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The map label for this gene is ipdC [H]

Identifier: 227814705

GI number: 227814705

Start: 1924285

End: 1925961

Strand: Direct

Name: ipdC [H]

Synonym: BAMEG_2115

Alternate gene names: 227814705

Gene position: 1924285-1925961 (Clockwise)

Preceding gene: 227814699

Following gene: 227814715

Centisome position: 36.79

GC content: 34.53

Gene sequence:

>1677_bases
TTGAAAACTCAATATACTGTAAGTACATATTTATTAGACCGACTAAGCGAATTAGGAATTGAGCATATTTTTGGTATCCC
TGGTGATTATAATTTGGCTTTTTTAGATTATGTACTCGCACATAAAAATTTAGAGTGGATTGGCAATTGTAATGAATTAA
ATGCGGCATATGCTGCAGATGGATATGCTCGTATAAAAGGAATAGCAGCTCTTATTACCACCTTTGGCGTTGGAGAATTA
AGCGCCATAAATGGCATTGCTGGCTCATATGCAGAAAACGTACCAGTTATAAAAATTACAGGTACACCACCAACAACAGT
AATGGAAAATGGAGAGCTAGTTCATCATACGTTAGGTGATGGAAAGTTCAATCATTTTTCCAAAATGTATCGAGAAATCA
CTATTGCACAAACTAATTTAACCCCAGAGCATGCAGTCGAGGAAATTGACCGTGTGTTACGTGCATGTTGGAATGAAAAA
CGTCCTGTTCATATTAATTTACCTATTGATGTGTATAATAAACCAATTAATAGACCTGCAGAACCAATTTTACATAAACC
GATTTTAAGTAATAAAGAAACACTGGATAAAATGCTTCTACATGCCATTTCAAAAATAAATAGCGCAAAGAAACCTATTA
TTTTAGCTGATTTTGAAGTAGATCGTTTTCATGCAAAAGAATATTTATATCAATTTGTAGAAAAAACGGGGTTTCCTATT
GCAACGTTAAGTATGGGAAAAGGAATATTTCCAGAAAAACACCCTCAATTTATAGGGGTTTATGTTGGTGATGTAAGTCC
TCCATACTTGCGTAAAAGAATTGATGAATCTGACTGTATTATTAGTATTGGCGTGAAGTTAACTGATACTATTACAGGTG
GCTTCACACAAGGTTTTACGAAAGAACAAGTTATTGAAATTCATCCCTACACTGTGAAAATTACAGATAAAAAATACGGG
CCAGTTGTAATGAAAGATGTTTTACAACAGTTAAGTGATGTAATTGAGCATCGAAATGAAGAAACGCTTGATATTAAGCC
ATTTATTTCAGAATCTCTATCTATGACAGAAGAGTTCAATCCAAAAGCACACATGGTTACACAAAAACGTTTTTGGCAAC
AAATATACCATTTCTTACAAGAAAACGACGTCTTACTTGCAGAGCAAGGAACACCTTTCTTTGGTAGTGCCGCTATCCCT
TTACCAAACAACACTACATATGTAGCGCAACCATTATGGGGATCGATCGGCTATACGTTACCTGCTCTACTTGGTACACA
GCTCGCTAATTTATCGCGGCGCAACATTTTAATTATTGGTGATGGTTCTTTTCAATTAATTGTCCAAGAATTATCAACTA
TACTACGTCAAAATTTAAACCCAATTATATTTTTAATTAACAACAATGGTTATACTGTTGAACGTGCAATTCATGGTCAA
AACGAACCGTATAATGACATACAAATGTGGGAGTACACAAAACTAGCGAAAGTATTCGGAACAGAAGAAAAAAGCCAAAC
ATTTAAAGTACAAAATGAAACAGAGTTACAAGAAGTCTTAACTAAAATAAGTATTGATAAGAATCAACTTACCTTTGTTG
AAATTGTAATGAGCCAAGGGGATCAGCCTGAATTGTTAGCTAAGCTTGGGAAGAGATTCGGCCAGCAAAATTCTTAA

Upstream 100 bases:

>100_bases
ATGTAAATTATACCACATTCTAGTAATGAATATTTTAATCAATGCTCTAGAGCTGCTTTCGTTTATTACAAGAAAGCAAA
ACGATTAGGAGATGATTCAC

Downstream 100 bases:

>100_bases
TATAAAAAGCATAACCTAATTATATAAAAGGAAAAGGATGGAAGGTGCCACCCTTTTCCTTTTATATATACTATTTTAAG
AACCTTCTTCGACTAACTTC

Product: putative indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAIHGQ
NEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQNS

Sequences:

>Translated_558_residues
MKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAIHGQ
NEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQNS
>Mature_558_residues
MKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAIHGQ
NEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQNS

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=549, Percent_Identity=22.040072859745, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=22.5688073394495, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786717, Length=480, Percent_Identity=23.75, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787096, Length=556, Percent_Identity=21.9424460431655, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=25.8264462809917, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=25.8264462809917, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=567, Percent_Identity=39.1534391534392, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323073, Length=571, Percent_Identity=38.7040280210158, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321524, Length=574, Percent_Identity=37.4564459930314, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320123, Length=560, Percent_Identity=36.25, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320588, Length=597, Percent_Identity=29.9832495812395, Blast_Score=269, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6323755, Length=301, Percent_Identity=22.2591362126246, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 62952; Mature: 62952

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAAD
CCCEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGD
CHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEECCC
GKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPINRPA
CCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
EPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
CHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFN
CCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHCC
PKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNNTTYVAQPLWGSIGYTL
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCCCHHHHHH
PALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
NEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQG
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEHHHCCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAAD
CCCEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGD
CHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEECCC
GKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPINRPA
CCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
EPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
CHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFN
CCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHCC
PKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNNTTYVAQPLWGSIGYTL
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCCCHHHHHH
PALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
NEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQG
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEHHHCCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]