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The map label for this gene is htpX1 [H]

Identifier: 227827094

GI number: 227827094

Start: 705934

End: 706869

Strand: Direct

Name: htpX1 [H]

Synonym: M1425_0760

Alternate gene names: 227827094

Gene position: 705934-706869 (Clockwise)

Preceding gene: 227827093

Following gene: 227827095

Centisome position: 27.06

GC content: 36.0

Gene sequence:

>936_bases
ATGGATGTAAAACAAAGGTTAATATCGAGTATGGTTATCTCATTAGGTCTAACTATTATATCAGAGGGCATAGTATTAAT
GGGAATAGCCTCTCTACTTCATATATCTTTATTTTTTATATTTCCAGCTCTCGTAATTTTTTGGTTATTCCAATGGATTA
TATCTCCTTATGTAGTGGGAAGAGGTGGTTATGAGGTTTTTCCAAACGATCCACAGTACGGCTGGCTTTACAATTTAGTT
AGGAAAATAGCGGAAGAGTCTAAAATTAAACCCCCTAGGGTTTTCGTGATTGACGCACCTTATCCTAATGCCTTTGCTTA
CGGCAATAGATTAAGCGGGATGAGAGTTGGAATAACTTTACCCCTATTAAATATCCTTAACATTGATGAATTAACTGCAG
TTGTAGCTCATGAAATAGGGCACATAAAGCATAGGGATGTTGAGATAGGTATGACAATAGGTCTAATTCCTACAGTATTA
GGATATATTAGTACGCTACTGATGAATTTCGGATATTTGGCAATATTCCTAGCAGCTGATGAAATTGAACTATTATTCGC
TATAGCAGCTTTGGCAATAGGATTTGTCATTTTCATCGTAACTTTCATCTTACAAATATTCGTCTTATGGTTTAATAGGC
TTAGAGAATCCTATGCGGATTATAACTCATATCTGGTATTAGGAGAGGGATCGAAGGCTTTAGCTACCGCGTTAGCTAAA
ATTGAGATTTATATGCAAAATATCAGGATTGACCCGTTTACTGGAATTATAGTGACAGCACCACGAGTAAAGGTTGAAGA
GAAAGATCCTTACTTGCTGGTTGAACAGTGGTTGAGAACTAAGGTTAGTATATTTAAGGACATTTTATCCACTCATCCTT
ATCCAGCTAGGAGAGCACAAATGATTTACAGGTTAATCTATGGTAGTGATATATAG

Upstream 100 bases:

>100_bases
TAGTTGTACTCGTAATAATCTTGGGAATTATAGCAATTATTAGCGGAATCTTAAGTGGTATTGCAAAAGGTTTTTATTAA
AAGATATACAAGGTTTTATC

Downstream 100 bases:

>100_bases
TTTTATCATAATAAATATTATATACCCTCTATATAGAGAATCTTTACAATGATCCATAAAAACGTATAGAATAATGAAAT
TCAATGAAATAAAATTCGAT

Product: peptidase M48 Ste24p

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MDVKQRLISSMVISLGLTIISEGIVLMGIASLLHISLFFIFPALVIFWLFQWIISPYVVGRGGYEVFPNDPQYGWLYNLV
RKIAEESKIKPPRVFVIDAPYPNAFAYGNRLSGMRVGITLPLLNILNIDELTAVVAHEIGHIKHRDVEIGMTIGLIPTVL
GYISTLLMNFGYLAIFLAADEIELLFAIAALAIGFVIFIVTFILQIFVLWFNRLRESYADYNSYLVLGEGSKALATALAK
IEIYMQNIRIDPFTGIIVTAPRVKVEEKDPYLLVEQWLRTKVSIFKDILSTHPYPARRAQMIYRLIYGSDI

Sequences:

>Translated_311_residues
MDVKQRLISSMVISLGLTIISEGIVLMGIASLLHISLFFIFPALVIFWLFQWIISPYVVGRGGYEVFPNDPQYGWLYNLV
RKIAEESKIKPPRVFVIDAPYPNAFAYGNRLSGMRVGITLPLLNILNIDELTAVVAHEIGHIKHRDVEIGMTIGLIPTVL
GYISTLLMNFGYLAIFLAADEIELLFAIAALAIGFVIFIVTFILQIFVLWFNRLRESYADYNSYLVLGEGSKALATALAK
IEIYMQNIRIDPFTGIIVTAPRVKVEEKDPYLLVEQWLRTKVSIFKDILSTHPYPARRAQMIYRLIYGSDI
>Mature_311_residues
MDVKQRLISSMVISLGLTIISEGIVLMGIASLLHISLFFIFPALVIFWLFQWIISPYVVGRGGYEVFPNDPQYGWLYNLV
RKIAEESKIKPPRVFVIDAPYPNAFAYGNRLSGMRVGITLPLLNILNIDELTAVVAHEIGHIKHRDVEIGMTIGLIPTVL
GYISTLLMNFGYLAIFLAADEIELLFAIAALAIGFVIFIVTFILQIFVLWFNRLRESYADYNSYLVLGEGSKALATALAK
IEIYMQNIRIDPFTGIIVTAPRVKVEEKDPYLLVEQWLRTKVSIFKDILSTHPYPARRAQMIYRLIYGSDI

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=233, Percent_Identity=29.1845493562232, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 35209; Mature: 35209

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKQRLISSMVISLGLTIISEGIVLMGIASLLHISLFFIFPALVIFWLFQWIISPYVVG
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
RGGYEVFPNDPQYGWLYNLVRKIAEESKIKPPRVFVIDAPYPNAFAYGNRLSGMRVGITL
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCCCEEEEHHH
PLLNILNIDELTAVVAHEIGHIKHRDVEIGMTIGLIPTVLGYISTLLMNFGYLAIFLAAD
HHHHHHCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIELLFAIAALAIGFVIFIVTFILQIFVLWFNRLRESYADYNSYLVLGEGSKALATALAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
IEIYMQNIRIDPFTGIIVTAPRVKVEEKDPYLLVEQWLRTKVSIFKDILSTHPYPARRAQ
HHHHHHHCCCCCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MIYRLIYGSDI
HHHHHHHCCCC
>Mature Secondary Structure
MDVKQRLISSMVISLGLTIISEGIVLMGIASLLHISLFFIFPALVIFWLFQWIISPYVVG
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
RGGYEVFPNDPQYGWLYNLVRKIAEESKIKPPRVFVIDAPYPNAFAYGNRLSGMRVGITL
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCCCEEEEHHH
PLLNILNIDELTAVVAHEIGHIKHRDVEIGMTIGLIPTVLGYISTLLMNFGYLAIFLAAD
HHHHHHCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIELLFAIAALAIGFVIFIVTFILQIFVLWFNRLRESYADYNSYLVLGEGSKALATALAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
IEIYMQNIRIDPFTGIIVTAPRVKVEEKDPYLLVEQWLRTKVSIFKDILSTHPYPARRAQ
HHHHHHHCCCCCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MIYRLIYGSDI
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]