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The map label for this gene is prlC [H]

Identifier: 227080410

GI number: 227080410

Start: 178017

End: 180059

Strand: Direct

Name: prlC [H]

Synonym: VCM66_0176

Alternate gene names: 227080410

Gene position: 178017-180059 (Clockwise)

Preceding gene: 227080407

Following gene: 227080411

Centisome position: 6.15

GC content: 52.18

Gene sequence:

>2043_bases
ATGTCAAACCCACTTCTTACCTTTACGGATCTGCCGCCGTTTTCTGCGATTAAACCGGAGCACGTAAAGCCAGCGGTTGA
GCAGGCGATAGCGGATTGTCGCCACACCATAGATAAGGTTTTAGCCGAAAATCCACAACCGAGCTGGGAAAGTGTGATTG
CGCCGATTGAAGAGGTCGATGATCGCTTAAGTCGTATCTGGTCACCGGTCAGCCATATGAATTCGGTGGTGAACAGTGAT
GAGCTGCGTGAAGCCTACGAAAGCTGCTTACCGCTGTTGTCCGAGTACAGCACTTGGGTTGGTCAGCATAAAGGGCTGTT
TGAAGCCTACAAAACCATTAAAGAGAGCGCGGAGTTTGCCAAGCTCGATCGCGCGCAGCAAAAAACCATCAGCGACAGTC
TGCGTGATTTTGAATTGTCAGGCATCGGCTTGCCACTGCAAGAGCAAAAGCGCTATGGCGAAATCAGTAAGCGTATGTCT
GAGCTTGGCTCTAAGTTCTCCAACAACGTGCTGGATGCCACCATGGGGTGGACCAAGCAGATCACCGATGTAAACCTGCT
CGCGGGCATTCCGGAATCGGCACTGGCGGCGGCACAAGCAGCAGCCGAAGCCAAAGGTTTAGAGGGGTATCTGCTGACCT
TGGATATTCCGTCTTATCTACCAGTGATGACTTACTGTGATAACCAAGCACTGCGCAAAGAAGTGTATGAAGCGTATGTC
ACGCGTGCTTCGGATCGCGGCCCGAATGCGGGTAAATGGGATAACAGCGAAATCATTGCTGAGCAGCTCAAACTGCGCCA
TGAGATCGCGCGTATGCTAGGCTTTAGCACTTACAGCGAAAAATCGCTGGCGACCAAAATGGCGCAAACCACTGATCAAG
TGCTTGGTTTCTTAAATGATCTCGCCAGCAAAGCCAAACCACAAGGTGAACGTGAAGTGGAAGAGCTGCGCCAATTTGCC
GAAAGTGAGTTTGGCGTCAAGCAGCTTGAGCTGTGGGATATTGCTTACTACAGCGAAAAGCAAAAGCAGCATCTGTTTGA
AATCTCCGATGAAGAGCTGCGCCCTTACTTCCCAGAACAAAAAGTGGTGAATGGCCTGTTTGAAGTGCTGAGCCGTTTGT
TTGGCATGCAAGTCAAAGAGCGCCAAGGGGTAGATGTATGGCACGAATCGGTGCGCTTTTTTGATATTTTTGATGCGCAA
GGCACGCTGCGTGGCAGCTTCTACCTCGACCTGTATGCGCGTGAACACAAACGCGGTGGCGCGTGGATGGATGAGTGTCG
TGTGCGTCGCACTACCGACAGTGGCGCACTGCAAACACCAGTGGCTTACCTGACGTGTAACTTCAACCGCCCAGTTGGCG
ATAAGCCTGCGCTGTTTACCCACGATGAAGTGACCACCCTGTTCCACGAATTTGGTCACGGCATTCACCATATGCTGACG
CAAGTGGAAGTGGGCGCGGTATCCGGCATCAATGGTGTGCCTTGGGATGCAGTCGAGCTGCCAAGCCAATTCTTGGAAAA
CTGGTGCTGGCAAGAAGAGGCGCTGGCGTTCATTTCTGGTCATTACCAAACGGGTGAGCCACTGCCGAAAGCCATGCTCG
ATAAAATGCTGGCGGCGAAAAACTTCCAATCGGCGATGTTTATTCTGCGTCAGTTGGAGTTCGGATTGTTCGATTTCACG
CTGCACACCACTTACGACCCAGAAGTGGGGCCAAAAGTGCTGGAAACCTTGGCGGAAGTGAAAAAGAAAGTAGCGGTGCT
GCCGGGCTTGGAGTGGAACCGCTTCTCGCACAGCTTTAGCCATATCTTTGCGGGTGGCTACAGCGCCGGTTACTACAGCT
ACTTGTGGGCAGAAGTGCTTTCGGCGGATGCGTTCTCACGCTTTGAAGAAGAAGGCATTTTCAACCGTGAGACTGGCCAA
AGCTTCCTCAACAACATCCTTGAGATGGGTGGCAGCGAAGAGCCGATGGAGCTGTTTAAGCGCTTCCGTGGCCGCGAACC
ACAAATTGATGCTTTGTTGCGTCATGCCGGAATCGCCGCGTAA

Upstream 100 bases:

>100_bases
CTTGGGTCAGCTATTGAAAAATCGTTCTGCTACCTATATTTACTTATACAACTCACAGGTCAAAATTCGGCCTGTCTCTA
TGCTGAAAAGGAATCTTTTT

Downstream 100 bases:

>100_bases
TCGATAGTACTTTCAGCCCACCTCGTGTGGGCTGAAATTTTTCCGGTCACCGCTGCGCCCATTCAAGACGTTTGGGTATC
TGCGACACTTGGGGTTATAA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MSNPLLTFTDLPPFSAIKPEHVKPAVEQAIADCRHTIDKVLAENPQPSWESVIAPIEEVDDRLSRIWSPVSHMNSVVNSD
ELREAYESCLPLLSEYSTWVGQHKGLFEAYKTIKESAEFAKLDRAQQKTISDSLRDFELSGIGLPLQEQKRYGEISKRMS
ELGSKFSNNVLDATMGWTKQITDVNLLAGIPESALAAAQAAAEAKGLEGYLLTLDIPSYLPVMTYCDNQALRKEVYEAYV
TRASDRGPNAGKWDNSEIIAEQLKLRHEIARMLGFSTYSEKSLATKMAQTTDQVLGFLNDLASKAKPQGEREVEELRQFA
ESEFGVKQLELWDIAYYSEKQKQHLFEISDEELRPYFPEQKVVNGLFEVLSRLFGMQVKERQGVDVWHESVRFFDIFDAQ
GTLRGSFYLDLYAREHKRGGAWMDECRVRRTTDSGALQTPVAYLTCNFNRPVGDKPALFTHDEVTTLFHEFGHGIHHMLT
QVEVGAVSGINGVPWDAVELPSQFLENWCWQEEALAFISGHYQTGEPLPKAMLDKMLAAKNFQSAMFILRQLEFGLFDFT
LHTTYDPEVGPKVLETLAEVKKKVAVLPGLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFNRETGQ
SFLNNILEMGGSEEPMELFKRFRGREPQIDALLRHAGIAA

Sequences:

>Translated_680_residues
MSNPLLTFTDLPPFSAIKPEHVKPAVEQAIADCRHTIDKVLAENPQPSWESVIAPIEEVDDRLSRIWSPVSHMNSVVNSD
ELREAYESCLPLLSEYSTWVGQHKGLFEAYKTIKESAEFAKLDRAQQKTISDSLRDFELSGIGLPLQEQKRYGEISKRMS
ELGSKFSNNVLDATMGWTKQITDVNLLAGIPESALAAAQAAAEAKGLEGYLLTLDIPSYLPVMTYCDNQALRKEVYEAYV
TRASDRGPNAGKWDNSEIIAEQLKLRHEIARMLGFSTYSEKSLATKMAQTTDQVLGFLNDLASKAKPQGEREVEELRQFA
ESEFGVKQLELWDIAYYSEKQKQHLFEISDEELRPYFPEQKVVNGLFEVLSRLFGMQVKERQGVDVWHESVRFFDIFDAQ
GTLRGSFYLDLYAREHKRGGAWMDECRVRRTTDSGALQTPVAYLTCNFNRPVGDKPALFTHDEVTTLFHEFGHGIHHMLT
QVEVGAVSGINGVPWDAVELPSQFLENWCWQEEALAFISGHYQTGEPLPKAMLDKMLAAKNFQSAMFILRQLEFGLFDFT
LHTTYDPEVGPKVLETLAEVKKKVAVLPGLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFNRETGQ
SFLNNILEMGGSEEPMELFKRFRGREPQIDALLRHAGIAA
>Mature_679_residues
SNPLLTFTDLPPFSAIKPEHVKPAVEQAIADCRHTIDKVLAENPQPSWESVIAPIEEVDDRLSRIWSPVSHMNSVVNSDE
LREAYESCLPLLSEYSTWVGQHKGLFEAYKTIKESAEFAKLDRAQQKTISDSLRDFELSGIGLPLQEQKRYGEISKRMSE
LGSKFSNNVLDATMGWTKQITDVNLLAGIPESALAAAQAAAEAKGLEGYLLTLDIPSYLPVMTYCDNQALRKEVYEAYVT
RASDRGPNAGKWDNSEIIAEQLKLRHEIARMLGFSTYSEKSLATKMAQTTDQVLGFLNDLASKAKPQGEREVEELRQFAE
SEFGVKQLELWDIAYYSEKQKQHLFEISDEELRPYFPEQKVVNGLFEVLSRLFGMQVKERQGVDVWHESVRFFDIFDAQG
TLRGSFYLDLYAREHKRGGAWMDECRVRRTTDSGALQTPVAYLTCNFNRPVGDKPALFTHDEVTTLFHEFGHGIHHMLTQ
VEVGAVSGINGVPWDAVELPSQFLENWCWQEEALAFISGHYQTGEPLPKAMLDKMLAAKNFQSAMFILRQLEFGLFDFTL
HTTYDPEVGPKVLETLAEVKKKVAVLPGLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFNRETGQS
FLNNILEMGGSEEPMELFKRFRGREPQIDALLRHAGIAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=639, Percent_Identity=31.6118935837246, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI14149738, Length=675, Percent_Identity=31.1111111111111, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI156105687, Length=666, Percent_Identity=25.2252252252252, Blast_Score=186, Evalue=8e-47,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=70.7964601769911, Blast_Score=1019, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=685, Percent_Identity=30.9489051094891, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71999758, Length=546, Percent_Identity=26.3736263736264, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI32565901, Length=656, Percent_Identity=20.8841463414634, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319793, Length=691, Percent_Identity=29.232995658466, Blast_Score=310, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6322715, Length=700, Percent_Identity=23.5714285714286, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356111, Length=584, Percent_Identity=29.4520547945205, Blast_Score=251, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20129717, Length=586, Percent_Identity=24.4027303754266, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76978; Mature: 76847

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLTFTDLPPFSAIKPEHVKPAVEQAIADCRHTIDKVLAENPQPSWESVIAPIEEVD
CCCCCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
DRLSRIWSPVSHMNSVVNSDELREAYESCLPLLSEYSTWVGQHKGLFEAYKTIKESAEFA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KLDRAQQKTISDSLRDFELSGIGLPLQEQKRYGEISKRMSELGSKFSNNVLDATMGWTKQ
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
ITDVNLLAGIPESALAAAQAAAEAKGLEGYLLTLDIPSYLPVMTYCDNQALRKEVYEAYV
HCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDRGPNAGKWDNSEIIAEQLKLRHEIARMLGFSTYSEKSLATKMAQTTDQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LASKAKPQGEREVEELRQFAESEFGVKQLELWDIAYYSEKQKQHLFEISDEELRPYFPEQ
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHH
KVVNGLFEVLSRLFGMQVKERQGVDVWHESVRFFDIFDAQGTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHEEECCCCCCCCEEEEEHHHHHHCCCC
AWMDECRVRRTTDSGALQTPVAYLTCNFNRPVGDKPALFTHDEVTTLFHEFGHGIHHMLT
CCHHHHHHHCCCCCCCHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
QVEVGAVSGINGVPWDAVELPSQFLENWCWQEEALAFISGHYQTGEPLPKAMLDKMLAAK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NFQSAMFILRQLEFGLFDFTLHTTYDPEVGPKVLETLAEVKKKVAVLPGLEWNRFSHSFS
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
HIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFNRETGQSFLNNILEMGGSEEPMELFK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQIDALLRHAGIAA
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLTFTDLPPFSAIKPEHVKPAVEQAIADCRHTIDKVLAENPQPSWESVIAPIEEVD
CCCCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
DRLSRIWSPVSHMNSVVNSDELREAYESCLPLLSEYSTWVGQHKGLFEAYKTIKESAEFA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KLDRAQQKTISDSLRDFELSGIGLPLQEQKRYGEISKRMSELGSKFSNNVLDATMGWTKQ
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
ITDVNLLAGIPESALAAAQAAAEAKGLEGYLLTLDIPSYLPVMTYCDNQALRKEVYEAYV
HCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDRGPNAGKWDNSEIIAEQLKLRHEIARMLGFSTYSEKSLATKMAQTTDQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LASKAKPQGEREVEELRQFAESEFGVKQLELWDIAYYSEKQKQHLFEISDEELRPYFPEQ
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHH
KVVNGLFEVLSRLFGMQVKERQGVDVWHESVRFFDIFDAQGTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHEEECCCCCCCCEEEEEHHHHHHCCCC
AWMDECRVRRTTDSGALQTPVAYLTCNFNRPVGDKPALFTHDEVTTLFHEFGHGIHHMLT
CCHHHHHHHCCCCCCCHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
QVEVGAVSGINGVPWDAVELPSQFLENWCWQEEALAFISGHYQTGEPLPKAMLDKMLAAK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NFQSAMFILRQLEFGLFDFTLHTTYDPEVGPKVLETLAEVKKKVAVLPGLEWNRFSHSFS
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
HIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFNRETGQSFLNNILEMGGSEEPMELFK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQIDALLRHAGIAA
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]