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The map label for this gene is vanR [H]

Identifier: 227814629

GI number: 227814629

Start: 1854535

End: 1855230

Strand: Direct

Name: vanR [H]

Synonym: BAMEG_2039

Alternate gene names: 227814629

Gene position: 1854535-1855230 (Clockwise)

Preceding gene: 227814610

Following gene: 227814630

Centisome position: 35.46

GC content: 30.89

Gene sequence:

>696_bases
ATGAATAAAAATATATTAATTATTGATGATGATAAAGAAATTGTCGAATTACTTGCTGTTTATTTGCGAAATGAAGGCTA
TAACATTTATAAAGCATATGATGGTGATGAAGCATTACAAATGATTTCTACATATGAAGTTGACCTTATGATTTTGGATA
TTATGATGCCAAAACGAAATGGATTAGAAGTTTGCCAAGAAGTTCGTGAAAATAATACTGTACCTATTCTTATGCTGAGT
GCAAAAGCAGAAGATATGGATAAAATATTAGGACTTATGACAGGCGCCGATGATTATATGATTAAACCATTTAATCCATT
AGAATTAGTAGCTAGAGTGAAAGCTTTGCTTCGACGATCATCTTTCCAAAATGCTTCTTCTCCCAAAAATGAAGATGGTA
TGATTCGCATTCGTTCCGCTGAAATACACAAACATAATCATACTGTGAAAGTAAATGGAGAATATATTAAGCTTACATCT
ATTGAATTTGATATTTTATATTTACTTGCGAGTAATACAGGAAGAGTATTTAGTTCTGAAGAAATATTTGAGCGTGTTTG
GAATGAAGATGGTTATGGTTCAAATAAAACTGTAATGGTCCACATTAGTAATTTACGAGATAAGCTTGAAACAGGAATGA
ATGGAGAAAAATTTATTCATACTGTTTGGGGAGTAGGCTATAAAATTGAGAAATGA

Upstream 100 bases:

>100_bases
TAATACGTTACATGAAATTTTATACAGAATCATCGCTACAAATACATAAATGTTTGATATTATAGTAATGTTAATGATTT
GTAAGGAAAGGAACTACATA

Downstream 100 bases:

>100_bases
AGCATTTGATATATTAAAAGATATCCCGAAATGGAAACTTATTTTTTGGCTCTTATTAGCTATCACACTCACTCCTATTA
CTGAATTAATTATATATCGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK

Sequences:

>Translated_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
>Mature_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=35.8078602620087, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.117903930131, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.4827586206897, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.4561403508772, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=32.7659574468085, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=32.3144104803493, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.6206896551724, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=33.1838565022422, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=33.6283185840708, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.7180616740088, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=34.1880341880342, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=29.9559471365639, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=31.25, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=124, Percent_Identity=33.8709677419355, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=30.6930693069307, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26488; Mature: 26488

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
CCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
CCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]