCCGAAAGCACGTAAGCAATTAGCTCAATAT
GAAGGCGAAGGTTGGAGTAACCTACCAATTTGTATGGCGAAAACACAATACTCTCTTTCTGACGATGCAACGAAATTAGG
TCGTCCATCTGACTTTATCGTTACAATTCGTGAGCTAAAACCATCTATTGGTGCAGGCTTTATCGTTGCGTTAACAGGAA
CAATGTTAACAATGCCAGGCCTTCCAAAACAACCAGCAGCACTACAAATGGATGTAAATGAAGATGGAAAAGCAGTAGGT
TTATTCTAA

Upstream 100 bases:

>100_bases
GCATAAAGAAATGAAAGAATTTTTAGGAGGTAAATAAGTGCAGAAAATACAAAAAACTGATACAATATCATCAGAACCAA
TTAAAGGGGGACTAGGGTAT

Downstream 100 bases:

>100_bases
AAGGTTGTAATTCATCTCGTTTATCTGTAAACTATATATACATCAAGTGGCGCCTTTCCATCGAAAGGCGCCTGTTTTTT
GGAGGAAATTATGTTTGATC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTTTTTVKSDIEIAQEASMKKIQEIAADLNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTV
TVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTL
GIDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIK
ARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQE
WCNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVG
LF

Sequences:

>Translated_562_residues
MTTTTTVKSDIEIAQEASMKKIQEIAADLNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTV
TVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTL
GIDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIK
ARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQE
WCNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVG
LF
>Mature_561_residues
TTTTTVKSDIEIAQEASMKKIQEIAADLNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTVT
VGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLG
IDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVTV
KDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIKA
RAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEW
CNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQYE
GEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVGL
F

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI36796743, Length=623, Percent_Identity=47.6725521669342, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI222136639, Length=625, Percent_Identity=45.12, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI310124614, Length=102, Percent_Identity=53.921568627451, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17568737, Length=629, Percent_Identity=44.8330683624801, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17568739, Length=629, Percent_Identity=44.8330683624801, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319558, Length=635, Percent_Identity=43.4645669291339, Blast_Score=489, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.7699680511182, Blast_Score=472, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24645718, Length=622, Percent_Identity=42.9260450160772, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17137370, Length=622, Percent_Identity=42.9260450160772, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI62472483, Length=622, Percent_Identity=42.9260450160772, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=622, Percent_Identity=42.9260450160772, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60462; Mature: 60331

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTTVKSDIEIAQEASMKKIQEIAADLNILEDELEPYGHYKGKLSLDIFKRLQNEKDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCC
KVVLVTAINPTPAGEGKSTVTVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFS
CEEEEEEECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
QVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLGIDTRKIVWKRCVDLNDRAL
CCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCHHHH
RNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
HHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCEE
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDY
EEECCCCHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCE
VITEAGFGADLGAEKFLDIKARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALA
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHCCHHHHH
KGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEWCNERGYAVSLTEVWEKGGQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCC
GGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
CCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPG
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHEEEHHHHCCCCCCCEEEEEHHHHHCCCC
LPKQPAALQMDVNEDGKAVGLF
CCCCCCEEEEECCCCCCEECCC
>Mature Secondary Structure 
TTTTTVKSDIEIAQEASMKKIQEIAADLNILEDELEPYGHYKGKLSLDIFKRLQNEKDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCC
KVVLVTAINPTPAGEGKSTVTVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFS
CEEEEEEECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
QVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLGIDTRKIVWKRCVDLNDRAL
CCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCHHHH
RNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
HHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCEE
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDY
EEECCCCHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCE
VITEAGFGADLGAEKFLDIKARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALA
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHCCHHHHH
KGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEWCNERGYAVSLTEVWEKGGQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCC
GGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
CCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPG
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHEEEHHHHCCCCCCCEEEEEHHHHHCCCC
LPKQPAALQMDVNEDGKAVGLF
CCCCCCEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA