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The map label for this gene is accC [H]

Identifier: 227080509

GI number: 227080509

Start: 287139

End: 288482

Strand: Reverse

Name: accC [H]

Synonym: VCM66_0280

Alternate gene names: 227080509

Gene position: 288482-287139 (Counterclockwise)

Preceding gene: 227080510

Following gene: 227080508

Centisome position: 9.97

GC content: 51.49

Gene sequence:

>1344_bases
ATGTTAGATAAAGTTGTCATCGCGAACCGAGGCGAAATTGCGCTTCGTATTCTCCGCGCTTGTAAAGAATTAGGCATTAA
AACGGTTGCCGTGCACTCCACGGCTGACCGCGACTTAAAACACGTACTGCTGGCGGATGAGTCTATCTGTATCGGTCCTG
CCAAAAGCATCGACAGTTACCTGAACATTCCACGCATTATCTCTGCGGCGGAAGTGACGGGCGCGGTAGCTATCCACCCG
GGTTACGGCTTTTTGTCTGAAAACGCGGATTTTGCTGAGCAAGTGGAGCGCAGCGGCTTCATTTTTGTCGGCCCTCGCGC
CGAAACCATCCGTTTGATGGGTGACAAAGTCTCCGCCATCAACGCGATGAAAAAAGCGGGCGTACCTTGTGTACCGGGTT
CAGACGGCCCACTGGATAACGACGAAGCGAAAAACAAAGCTCACGCAAAACGCATCGGCTACCCAGTTATTATCAAAGCC
TCTGGCGGCGGCGGTGGTCGCGGTATGCGTGTCGTACGTAACGAAGCCGAATTGACCAAATCTATCCAGATGACGCGTGC
GGAAGCGAAAGCCGCCTTCAACAACGACATGGTGTACATGGAGAAATTCCTAGAAAACCCACGTCACGTTGAAGTGCAAG
TGATCGCTGACGGTCAAGGCAATGCAATTCACCTCGCTGAGCGTGACTGTTCCATGCAGCGCCGTCACCAGAAAGTGGTG
GAAGAAGCACCCGCACCGGGTATCACTGAAGAAATGCGTAAGTTCATCGGTGAACGTTGTACCCGTGCGTGTATCGAAAT
CGGCTACCGCGGCGCTGGTACCTTTGAATTCCTGTACGAAAACGGTGAATTCTACTTCATTGAGATGAACACGCGTATTC
AGGTTGAGCACCCAGTAACAGAAATGATTACTGGCGTTGACCTGATCAAAGAGCAGCTGCGAATCGCCGCGGGTCAACCG
CTGTCTTTCAAACAAGAAGACATCAAAATTCGCGGCCATGCCGTTGAGTGTCGTATTAACGCGGAAGATCCAGAGCGCTT
CCTACCTTGCCCAGGCAAGATTGAACGCTTCCATGCACCTGGCGGCATGGGTGTGCGTTGGGAATCACACATTTACTCTG
GCTACACCGTACCCGCGCATTACGACTCGATGATCGGCAAACTCATCACTTACGGTGAGAACCGCGATGTGGCGATTGCT
CGTATGCGTAACGCACTCAATGAGATGATTGTGGAAGGGATCAAAACCAATATCCCACTACAACAAGCTATCATGGCAGA
TGAGAACTTCCAGAAAGGCGGTACCAACATCCACTATCTGGAGAAAAAACTCGGCATCAAGTAA

Upstream 100 bases:

>100_bases
CCGACAAATCTGGCGTTGTGACCGCGATTCTTGTTGAAGATGGTCAGACCGTTGAATTCGACCAACCGCTTGTTGTTATC
GAATAATCGAGGCCACCTTT

Downstream 100 bases:

>100_bases
GCCGCCGTTTTTACTCTCATCGCGCATAACCCAATCAATCATACCCAAACTACTTGGATTGGCTGATTGCACTAGGAATA
CGATAAAGCCCACTCCGGTG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADESICIGPAKSIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPRAETIRLMGDKVSAINAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRNEAELTKSIQMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGNAIHLAERDCSMQRRHQKVV
EEAPAPGITEEMRKFIGERCTRACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP
LSFKQEDIKIRGHAVECRINAEDPERFLPCPGKIERFHAPGGMGVRWESHIYSGYTVPAHYDSMIGKLITYGENRDVAIA
RMRNALNEMIVEGIKTNIPLQQAIMADENFQKGGTNIHYLEKKLGIK

Sequences:

>Translated_447_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADESICIGPAKSIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPRAETIRLMGDKVSAINAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRNEAELTKSIQMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGNAIHLAERDCSMQRRHQKVV
EEAPAPGITEEMRKFIGERCTRACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP
LSFKQEDIKIRGHAVECRINAEDPERFLPCPGKIERFHAPGGMGVRWESHIYSGYTVPAHYDSMIGKLITYGENRDVAIA
RMRNALNEMIVEGIKTNIPLQQAIMADENFQKGGTNIHYLEKKLGIK
>Mature_447_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADESICIGPAKSIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPRAETIRLMGDKVSAINAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRNEAELTKSIQMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGNAIHLAERDCSMQRRHQKVV
EEAPAPGITEEMRKFIGERCTRACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQP
LSFKQEDIKIRGHAVECRINAEDPERFLPCPGKIERFHAPGGMGVRWESHIYSGYTVPAHYDSMIGKLITYGENRDVAIA
RMRNALNEMIVEGIKTNIPLQQAIMADENFQKGGTNIHYLEKKLGIK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=49.3212669683258, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=46.9525959367946, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=46.9525959367946, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=46.9525959367946, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=45.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=45.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=45.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI38679971, Length=520, Percent_Identity=30.5769230769231, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679974, Length=520, Percent_Identity=30.5769230769231, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679977, Length=520, Percent_Identity=30.5769230769231, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679967, Length=520, Percent_Identity=30.5769230769231, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679960, Length=520, Percent_Identity=30.5769230769231, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=29.8039215686275, Blast_Score=232, Evalue=6e-61,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=85.4586129753915, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=238, Percent_Identity=25.6302521008403, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.5981941309255, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.5113122171946, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.097995545657, Blast_Score=357, Evalue=7e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.2338709677419, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=443, Percent_Identity=29.7968397291196, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=443, Percent_Identity=29.7968397291196, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.7607223476298, Blast_Score=348, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=44.8979591836735, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=45.43429844098, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.1960784313725, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=456, Percent_Identity=32.6754385964912, Blast_Score=223, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.8612975391499, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.7415730337079, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.8333333333333, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24586458, Length=508, Percent_Identity=29.7244094488189, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI161076409, Length=508, Percent_Identity=29.7244094488189, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI161076407, Length=508, Percent_Identity=29.7244094488189, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24586460, Length=508, Percent_Identity=29.7244094488189, Blast_Score=221, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49459; Mature: 49459

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADESICIGPAKSIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEEECCCEECCCHHHHHHH
LNIPRIISAAEVTGAVAIHPGYGFLSENADFAEQVERSGFIFVGPRAETIRLMGDKVSAI
CCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
NAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKASGGGGGRGMRVVRNEAELTK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHEEHHHHHHHH
SIQMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGNAIHLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHH
EEAPAPGITEEMRKFIGERCTRACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLIKEQLRIAAGQPLSFKQEDIKIRGHAVECRINAEDPERFLPCPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCCCEEECC
GGMGVRWESHIYSGYTVPAHYDSMIGKLITYGENRDVAIARMRNALNEMIVEGIKTNIPL
CCCCCEECCCEECCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
QQAIMADENFQKGGTNIHYLEKKLGIK
HHHHHCCCCCCCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADESICIGPAKSIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEEECCCEECCCHHHHHHH
LNIPRIISAAEVTGAVAIHPGYGFLSENADFAEQVERSGFIFVGPRAETIRLMGDKVSAI
CCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
NAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKASGGGGGRGMRVVRNEAELTK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHEEHHHHHHHH
SIQMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGNAIHLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHH
EEAPAPGITEEMRKFIGERCTRACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLIKEQLRIAAGQPLSFKQEDIKIRGHAVECRINAEDPERFLPCPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCCCEEECC
GGMGVRWESHIYSGYTVPAHYDSMIGKLITYGENRDVAIARMRNALNEMIVEGIKTNIPL
CCCCCEECCCEECCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
QQAIMADENFQKGGTNIHYLEKKLGIK
HHHHHCCCCCCCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]