Click here to switch to the map view.

The map label for this gene is acs-1 [H]

Identifier: 227080512

GI number: 227080512

Start: 289847

End: 291847

Strand: Reverse

Name: acs-1 [H]

Synonym: VCM66_0283

Alternate gene names: 227080512

Gene position: 291847-289847 (Counterclockwise)

Preceding gene: 227080513

Following gene: 227080511

Centisome position: 10.09

GC content: 51.42

Gene sequence:

>2001_bases
TTGAAACGCGCCCTTTCAGGAAATTTGCCGAATTCACAAGGAGAACCCGTAATGAGTGAAGCCCATATTTATCCGGTCAA
ACAGAACATCAAAGCGCATACGCATGCCGATAACGACACCTATCTGGCGATGTATCAACAGTCCATCAAAGATCCGGAAG
GCTTTTGGAGCGAACACGGCAAAATCGTCGACTGGATTAAACCTTTCACCAAGGTGAAACACACCTCTTTTGACCCAGGG
CACATCGATATCCGCTGGTTTGAAGATGGCACGTTAAACGTTTCTGCCAACTGTATTGATCGCCATTTGGCGACCCGTGG
CGACCAAGTCGCGATCATTTGGGAAGGCGACGACCCGACTCAAGACAAAACTCTGACGTATAAGCAACTGCACCAAGAAG
TGTGCCGTTTTGCCAATGCGCTGAAAGAGCAAGGCGTACGCAAGGGTGATGTTGTCTGTATCTACATGCCTATGGTGCCA
GAAGCGGCGGTTGCTATGTTGGCTTGTACCCGTATTGGCGCAGTGCACACTATCGTCTTTGGTGGCTTCTCGCCAGAAGC
ACTGGCTGGACGCATTATCGACTCGAACGCCAAATTAGTGATCACTGCCGACGAAGGTGTTCGCGGCGGCCGCGCCGTCC
CCCTAAAGAAAAACGTCGATGAAGCACTGTGCAATCCAGAAGTCAAAAACATCAGTAAAGTGATGGTTCTTAAGCGTACT
GGCGGCAATGTCGCTTGGCATGAACACCGTGACATTTGGTGGCATGAAGCAACCGCAAAAGCCTCCGATAATTGTCCACC
AGAAGAGATGAAAGCCGAAGATCCGCTGTTTATCCTCTACACCTCTGGCTCAACCGGTAAACCGAAAGGCGTATTGCACA
CCACTGGCGGTTATTTGGTTTATGCGACTATGACCTTCAAATATGTATTCGACTATCAGCCCAATGAAGTGTTCTGGTGT
ACCGCTGATGTGGGTTGGATAACGGGTCACTCCTATCTGGTGTATGGCCCATTGGCGAATGGCGCAAAAACCATTCTGTT
TGAAGGCGTGCCAAACTACCCCACCACCGCACGCATGAGCGAGGTGGTAGACAAGCATAAGGTCAATATCCTTTACACTG
CGCCAACGGCGATCCGTGCGCTGATGGCCAAAGGTGATGAAGCGATTAAAGGCACTAGCCGTGACAGCTTGCGCATTATG
GGCTCTGTGGGTGAACCGATTAACCCAGAAGCGTGGGAGTGGTACTACCGCACGATCGGTAACGAAGAATCGCCGATTGT
CGATACTTGGTGGCAAACCGAAACCGGCGGTATCTTGATCACACCACTGCCGGGGGCAACGGCGTTGAAACCGGGTTCGG
CCACACGCCCCTTCTTTGGTGTGCAGCCAGCGTTAGTCGATAACATGGGCGAAATCGTGGAAGGCGCAACTGAAGGCAAC
TTGGTGCTGCTCGATTCATGGCCGGGTCAAATGCGCACTGTGTATGGCGATCACGACCGCTTTGAACAAACCTACTTCTC
TACCTTTAAAGGCATGTACTTTACCGGTGACGGTGCGCGTCGCGATGAAGACGGTTACTACTGGATCACAGGCCGTGTCG
ATGACGTACTCAACGTTTCGGGTCACCGTATGGGAACGGCAGAAATTGAATCCGCACTGGTGGCATTCAATAAGATTGCA
GAAGCCGCCGTGGTCGGTGTTCCACACGATATCAAAGGCCAAGCGATTTACGCTTACATCACACTCAATGATGGGGTGTA
TCCGAGCGCTGAACTGCATAAAGAAGTGAAAGATTGGGTACGCAAAGAGATTGGCGCTATCGCGACACCGGATGTCCTAC
ACTGGACCGATGCGCTACCGAAAACCCGTTCAGGTAAAATTATGCGCCGTATTTTGCGTAAAATTGCCACCGGCGATACC
AGCAACTTGGGGGATACCTCAACGCTGGCCGATCCAAGCGTGGTTGACCGCCTGATTGCCGAAAAAGCCCAACTTAAATA
A

Upstream 100 bases:

>100_bases
TTGCACACATATCCCATCAGGCTTTCATCCTAAAGTCTAATTGTAGAAATCCCTGCTCTGACTGAGAGTTATAAACGAAA
CGAATTTCCTCCTCTCGTGT

Downstream 100 bases:

>100_bases
CAAACCCTGTGGTTTGAGGTTGTAGCCTCAAGTCACAAGGGAATACACATTTGCTTGCGCTTTCAAACTCCGGTGCACCT
CATGGCCGGAGTTTTTGTTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MKRALSGNLPNSQGEPVMSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPG
HIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVP
EAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRT
GGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWC
TADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIM
GSVGEPINPEAWEWYYRTIGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGN
LVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIA
EAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDT
SNLGDTSTLADPSVVDRLIAEKAQLK

Sequences:

>Translated_666_residues
MKRALSGNLPNSQGEPVMSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPG
HIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVP
EAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRT
GGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWC
TADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIM
GSVGEPINPEAWEWYYRTIGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGN
LVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIA
EAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDT
SNLGDTSTLADPSVVDRLIAEKAQLK
>Mature_666_residues
MKRALSGNLPNSQGEPVMSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPG
HIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVP
EAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRT
GGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWC
TADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIM
GSVGEPINPEAWEWYYRTIGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGN
LVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIA
EAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDT
SNLGDTSTLADPSVVDRLIAEKAQLK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=652, Percent_Identity=53.8343558282209, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=665, Percent_Identity=52.6315789473684, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=50.3164556962025, Blast_Score=640, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=36.8503937007874, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI42544132, Length=541, Percent_Identity=28.0961182994455, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI31982927, Length=648, Percent_Identity=24.2283950617284, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI38505220, Length=518, Percent_Identity=29.7297297297297, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=26.953125, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI115511026, Length=546, Percent_Identity=28.021978021978, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI58082049, Length=529, Percent_Identity=24.1965973534972, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI157311624, Length=529, Percent_Identity=23.2514177693762, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI157311622, Length=529, Percent_Identity=23.2514177693762, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI187761345, Length=574, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761343, Length=574, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=25.7990867579909, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI42544134, Length=359, Percent_Identity=25.0696378830084, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156151445, Length=553, Percent_Identity=23.3273056057866, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790505, Length=648, Percent_Identity=74.2283950617284, Blast_Score=1037, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=35.8161648177496, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=22.4528301886792, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788107, Length=598, Percent_Identity=22.5752508361204, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI145693145, Length=523, Percent_Identity=23.5181644359465, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71982997, Length=671, Percent_Identity=50.2235469448584, Blast_Score=643, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=639, Percent_Identity=51.3302034428795, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=595, Percent_Identity=22.8571428571429, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=572, Percent_Identity=24.3006993006993, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=517, Percent_Identity=23.5976789168279, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=577, Percent_Identity=24.263431542461, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=23.6190476190476, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=147, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=378, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=48.125, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=48.1889763779528, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319699, Length=402, Percent_Identity=22.636815920398, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=52.8614457831325, Blast_Score=690, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.1174377224199, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=57.1153846153846, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI21355225, Length=638, Percent_Identity=34.9529780564263, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI18859661, Length=545, Percent_Identity=25.1376146788991, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=23.3716475095785, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656500, Length=533, Percent_Identity=25.515947467167, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24581924, Length=538, Percent_Identity=21.3754646840149, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21358303, Length=502, Percent_Identity=19.9203187250996, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 73676; Mature: 73676

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRALSGNLPNSQGEPVMSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHG
CCCCCCCCCCCCCCCCCCCCCEEEEHHCCCEEEECCCCCCEEEEEHHHCCCCCHHHHHCC
KIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPT
CEEHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
QDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTIVF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEE
GGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRT
CCCCHHHHCCEEECCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCHHCCEEEEEEEEC
GGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLV
CCCEEEECCCCEEEEECCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEE
YATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMS
EEEEEEEEEEECCCCEEEEEECCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCHHHHH
EVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRTIG
HHHHHHCEEEEEECHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCC
NEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGN
CCCCCEEEECEECCCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
LVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVS
EEEEECCCCCEEEEECCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCC
GHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWV
CCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHH
RKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRLIA
HHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
EKAQLK
HHHCCC
>Mature Secondary Structure
MKRALSGNLPNSQGEPVMSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHG
CCCCCCCCCCCCCCCCCCCCCEEEEHHCCCEEEECCCCCCEEEEEHHHCCCCCHHHHHCC
KIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPT
CEEHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
QDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTIVF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEE
GGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRT
CCCCHHHHCCEEECCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCHHCCEEEEEEEEC
GGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLV
CCCEEEECCCCEEEEECCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEE
YATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMS
EEEEEEEEEEECCCCEEEEEECCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCHHHHH
EVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRTIG
HHHHHHCEEEEEECHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCC
NEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGN
CCCCCEEEECEECCCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
LVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVS
EEEEECCCCCEEEEECCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCC
GHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWV
CCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHH
RKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRLIA
HHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
EKAQLK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]