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The map label for this gene is pbp [H]

Identifier: 227813991

GI number: 227813991

Start: 1276412

End: 1278487

Strand: Direct

Name: pbp [H]

Synonym: BAMEG_1397

Alternate gene names: 227813991

Gene position: 1276412-1278487 (Clockwise)

Preceding gene: 227813989

Following gene: 227813992

Centisome position: 24.41

GC content: 41.47

Gene sequence:

>2076_bases
ATGGAAAATAAATTATCTGGAGTGTTAGCCGCTACCTTAGCTCTAACGATGAGCCTACCAACAGGAGCGATAGCGTCTTC
TAGCAGTAAGACTCCGGTTGTATCTAGCCAAGAAGTTGCTAGCAAAGATTTGGAGAAGATTGCTGCAGAGAACGCTGCAC
TGCTCACGAAGTCCTATGAGACGACTAGTGTACAGTATGCGCTGATTGATAATGGTAAACTTATTTTGTCAGGACAGACA
GGCAAGAATGACATAGAGGGGAAAGAGCCATTAACCAAAGATACTCTATACGGAATTGGTTCAACCAGTAAAGTATATAC
AGCTGCGGCTGTTATGAAATTAGTAGACGAAGGAAAAGTTGATTTGGATGCTTCTGTTACCCGCTATATTCCTGAGTTCA
AAATGAAAGATGAACGATATAAACGCATTACACCGCGTATGCTGTTGAATCACTCCTCAGGTTTGCAAGGTTCGACGCTC
AATAATGCATTTTTATTTAAAGATAATGATGTTTATGCCCATGATATCTTGTTGCAACAATTGTCCAACCAAAACTTGAA
GGCAGACCCTGGCGCGTTCTCAGTATACTGTAATGACGGTTTTACGCTGGCTGAGATCTTGGTAGAAAGAGTCAGCGGTA
TGAGTTTTACTGAATTTCTACATCAAAAGTTTACAGAGCCATTAAAACTGAATCATACGATAACATCGCAAGATAAATGG
GAAGACGAAAAGCGGGCTGGACAATATTCTCCGACATACCAGGGACAGCTTCCAAGTGAAATGGTAAATGTGATTGGTAC
GGGAGGAATCTCTTCTACTGCAGAAGATGTGGTGCGATTCTCACAAATATTTATGGGACAGGGAAAAGAAATCCTCTCTA
ATAAAGCAGTCAAGGCGATGGAACAAGAAGAATATAAAAAAGGAATGTGGCCGGGAGATAGCGGAAATGTGTTCAACTAT
GGTCTTGGCTGGGATAGTGTGAAACTATACCCATTCAGTGAATATGGGATAAAAGCGTTGACTAAGGGTGGGGATACGAT
GCTGCAACATGCTACATTGGTCGTACTTCCAGAACAGAAGATGGCAGCAGCTGTATTGTCCTCCGGCGGCTCCAGCATGA
CAAATCAACTGTTGGCAAATAAATTACTGCTAGCTAGGCTTAAAGAGAAAGGGACAATTAAGGATATAAAACCAGATAGA
TCCTTCGGCAAGCCCGTCAAGGCTAAAGTGCCTCAAGACGTGGTAAAAAAAGCAGGATTTTATGGAAATAGTTATAGCCA
TTTCAAAATAGAAATTACGAAGAAGGGAGAACTGTTTTTACCAACTAAACCAGAAGAAAAATATGTATATACGGCGGATG
GAAGCTTTATAAATGAGAAGGGCACTTCCAAGCTTAACTTCGTCACAGAGAAGAATGGAAAAGTTTATTTGAGAGAGAGC
GCATATGAATTATCGCCGGGATTGGGGCAAAATGTGCTGACTCACTATTTAGCCCAGAAATTAGAAAACAATGTGTTACC
GAAGAAAACAGCTGCTGCATGGGCGAAGCGCGAGGGCGGCAAGTTCTACCTCGTTAACGAAAAATTTAATTCTATAAATT
ATCTAGGACAACAGATACCTCTTAATACACAAATTACGCTCAAAGATGGCTATTGGGACGGCAAAAAAATTACAGGTCCG
AATACGGCGACGCATCAAATTCAAATTCCCGTGATGAATGGGCGGGATACAAAGGAAGCCCATTTCTATACAGAGGATGG
TACTGAATATATGGAGATGTCCAGCTTTTTATACGTCAGTGAATCTAACGTAAAATCCCTTGATACAGGTCAATTATCGA
AAGTTACATTGCAAAAAAGTGGGCATGCGAAATGGTTTACGATCCCGCAAGAGGCAGCAGGGAAAACGATGAATGTGGAA
TTGCCATCAGGAAGTTCATTCGCGGTGTATGATGAGAATGGAGTATGCGTCAATTTTAGCGTTGTTAGTAATAATAACAA
AGTGAAACTACCAGAGAACGGAACGGTTGTATTTGCTGGCGCACCGAACTCCGAATTTACAGTCGCATTGAACTAG

Upstream 100 bases:

>100_bases
ACGACAGTAGAGATAAAGCCAGAATAGTAGTTTATGTGATGTTTGTAATTGAGCAAATAAAAGATGAAACCGATCATTTA
TCTAAGGAGGAATTTTTCTT

Downstream 100 bases:

>100_bases
CTACAACTCGGGATAGACTTTAATAAAACAGTATCACTTGGAAAAGATATTTTATTTGTATCTTAAGTATTCCCTTAAAT
GATATTACACTTAAATTCTT

Product: putative penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDR
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGQLSKVTLQKSGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN

Sequences:

>Translated_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDR
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGQLSKVTLQKSGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN
>Mature_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDR
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGQLSKVTLQKSGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=207, Percent_Identity=28.9855072463768, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786574, Length=315, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=280, Percent_Identity=27.5, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17550934, Length=298, Percent_Identity=27.1812080536913, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 75894; Mature: 75894

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTLNNAFLFKDNDVYAHDILLQQ
CCCCHHHHHCCCCCCCCHHHHHCCHHHEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCCHHHHCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDRSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
YGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEECC
AYELSPGLGQNVLTHYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSINYLGQQIP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCC
LNTQITLKDGYWDGKKITGPNTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVS
CCEEEEEECCCCCCCEECCCCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHCEEEEEE
ESNVKSLDTGQLSKVTLQKSGHAKWFTIPQEAAGKTMNVELPSGSSFAVYDENGVCVNFS
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSNNNKVKLPENGTVVFAGAPNSEFTVALN
EEECCCEEECCCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTLNNAFLFKDNDVYAHDILLQQ
CCCCHHHHHCCCCCCCCHHHHHCCHHHEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCCHHHHCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDRSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
YGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEECC
AYELSPGLGQNVLTHYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSINYLGQQIP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCC
LNTQITLKDGYWDGKKITGPNTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVS
CCEEEEEECCCCCCCEECCCCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHCEEEEEE
ESNVKSLDTGQLSKVTLQKSGHAKWFTIPQEAAGKTMNVELPSGSSFAVYDENGVCVNFS
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSNNNKVKLPENGTVVFAGAPNSEFTVALN
EEECCCEEECCCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]