Click here to switch to the map view.

The map label for this gene is mepA [H]

Identifier: 226949409

GI number: 226949409

Start: 2408390

End: 2409703

Strand: Direct

Name: mepA [H]

Synonym: CLM_2334

Alternate gene names: 226949409

Gene position: 2408390-2409703 (Clockwise)

Preceding gene: 226949383

Following gene: 226949412

Centisome position: 57.96

GC content: 29.15

Gene sequence:

>1314_bases
ATGAGTATTAAAAATACATTTATGCGCTATATTTTAACGAATATTATAGGGATGATTGGTCTTTCATGCTATATTTTAGC
GGATACTTTTTTTGTATCTAAGGGATTAGGCGTACAGGGCTTAACAGCTCTAAATTTATCAATTTCCATTTATAGTTTTA
TTAATGCAACAGGACTTTTAATTGGAATTGGTGGTGCTACAAAATATTCTATTTATCAAGCACGAAATAAGCATAACAAA
GCAAATATTGTTTTTACAAACTCTATTAAAATTGGAGTCATATGTGGAATAATTTTCTTATTAATTGGCTTATTGGCGTC
CTCATCACTTAGTAGTTTATTAGGAGCAGATGAAAATATCTTTCGCATGACAAATACCTATCTAAAAACACTACTATGTT
TTGCACCTTTTTTTATTCTTAATAATATTTTTATAGCTTTTATTAGAAATGACGGAAATCCTAAGCTGTCAATGGCAGGA
ATGTTAATTGGAAGTTTATCAAACATTATTTTAGACTATGTTTTTATTTTTCCTCTTCAGTGGGGAATGTTTGGAGCAGC
TTTTGCAACAGGGCTAGCACCTATTATTAGTATGTGTATTTTAACAAGGCACTATATTAAAAAGAAAAACCACTTCCATT
TTCATAAGGCAAAATTATCAATAAAGCAGGTAACTTATATTTGTAGCTTAGGTTTATCCTCTTTTATCACAGAAATTGCT
TCTGGTATTATTCTTATTGTATTTAATTTACTTATATTAAATATTTCCGGAAATATAGGTGTGGCAGCCTATGGTATTGT
GGCTAATTTGGCTTTAGTTGCAACTTCTATTTTCACAGGCATTGCTCAAGGAACACAACCTTTATTGAGTGAAAATTTTG
GACAAGGGAATAATAAAAAAATTCTACAATTATTTAAATATGCAATCTATGCATCCCTTGTAGTTTCAGTTGTTTTATAT
TTTCTCGTTGTTATTTTTAATAATCAATTGGTAGAAATATTCAATAGAGATCATATAAAAATTCTCTCAAAAACTGCATC
TGATGGGTTGATTATTTATTTCGCTGGTTTCTTCTTTGCAGGAATTAATATTATTACATCCGCTGTATTAAGTTCTATAA
ATGAACCAAAATATGCTTTCACCATTTCAATTTTACGTAGCGGTTGTATTATTGTTCCTGTAGCTTTATTTCTATCTTAT
TTATTTAAAATGACTGGAATATGGCTAAGTTTTCCTTTGTCAGAAATAATAACACTAATTTTAGGAGTATTCCTTGCTAA
GAAATCCTTAAAAAGATTACGAGAAAACACATAG

Upstream 100 bases:

>100_bases
GGGTAACTCATTTCATAGTACTTAACTTTATTCCTTTAGGTCTTAGTAGGAATAAATGTTAGGTATTTTTTTATGTTTAT
TTTTAGGAGGAATCACGAAA

Downstream 100 bases:

>100_bases
GTTCAAAATCAAAATAACTCAAAATTATCAAAACTAACCATCATTATAACTGTGATAATGATGGTTAGTTTTGTTTTTAT
TTTACATAGATTTCATCTAC

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSIKNTFMRYILTNIIGMIGLSCYILADTFFVSKGLGVQGLTALNLSISIYSFINATGLLIGIGGATKYSIYQARNKHNK
ANIVFTNSIKIGVICGIIFLLIGLLASSSLSSLLGADENIFRMTNTYLKTLLCFAPFFILNNIFIAFIRNDGNPKLSMAG
MLIGSLSNIILDYVFIFPLQWGMFGAAFATGLAPIISMCILTRHYIKKKNHFHFHKAKLSIKQVTYICSLGLSSFITEIA
SGIILIVFNLLILNISGNIGVAAYGIVANLALVATSIFTGIAQGTQPLLSENFGQGNNKKILQLFKYAIYASLVVSVVLY
FLVVIFNNQLVEIFNRDHIKILSKTASDGLIIYFAGFFFAGINIITSAVLSSINEPKYAFTISILRSGCIIVPVALFLSY
LFKMTGIWLSFPLSEIITLILGVFLAKKSLKRLRENT

Sequences:

>Translated_437_residues
MSIKNTFMRYILTNIIGMIGLSCYILADTFFVSKGLGVQGLTALNLSISIYSFINATGLLIGIGGATKYSIYQARNKHNK
ANIVFTNSIKIGVICGIIFLLIGLLASSSLSSLLGADENIFRMTNTYLKTLLCFAPFFILNNIFIAFIRNDGNPKLSMAG
MLIGSLSNIILDYVFIFPLQWGMFGAAFATGLAPIISMCILTRHYIKKKNHFHFHKAKLSIKQVTYICSLGLSSFITEIA
SGIILIVFNLLILNISGNIGVAAYGIVANLALVATSIFTGIAQGTQPLLSENFGQGNNKKILQLFKYAIYASLVVSVVLY
FLVVIFNNQLVEIFNRDHIKILSKTASDGLIIYFAGFFFAGINIITSAVLSSINEPKYAFTISILRSGCIIVPVALFLSY
LFKMTGIWLSFPLSEIITLILGVFLAKKSLKRLRENT
>Mature_436_residues
SIKNTFMRYILTNIIGMIGLSCYILADTFFVSKGLGVQGLTALNLSISIYSFINATGLLIGIGGATKYSIYQARNKHNKA
NIVFTNSIKIGVICGIIFLLIGLLASSSLSSLLGADENIFRMTNTYLKTLLCFAPFFILNNIFIAFIRNDGNPKLSMAGM
LIGSLSNIILDYVFIFPLQWGMFGAAFATGLAPIISMCILTRHYIKKKNHFHFHKAKLSIKQVTYICSLGLSSFITEIAS
GIILIVFNLLILNISGNIGVAAYGIVANLALVATSIFTGIAQGTQPLLSENFGQGNNKKILQLFKYAIYASLVVSVVLYF
LVVIFNNQLVEIFNRDHIKILSKTASDGLIIYFAGFFFAGINIITSAVLSSINEPKYAFTISILRSGCIIVPVALFLSYL
FKMTGIWLSFPLSEIITLILGVFLAKKSLKRLRENT

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47940; Mature: 47809

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKNTFMRYILTNIIGMIGLSCYILADTFFVSKGLGVQGLTALNLSISIYSFINATGLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCEEE
IGIGGATKYSIYQARNKHNKANIVFTNSIKIGVICGIIFLLIGLLASSSLSSLLGADENI
EECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FRMTNTYLKTLLCFAPFFILNNIFIAFIRNDGNPKLSMAGMLIGSLSNIILDYVFIFPLQ
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WGMFGAAFATGLAPIISMCILTRHYIKKKNHFHFHKAKLSIKQVTYICSLGLSSFITEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SGIILIVFNLLILNISGNIGVAAYGIVANLALVATSIFTGIAQGTQPLLSENFGQGNNKK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHH
ILQLFKYAIYASLVVSVVLYFLVVIFNNQLVEIFNRDHIKILSKTASDGLIIYFAGFFFA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHH
GINIITSAVLSSINEPKYAFTISILRSGCIIVPVALFLSYLFKMTGIWLSFPLSEIITLI
HHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LGVFLAKKSLKRLRENT
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIKNTFMRYILTNIIGMIGLSCYILADTFFVSKGLGVQGLTALNLSISIYSFINATGLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCEEE
IGIGGATKYSIYQARNKHNKANIVFTNSIKIGVICGIIFLLIGLLASSSLSSLLGADENI
EECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FRMTNTYLKTLLCFAPFFILNNIFIAFIRNDGNPKLSMAGMLIGSLSNIILDYVFIFPLQ
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WGMFGAAFATGLAPIISMCILTRHYIKKKNHFHFHKAKLSIKQVTYICSLGLSSFITEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
SGIILIVFNLLILNISGNIGVAAYGIVANLALVATSIFTGIAQGTQPLLSENFGQGNNKK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHH
ILQLFKYAIYASLVVSVVLYFLVVIFNNQLVEIFNRDHIKILSKTASDGLIIYFAGFFFA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHH
GINIITSAVLSSINEPKYAFTISILRSGCIIVPVALFLSYLFKMTGIWLSFPLSEIITLI
HHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LGVFLAKKSLKRLRENT
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA