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The map label for this gene is kynA [H]

Identifier: 227814436

GI number: 227814436

Start: 1673157

End: 1673996

Strand: Direct

Name: kynA [H]

Synonym: BAMEG_1844

Alternate gene names: 227814436

Gene position: 1673157-1673996 (Clockwise)

Preceding gene: 227814435

Following gene: 227814437

Centisome position: 31.99

GC content: 36.43

Gene sequence:

>840_bases
ATGAAAGAAAATGAAAAGGTAATTATGGAAAAAGGGATTCATACGGACTTTAAAGAGAATATGACGTACGGGGAATATTT
ACAATTAGATAGTTTACTATCTTCTCAAAAGAGATTATCAGACCACCATGATGAAATGTTGTTCATCGTTATTCACCAAG
CAAGCGAACTTTGGATGAAGCTTATTTTACATGAGTTAAACGCAGCAATTGAATCTATTAAACAAGACAAATTACAACCA
GCTTTTAAAATGTTAGCACGTGTATCAAAAATCCAATCACAAATCATTCAATCTTGGGATATTCTTGCGACATTAACGCC
GTCAGAGTACATTGAGTTTCGTGACTCGCTCGGTCAAGCTTCAGGTTTTCAATCGTATCAATATCGTATGATTGAGTATG
CGCTTGGTTATAAAACGCCGCATGCCTTAAAAATTTATGAAAAAGATCCAGAATTACACGCTCGACTTCATACGGCGCTA
CATGCACCAAGTTTATATAATGTGGCAATTCAAGCTCTTGTAAAAGAAGGATTCCCAATTCATAAAGACGTGTTAAATCG
TGATATTACGCAGCCATACGAAGAAGATGCAACAGTAGAAGCAGCATGGCTTGAAGTGTATGCTGATGTGAAAAAATATT
GGAATTTATATCAGCTCGCTGAAAAACTTATCGATATTGAAGATTGGCTACAACAATGGCGTTTCCGTCATATGAAAACA
GTAGAACGCATTATCGGACATAAAATGGGAACAGGTGGCTCTTCTGGTGTATCTTATTTAAAACGAGTACTTGATCAACG
TTTCTTCCCAGAGCTTTGGAATGTTCGCACGAAATTATAA

Upstream 100 bases:

>100_bases
CGCATTACCACTTGCCTTATCAGATGCAGATGGAAGTCCAGTTCGAGCAGTTATTAGACCAATATAAGTAGAAATATATA
TAAAGGGGCGTTTTGCTAAT

Downstream 100 bases:

>100_bases
AAACAAACCTGTCAGTTCATTACTGGCAGGTTTGTTTTTTATTTGAACACAAGTATGTTTTAATTAAAACTACAAGATAT
AATAAATTAGGTAATGATTT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYNVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Sequences:

>Translated_279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYNVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
>Mature_279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYNVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=138, Percent_Identity=37.6811594202899, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32564651, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=136, Percent_Identity=38.9705882352941, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=31.7220543806647, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 32758; Mature: 32758

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMK
CCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LILHELNAAIESIKQDKLQPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHAPSLYNVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
HKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMK
CCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LILHELNAAIESIKQDKLQPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHAPSLYNVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
HKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA