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The map label for this gene is cutL [H]

Identifier: 227826849

GI number: 227826849

Start: 412843

End: 414939

Strand: Direct

Name: cutL [H]

Synonym: M1425_0475

Alternate gene names: 227826849

Gene position: 412843-414939 (Clockwise)

Preceding gene: 227826843

Following gene: 227826850

Centisome position: 15.82

GC content: 39.15

Gene sequence:

>2097_bases
ATGAGAAGAATAGACGTATATGATCTATTAATAGGAAAGGGTAATTATGTAGATGATATATCATATAAGGGAAGATATGC
AGTATTTATCAGAAGTCCATACCCCCATGCGAGAATAGTTAATATCAATAAAGAAGATGCAGAAAGAAGAGGTGCACTAG
TTCTAACTGGTAAAGATTTAGTATCTAGAAGCGTTGAATCTGGCGAAAGAGAAGGAGCTAGTTTAACAATTCCATTGATG
GCGATAAATAAGGCATTATACGTTGGCCAACCAGTAGCTTTAGTTATTGCAAACGATCCTTATGAAGCTACGGATTTAGC
AGAATTAGTTCAAGTTGATTATGAACCGTTAGAAGGTATAGGAAGCATCGAAAAAGCACTACAGAACAAAGTAGTAGTAT
TCGAGGATTTGAAGACAAACATAGTAAGAGAACAAACCTTTGAGTTTGGAAAGATTAATACGCAAGGTAGGCACTTAGAA
TTAGATTTATACTGGTCTAGAAGTTCTGGAAATCCAATAGAACCTTATGGGGCAATTATAATTCCAACAGATGATGGATT
GACCATAATTTCGAATCAGCAAGCAGGGAACGTAGTATCCAATGAAATCCAGAAGGCATTAGGAGTTAAAGTAATCCATA
AGAACGCTAGGCAAGGAGGAAGTTTTGGTGAGAAGTTCTCTCTAGTCAGATACTTAACAGTATTAGGCTTTGCAGCGTTA
AAGTTTAATGTACCAATAAAGTGGATTGAAACTAGAACTGAGCATTTGATGGCATCAAACGGAAGTGGACCAGAAAGGAA
ATTCAAAATTCACGCCTATTATTCCTCTGATGGAAGAGTAAATAGTTTAGATATCCACATATGGGAAGATGTTGGTGCCT
CTAGAGACGCTGGCCAACCCTTTAAACCTTTAGGGTTCTTAACGGGACCATATAAGATTGGAGGTATAAGATATACTGGA
ACCTTAGTTGCCACAAATAAGAACCCAGCTGGAGCATTTAGAGGTGCTGGTACGCCGCCTCATACATGGGCACTGGAAAG
AACAATGGATGCTATAGCTGATGATTTAGGTATTAGTAAGGCTGAAGTGAGAAAAATTAATGCAATAGATATCTTTCCCT
ACGATACTGGATTTGCGTACTACGATTCTGGAAATCCGAAAGGCTTACTAGATTTAGCATTATCAAGAAATGACATCTTT
GCATTGAGGAATAAGAACACTGGAGTAGGCTTAGCATTATCAACTGATCCCAGTACGCCTTCTGGTAGTGAGAGAGTGAA
AATTAAGGTTAAGAATAACAAAGTTGTAATCGGTTTGGGATTCGGTCCAGAGGGTCAAGGCAACGAGCATTCAGCAGTAG
TAATGGCTTCAAGACTATTAGGAATAAGCCCAGATAACGTTACATATGAGATTCTAGATAACACTGAATTACCAACATCC
TTTGGACCTGGAGGAAGTAGAATGGCGATTTACACTTTTGGAGCAGTTTCTGGAGCGGTAGAAGAGTTAAAGGCTAGATT
GAGGAGGAAGGCTGAAGTTATCCTAAACGATAAGGTCGTTGACTATAGGGATGGGTACTTTATAGGAGAAAATGGAGGAA
AAGTTAGAATTACGTCACTTGAGGGAGAAGAGGTTGACTTCACTTACACATTGCAAGGTAAGTATAGATTCAATGCCTAT
CCATTCGCTTGTGATTTGGCAGTAGTTAGAATTGAGGACGGTAAGATAAAGCCAATAAAACACGTGGTTTACATTGACCC
TGGAACTCCAATAGATGAGGATTTAGTAAAGGAACAAGTAATAGGAGGTACTGCAATTGGAATTTCTCTCGCGCTATACG
AACGTTACGCATACGATGATAACGCTAACTTATTAACAACCAACTTAGCGGACTACGGAATGCCAACAGCTGCTGATTTA
CCAGAAATAGAGGTTAACATAGTTCCAACTCCTTCTCCCTCAACTCCTTATGGAGCTAAGGGAATAGGGGAAATTCCGGT
TGGAATAGCTGCAGCTGCAGTCACTAGCGCTATTGAAGACGTTATAAAGAGAAGGATAAATAGAGTTCCAGTAAGCCTAG
AAGGCCTTTTTGAATAA

Upstream 100 bases:

>100_bases
ATTATAAATCATTTTATAAGTTGCTTATATCTAGCCATAATAAATTGCTCCTTCACAGCAGCTAGATAAATTTTTATGTT
AGTTAGTTAACAAACAAGCA

Downstream 100 bases:

>100_bases
GCGCTTTAATTCATTTAAATTTATTTTTGAAACACGAAGAGGTAAACCTATGAATGTAATTTTCGATGTATTAAACGAGA
TCCATGGGTTTTTTGGTGCA

Product: aldehyde oxidase and xanthine dehydrogenasemolybdopterin binding

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MRRIDVYDLLIGKGNYVDDISYKGRYAVFIRSPYPHARIVNINKEDAERRGALVLTGKDLVSRSVESGEREGASLTIPLM
AINKALYVGQPVALVIANDPYEATDLAELVQVDYEPLEGIGSIEKALQNKVVVFEDLKTNIVREQTFEFGKINTQGRHLE
LDLYWSRSSGNPIEPYGAIIIPTDDGLTIISNQQAGNVVSNEIQKALGVKVIHKNARQGGSFGEKFSLVRYLTVLGFAAL
KFNVPIKWIETRTEHLMASNGSGPERKFKIHAYYSSDGRVNSLDIHIWEDVGASRDAGQPFKPLGFLTGPYKIGGIRYTG
TLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISKAEVRKINAIDIFPYDTGFAYYDSGNPKGLLDLALSRNDIF
ALRNKNTGVGLALSTDPSTPSGSERVKIKVKNNKVVIGLGFGPEGQGNEHSAVVMASRLLGISPDNVTYEILDNTELPTS
FGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVILNDKVVDYRDGYFIGENGGKVRITSLEGEEVDFTYTLQGKYRFNAY
PFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQVIGGTAIGISLALYERYAYDDNANLLTTNLADYGMPTAADL
PEIEVNIVPTPSPSTPYGAKGIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEGLFE

Sequences:

>Translated_698_residues
MRRIDVYDLLIGKGNYVDDISYKGRYAVFIRSPYPHARIVNINKEDAERRGALVLTGKDLVSRSVESGEREGASLTIPLM
AINKALYVGQPVALVIANDPYEATDLAELVQVDYEPLEGIGSIEKALQNKVVVFEDLKTNIVREQTFEFGKINTQGRHLE
LDLYWSRSSGNPIEPYGAIIIPTDDGLTIISNQQAGNVVSNEIQKALGVKVIHKNARQGGSFGEKFSLVRYLTVLGFAAL
KFNVPIKWIETRTEHLMASNGSGPERKFKIHAYYSSDGRVNSLDIHIWEDVGASRDAGQPFKPLGFLTGPYKIGGIRYTG
TLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISKAEVRKINAIDIFPYDTGFAYYDSGNPKGLLDLALSRNDIF
ALRNKNTGVGLALSTDPSTPSGSERVKIKVKNNKVVIGLGFGPEGQGNEHSAVVMASRLLGISPDNVTYEILDNTELPTS
FGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVILNDKVVDYRDGYFIGENGGKVRITSLEGEEVDFTYTLQGKYRFNAY
PFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQVIGGTAIGISLALYERYAYDDNANLLTTNLADYGMPTAADL
PEIEVNIVPTPSPSTPYGAKGIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEGLFE
>Mature_698_residues
MRRIDVYDLLIGKGNYVDDISYKGRYAVFIRSPYPHARIVNINKEDAERRGALVLTGKDLVSRSVESGEREGASLTIPLM
AINKALYVGQPVALVIANDPYEATDLAELVQVDYEPLEGIGSIEKALQNKVVVFEDLKTNIVREQTFEFGKINTQGRHLE
LDLYWSRSSGNPIEPYGAIIIPTDDGLTIISNQQAGNVVSNEIQKALGVKVIHKNARQGGSFGEKFSLVRYLTVLGFAAL
KFNVPIKWIETRTEHLMASNGSGPERKFKIHAYYSSDGRVNSLDIHIWEDVGASRDAGQPFKPLGFLTGPYKIGGIRYTG
TLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISKAEVRKINAIDIFPYDTGFAYYDSGNPKGLLDLALSRNDIF
ALRNKNTGVGLALSTDPSTPSGSERVKIKVKNNKVVIGLGFGPEGQGNEHSAVVMASRLLGISPDNVTYEILDNTELPTS
FGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVILNDKVVDYRDGYFIGENGGKVRITSLEGEEVDFTYTLQGKYRFNAY
PFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQVIGGTAIGISLALYERYAYDDNANLLTTNLADYGMPTAADL
PEIEVNIVPTPSPSTPYGAKGIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEGLFE

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=724, Percent_Identity=24.0331491712707, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI91823271, Length=708, Percent_Identity=23.3050847457627, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789230, Length=764, Percent_Identity=25.130890052356, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1789246, Length=762, Percent_Identity=22.0472440944882, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786478, Length=410, Percent_Identity=24.390243902439, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539860, Length=718, Percent_Identity=24.2339832869081, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17540638, Length=715, Percent_Identity=23.2167832167832, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=559, Percent_Identity=23.0769230769231, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737937, Length=734, Percent_Identity=23.0245231607629, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24647193, Length=639, Percent_Identity=22.3787167449139, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 76069; Mature: 76069

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIDVYDLLIGKGNYVDDISYKGRYAVFIRSPYPHARIVNINKEDAERRGALVLTGKDL
CCEEEEEEEEECCCCEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHCCEEEEECHHH
VSRSVESGEREGASLTIPLMAINKALYVGQPVALVIANDPYEATDLAELVQVDYEPLEGI
HHHHHHCCCCCCCEEEEEHHEECCEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHCCC
GSIEKALQNKVVVFEDLKTNIVREQTFEFGKINTQGRHLELDLYWSRSSGNPIEPYGAII
HHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEE
IPTDDGLTIISNQQAGNVVSNEIQKALGVKVIHKNARQGGSFGEKFSLVRYLTVLGFAAL
EECCCCEEEEECCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEE
KFNVPIKWIETRTEHLMASNGSGPERKFKIHAYYSSDGRVNSLDIHIWEDVGASRDAGQP
EECCCEEEEECHHHHHEECCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCC
FKPLGFLTGPYKIGGIRYTGTLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISK
CCCCCEECCCEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AEVRKINAIDIFPYDTGFAYYDSGNPKGLLDLALSRNDIFALRNKNTGVGLALSTDPSTP
HHHEEEEEEEEEECCCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCCCCC
SGSERVKIKVKNNKVVIGLGFGPEGQGNEHSAVVMASRLLGISPDNVTYEILDNTELPTS
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCC
FGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVILNDKVVDYRDGYFIGENGGKVRITSL
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEECCCEEEECCCEEECCCCCEEEEEEE
EGEEVDFTYTLQGKYRFNAYPFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQV
CCCEEEEEEEEECEEEECCCCEEEEEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHH
IGGTAIGISLALYERYAYDDNANLLTTNLADYGMPTAADLPEIEVNIVPTPSPSTPYGAK
CCCEEHHEEEEEEEHEEECCCCCEEEECHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCC
GIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEGLFE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MRRIDVYDLLIGKGNYVDDISYKGRYAVFIRSPYPHARIVNINKEDAERRGALVLTGKDL
CCEEEEEEEEECCCCEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHCCEEEEECHHH
VSRSVESGEREGASLTIPLMAINKALYVGQPVALVIANDPYEATDLAELVQVDYEPLEGI
HHHHHHCCCCCCCEEEEEHHEECCEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHCCC
GSIEKALQNKVVVFEDLKTNIVREQTFEFGKINTQGRHLELDLYWSRSSGNPIEPYGAII
HHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEE
IPTDDGLTIISNQQAGNVVSNEIQKALGVKVIHKNARQGGSFGEKFSLVRYLTVLGFAAL
EECCCCEEEEECCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEE
KFNVPIKWIETRTEHLMASNGSGPERKFKIHAYYSSDGRVNSLDIHIWEDVGASRDAGQP
EECCCEEEEECHHHHHEECCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCC
FKPLGFLTGPYKIGGIRYTGTLVATNKNPAGAFRGAGTPPHTWALERTMDAIADDLGISK
CCCCCEECCCEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AEVRKINAIDIFPYDTGFAYYDSGNPKGLLDLALSRNDIFALRNKNTGVGLALSTDPSTP
HHHEEEEEEEEEECCCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCCCCC
SGSERVKIKVKNNKVVIGLGFGPEGQGNEHSAVVMASRLLGISPDNVTYEILDNTELPTS
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCC
FGPGGSRMAIYTFGAVSGAVEELKARLRRKAEVILNDKVVDYRDGYFIGENGGKVRITSL
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEECCCEEEECCCEEECCCCCEEEEEEE
EGEEVDFTYTLQGKYRFNAYPFACDLAVVRIEDGKIKPIKHVVYIDPGTPIDEDLVKEQV
CCCEEEEEEEEECEEEECCCCEEEEEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHH
IGGTAIGISLALYERYAYDDNANLLTTNLADYGMPTAADLPEIEVNIVPTPSPSTPYGAK
CCCEEHHEEEEEEEHEEECCCCCEEEECHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCC
GIGEIPVGIAAAAVTSAIEDVIKRRINRVPVSLEGLFE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]