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The map label for this gene is copA [H]

Identifier: 227815279

GI number: 227815279

Start: 2452830

End: 2453411

Strand: Reverse

Name: copA [H]

Synonym: BAMEG_2690

Alternate gene names: 227815279

Gene position: 2453411-2452830 (Counterclockwise)

Preceding gene: 227815280

Following gene: 227815278

Centisome position: 46.91

GC content: 35.05

Gene sequence:

>582_bases
ATGATGCGATATATATTAACAGCGGTTACAGTCTCAGTAATATTTTTAATTGCTGCATGTTCTGTGACGACAAATACAAC
AAATGACCATAAAAATAGGAATGATAAAAAAACTAAACAAACTGAAACGGCTACAAAACCATTGGAAATTGTTAAGGGAC
CAGAAGTTACTTTAATAGCGAAAGAAGAAAAGCAAAAATTAAGTAACGGTGTTATTGTTCCGGTCTGGACATTTAATGGC
TCATCTCCTGGTCCGGAAATTCGGGTAAAAAAAGGTGAAAAGGTGAAAGTGACATTAAAAAATGAACTATCTGCACCAGT
ATCTATTCACTGGCATGGGTATCCTGTCCCAAATGATATGGATGGAATTCCAGGTGTGACGCAAGATGCAGTCGAACCAG
GAAAAAGTTTCACTTACGAATTTGAAGCGAACGTACTAGGAACGTACTGGTATCATTCACATCAAGATTCTGTAAATCAA
TTAGATAGAGGATTATATGGTACTTTCGTTGTAGAAGATACAAATGAAAAGTATGATAAAGATTACACATTAATGTTAGA
TGAATGGATAAAGAAGAGATGA

Upstream 100 bases:

>100_bases
CAATTTTGGGCGTCCTTTTATTTTGCCCATTTTAAATCTCCTTATTTTCTTGAAAATCATCTTCTAGAATGATTTTGAAA
AAGAAAAGGAGGGATTTTCT

Downstream 100 bases:

>100_bases
ATAAACAGTTAAAAGAAATGACAAAAGGAAAAACAGAAAAAGCAGACGGTAATAAATCTAGTAAGGGTAATGAAAATACG
AAAAAGAATGATGATAAGAA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWIKKR

Sequences:

>Translated_193_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWIKKR
>Mature_193_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWIKKR

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=126, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=122, Percent_Identity=40.1639344262295, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320714, Length=118, Percent_Identity=36.4406779661017, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=114, Percent_Identity=35.0877192982456, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650186, Length=154, Percent_Identity=35.0649350649351, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859919, Length=145, Percent_Identity=33.7931034482759, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574104, Length=136, Percent_Identity=31.6176470588235, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281360167, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585842, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330000, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221329998, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 21792; Mature: 21792

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEEKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGTFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWIKKR
CEEEEEHHHHHCC
>Mature Secondary Structure
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEEKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGTFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWIKKR
CEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]