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The map label for this gene is fabR [H]

Identifier: 227080387

GI number: 227080387

Start: 142745

End: 143386

Strand: Direct

Name: fabR [H]

Synonym: VCM66_0152

Alternate gene names: 227080387

Gene position: 142745-143386 (Clockwise)

Preceding gene: 227080385

Following gene: 227080388

Centisome position: 4.93

GC content: 51.87

Gene sequence:

>642_bases
ATGAAATCGTTGGGAATCCGAGCACAACAAAAAGAAAAGACGCGCCGCTCTTTAATTGATGCCGCGTTTAGCCAACTGAG
CGCTGACCGAAGTTTCTCTAACCTGAGTCTACGTGAAGTCGCCCGAGAAGCGGGCATTGCGCCGACCTCGTTTTATCGTC
ACTTCAAAGACATGGATGAACTGGGTTTAACCATGGTGGATGAAGGTGGTCTGTTATTGCGTCAGTTGATGCGTCAAGCT
CGCCAGCGCATCGTCAAGGAAGGCAGTGTGATCCGCACTTCAGTGGAAACCTTTATGGAGTTCATTGAGAGCAGCCCTAA
CGTATTTCGTTTGTTGTTGCGAGAACGTTCTGGCACTTCCTGCGAGTTTCGAGCGGCGGTAGTGCGTGAAATTCAACACT
TTGCGGCTGAGCTCACCGAATATCTGGTTGCCACAGGGATGACGCGGGAAGAGGCGATGACTCAAGCAGAAGCTTCCGTC
ACCTTGGTCTTTAGTTCAGGCGCAGAAGCGCTCGATTTGGATCGCCGTGAACGCGATGAACTGGCCGAGCGTTTGATCAT
GCAACTGCGCATGCTGGCCAAAGGGGCACATTGGTATCGTAAAGAGCGTGAACGTCATCGCCTGAAAGGCGCGTTGGAAT
AA

Upstream 100 bases:

>100_bases
GGCTGCTGTCTCATACTGACGAGCTTTGTTGCTTAGACAAGCCAACCAATCAGGTTATAGTATGAACCACATTTTTCGAC
TTAGCTGAGAACTGATTGGA

Downstream 100 bases:

>100_bases
GTGCAATATCCAAAATAAAAGAGGAAAAAGGAAAGAGAGATGTCGAGAGAAAACAACGTTCAGTCCACTCGCGCAGAGCG
TAAAACATTAATACTGGCGC

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKSLGIRAQQKEKTRRSLIDAAFSQLSADRSFSNLSLREVAREAGIAPTSFYRHFKDMDELGLTMVDEGGLLLRQLMRQA
RQRIVKEGSVIRTSVETFMEFIESSPNVFRLLLRERSGTSCEFRAAVVREIQHFAAELTEYLVATGMTREEAMTQAEASV
TLVFSSGAEALDLDRRERDELAERLIMQLRMLAKGAHWYRKERERHRLKGALE

Sequences:

>Translated_213_residues
MKSLGIRAQQKEKTRRSLIDAAFSQLSADRSFSNLSLREVAREAGIAPTSFYRHFKDMDELGLTMVDEGGLLLRQLMRQA
RQRIVKEGSVIRTSVETFMEFIESSPNVFRLLLRERSGTSCEFRAAVVREIQHFAAELTEYLVATGMTREEAMTQAEASV
TLVFSSGAEALDLDRRERDELAERLIMQLRMLAKGAHWYRKERERHRLKGALE
>Mature_213_residues
MKSLGIRAQQKEKTRRSLIDAAFSQLSADRSFSNLSLREVAREAGIAPTSFYRHFKDMDELGLTMVDEGGLLLRQLMRQA
RQRIVKEGSVIRTSVETFMEFIESSPNVFRLLLRERSGTSCEFRAAVVREIQHFAAELTEYLVATGMTREEAMTQAEASV
TLVFSSGAEALDLDRRERDELAERLIMQLRMLAKGAHWYRKERERHRLKGALE

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=204, Percent_Identity=73.0392156862745, Blast_Score=296, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24444; Mature: 24444

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLGIRAQQKEKTRRSLIDAAFSQLSADRSFSNLSLREVAREAGIAPTSFYRHFKDMDE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHH
LGLTMVDEGGLLLRQLMRQARQRIVKEGSVIRTSVETFMEFIESSPNVFRLLLRERSGTS
HCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
CEFRAAVVREIQHFAAELTEYLVATGMTREEAMTQAEASVTLVFSSGAEALDLDRRERDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCHHHCCHHHHHH
LAERLIMQLRMLAKGAHWYRKERERHRLKGALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKSLGIRAQQKEKTRRSLIDAAFSQLSADRSFSNLSLREVAREAGIAPTSFYRHFKDMDE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHH
LGLTMVDEGGLLLRQLMRQARQRIVKEGSVIRTSVETFMEFIESSPNVFRLLLRERSGTS
HCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
CEFRAAVVREIQHFAAELTEYLVATGMTREEAMTQAEASVTLVFSSGAEALDLDRRERDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCHHHCCHHHHHH
LAERLIMQLRMLAKGAHWYRKERERHRLKGALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA