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The map label for this gene is nrdA [H]

Identifier: 226950224

GI number: 226950224

Start: 3193193

End: 3195484

Strand: Reverse

Name: nrdA [H]

Synonym: CLM_3178

Alternate gene names: 226950224

Gene position: 3195484-3193193 (Counterclockwise)

Preceding gene: 226950227

Following gene: 226950223

Centisome position: 76.9

GC content: 31.28

Gene sequence:

>2292_bases
ATGAATATTAAAATAAAAAAGAGAGATGGACAATATGAATCACTACAAGTAGAAAAAACAAAGAAAATGGTTAAGTTAGC
CTGTGAGGGTATAGAAGGATGTGATCCTCTTGAACTAGAATTGGATTCCAGAATACAATTTAGAGATGGTATGACTACTA
AGGAAATTCAAAGAACTTTGATACAAACTGCCATCGAAAAAGTTATTCAAAATAGCAAAGATAACAATGGGAATAATATA
AAAAAAACTAATGCTAATTGGCAGTATGTTGCTGCAAGACTTTTATGTTTTGATTTATACAAGGAAGCTAAAATCAGCCG
ACACTATAATAGCTTTGGTTATGGTGATTATTATGAATTGGTAAAGAAATTAGTTAAAATGAAACTTTATGGAGAATATT
TAATTCAAAATTATTCTGATGAAGAAATCAAAGAATTAGCAAAGTACATAGTACCAGAAAGAGATGAATTATTTAATTAT
GAAGGATTAAAATTATTAAATGATAGATATTTAATTAAGGGGCATAATGGAGAAATATTAGAGCTTCCTCAAGAACGTTT
TATGACAATAGCTATGCATTTAGCTATTCCTGAGGGGGATAAAAAAGTTTTTTATGGAAAAAAGTTTTATGATCTTTTAA
GTGAGTTAAAAGTTACAGTGGCTACTCCTACTTTAGGAAATGCAGGTACACCTTTTTATCAGTTAAGTAGCTGTTTTATA
TCTGTTGTAGGGGATAATTTATGGTCAATTTATGATGTTAATCAAAAGTTTGCGCAAGTCTCAAAACATGGTGGAGCACT
AGGCATTTATACTGGAAAAATAAGAGCGTTAAACAGTGAAATAAGAGGACATAAAAATGCATCAGGCGGGGTTGTACCTT
GGATAAGACTTTATAATGATACAGCTGTAGCTGTAGACCAGCTTGGCAAGAGAAAAGGTGGAGCAGCTATAACTTTAGAT
ATATGGCATAAAGATATATTTGATTTTTTAGATCTTAAAACTAATAATGGAGATGATAGAAGAAAGGCTCATGATATTTT
TCCTTCTGTAAGCATTCCAGATTTATTCATGAAAAGATTAGAGAAAAGAGAAAGTTGGTCTTTATTTGATCCTTATATTG
TAGAGAAGATAATGGGCTACAAGCTGGAGGATTATTTTGATGATGAAGATTGCAGGGAATTTACAAATAAGTACTTAGAA
TGTGAAAGAAATACTAATATTCCAAGAGATACAGTACCGACTCTTGATATTATGAAAAAATTAATGAAAAGTGCAGTAGA
GACAGGTACTCCTTTTATTTTTTTTAGGGATACTGTAAATAAAGCAAATCCTAATAAACATAGAGGTATGATATATTCAT
CAAATCTTTGCCATGAAATAGCTCAAAATATGAGCGAAAGTCAACTTCTAGAAGAGGAAATAATTGATGAAAATGGTTAT
CCAGAGGTTGTTCAAAGAGTTAAAGCTGGAGATATGGTAACCTGTAATCTTAATTCAATAAATCTTAGCAAAGTGAAAAA
AGAGGAATTTAGTGAGTGTATCCCTCTTCAAATAAGGATGCTAGATAATGTTATATCTCTTAATAAGCTTCCTGTTAAAG
AGGCCAAAGTTACAAGTGACAAGTATAGAGCTATTGGTTTAGGAACAAGTGGATATCATCATTTCCTTGCAAATAATAAG
ATAAGATGGGAAAGTGATGAACATATTAAGGTAGCGGATGAAATCTATGAAGAGATAGCCTATACAGCTATAAAATCTTC
CATGGAATTAGCTAAGGAAAAAGGCAGCTATCCAGCTTTTAAAGGTTCAGAATGGGAAACAGGAAAATATTTTGAACGAA
GAGGTTACAATTCTGAAAGATGGAAGAAGCTACAAAGTAATATCAAAAAATATGGTATGAGAAATGGTTATATTACTGCT
ATTGCCCCTACAGGAAGTACTTCTAATATAGCTAATACAACAGCAGGAATAGATCCTGTATTTAAAAAGTTTTTTATGGA
AGAAAAGAAGGGTAGTTTTACACCGAAAACAGCACCAGACTTAAATGAAGAAAATTTTTGGTATTACAAAGAAGCACATA
CTATAGACCAACAATGGAGCATTAAGGCTTGTGCCGTAAGACAAAAACATATAGACCAGGCCCAATCCTTTAATTTATAT
ATAACCCCAGAAATAAAAGCTAAAGAAATTCTTAATATGTATATGGAATCTTGGAAGCAAGGAGTTAAAACTATCTATTA
TGTAAGAAATAAATCTTTAGAAATGGATGAATGTACAAGTTGCTCAAGCTAA

Upstream 100 bases:

>100_bases
TGATTTTAAAAATGATAACTTATATAATTTGTTTAACAACAGTTATTTTATAATATGTTTTATTGATTAAATAAATTTTT
TAGAAAGTAAGGTTTGAGCA

Downstream 100 bases:

>100_bases
ATGTATATTTAAGTTTATAACAAGAGAAAGATTGTAATTTAAAAGCAGATGAAGTGCTAGGTTAAAAGTATATACTTAAT
ATAATACCTAGATAGGTAAC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MNIKIKKRDGQYESLQVEKTKKMVKLACEGIEGCDPLELELDSRIQFRDGMTTKEIQRTLIQTAIEKVIQNSKDNNGNNI
KKTNANWQYVAARLLCFDLYKEAKISRHYNSFGYGDYYELVKKLVKMKLYGEYLIQNYSDEEIKELAKYIVPERDELFNY
EGLKLLNDRYLIKGHNGEILELPQERFMTIAMHLAIPEGDKKVFYGKKFYDLLSELKVTVATPTLGNAGTPFYQLSSCFI
SVVGDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGHKNASGGVVPWIRLYNDTAVAVDQLGKRKGGAAITLD
IWHKDIFDFLDLKTNNGDDRRKAHDIFPSVSIPDLFMKRLEKRESWSLFDPYIVEKIMGYKLEDYFDDEDCREFTNKYLE
CERNTNIPRDTVPTLDIMKKLMKSAVETGTPFIFFRDTVNKANPNKHRGMIYSSNLCHEIAQNMSESQLLEEEIIDENGY
PEVVQRVKAGDMVTCNLNSINLSKVKKEEFSECIPLQIRMLDNVISLNKLPVKEAKVTSDKYRAIGLGTSGYHHFLANNK
IRWESDEHIKVADEIYEEIAYTAIKSSMELAKEKGSYPAFKGSEWETGKYFERRGYNSERWKKLQSNIKKYGMRNGYITA
IAPTGSTSNIANTTAGIDPVFKKFFMEEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACAVRQKHIDQAQSFNLY
ITPEIKAKEILNMYMESWKQGVKTIYYVRNKSLEMDECTSCSS

Sequences:

>Translated_763_residues
MNIKIKKRDGQYESLQVEKTKKMVKLACEGIEGCDPLELELDSRIQFRDGMTTKEIQRTLIQTAIEKVIQNSKDNNGNNI
KKTNANWQYVAARLLCFDLYKEAKISRHYNSFGYGDYYELVKKLVKMKLYGEYLIQNYSDEEIKELAKYIVPERDELFNY
EGLKLLNDRYLIKGHNGEILELPQERFMTIAMHLAIPEGDKKVFYGKKFYDLLSELKVTVATPTLGNAGTPFYQLSSCFI
SVVGDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGHKNASGGVVPWIRLYNDTAVAVDQLGKRKGGAAITLD
IWHKDIFDFLDLKTNNGDDRRKAHDIFPSVSIPDLFMKRLEKRESWSLFDPYIVEKIMGYKLEDYFDDEDCREFTNKYLE
CERNTNIPRDTVPTLDIMKKLMKSAVETGTPFIFFRDTVNKANPNKHRGMIYSSNLCHEIAQNMSESQLLEEEIIDENGY
PEVVQRVKAGDMVTCNLNSINLSKVKKEEFSECIPLQIRMLDNVISLNKLPVKEAKVTSDKYRAIGLGTSGYHHFLANNK
IRWESDEHIKVADEIYEEIAYTAIKSSMELAKEKGSYPAFKGSEWETGKYFERRGYNSERWKKLQSNIKKYGMRNGYITA
IAPTGSTSNIANTTAGIDPVFKKFFMEEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACAVRQKHIDQAQSFNLY
ITPEIKAKEILNMYMESWKQGVKTIYYVRNKSLEMDECTSCSS
>Mature_763_residues
MNIKIKKRDGQYESLQVEKTKKMVKLACEGIEGCDPLELELDSRIQFRDGMTTKEIQRTLIQTAIEKVIQNSKDNNGNNI
KKTNANWQYVAARLLCFDLYKEAKISRHYNSFGYGDYYELVKKLVKMKLYGEYLIQNYSDEEIKELAKYIVPERDELFNY
EGLKLLNDRYLIKGHNGEILELPQERFMTIAMHLAIPEGDKKVFYGKKFYDLLSELKVTVATPTLGNAGTPFYQLSSCFI
SVVGDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGHKNASGGVVPWIRLYNDTAVAVDQLGKRKGGAAITLD
IWHKDIFDFLDLKTNNGDDRRKAHDIFPSVSIPDLFMKRLEKRESWSLFDPYIVEKIMGYKLEDYFDDEDCREFTNKYLE
CERNTNIPRDTVPTLDIMKKLMKSAVETGTPFIFFRDTVNKANPNKHRGMIYSSNLCHEIAQNMSESQLLEEEIIDENGY
PEVVQRVKAGDMVTCNLNSINLSKVKKEEFSECIPLQIRMLDNVISLNKLPVKEAKVTSDKYRAIGLGTSGYHHFLANNK
IRWESDEHIKVADEIYEEIAYTAIKSSMELAKEKGSYPAFKGSEWETGKYFERRGYNSERWKKLQSNIKKYGMRNGYITA
IAPTGSTSNIANTTAGIDPVFKKFFMEEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACAVRQKHIDQAQSFNLY
ITPEIKAKEILNMYMESWKQGVKTIYYVRNKSLEMDECTSCSS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=805, Percent_Identity=30.0621118012422, Blast_Score=312, Evalue=6e-85,
Organism=Escherichia coli, GI2367133, Length=768, Percent_Identity=28.2552083333333, Blast_Score=306, Evalue=4e-84,
Organism=Escherichia coli, GI1789030, Length=696, Percent_Identity=27.5862068965517, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17555242, Length=804, Percent_Identity=29.6019900497512, Blast_Score=298, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6320914, Length=789, Percent_Identity=28.7705956907478, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6322123, Length=795, Percent_Identity=29.937106918239, Blast_Score=293, Evalue=5e-80,
Organism=Drosophila melanogaster, GI17352481, Length=796, Percent_Identity=29.5226130653266, Blast_Score=303, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 87992; Mature: 87992

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKIKKRDGQYESLQVEKTKKMVKLACEGIEGCDPLELELDSRIQFRDGMTTKEIQRTL
CCEEEECCCCCCHHEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECCCCCHHHHHHHH
IQTAIEKVIQNSKDNNGNNIKKTNANWQYVAARLLCFDLYKEAKISRHYNSFGYGDYYEL
HHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VKKLVKMKLYGEYLIQNYSDEEIKELAKYIVPERDELFNYEGLKLLNDRYLIKGHNGEIL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCEEEECCEEEEECCCCCEE
ELPQERFMTIAMHLAIPEGDKKVFYGKKFYDLLSELKVTVATPTLGNAGTPFYQLSSCFI
ECCHHHHHEEHEEEECCCCCCEEEECHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHH
SVVGDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGHKNASGGVVPWIRLYND
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECHHEEHHHHHCCCCCCCCCCCCEEEEECC
TAVAVDQLGKRKGGAAITLDIWHKDIFDFLDLKTNNGDDRRKAHDIFPSVSIPDLFMKRL
CHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
EKRESWSLFDPYIVEKIMGYKLEDYFDDEDCREFTNKYLECERNTNIPRDTVPTLDIMKK
HHCCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LMKSAVETGTPFIFFRDTVNKANPNKHRGMIYSSNLCHEIAQNMSESQLLEEEIIDENGY
HHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHCCCHHHHHHHHHHCCCCC
PEVVQRVKAGDMVTCNLNSINLSKVKKEEFSECIPLQIRMLDNVISLNKLPVKEAKVTSD
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHCCCC
KYRAIGLGTSGYHHFLANNKIRWESDEHIKVADEIYEEIAYTAIKSSMELAKEKGSYPAF
CEEEEECCCCCHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KGSEWETGKYFERRGYNSERWKKLQSNIKKYGMRNGYITAIAPTGSTSNIANTTAGIDPV
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
FKKFFMEEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACAVRQKHIDQAQSFNLY
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
ITPEIKAKEILNMYMESWKQGVKTIYYVRNKSLEMDECTSCSS
ECCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCCC
>Mature Secondary Structure
MNIKIKKRDGQYESLQVEKTKKMVKLACEGIEGCDPLELELDSRIQFRDGMTTKEIQRTL
CCEEEECCCCCCHHEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECCCCCHHHHHHHH
IQTAIEKVIQNSKDNNGNNIKKTNANWQYVAARLLCFDLYKEAKISRHYNSFGYGDYYEL
HHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VKKLVKMKLYGEYLIQNYSDEEIKELAKYIVPERDELFNYEGLKLLNDRYLIKGHNGEIL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCEEEECCEEEEECCCCCEE
ELPQERFMTIAMHLAIPEGDKKVFYGKKFYDLLSELKVTVATPTLGNAGTPFYQLSSCFI
ECCHHHHHEEHEEEECCCCCCEEEECHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHH
SVVGDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGHKNASGGVVPWIRLYND
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECHHEEHHHHHCCCCCCCCCCCCEEEEECC
TAVAVDQLGKRKGGAAITLDIWHKDIFDFLDLKTNNGDDRRKAHDIFPSVSIPDLFMKRL
CHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
EKRESWSLFDPYIVEKIMGYKLEDYFDDEDCREFTNKYLECERNTNIPRDTVPTLDIMKK
HHCCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LMKSAVETGTPFIFFRDTVNKANPNKHRGMIYSSNLCHEIAQNMSESQLLEEEIIDENGY
HHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECHHHHHHHHCCCHHHHHHHHHHCCCCC
PEVVQRVKAGDMVTCNLNSINLSKVKKEEFSECIPLQIRMLDNVISLNKLPVKEAKVTSD
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHCCCC
KYRAIGLGTSGYHHFLANNKIRWESDEHIKVADEIYEEIAYTAIKSSMELAKEKGSYPAF
CEEEEECCCCCHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KGSEWETGKYFERRGYNSERWKKLQSNIKKYGMRNGYITAIAPTGSTSNIANTTAGIDPV
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
FKKFFMEEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACAVRQKHIDQAQSFNLY
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
ITPEIKAKEILNMYMESWKQGVKTIYYVRNKSLEMDECTSCSS
ECCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]