| Definition | Vibrio cholerae M66-2 chromosome I, complete genome. |
|---|---|
| Accession | NC_012578 |
| Length | 2,892,523 |
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The map label for this gene is hemN [H]
Identifier: 227080352
GI number: 227080352
Start: 110016
End: 111458
Strand: Direct
Name: hemN [H]
Synonym: VCM66_0116
Alternate gene names: 227080352
Gene position: 110016-111458 (Clockwise)
Preceding gene: 227080351
Following gene: 227080358
Centisome position: 3.8
GC content: 47.96
Gene sequence:
>1443_bases ATGTCGTGTGGCAGAATAGCCCGTCAAGAATTGAGCAAAACGGAAAGATTCATTATGTCGTCGTATGTCGTACCCAGCCA ACAGATCGTATGGGATCAGGCCATTCTGGATAAGTACAACTACTCCGGTCCGCGTTACACTTCATACCCGACTGCGGTTG AGTTCCATGAAGCCTTTACCATCGCTGACTTTGATATGGCCTGTACTCAGTACCCAGAGCGACCATTATCGCTGTACATT CATATCCCGTTTTGCCATAAGCTTTGTTACTACTGTGGTTGTAACAAGGTGATCACTCGTCATTCGCACAAAGCGGATGA GTACCTTGATGTGCTTGAGCATGAAATTCGTCAACGCGCCTCACTATTAATCGGAAGAAACGTCACTCAACTCCACTTCG GTGGTGGTACGCCGACGTTCTTGACCAACGCTCAAATCAGTCGTTTGATGACGCTGCTGCATAGCGAGTTTCACTTCGCC GATGAGGCGGAAATCAGTATTGAAATCGATCCGCGTGAAATCCAGTTAGAGGTGCTTGATCACCTGCGCCAAGAAGGCTT TAACCGAGTCAGCATCGGGGTGCAGGATTTCAATAAAGAAGTGCAGAAGCTGGTTAACCGTGAGCAAGATGAGCAGTTCA TTTTTGATCTGGTTGAACGCGCTAAACAGCTGGGTTTTCGTTCGACCAACCTTGACCTCATTTACGGCTTACCTAAGCAA ACCGCAGTAACCTTTGCCCAGACGTTGCAACAAGTGCTGACCATGCAACCGGGGCGTTTGTCGGTATTTAACTACGCGCA CATGCCGCAACTGTTCGCAGCGCAGCGCAAAATTAAAGAAGCCGATTTACCTGCCGCCGAAGAAAAACTGGCGATTTTAC AGCAGACAATCACCACGCTAACAGGCGCGGGGTATCAGTTCATCGGTATGGATCACTTTGCCTTGCCGGATGATGAGCTA GCGATTGCTCAGCGCAGTGGTATCTTGCACCGTAACTTCCAAGGCTATACCACCCAAGGTGAATGTGACTTAGTCGGCTT TGGGGTTTCGGCGATTTCCATGGTGGGCGATGCCTATGCACAAAACCAGAAAGAGCTGAAAAAATACTATGCGCAAGTCA ATGAGATGCGTCATGCCTTGTGGAAAGGTGTGACACTAGATAAGGATGATTTACTGCGCCGTGAAGTGATTAAGCAGCTG ATTTGTAATTTCAAGCTTGATAAAACAGCGATTGAGCGTGAGTTTAATCTGCGTTTCAATCACTACTTCCGCCAAGATTT AGCTCTGCTACAAACCTTTATCGACGATGGGTTGGTGACGGTGGATGAACGCATGATTGAAGTGACGCTGCGTGGGCGTT TGTTAATTCGCAACATCTGTATGTGTTTTGATAAATACTTGCGTGAGCGGGCGCGTCAGCAGCAGTTCTCGCGAGTCATT TAA
Upstream 100 bases:
>100_bases GATTCAGATGGTGTGAAACTAACCCGAAAGGGGGAGTGATCGCGCTAGCAGAATCGAATATTTTGTTGCCAGATCCTGTT CTGCCGCCCGACGTTCGTCA
Downstream 100 bases:
>100_bases GACCGCATTCCACAACAAGGCCACCGCATGCGGTGGCCTTGTTGTTTGTGCTCTGATTTTAATTCAGGATGACTGAGCGG AAGGTGACTCCAGCAAAGAG
Product: coproporphyrinogen III oxidase
Products: NA
Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]
Number of amino acids: Translated: 480; Mature: 479
Protein sequence:
>480_residues MSCGRIARQELSKTERFIMSSYVVPSQQIVWDQAILDKYNYSGPRYTSYPTAVEFHEAFTIADFDMACTQYPERPLSLYI HIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRASLLIGRNVTQLHFGGGTPTFLTNAQISRLMTLLHSEFHFA DEAEISIEIDPREIQLEVLDHLRQEGFNRVSIGVQDFNKEVQKLVNREQDEQFIFDLVERAKQLGFRSTNLDLIYGLPKQ TAVTFAQTLQQVLTMQPGRLSVFNYAHMPQLFAAQRKIKEADLPAAEEKLAILQQTITTLTGAGYQFIGMDHFALPDDEL AIAQRSGILHRNFQGYTTQGECDLVGFGVSAISMVGDAYAQNQKELKKYYAQVNEMRHALWKGVTLDKDDLLRREVIKQL ICNFKLDKTAIEREFNLRFNHYFRQDLALLQTFIDDGLVTVDERMIEVTLRGRLLIRNICMCFDKYLRERARQQQFSRVI
Sequences:
>Translated_480_residues MSCGRIARQELSKTERFIMSSYVVPSQQIVWDQAILDKYNYSGPRYTSYPTAVEFHEAFTIADFDMACTQYPERPLSLYI HIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRASLLIGRNVTQLHFGGGTPTFLTNAQISRLMTLLHSEFHFA DEAEISIEIDPREIQLEVLDHLRQEGFNRVSIGVQDFNKEVQKLVNREQDEQFIFDLVERAKQLGFRSTNLDLIYGLPKQ TAVTFAQTLQQVLTMQPGRLSVFNYAHMPQLFAAQRKIKEADLPAAEEKLAILQQTITTLTGAGYQFIGMDHFALPDDEL AIAQRSGILHRNFQGYTTQGECDLVGFGVSAISMVGDAYAQNQKELKKYYAQVNEMRHALWKGVTLDKDDLLRREVIKQL ICNFKLDKTAIEREFNLRFNHYFRQDLALLQTFIDDGLVTVDERMIEVTLRGRLLIRNICMCFDKYLRERARQQQFSRVI >Mature_479_residues SCGRIARQELSKTERFIMSSYVVPSQQIVWDQAILDKYNYSGPRYTSYPTAVEFHEAFTIADFDMACTQYPERPLSLYIH IPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRASLLIGRNVTQLHFGGGTPTFLTNAQISRLMTLLHSEFHFAD EAEISIEIDPREIQLEVLDHLRQEGFNRVSIGVQDFNKEVQKLVNREQDEQFIFDLVERAKQLGFRSTNLDLIYGLPKQT AVTFAQTLQQVLTMQPGRLSVFNYAHMPQLFAAQRKIKEADLPAAEEKLAILQQTITTLTGAGYQFIGMDHFALPDDELA IAQRSGILHRNFQGYTTQGECDLVGFGVSAISMVGDAYAQNQKELKKYYAQVNEMRHALWKGVTLDKDDLLRREVIKQLI CNFKLDKTAIEREFNLRFNHYFRQDLALLQTFIDDGLVTVDERMIEVTLRGRLLIRNICMCFDKYLRERARQQQFSRVI
Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]
COG id: COG0635
COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]
Homologues:
Organism=Homo sapiens, GI8922911, Length=246, Percent_Identity=27.2357723577236, Blast_Score=89, Evalue=1e-17, Organism=Escherichia coli, GI87082341, Length=454, Percent_Identity=68.942731277533, Blast_Score=674, Evalue=0.0, Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=32.5102880658436, Blast_Score=130, Evalue=2e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006638 - InterPro: IPR004558 - InterPro: IPR010723 - InterPro: IPR007197 [H]
Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]
EC number: =1.3.99.22 [H]
Molecular weight: Translated: 55598; Mature: 55467
Theoretical pI: Translated: 6.79; Mature: 6.79
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSCGRIARQELSKTERFIMSSYVVPSQQIVWDQAILDKYNYSGPRYTSYPTAVEFHEAFT CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEE IADFDMACTQYPERPLSLYIHIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRA EECHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHH SLLIGRNVTQLHFGGGTPTFLTNAQISRLMTLLHSEFHFADEAEISIEIDPREIQLEVLD HHHHCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHH HLRQEGFNRVSIGVQDFNKEVQKLVNREQDEQFIFDLVERAKQLGFRSTNLDLIYGLPKQ HHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHH TAVTFAQTLQQVLTMQPGRLSVFNYAHMPQLFAAQRKIKEADLPAAEEKLAILQQTITTL HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH TGAGYQFIGMDHFALPDDELAIAQRSGILHRNFQGYTTQGECDLVGFGVSAISMVGDAYA HCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHH QNQKELKKYYAQVNEMRHALWKGVTLDKDDLLRREVIKQLICNFKLDKTAIEREFNLRFN CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH HYFRQDLALLQTFIDDGLVTVDERMIEVTLRGRLLIRNICMCFDKYLRERARQQQFSRVI HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure SCGRIARQELSKTERFIMSSYVVPSQQIVWDQAILDKYNYSGPRYTSYPTAVEFHEAFT CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEE IADFDMACTQYPERPLSLYIHIPFCHKLCYYCGCNKVITRHSHKADEYLDVLEHEIRQRA EECHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHH SLLIGRNVTQLHFGGGTPTFLTNAQISRLMTLLHSEFHFADEAEISIEIDPREIQLEVLD HHHHCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHH HLRQEGFNRVSIGVQDFNKEVQKLVNREQDEQFIFDLVERAKQLGFRSTNLDLIYGLPKQ HHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHH TAVTFAQTLQQVLTMQPGRLSVFNYAHMPQLFAAQRKIKEADLPAAEEKLAILQQTITTL HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH TGAGYQFIGMDHFALPDDELAIAQRSGILHRNFQGYTTQGECDLVGFGVSAISMVGDAYA HCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHH QNQKELKKYYAQVNEMRHALWKGVTLDKDDLLRREVIKQLICNFKLDKTAIEREFNLRFN CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH HYFRQDLALLQTFIDDGLVTVDERMIEVTLRGRLLIRNICMCFDKYLRERARQQQFSRVI HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7768836; 8346018; 9278503 [H]