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The map label for this gene is purM

Identifier: 226950308

GI number: 226950308

Start: 3296220

End: 3297215

Strand: Reverse

Name: purM

Synonym: CLM_3272

Alternate gene names: 226950308

Gene position: 3297215-3296220 (Counterclockwise)

Preceding gene: 226950309

Following gene: 226950307

Centisome position: 79.35

GC content: 30.42

Gene sequence:

>996_bases
ATGGTATCTTATAAAGAAGCTGGGGTTAATATAGAGGAAGGTTATAAATCAGTAGATCTTATAAAAAAACATGCTTCAAA
GACATTTACAAAGGGAGTATTAAATAATTTAGGAAGTTTTGCAGGAATGTTTGAACTTCCTAAATATAAAAATCCCGTAT
TAGTATCAGGAACTGACGGAGTTGGAACTAAATTAGATATAGCCTTTAGAATGAAAAAATATAATACAGTGGGAATAGAC
TGCGTAGCTATGTGCATAAATGATATATTATGTCATGGTGCTAAGCCGTTATTTTTCTTAGATTATATAGCTTGTGGGAA
ATTGGAAGCAGAAGTTGCAGCTCAGCTTGTAGAAGGGGTTAGCAATGGTTGTATCCAAAGTGAATGTGCTCTAATAGGTG
GAGAAACAGCAGAAATGCCAGGCTTTTATAGAGATGGGGAATATGATATAGCTGGTTTTGCTGTAGGTATAGCAGAAAAA
GATGAAATAATAGATGGAAGTAAAATAGAAGATGGGGATATATTAATAGGTATAGCATCTTCAGGACCTCATAGCAACGG
ATATTCTCTTATAAGAAAATTAGTAGAAGATTTACATAAAGATTTTGAAGGAAATAAAATAGGAAATACTCTTTTAACTC
CTACAAAAATATATGTAAAACCTGTAATGAAACTTTTAGAAAAATATAATATAAAAGGTATGGCTCATGTAACTGGAGGA
GGTTTTTATGAAAATATTCCTAGAATGTTTAAAGAGGATTTTACAGCAGTTATAAATAAAAAATCTTATCCATTACCAAA
TATATTTAGCCATCTAATAAGTTTAGGGATAGAAGAAGATCATATGTACAATACTTTTAATATGGGGATTGGTTTTGTAT
TATGTGTAAATGAAAAAGATGGGGAAAATATAATAAAAGACCTGATAGAAATGGGAGAAAAGGGTTATAAAATAGGATAT
GTTAAAAAAGGAGATAAGTCTGTTGAACTAATTTAA

Upstream 100 bases:

>100_bases
ATCTGCACCTATAGAAATGCCTAAAGATAGTTTGGAATAGGGAATTTAAGTTTTTTAAATTTTGAGAATAACTAATAATG
TAAAGAAGGGAATGTTATTC

Downstream 100 bases:

>100_bases
AAAAGGCATTAAATAAATTTATAATAAAAATTAGTTCATAGATTAGATCTTTAAAATAATTGATTGGGGAATTAATTATT
TATAGAGTATATATGAAAAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI

Sequences:

>Translated_331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI
>Mature_331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=332, Percent_Identity=44.8795180722892, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI209869995, Length=332, Percent_Identity=44.8795180722892, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI209869993, Length=332, Percent_Identity=44.8795180722892, Blast_Score=288, Evalue=4e-78,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=48.0712166172107, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=41.2462908011869, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=40.7079646017699, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24582400, Length=270, Percent_Identity=43.3333333333333, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_CLOB1 (A7FXD5)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385139.1
- ProteinModelPortal:   A7FXD5
- SMR:   A7FXD5
- STRING:   A7FXD5
- GeneID:   5394948
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_2840
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   CBOT441770:CLB_2840-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36276; Mature: 36276

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
VGTKLDIAFRMKKYNTVGIDCVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGV
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
SNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEKDEIIDGSKIEDGDILIGIAS
HCCCHHHHHHEECCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEC
SGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKD
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCEEEEECCCEEEEEECCCC
GENIIKDLIEMGEKGYKIGYVKKGDKSVELI
CHHHHHHHHHHCCCCCEEEEEECCCCCEECC
>Mature Secondary Structure
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
VGTKLDIAFRMKKYNTVGIDCVAMCINDILCHGAKPLFFLDYIACGKLEAEVAAQLVEGV
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
SNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEKDEIIDGSKIEDGDILIGIAS
HCCCHHHHHHEECCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEC
SGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLISLGIEEDHMYNTFNMGIGFVLCVNEKD
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCEEEEECCCEEEEEECCCC
GENIIKDLIEMGEKGYKIGYVKKGDKSVELI
CHHHHHHHHHHCCCCCEEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA