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The map label for this gene is xasA [C]

Identifier: 226949825

GI number: 226949825

Start: 2782140

End: 2783585

Strand: Direct

Name: xasA [C]

Synonym: CLM_2768

Alternate gene names: 226949825

Gene position: 2782140-2783585 (Clockwise)

Preceding gene: 226949793

Following gene: 226949835

Centisome position: 66.95

GC content: 32.92

Gene sequence:

>1446_bases
ATGAAAAAGTCCTTGACATTCAAAGACATGGTTTTAATGACCATGACAGCTATTTTAGGATTGAGATGGGTAGCTGTTTC
AGCTAAATATGGCGCCTCCTGTGCAGTACTATGGGGAATAGCAGCATTACTATTCTTTATTCCCAGTGCATTAGTGGCTG
CAGAATTAGGAGGTAAATACCCAGAACAGGGTGGCTTAAGCGTATGGGTTACAAAAGCCTATGGTGAAAAAATGGGTTTT
TTAGTATCTTGGCTTAACTGGGTTAGCAAACTATTCTTTTATCCTGGATTTGTAACATATGCAGCAGTTACATTTGCATA
CGTTATAGATCCAAGTCTTGCAAACAATAAACTTTACAATTTATTTATGGTCTTAGGAATCTTTTGGTTTATAACTATAT
GGAGTTTTAGAGGCACTGGAAATAGTAAAATATTTGCAGTTATAGGTGGACTCGTAGGAAGTGTACTTCCTGCTTTATTA
ATTATAATATTAGGTTATGCATCTGCTTTCGTTCTTAAAAGACCTCTTGCAACACCCTATACTCTTCAAGGCATGATACC
TGATTTCAGTAATATAGCTAATTTAGCATTACTATCTTCTGTAATGTTTGGATTAACAGGCGCTGAAGTAACAGCAGCCT
TTGCTGGTGAAGTTGAAGACGCAAAAAAAACAATTCCTAAAGCAATTATATTCTGTGCTATCTTTATAACTATTTTATAT
ATACTATGTTCATCTGCCATTACTTTTGTAGTATCACCGGAAAAAATCGGTGCTGCAAATGGACTTATAGAAGCATTTAG
ATTAATAACAGAACAGTTTGGTATAGGACAATGGTTCCTAACTTTAATGGCAGTACTTATGACTATAGAAGCTTTGGGCG
GTGTTAGTTTATATATAATGTCTCCTATAACTATGTTATTTGAAACTAGTAAAAATGGTGTTTTACCACCATTCTTAACA
AAAACAAATAAAAATGGCGTACCAATTAATGCATTATTGGTACAAGGTATAGGTATTTCAATAGTAATAATAATTACAAC
TCTTTTACCAACAGTTAATGCTATATATTCAATACTTATAATAATGACGGCTATAACAGGCTTAATCCCTTACTTATTAA
TGTTTGCATCTTACATTAGATTAAAGAAAATGGAGAAATTACAAGCTAAGGGAGAATCCACAGAGGAATTTTACGAAATA
TCAAAATCAAAGCAATTTTCAACCTTTGTATCCATTGTAGGATTAATAAGTGTAATATTTGGAATTGTAACTTCATTCTT
CCCACCATCAGATTATACAACCACAGGACAAATTGTATTCTTTGAATTATTAAGTATCGGTGGACCAATTCTTCTAAGCT
GGATTGGTTGGAGAATGTTTAGCAAATATGAACAAAAAAGAGATACAGGTGAAATTCAATCCACAAATAATTCTTTATCA
GAATAA

Upstream 100 bases:

>100_bases
AAAAATGTCTTGATTTTGTTATAAAAATAACATAATATTAAATAGTATTTAACAATTTAACAATATTATCAAAAATTTTA
CAATAGGGGTGATTATTAAA

Downstream 100 bases:

>100_bases
ATTAATGAAAAAATCTATCTGATTATAAGTAAGAATCAGATAGATTTTTTTATTAATTTATAAATTTTTGCACAAATATA
AATTTTTTAAACAAAGATTA

Product: amino acid permease family protein

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATPYTLQGMIPDFSNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E

Sequences:

>Translated_481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATPYTLQGMIPDFSNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E
>Mature_481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATPYTLQGMIPDFSNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=435, Percent_Identity=23.9080459770115, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081798, Length=469, Percent_Identity=23.6673773987207, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI48994921, Length=446, Percent_Identity=24.4394618834081, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082380, Length=506, Percent_Identity=23.3201581027668, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081708, Length=406, Percent_Identity=23.3990147783251, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786789, Length=378, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357367, Length=315, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52542; Mature: 52542

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]