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The map label for this gene is strD [H]

Identifier: 226949348

GI number: 226949348

Start: 2341663

End: 2342724

Strand: Direct

Name: strD [H]

Synonym: CLM_2271

Alternate gene names: 226949348

Gene position: 2341663-2342724 (Clockwise)

Preceding gene: 226949343

Following gene: 226949349

Centisome position: 56.35

GC content: 35.69

Gene sequence:

>1062_bases
ATGAAAGCTTTAATTTTAAGTGGTGGTACAGGTACAAGACTAAGGCCATTAACCTATACCAATGCAAAACAATTGTTGCC
TTTGGCGAATAAACCAATATTGTTTTATATCATTGAAAAGATTGTAAAAGCAGGAATATACGATATTGGCATTATTGTTG
GTGATACTCGTGAAGAGGTAAAAAAGATGGTGGGAAACGGAGACCGATGGGGTGTAAAAATTAGTTACTTATACCAACCT
GCGCCATTAGGCCTTGCCCATGCAGTTAAAACGGCATCAGAATTCTTAATGGAAGATGATTTTTTAATGGTGCTGGGAGA
TAACGTATTTAATATGGAACTGAATAAATTGATTGATAGCTTTTATTCAAATAATGCAAACTCAGCTTTATTGCTTCACA
AAGTTGAAAATCCTTCACAATATGGGGTTGCCGTAGTAGAAGACACCCTTATCATAAAGCTCGTTGAAAAGCCGAAGGAA
TTCGTTAGTGATTTGATAATAACAGGAGTATATATTTTTGATAAGAGCATTTTTATGGCTATCGATAATATTAAACCATC
CCAAAGAGGAGAGTTGGAAATAACCGATGCTATTCAAAAGCAGTTGGAAACAGGGGGAAGAGTCACATATGAGCTTATTC
AAGGCTGGTGGAAAGACACTGGGCAACTGCAGGATATTTTGGAGGCCAATAGGTTAATGCTTGATGACATTGATTGTGAG
TCCAAGACTTTACCTCAATCTAATTGTGTATTTATGGGAAAAATCCAAATTGGGAGAAATGTTATTATCGAAAACAGTAC
AATTATAGGGCCTGTTGCCATAGCAGATGATACAACTATTACAAATAGTTGTATAGGGCCTTATACCTCTATAGATAAAG
CGGTTACGGTTAATGACTGTGAGATTGATAATTGTATTATTCTTGAAAATGCCAAAATTGATGGCATACACAAAAGAATC
AGCGGCAGTCTCATTGGAAGAAAAGTTCAAATCAAAGAACTTCATAAGAGACCGTTTTCTCATACTTTCCTTTTAGGTGA
TGATAGTGAAATTGATCTTTAG

Upstream 100 bases:

>100_bases
TTTAATAGAAACTATTTATATGCACCATTATGATACTCGAGAATATTATGTAAATATAAGAAATACATTAAAGCGCCAGA
AGGTATAAAGGAGGTATAAC

Downstream 100 bases:

>100_bases
AGAAAATTAAATATAAATTCATGATTGGAGGAAGTTTTTAAATGAGAGTTTTACTTGTAACAGGCGGTGCAGGCTTTATT
GGCAGCAATTTTATACGATA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
APLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDDIDCE
SKTLPQSNCVFMGKIQIGRNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL

Sequences:

>Translated_353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
APLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDDIDCE
SKTLPQSNCVFMGKIQIGRNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
>Mature_353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
APLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDDIDCE
SKTLPQSNCVFMGKIQIGRNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=355, Percent_Identity=31.5492957746479, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=32.0588235294118, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI31881779, Length=368, Percent_Identity=24.7282608695652, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI45447090, Length=368, Percent_Identity=24.7282608695652, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=38.135593220339, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=35.0210970464135, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788355, Length=270, Percent_Identity=25.1851851851852, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=338, Percent_Identity=30.1775147928994, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17509979, Length=332, Percent_Identity=25.6024096385542, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509981, Length=319, Percent_Identity=24.7648902821317, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=359, Percent_Identity=30.6406685236769, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21355443, Length=340, Percent_Identity=30.2941176470588, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24644084, Length=340, Percent_Identity=30.2941176470588, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24653912, Length=369, Percent_Identity=24.9322493224932, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39264; Mature: 39264

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEV
CCEEEEECCCCCEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHH
KKMVGNGDRWGVKISYLYQPAPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDS
HHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHH
FYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKEFVSDLIITGVYIFDKSIFMA
HHCCCCCCEEEEEECCCCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHEECCEEEEE
IDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDDIDCE
EECCCCCCCCCEEHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHCCEEEECCCCC
SKTLPQSNCVFMGKIQIGRNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDC
CCCCCCCCCEEEEEEEECCEEEEECCEEEEEEEECCCCEECCCCCCCCCCCCCEEEECCC
EIDNCIILENAKIDGIHKRISGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
CCCCEEEEECCCCCHHHHHHHHHHHCCEEHHHHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEV
CCEEEEECCCCCEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHH
KKMVGNGDRWGVKISYLYQPAPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDS
HHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHH
FYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKEFVSDLIITGVYIFDKSIFMA
HHCCCCCCEEEEEECCCCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHEECCEEEEE
IDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDDIDCE
EECCCCCCCCCEEHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHCCEEEECCCCC
SKTLPQSNCVFMGKIQIGRNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDC
CCCCCCCCCEEEEEEEECCEEEEECCEEEEEEEECCCCEECCCCCCCCCCCCCEEEECCC
EIDNCIILENAKIDGIHKRISGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
CCCCEEEEECCCCCHHHHHHHHHHHCCEEHHHHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]