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The map label for this gene is murC [H]

Identifier: 226951004

GI number: 226951004

Start: 4061922

End: 4063298

Strand: Direct

Name: murC [H]

Synonym: CLM_4040

Alternate gene names: 226951004

Gene position: 4061922-4063298 (Clockwise)

Preceding gene: 226950972

Following gene: 226951005

Centisome position: 97.75

GC content: 28.25

Gene sequence:

>1377_bases
TTGTTATTTAATTTTATAAAAGATAAAAATAAACATATACATTTTATAGGTATAGGTGGAATAAGCATGAGTGGGTTGGC
AGAAATACTGCTTTATCATAACTTTACCATATCTGGTTCAGATATGAATTCATCACCTATAACTAAAAAATTAAAAGATA
AAGGTGCACATATATATATTGGTCATAAAAAAGAAAATATAAAGGATGCTGATTTAATAGTATATACTGCTGCTATTGCT
TCTGATAACCCTGAAATAATAGAAGCAAAAGAAAAAAATATTAAGTTAATGGATAGAGCAGACTTCTTAGGTGACTTAAT
GAAAGGCTACAAATATAATATTGCCATATCTGGAACTCATGGTAAAACAACTACAACTTCCATGTTATCTCATGTAGCAT
TAAAAGCTAATGTTGATCCAACTATTTTAGTAGGTGGTAATTTAGATATAATAAATGGTAATGTAAGAGTAGGTAAAAGT
GACTTCTTTATAACAGAAGCTTGTGAGTACAAATCCTCATTTCTTAAATTTTTCCCATATATTGGGGCCATTTTAAACAT
AGATGCAGATCATTTAGATTACTATAGAGATTTAAATGATATAAAAAATGCTTTTTCAAAATTTATTAAATTAATTCCTA
AAGATGGCTATCTTGTAGCTTATGGAGAAGATAAAAATATACAAAGCATTATAAAGGAGGCTAACTGTAACGTTATAACC
TATGGTATAAACTCAGGAGATATACAAGCTCATAATATAGAATATGATGAAAAAGCTTGCGGAAATTTTGATGTAGTTAA
AGATAACCAAAAACTATTTTCAGTAAAACTAAATGTTCCTGGAAAACACAACATACTAAATTCCTTAGCTAGTATATGTA
TTGGATTGGCTTCAAATATGAAATGTAAAGATATAATTGAAGGTATTGAAAGCTTTTTTGGAACCCATAGAAGATTTGAA
CTAAAAGGCTGTAAGAATAATATTACTGTAATAGATGATTATGCTCATCATCCTACAGAAATATCTGCTACATTAGATGC
AGCTAAAAAATATCCTCACAATAAATTGTTCTGTGTTTTTCAACCACACACTTATTCCAGAACATTAACCTTATTTGATG
ACTTCACTAAATGCTTTGACAATGCAGACGAAATTATTTTAGCTGATATATATGCTGCTAGGGAAAAGGACACTGGTATT
ATAAGTTCAGATATGTTGGGAGATAAACTAAGAGATCGAGGATTAAAATGTACTAATTTTCATAAGTTTGATGATATAAA
AAATTATCTCATAGAAAATGCTAAAGATGGTGACTTAATATTAACTGTTGGAGCTGGAGATATATATAAAGTAGGAGAAA
TGTATATTAATTTATAA

Upstream 100 bases:

>100_bases
AATTAAAATTTAAAATAAAACATTCTACTTTAATGTGTTTTTTTGTTTTGTTTTTGTATATAATTATCTAATATAACTAA
TATTTGAGGAGTTGATTAGG

Downstream 100 bases:

>100_bases
AATTATGCTTAAAACATCTTCCTTTGGGAAATACTATTTTTAAAATCCATCGGGAGGTGTTTTTATGAGAAACTTTTTAA
TATCTTCTATAGTAAATTTA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLFNFIKDKNKHIHFIGIGGISMSGLAEILLYHNFTISGSDMNSSPITKKLKDKGAHIYIGHKKENIKDADLIVYTAAIA
SDNPEIIEAKEKNIKLMDRADFLGDLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGKS
DFFITEACEYKSSFLKFFPYIGAILNIDADHLDYYRDLNDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEANCNVIT
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKCKDIIEGIESFFGTHRRFE
LKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGI
ISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENAKDGDLILTVGAGDIYKVGEMYINL

Sequences:

>Translated_458_residues
MLFNFIKDKNKHIHFIGIGGISMSGLAEILLYHNFTISGSDMNSSPITKKLKDKGAHIYIGHKKENIKDADLIVYTAAIA
SDNPEIIEAKEKNIKLMDRADFLGDLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGKS
DFFITEACEYKSSFLKFFPYIGAILNIDADHLDYYRDLNDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEANCNVIT
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKCKDIIEGIESFFGTHRRFE
LKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGI
ISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENAKDGDLILTVGAGDIYKVGEMYINL
>Mature_458_residues
MLFNFIKDKNKHIHFIGIGGISMSGLAEILLYHNFTISGSDMNSSPITKKLKDKGAHIYIGHKKENIKDADLIVYTAAIA
SDNPEIIEAKEKNIKLMDRADFLGDLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGKS
DFFITEACEYKSSFLKFFPYIGAILNIDADHLDYYRDLNDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEANCNVIT
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKCKDIIEGIESFFGTHRRFE
LKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGI
ISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENAKDGDLILTVGAGDIYKVGEMYINL

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=458, Percent_Identity=35.589519650655, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1790680, Length=451, Percent_Identity=27.2727272727273, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786276, Length=331, Percent_Identity=22.3564954682779, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51228; Mature: 51228

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFNFIKDKNKHIHFIGIGGISMSGLAEILLYHNFTISGSDMNSSPITKKLKDKGAHIYI
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHHHCCCCEEEE
GHKKENIKDADLIVYTAAIASDNPEIIEAKEKNIKLMDRADFLGDLMKGYKYNIAISGTH
ECCCCCCCCCEEEEEEEEECCCCCCEEECCCCCEEEEHHHHHHHHHHCCCEEEEEEECCC
GKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGKSDFFITEACEYKSSFLKFFPY
CCCHHHHHHHHHEEEECCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHHHHHHHHHHH
IGAILNIDADHLDYYRDLNDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEANCNVIT
HHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCEEE
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNM
EECCCCCEEEECCCCCHHCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
KCKDIIEGIESFFGTHRRFELKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
QPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGIISSDMLGDKLRDRGLKCTNF
CCCCCCEEEHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCC
HKFDDIKNYLIENAKDGDLILTVGAGDIYKVGEMYINL
CCHHHHHHHHHCCCCCCCEEEEECCCCCEEECEEEECC
>Mature Secondary Structure
MLFNFIKDKNKHIHFIGIGGISMSGLAEILLYHNFTISGSDMNSSPITKKLKDKGAHIYI
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHHHCCCCEEEE
GHKKENIKDADLIVYTAAIASDNPEIIEAKEKNIKLMDRADFLGDLMKGYKYNIAISGTH
ECCCCCCCCCEEEEEEEEECCCCCCEEECCCCCEEEEHHHHHHHHHHCCCEEEEEEECCC
GKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGKSDFFITEACEYKSSFLKFFPY
CCCHHHHHHHHHEEEECCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHHHHHHHHHHH
IGAILNIDADHLDYYRDLNDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEANCNVIT
HHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCEEE
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNM
EECCCCCEEEECCCCCHHCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
KCKDIIEGIESFFGTHRRFELKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
QPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGIISSDMLGDKLRDRGLKCTNF
CCCCCCEEEHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCC
HKFDDIKNYLIENAKDGDLILTVGAGDIYKVGEMYINL
CCHHHHHHHHHCCCCCCCEEEEECCCCCEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA