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The map label for this gene is mepA [H]

Identifier: 226950253

GI number: 226950253

Start: 3231947

End: 3233341

Strand: Reverse

Name: mepA [H]

Synonym: CLM_3208

Alternate gene names: 226950253

Gene position: 3233341-3231947 (Counterclockwise)

Preceding gene: 226950254

Following gene: 226950251

Centisome position: 77.81

GC content: 31.4

Gene sequence:

>1395_bases
ATGAAAAACAAAATATCTACAACAGAAATGATGGAGAAAGAAAGTATATCAAAGGTGCTTTTGAAATTATCAGTACCTGC
AATAATAGCTATGCTAATTAATGCTATTTACAATATAGTGGATACTATGTTTGTGGGAATGTTAAATAATACTAGCGCCA
TTGCCGCCGTATCTATAGTATATCCACTATTTATGTTTATTGGAGCTATAGGGGTTATGTTTGGTGCAGGAGGTGCTTCT
TATCTATCAAGATTGTTGGGAGAAAAGAAAAAAGAGGAAGCTGATAGAACTCTAACATCTACCATAGTAATTGGGTGTAT
ATTCAGTTTGATTTTTACTGTGATTTGTATAATATTTTTAGAACAATTTTTATTGATGTATGGAGCAACAGAAACTACAA
TGCCTTATGCTAAAGAATATGGATATACAATAGTAGCAGGATCCATTTTTACCATTGGAACAGCAATAATGAGTAATACT
ATTAGAGCAGAGGGAAATTCAAAATATAGTATGATTGCTACCTGTATAGGAGGAGTTATAAACATAATACTAGACCCTAT
ATTCATGTTCAAGTTTGGTATGGGTATAAAAGGTGCCGCAGTTGCTACGGTCATATCACAGCTAGTATCCTTCATTTTTC
TTTTAAGATATTATTATTCTAAGAAAAGCTATATAAAATTAGGAATCAAGTTTTTTAAACCAACCTTTAATATGTTTTTT
GAAATACTTAAGATAGGTATTCCTATTTTTGTAACTCAAGTACTGGCAAGTTTTGCTTTAGGTTTCATGAATTTAGGAGC
AAAACCTTATGGAGATGCAGCAGTAGCTGCGATGGGTATAGTATTTAGAGTTATGTCTATAGGATTTTATATAGTGTTTG
GAATTGGTCAAGGATTCCAGCCTGTTGCAGGATATAATTATGGGGCTAAGAACTTTACTAGATTAAAAGAAGCTGTAAAA
TTATCTATTAAATGGAGTGTTGTATCTGGTATTGTTATATCTATTTTATTTATAGTTTTTGCAGAAGGATGTATGCTTAT
ATTTACAAGGGATAGAGAAGTTATAAATATAGGAATAAAAGCCTTTAGAGCAGCAAGTTTATTGTTTCCACTTTTTGGAT
ATGTAAATACTTATGCAGTGTTATATCAAGCTTTAGGTAAGGCTTTAGGGGCCTTTATATTGTCTATTTCTAGACAGGGA
ATATTTTATATACCTTTAATGTATATATTACCAAAGTTTATGGGATTAGCAGGAGTGATATTCTGTCAAACTGCAGCGGA
TGGATTGGCATTTATAGAAACTTTTATAATGGCAATTTGGTTAAATAAGAGCCTAAAAAAGGAAATGGTTGAAGAAACTA
ATTTAGACTCAGTAAAGAAAGTTTCAGCCTTCTAA

Upstream 100 bases:

>100_bases
ACCAAAGCCTAGCGCTATAATAAAAATAGAAAATTAAGATTTAAATTATGAAGGGAGGCATGTCTAAGCTTTTCTAGGCT
TTTATTAGGCAAGAAAGAAT

Downstream 100 bases:

>100_bases
AGACCAAATTGAAAGTATATATATGAAAAAATGCTTACAAATATATGTTAGTTAGAGTTTCTCAAAAGTCTTATTTATTA
ATACAAATAAAAATAAGCAA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKNKISTTEMMEKESISKVLLKLSVPAIIAMLINAIYNIVDTMFVGMLNNTSAIAAVSIVYPLFMFIGAIGVMFGAGGAS
YLSRLLGEKKKEEADRTLTSTIVIGCIFSLIFTVICIIFLEQFLLMYGATETTMPYAKEYGYTIVAGSIFTIGTAIMSNT
IRAEGNSKYSMIATCIGGVINIILDPIFMFKFGMGIKGAAVATVISQLVSFIFLLRYYYSKKSYIKLGIKFFKPTFNMFF
EILKIGIPIFVTQVLASFALGFMNLGAKPYGDAAVAAMGIVFRVMSIGFYIVFGIGQGFQPVAGYNYGAKNFTRLKEAVK
LSIKWSVVSGIVISILFIVFAEGCMLIFTRDREVINIGIKAFRAASLLFPLFGYVNTYAVLYQALGKALGAFILSISRQG
IFYIPLMYILPKFMGLAGVIFCQTAADGLAFIETFIMAIWLNKSLKKEMVEETNLDSVKKVSAF

Sequences:

>Translated_464_residues
MKNKISTTEMMEKESISKVLLKLSVPAIIAMLINAIYNIVDTMFVGMLNNTSAIAAVSIVYPLFMFIGAIGVMFGAGGAS
YLSRLLGEKKKEEADRTLTSTIVIGCIFSLIFTVICIIFLEQFLLMYGATETTMPYAKEYGYTIVAGSIFTIGTAIMSNT
IRAEGNSKYSMIATCIGGVINIILDPIFMFKFGMGIKGAAVATVISQLVSFIFLLRYYYSKKSYIKLGIKFFKPTFNMFF
EILKIGIPIFVTQVLASFALGFMNLGAKPYGDAAVAAMGIVFRVMSIGFYIVFGIGQGFQPVAGYNYGAKNFTRLKEAVK
LSIKWSVVSGIVISILFIVFAEGCMLIFTRDREVINIGIKAFRAASLLFPLFGYVNTYAVLYQALGKALGAFILSISRQG
IFYIPLMYILPKFMGLAGVIFCQTAADGLAFIETFIMAIWLNKSLKKEMVEETNLDSVKKVSAF
>Mature_464_residues
MKNKISTTEMMEKESISKVLLKLSVPAIIAMLINAIYNIVDTMFVGMLNNTSAIAAVSIVYPLFMFIGAIGVMFGAGGAS
YLSRLLGEKKKEEADRTLTSTIVIGCIFSLIFTVICIIFLEQFLLMYGATETTMPYAKEYGYTIVAGSIFTIGTAIMSNT
IRAEGNSKYSMIATCIGGVINIILDPIFMFKFGMGIKGAAVATVISQLVSFIFLLRYYYSKKSYIKLGIKFFKPTFNMFF
EILKIGIPIFVTQVLASFALGFMNLGAKPYGDAAVAAMGIVFRVMSIGFYIVFGIGQGFQPVAGYNYGAKNFTRLKEAVK
LSIKWSVVSGIVISILFIVFAEGCMLIFTRDREVINIGIKAFRAASLLFPLFGYVNTYAVLYQALGKALGAFILSISRQG
IFYIPLMYILPKFMGLAGVIFCQTAADGLAFIETFIMAIWLNKSLKKEMVEETNLDSVKKVSAF

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51001; Mature: 51001

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA