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The map label for this gene is lysA

Identifier: 227080361

GI number: 227080361

Start: 119194

End: 120447

Strand: Direct

Name: lysA

Synonym: VCM66_0125

Alternate gene names: 227080361

Gene position: 119194-120447 (Clockwise)

Preceding gene: 227080360

Following gene: 227080362

Centisome position: 4.12

GC content: 50.4

Gene sequence:

>1254_bases
TTGGATTACTTCAATTATCAGGAAGATGGTCAGTTGTGGGCTGAGCAAGTTCCACTCGCCGATTTGGCAAACCAGTACGG
TACACCGCTTTATGTTTACTCAAGAGCGACACTTGAGCGCCATTGGCACGCGTTTGATAAATCAGTCGGTGATTATCCTC
ACCTAATTTGTTATGCGGTGAAAGCCAACTCTAACTTAGGGGTATTGAATACTTTAGCTCGTTTGGGTTCAGGTTTTGAT
ATCGTCTCCGTTGGCGAATTAGAGCGTGTATTGGCCGCCGGTGGTGACCCAAGCAAGGTGGTATTCTCTGGTGTGGGTAA
AACCGAAGCTGAGATGAAGCGCGCCCTGCAATTGAAGATCAAATGCTTTAACGTGGAATCGGAGCCTGAGCTGCAGCGCC
TGAATAAAGTGGCTGGCGAGCTTGGTGTTAAAGCGCCGATTTCACTGCGCATCAATCCTGATGTGGATGCCAAAACTCAC
CCTTACATTTCAACGGGTCTACGTGATAACAAATTTGGTATCACCTTTGACCGCGCAGCGCAGGTATATCGCTTAGCGCA
CAGCTTACCCAACCTCGATGTACATGGTATTGACTGCCATATCGGCTCACAGCTAACCGCTCTCGCACCGTTTATTGATG
CGACTGACCGTTTACTGGCACTGATTGATTCGCTGAAAGCGGAAGGCATTCATATCCGCCACTTGGATGTCGGCGGTGGT
TTAGGGGTGGTTTATCGTGATGAACTGCCTCCGCAGCCTTCGGAATACGCCAAAGCATTGCTGGACCGCCTAGAGCGCCA
CCGCGATTTAGAGCTGATTTTTGAACCGGGACGCGCGATTGCGGCTAACGCGGGAGTATTGGTGACTAAGGTGGAGTTTC
TCAAACACACTGAGCACAAAAACTTCGCGATCATTGATGCGGCGATGAACGATTTGATCCGCCCGGCGCTATACCAAGCG
TGGCAAGACATCATTCCACTGCGTCCGCGCCAAGGCGAAGCCCAAACTTATGATTTGGTTGGCCCGGTGTGTGAAACCAG
TGATTTCCTAGGGAAAGATCGCGACTTAGTGTTGCAAGAGGGGGATTTACTGGCGGTGCGCTCTTCTGGTGCGTATGGGT
TTACCATGTCGTCGAATTACAATACCCGTCCGCGAGTGGCTGAAGTCATGGTTGATGGCAATAAAACCTATTTGGTGCGT
CAGCGTGAAGAGCTTAGCAGCTTGTGGGCGTTAGAATCGGTATTACCGGAGTAA

Upstream 100 bases:

>100_bases
CGGGATGCGGGCAAACTGGGCCACTGTATATGCCTGATGATGCAAAACAAAGTGAGCAAAGTCAGTAAATCACGCTACTA
AGAATAAAAGGGAAAGCATT

Downstream 100 bases:

>100_bases
AGTTATCTTCTATGCATTTCCATTTTTCTAAAATGCACGGTTTGGGCAACGACTTTATGGTCGTGGACTGTATTACCCAA
AACGTCTTCTTCTCTCCGGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDYPHLICYAVKANSNLGVLNTLARLGSGFD
IVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTH
PYISTGLRDNKFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGG
LGVVYRDELPPQPSEYAKALLDRLERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHKNFAIIDAAMNDLIRPALYQA
WQDIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDLVLQEGDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVR
QREELSSLWALESVLPE

Sequences:

>Translated_417_residues
MDYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDYPHLICYAVKANSNLGVLNTLARLGSGFD
IVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTH
PYISTGLRDNKFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGG
LGVVYRDELPPQPSEYAKALLDRLERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHKNFAIIDAAMNDLIRPALYQA
WQDIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDLVLQEGDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVR
QREELSSLWALESVLPE
>Mature_417_residues
MDYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDYPHLICYAVKANSNLGVLNTLARLGSGFD
IVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTH
PYISTGLRDNKFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGG
LGVVYRDELPPQPSEYAKALLDRLERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHKNFAIIDAAMNDLIRPALYQA
WQDIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDLVLQEGDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVR
QREELSSLWALESVLPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Homo sapiens, GI4505489, Length=357, Percent_Identity=25.7703081232493, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789203, Length=431, Percent_Identity=30.6264501160093, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562780, Length=354, Percent_Identity=25.9887005649718, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=364, Percent_Identity=23.3516483516484, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586474, Length=372, Percent_Identity=26.0752688172043, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586472, Length=340, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_VIBCH (Q9KVL7)

Other databases:

- EMBL:   AE003852
- PIR:   F82360
- RefSeq:   NP_229783.1
- PDB:   3N2B
- PDBsum:   3N2B
- ProteinModelPortal:   Q9KVL7
- SMR:   Q9KVL7
- GeneID:   2615366
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0125
- TIGR:   VC_0125
- HOGENOM:   HBG672375
- OMA:   HLICFAV
- ProtClustDB:   CLSK873868
- BRENDA:   4.1.1.20
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 46277; Mature: 46277

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDYPHLICYAV
CCCCCCCCCCHHHHHHCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEE
KANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKI
ECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHEEEE
KCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDNKFGITFDRAA
EEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCEEHHHHH
QVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGG
HHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LGVVYRDELPPQPSEYAKALLDRLERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHK
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCEEEEEHHHHHHCCCC
NFAIIDAAMNDLIRPALYQAWQDIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDLVLQE
CEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHCCHHHCCCCCCEEEEC
GDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVRQREELSSLWALESVLPE
CCEEEEECCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVGDYPHLICYAV
CCCCCCCCCCHHHHHHCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEE
KANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKI
ECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHEEEE
KCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDNKFGITFDRAA
EEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCEEHHHHH
QVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGG
HHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LGVVYRDELPPQPSEYAKALLDRLERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHK
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCEEEEEHHHHHHCCCC
NFAIIDAAMNDLIRPALYQAWQDIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDLVLQE
CEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHCCHHHCCCCCCEEEEC
GDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGNKTYLVRQREELSSLWALESVLPE
CCEEEEECCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301