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The map label for this gene is pucD [H]

Identifier: 226950312

GI number: 226950312

Start: 3300628

End: 3303183

Strand: Reverse

Name: pucD [H]

Synonym: CLM_3277

Alternate gene names: 226950312

Gene position: 3303183-3300628 (Counterclockwise)

Preceding gene: 226950313

Following gene: 226950311

Centisome position: 79.49

GC content: 34.35

Gene sequence:

>2556_bases
GTGTATGAATTTATATTAAATGAAAGAAATGTATCTGTTTCAGAGGATATTAATTTACTTGAATATTTGAGGGATAATGA
GGATTTAACTTCAGTAAAAAATGGGTGTGCAGAAGGAGCCTGTGGAGCCTGTATGATACTTGTTAATGGTAAGGCACTTA
GAGCCTGTATATGTACAACTGCAAAGGTGAATGGAAAAGATGTTAAGACTGTAGAGGGGTTAACAGAATTTGAAAAGGAT
GTTTTTACTTGGGCTTTTTCTAAAGCTGGAGCAGTACAGTGTGGATATTGTATTCCAGGGATGATAATAAGTGCAAAGGC
ACTTTTAGATAAAAATCTAAATCCAAATAAGAAAGAAATTAAAACTGCTATTAGAGGAAATGTATGTAGATGTACTGGAT
ATGTGAAAATAATAAAAGCCATTGAAATGGCAGCAGAGGCATTTAGAAATGGTAAACTTCCATTTGCGAAAGAATATAAA
GGGAAAATAGGTGAAAATATTCCAAGAATAGATGCAAAAGATAAAATTTTAGGTATAGGAAAATATGTAGATGACATGAA
GATAGAAGGAATGGTTTATGGTTCTGCTTTAAGATCAAAATATCCTAGAGCTTTAGTAAAAAGCATTGATATAAGTGAAG
CTTTAAAACATCCAGAAGTTGAAGCTATTCTTACAGCAGAAGATGTCCCAGGAAATAGGCTTATAGGACATATTGTAAAG
GATTGGCCAGCAATGATAGCCGTAGGAGAAGAAACAAGGTATGTTGGTGATGCAGTGGCTTTAGTGGCAGCAAAAAGCAA
GAAGACTTTAAAAGAAATACTTAATTTAATAAAGGTAGAATATGAAGAATTAGAACCTATTTCTAATCCTAATATTGCAA
TAGCTGAAGATGCTCCTAAAATTCATCCTAAGGGAAATATTTTAACAGTGGAAAAAGTTAATAGAGGAGATGTAGATGAG
GCAATAGCCAATTCTAAGTATGTGGTTACTAATCATTATTCTACTCCCTTTACTGAACATGCTTTTTTAGAGCCTGAAAG
TGCTTTAGCTATGCCAGATGGGGATGGAGTTATTATTTATACAGGAAGCCAAGGTATATATGATGAGCAGAGAGAGATTT
CTGAGCTTTTAGGGCTTCCTAAAGAAAAAGTAAGGACTATTAGCAAATATGTGGGTGGAGGCTTTGGTGGAAAAGAAGAT
ATGAGTGTACAACATCATGCCGCTCTTCTTGCATGGACTATTAAAAAGCCCGTTAAAATAACTTTAAGTCGTAAGGAAAG
TATAAAGATTCATCCTAAAAGACATGCTATGGAAATGACAATTACTACTGCATGTGATGAAAAAGGAAATTTAACTGCTT
TTAAAGCAGATATTATATCAGATACTGGTGCCTATGCATCATTAGGAGGACCTGTACTTCAAAGAGCTTGTACTCATGCA
GCTGGCCCATATAAATGCCCTAATGTGAAGATAAAAGGTACAGCTGTATATACTAACAATCCCCCAGGAGGAGCTTTTAG
GGGATTTGGAGTAACACAATCAGTTTTTGGATCAGAGTGCAACTTAAATCTTTTAGCTGAAAAAGTTGGTATATCTCCTT
GGGAAATAAGATTTAAAAACGCAGTAGAACCTGGAGATGCACTACCTAATGGACAAATTGCCGATAAAGGAACTGCAATT
AAAGAAACTATATTAGCTGTGAAAGATGTATATAAAAAGAGTAAATGTGCAGGAATAGCCTGTTGTATGAAAAATTCAGG
AGTTGGTGTTGGAATACCGGATATTGGAAGATGTAACTTAATAGTAATAGATGGAAAGGTTCATATAAGAACTAGTGCAG
CTTGCATAGGTCAAGGTCTTGGAACAATTCTTACACAAATAATATGTGAAACAATAGGTTTATTACCAGAACAGATAATT
TTAGATTTACCAGATACAAAATTTGCACCAGATTCAGGGACAACTACAGCATCAAGACAAACAGTATTTACTGGAGAAGC
CACAAGAATGGCATCATTAAAGCTTAAGGAAAAATTATTAACTACATCATTAGAAGAGTGTGAAGGTGAAGAATTTTATG
GGGAATATGAAAGTATTACAGATCCTATTAATTCTGATAAAAAGAATCCAGTAAGCCACGTGGCTTATGGCTATGCAACA
CAAGTTGTTATTCTTGATGATGATGGAAAAGTAGAAAAAGTGGTTGCAGCACATGATGTGGGAAAAGCTATAAATTTAAC
TAATGTAGAAGGACAAATTGAAGGTGGAATAGTTATGGGACTTGGGTATGCATTTACAGAAGATTATCCATTAAATAAAT
CTATCCCAACTGCTAAATTTGGCACATTAGGTTTGTTTAGAGCTACTGATATACCAGAAATTGAAACAACAATAATTGAA
AAGAATACTAATGATTTAGCTTATGGTGCAAAAGGAATAGGAGAAATTACAACCATACCAACAGCCCCAGCAGCTCAAGG
TGCTTACTATAAATTTGATGGAAACTTTAGAAAAAAGCTTCCACTTGAGGATACTGCTTATAGAAGGAAAAAATAA

Upstream 100 bases:

>100_bases
AGTAGTCATCGTATAAAGTTCATTTATAGTTTTATACATTTAGACATATAAAGAGAAAATAATAGGCTTATTGATACATA
AATATATGGGGGTAATAAAT

Downstream 100 bases:

>100_bases
TTTTTTTGCATGAAACTATTCTAAAATAGATTTAATTTTAACTATGCAAATATAAAAAAATATATATAAACTGCTTATTT
TTGAAACGTTTAAATTTTTT

Product: xanthine dehydrogenase family protein molybdopterin-binding subunit

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 851; Mature: 851

Protein sequence:

>851_residues
MYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLTEFEKD
VFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAEAFRNGKLPFAKEYK
GKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISEALKHPEVEAILTAEDVPGNRLIGHIVK
DWPAMIAVGEETRYVGDAVALVAAKSKKTLKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNRGDVDE
AIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKED
MSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRACTHA
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIADKGTAI
KETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQII
LDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYESITDPINSDKKNPVSHVAYGYAT
QVVILDDDGKVEKVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIETTIIE
KNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK

Sequences:

>Translated_851_residues
MYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLTEFEKD
VFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAEAFRNGKLPFAKEYK
GKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISEALKHPEVEAILTAEDVPGNRLIGHIVK
DWPAMIAVGEETRYVGDAVALVAAKSKKTLKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNRGDVDE
AIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKED
MSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRACTHA
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIADKGTAI
KETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQII
LDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYESITDPINSDKKNPVSHVAYGYAT
QVVILDDDGKVEKVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIETTIIE
KNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK
>Mature_851_residues
MYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLTEFEKD
VFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAEAFRNGKLPFAKEYK
GKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISEALKHPEVEAILTAEDVPGNRLIGHIVK
DWPAMIAVGEETRYVGDAVALVAAKSKKTLKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNRGDVDE
AIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKED
MSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRACTHA
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIADKGTAI
KETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQII
LDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYESITDPINSDKKNPVSHVAYGYAT
QVVILDDDGKVEKVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIETTIIE
KNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=711, Percent_Identity=26.5822784810127, Blast_Score=194, Evalue=4e-49,
Organism=Homo sapiens, GI71773480, Length=704, Percent_Identity=25.4261363636364, Blast_Score=150, Evalue=6e-36,
Organism=Escherichia coli, GI1789230, Length=736, Percent_Identity=29.6195652173913, Blast_Score=292, Evalue=5e-80,
Organism=Escherichia coli, GI1789246, Length=948, Percent_Identity=26.0548523206751, Blast_Score=255, Evalue=1e-68,
Organism=Escherichia coli, GI1786478, Length=732, Percent_Identity=24.0437158469945, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1789232, Length=129, Percent_Identity=42.6356589147287, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786480, Length=152, Percent_Identity=35.5263157894737, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=716, Percent_Identity=25.4189944134078, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566215, Length=715, Percent_Identity=24.1958041958042, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17539860, Length=756, Percent_Identity=23.1481481481481, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17737937, Length=686, Percent_Identity=27.4052478134111, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24647193, Length=691, Percent_Identity=23.7337192474674, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647199, Length=645, Percent_Identity=22.6356589147287, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647201, Length=657, Percent_Identity=22.9832572298326, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24647197, Length=148, Percent_Identity=29.0540540540541, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24647195, Length=148, Percent_Identity=29.0540540540541, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 92108; Mature: 92108

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTT
CCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEC
AKVNGKDVKTVEGLTEFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCHHHH
KTAIRGNVCRCTGYVKIIKAIEMAAEAFRNGKLPFAKEYKGKIGENIPRIDAKDKILGIG
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCCCCCCCCEEECC
KYVDDMKIEGMVYGSALRSKYPRALVKSIDISEALKHPEVEAILTAEDVPGNRLIGHIVK
CHHCCEEECEEEEHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
DWPAMIAVGEETRYVGDAVALVAAKSKKTLKEILNLIKVEYEELEPISNPNIAIAEDAPK
CCCEEEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
IHPKGNILTVEKVNRGDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIY
CCCCCCEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCEEECCCCCEECCCCCEEEEE
TGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWTIKKPVKI
ECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEECCCEEE
TLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRACTHA
EEECCCCEEECCCCCEEEEEEEEECCCCCCEEEEEEEHHCCCCCCHHCCHHHHHHHHHHC
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKN
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHCCCCEEEEECC
AVEPGDALPNGQIADKGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCEEE
IVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQIILDLPDTKFAPDSGTTTASRQ
EEECCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCCCCCCCCCC
TVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYESITDPINSDKKNPVSHVAYGYAT
EEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHCCCCCCCCCCCHHHHEECEEE
QVVILDDDGKVEKVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKF
EEEEECCCCCEEHEEHHHHCCCEEEEECCCCEECCCEEEEECEEECCCCCCCCCCCCCCC
GTLGLFRATDIPEIETTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKL
CCEEEEECCCCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCC
PLEDTAYRRKK
CCCCCHHHCCC
>Mature Secondary Structure
MYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTT
CCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEC
AKVNGKDVKTVEGLTEFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCHHHH
KTAIRGNVCRCTGYVKIIKAIEMAAEAFRNGKLPFAKEYKGKIGENIPRIDAKDKILGIG
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCCCCCCCCEEECC
KYVDDMKIEGMVYGSALRSKYPRALVKSIDISEALKHPEVEAILTAEDVPGNRLIGHIVK
CHHCCEEECEEEEHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
DWPAMIAVGEETRYVGDAVALVAAKSKKTLKEILNLIKVEYEELEPISNPNIAIAEDAPK
CCCEEEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
IHPKGNILTVEKVNRGDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIY
CCCCCCEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCEEECCCCCEECCCCCEEEEE
TGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWTIKKPVKI
ECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEECCCEEE
TLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRACTHA
EEECCCCEEECCCCCEEEEEEEEECCCCCCEEEEEEEHHCCCCCCHHCCHHHHHHHHHHC
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKN
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHCCCCEEEEECC
AVEPGDALPNGQIADKGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCEEE
IVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQIILDLPDTKFAPDSGTTTASRQ
EEECCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCCCCCCCCCC
TVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYESITDPINSDKKNPVSHVAYGYAT
EEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHCCCCCCCCCCCHHHHEECEEE
QVVILDDDGKVEKVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKF
EEEEECCCCCEEHEEHHHHCCCEEEEECCCCEECCCEEEEECEEECCCCCCCCCCCCCCC
GTLGLFRATDIPEIETTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKL
CCEEEEECCCCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCC
PLEDTAYRRKK
CCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]