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The map label for this gene is hisA

Identifier: 227815743

GI number: 227815743

Start: 2885519

End: 2886238

Strand: Reverse

Name: hisA

Synonym: BAMEG_3166

Alternate gene names: 227815743

Gene position: 2886238-2885519 (Counterclockwise)

Preceding gene: 227815744

Following gene: 227815742

Centisome position: 55.18

GC content: 38.47

Gene sequence:

>720_bases
ATGGAAATCTTCCCAGCTATCGATTTAAAAGAAGGGCGATGCGTGAGACTGTATCAAGGCGAGTTTAGTAAAGAAACAGT
AATGAATGAGGACCCGGTTGCGCAAGCGATTATATTTGAAAAATTTGGGGCGAAAAGGTTGCACATTGTTGATTTAGATG
GAGCAGTTGCTGGCGAGTCATTAAACTTGTCCGTCATTGAAAGGATTTGCAAGGCAGTACGTATTCCTGTGCAAGTTGGA
GGAGGAATTCGATCACTTGTAGCGGTAGAGAAGTTATTTTCAGTAGGGGTAGATAAAGTGATTTTAGGAACAGCTGCTCT
TTATGATAAGACATTTTTAGAAGAAGCAGTTCTTCTATATAAAGAAAAAATCATCGTTGGAATTGATGCGAAAAATGGTT
TCGTAGCAACGAGAGGTTGGCTTGATGTGTCTGAAATTTCTTACATTGATTTAGCAAAGCAAATGGAGAAGATAGGTGTT
CAAACGATTGTATTTACAGACATTTCGAAAGACGGGACACTTGCAGGGCCGAATATAGAGCAATTGGAGTTACTACAAAA
AAGCGTTGCTATTCGTCTTATTGCTTCTGGAGGAGTTGCATCTATACAAGATGTGAAAAAGTTAAATGATATGAACATAT
ACGGCGTCATAATTGGTAAGGCTCTTTACGAGAAAACGATTGATTTAGAAGAAGTGGTAGAGGTAACAAAGTTATGTTAG

Upstream 100 bases:

>100_bases
TTGTAGCAAAAGGAAATATATATGGTGCGCAGTTTCATCCTGAAAAAAGTGGTGACATTGGCATGCAAATGTTGAAAAAT
TTTAAAGGAGTGGTAGAAAC

Downstream 100 bases:

>100_bases
CGAAACGTATTATTCCATGTCTAGATGTGAAAGAAGGGCGAGTCGTAAAGGGGGTAAATTTTATAGGGTTACAAGATGTC
GGTGATCCTGTTGAAATAGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLAGPNIEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVVEVTKLC

Sequences:

>Translated_239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLAGPNIEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVVEVTKLC
>Mature_239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLAGPNIEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVVEVTKLC

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=238, Percent_Identity=32.7731092436975, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1788336, Length=242, Percent_Identity=25.6198347107438, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BACAA (C3P505)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002865921.1
- ProteinModelPortal:   C3P505
- SMR:   C3P505
- EnsemblBacteria:   EBBACT00000125983
- GeneID:   7851292
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1496
- GeneTree:   EBGT00050000001074
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26131; Mature: 26131

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGES
CCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LNLSVIERICKAVRIPVQVGGGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLY
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGVQTIVFTDISKDGTLAGPNIE
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
QLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVVEVTKLC
HHHHHHHHHHEEEEECCCCHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGES
CCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LNLSVIERICKAVRIPVQVGGGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLY
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGVQTIVFTDISKDGTLAGPNIE
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
QLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVVEVTKLC
HHHHHHHHHHEEEEECCCCHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA