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The map label for this gene is thrC [H]

Identifier: 229007179

GI number: 229007179

Start: 784519

End: 785916

Strand: Reverse

Name: thrC [H]

Synonym: Atu0787

Alternate gene names: 229007179

Gene position: 785916-784519 (Counterclockwise)

Preceding gene: 159184465

Following gene: 159184464

Centisome position: 27.66

GC content: 59.66

Gene sequence:

>1398_bases
GTGAAATATGTATCGACCAGGGGTGCGGCCCCTTCGCTTGGTTTCTGCGACGCGCTGCTGGCAGGCCTTGGCCGTGACGG
CGGGCTTTACGTGCCGCGCGAGTGGCCTTCCATGTCGAAGAAGGAAATCCGCAACCTGCGCGGAAAATCCTATCAGGACG
TCGCCTTCGAGGTTCTCTACCGTTTCACCGGCGGCGAAATTCCGGCCGACAAGTTCAAGGCGATGATCGACGACGCCTAT
TCGACGTTCCGTCACCCTGCCGTCGTGCCACTGACGCAGACCGGCCCGAACACCTTCGTGCTGGAGCTTTTCCATGGCAC
CACGCTCGCCTTCAAGGATGTGGCGATGCAGCTTCTCGCCCGCCTGATGGACTATACGCTGACGGAACGCGGCGAGCGCG
CCGCCATTGTCGGCGCCACATCGGGCGACACCGGCGGTGCGGCGATCGATGCCTTTGCCGGGCGCGAACGCACCGATATC
TTCATCCTTTTCCCGAACGGCAAGGTCTCGCCGGTGCAGCAGCGCCAGATGACGACATCCACCGCTTCCAACGTGTATGC
GCTGGCGATCAACGGCAATTTCGACGATTGCCAGACGCTGGTCAAAGAGATGTTCAACGACGTGAAGTTCCGCGACGGCG
TGAAGCTTTCCGGCGTCAACTCCATCAACTGGGCGCGCATCATGGCGCAGGTGGTGTATTATTTCACCGCCTCGCTGTCG
CTCGGCGGCCCGGACCGGAAGATTTCCTTCACCGTTCCGACAGGCAATTTCGGCGATATCTTCGCCGGTTACGTCGCCAA
GAAGATGGGGCTGCCGATCGACAAGCTGGTCATCGCCACCAATGACAACGACATTCTGGCACGCACGCTGAAGACCGGCC
GTTACGAGATGCGCGGCGTCAAGCCCACCACCTCGCCTTCGATGGATATCCAGATTTCGTCCAACTTCGAACGCCTGCTG
TTTGAAGCCTATGATCGCGATTCCGCTGCGGTGAAGGCGTCCATGGATGGCCTGAAGCAGTCCGGCGCGTTTGAAATTCC
GCCGAAGGCACTGAAATTCATCAAAAAGGATTTCCGTGCCGGCCGCGCCACCGAAAAGCAGGTTGCGGCGACCATTCGCG
ACACACTTGAAAAGACCGGATACCTGATCGACCCGCATACGGCGACCGGCGTTTTCGTGGCTGAGAAGCACGAAAAAGCG
GGAAGCCCGATGGTGGTTCTGTCGACCGCCCACCCGGCTAAATTCCCGGCCGCTGTAAAATCCGCTTGCGCAATCGAGCC
TGCGCTTCCAGTATGGCTAGCTGACATTATGAACCGGGAGGAGCGTTTCGACATTCTGGACGCAGAGCTGAAAGCCGTGG
AAACCTTCATCGGCCAACATGCACGCGCCGGCAAATAG

Upstream 100 bases:

>100_bases
GCCCTTCATTACCTCGCCAATCGCCTCATTCCGGCGGGATGCTGCTGATAAAGAGCCGGTAACGGCACGGACAGACCGGT
TAAGGACAAGGGACTATCTC

Downstream 100 bases:

>100_bases
AGACGCGGAAAGACGTTGAGTATGAGAGTTAATGTGACCCGGCTTTCGTCCGGGTTGACCGTTGTTACGGAAAGAATGCC
ACATCTCGAAAGCGTTGCTC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKYVSTRGAAPSLGFCDALLAGLGRDGGLYVPREWPSMSKKEIRNLRGKSYQDVAFEVLYRFTGGEIPADKFKAMIDDAY
STFRHPAVVPLTQTGPNTFVLELFHGTTLAFKDVAMQLLARLMDYTLTERGERAAIVGATSGDTGGAAIDAFAGRERTDI
FILFPNGKVSPVQQRQMTTSTASNVYALAINGNFDDCQTLVKEMFNDVKFRDGVKLSGVNSINWARIMAQVVYYFTASLS
LGGPDRKISFTVPTGNFGDIFAGYVAKKMGLPIDKLVIATNDNDILARTLKTGRYEMRGVKPTTSPSMDIQISSNFERLL
FEAYDRDSAAVKASMDGLKQSGAFEIPPKALKFIKKDFRAGRATEKQVAATIRDTLEKTGYLIDPHTATGVFVAEKHEKA
GSPMVVLSTAHPAKFPAAVKSACAIEPALPVWLADIMNREERFDILDAELKAVETFIGQHARAGK

Sequences:

>Translated_465_residues
MKYVSTRGAAPSLGFCDALLAGLGRDGGLYVPREWPSMSKKEIRNLRGKSYQDVAFEVLYRFTGGEIPADKFKAMIDDAY
STFRHPAVVPLTQTGPNTFVLELFHGTTLAFKDVAMQLLARLMDYTLTERGERAAIVGATSGDTGGAAIDAFAGRERTDI
FILFPNGKVSPVQQRQMTTSTASNVYALAINGNFDDCQTLVKEMFNDVKFRDGVKLSGVNSINWARIMAQVVYYFTASLS
LGGPDRKISFTVPTGNFGDIFAGYVAKKMGLPIDKLVIATNDNDILARTLKTGRYEMRGVKPTTSPSMDIQISSNFERLL
FEAYDRDSAAVKASMDGLKQSGAFEIPPKALKFIKKDFRAGRATEKQVAATIRDTLEKTGYLIDPHTATGVFVAEKHEKA
GSPMVVLSTAHPAKFPAAVKSACAIEPALPVWLADIMNREERFDILDAELKAVETFIGQHARAGK
>Mature_465_residues
MKYVSTRGAAPSLGFCDALLAGLGRDGGLYVPREWPSMSKKEIRNLRGKSYQDVAFEVLYRFTGGEIPADKFKAMIDDAY
STFRHPAVVPLTQTGPNTFVLELFHGTTLAFKDVAMQLLARLMDYTLTERGERAAIVGATSGDTGGAAIDAFAGRERTDI
FILFPNGKVSPVQQRQMTTSTASNVYALAINGNFDDCQTLVKEMFNDVKFRDGVKLSGVNSINWARIMAQVVYYFTASLS
LGGPDRKISFTVPTGNFGDIFAGYVAKKMGLPIDKLVIATNDNDILARTLKTGRYEMRGVKPTTSPSMDIQISSNFERLL
FEAYDRDSAAVKASMDGLKQSGAFEIPPKALKFIKKDFRAGRATEKQVAATIRDTLEKTGYLIDPHTATGVFVAEKHEKA
GSPMVVLSTAHPAKFPAAVKSACAIEPALPVWLADIMNREERFDILDAELKAVETFIGQHARAGK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=34.2105263157895, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI153792148, Length=456, Percent_Identity=35.5263157894737, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI1786185, Length=436, Percent_Identity=31.4220183486239, Blast_Score=213, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=43.9824945295405, Blast_Score=346, Evalue=4e-96,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50835; Mature: 50835

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVSTRGAAPSLGFCDALLAGLGRDGGLYVPREWPSMSKKEIRNLRGKSYQDVAFEVLY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
RFTGGEIPADKFKAMIDDAYSTFRHPAVVPLTQTGPNTFVLELFHGTTLAFKDVAMQLLA
HHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
RLMDYTLTERGERAAIVGATSGDTGGAAIDAFAGRERTDIFILFPNGKVSPVQQRQMTTS
HHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHH
TASNVYALAINGNFDDCQTLVKEMFNDVKFRDGVKLSGVNSINWARIMAQVVYYFTASLS
CCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCC
LGGPDRKISFTVPTGNFGDIFAGYVAKKMGLPIDKLVIATNDNDILARTLKTGRYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHCCCEEECCC
KPTTSPSMDIQISSNFERLLFEAYDRDSAAVKASMDGLKQSGAFEIPPKALKFIKKDFRA
CCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GRATEKQVAATIRDTLEKTGYLIDPHTATGVFVAEKHEKAGSPMVVLSTAHPAKFPAAVK
CCCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHH
SACAIEPALPVWLADIMNREERFDILDAELKAVETFIGQHARAGK
HHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKYVSTRGAAPSLGFCDALLAGLGRDGGLYVPREWPSMSKKEIRNLRGKSYQDVAFEVLY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
RFTGGEIPADKFKAMIDDAYSTFRHPAVVPLTQTGPNTFVLELFHGTTLAFKDVAMQLLA
HHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
RLMDYTLTERGERAAIVGATSGDTGGAAIDAFAGRERTDIFILFPNGKVSPVQQRQMTTS
HHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHH
TASNVYALAINGNFDDCQTLVKEMFNDVKFRDGVKLSGVNSINWARIMAQVVYYFTASLS
CCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCC
LGGPDRKISFTVPTGNFGDIFAGYVAKKMGLPIDKLVIATNDNDILARTLKTGRYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHCCCEEECCC
KPTTSPSMDIQISSNFERLLFEAYDRDSAAVKASMDGLKQSGAFEIPPKALKFIKKDFRA
CCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GRATEKQVAATIRDTLEKTGYLIDPHTATGVFVAEKHEKAGSPMVVLSTAHPAKFPAAVK
CCCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHH
SACAIEPALPVWLADIMNREERFDILDAELKAVETFIGQHARAGK
HHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]