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The map label for this gene is mutL [H]

Identifier: 226949040

GI number: 226949040

Start: 2013965

End: 2015965

Strand: Reverse

Name: mutL [H]

Synonym: CLM_1956

Alternate gene names: 226949040

Gene position: 2015965-2013965 (Counterclockwise)

Preceding gene: 226949041

Following gene: 226949039

Centisome position: 48.52

GC content: 25.54

Gene sequence:

>2001_bases
ATGAGAAAAATAAACTTATTAGATTTAGAAACTACAAATAAAATAGCTGCAGGAGAAGTTATAGAAAGGCCCTTTTCTGT
AGTAAAAGAATTAGTAGAAAATAGTATAGACGCCGGTGCCAAAAATATAACCATAGAAATAGAAGATGGAGGACAAAATC
TTATAAAAATAATAGATGATGGAGAAGGTATTTATCCTATTGATATAAAAAATGCTTTTCTTCCTCATGCTACAAGTAAA
ATAAATTCTATAGAGGATATATACAAAATAAGTACTATGGGCTTTAGAGGTGAAGCACTAGCTAGCATTTCTTCCGTATC
AAAAACTAAACTTAAAAGTAGAGTTGACTCTTATAATTTTGGAAAAGAAATATATATAGAGGGTGGCAAAATAGAGTACT
TAAAAGATACAGGTTGCAATGTTGGCACTACTATAGAAGTTTCTGATTTATTTTATAATGTACCTGCAAGACTTAAATTT
TTGAAAAGTGCAAGAAGTGATAGTAGTTCTATATCAGATATTGTGAATAGGTTTATATTAGCCCATCCAGATATATCTTT
TAATTTAATAAATAAGGGAAAGCAAAGTATAAAGAGTTATGGTACCGGAAATTTAAAGGACTCTATACGATGTGTATACA
ATAAAACAATAAGTGAAAACCTTATAAACTTCGAAAGTCATAAAGATATAATATCTGTATATGGATTTATAGGTAAGCCT
GAAATAAGCCGTAAAAGCAGAACAAATCAAAGTATATTTGTAAATAAGCGATATGTTAAAAGTAAATTTATAACTGCTGC
AGTAGAAAATGCTTTTAAATCCTTTTTAACAGTAAATAGCTATCCTTTCTTTGTAATATTTATAGATATTTTTCCAGAAT
ATATTGATGTAAATGTACATCCTACTAAATCAGAAGTTAAATTTAAAGATGAGAGAGCTATGTTTAAAACTATATTTGAT
GCAGTTCATGAAGCTATAAAAGGAGAATTAAAAGAATCCTTTACAAACTTCTTTAATAAAGAAGATATTAATATGTATGA
TTCTGAAAAATCTATAGCTGAAACCATAAAACTAGAGAAAGAAGAAGTACAAATACCAATAGATTTAAATAGTAATAATA
AAATTGATATTTTTGGTAATAATATAAATAAACTACCTAACAATGCAGAACTTCTTAAAAATATAGGTATTAAAGAAAAA
AATACACTTGAAAATAATAATAATTTCTATACTTCTAAACAAAATGAAATATGCTATACTAATAAAAATGATGAATGTTT
AAATTCATGTAATAAAGATGACTATAGCAAAATAGAAAAGCCATTACAAAAAGATAATAAAAATCTAGATGCCTTATATC
TAAATGAGCACAATACAAATTCTTCACCTATAAATATTAAAGAAAATAAACCTAATAATTTTTATGTAGATATGAAAATA
ATAGGACAGTTTAATAATACATATATATTAATAGAAAAGGATAAAGAACTTTATATAATAGATCAACATGCGGCTCATGA
AAAAGTGTTATTTGAGAAATTCAAATCCGAAATAGAAAAGGGATATGTAATAAGTCAGATTTTATTATCTCCTGTAGTTA
TAGAACTTTCAGAAGATGAATTTAATATATACGAAGAAAACAAAGATATTTTTAAGAATTCAGGTTTTTCAGTGGAAACT
TTTGGAGAATGCACTATAAATATAAAAGAAGTACCTTTAATTCTAGGTAAACCCAATGTAGAAGATCTCTTTATGGATAT
ACTTTATAATTTAAAAAATATGAAATCTAAAGAAACCTCTACGATAAAATATAATGCCATTGCTACACTGGCATGCAAAT
CCGCAGTTAAAGCTAATGACAACTTAAAAGAAGAAGAAATAAAAAAATTAATAGAAAACATGCTTACATTAAATAATCCA
TATACTTGTCCCCATGGAAGACCTACTATGATTAAATTTACATTAAAAGATTTAGAAAAAAAATTTAAAAGAATACAATA
A

Upstream 100 bases:

>100_bases
TATATTAGTACATACAAAATCCTATAATTTTTATTGATCTAGTACCACTTATAAGTGGTGCTAACCTATATAATAAAATA
TAAGCTATGTGGTGATTTAG

Downstream 100 bases:

>100_bases
GGGGGATAAGCAAAATGATAGATTTATTAATAATTGCAGGTCCTACGGCAGTAGGGAAAACAGATATTTCCATAGAGCTT
GCAGAAAAACTAAATGGAGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQNLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINMYDSEKSIAETIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNAELLKNIGIKEK
NTLENNNNFYTSKQNEICYTNKNDECLNSCNKDDYSKIEKPLQKDNKNLDALYLNEHNTNSSPINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGECTINIKEVPLILGKPNVEDLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIENMLTLNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Sequences:

>Translated_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQNLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINMYDSEKSIAETIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNAELLKNIGIKEK
NTLENNNNFYTSKQNEICYTNKNDECLNSCNKDDYSKIEKPLQKDNKNLDALYLNEHNTNSSPINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGECTINIKEVPLILGKPNVEDLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIENMLTLNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ
>Mature_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQNLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINMYDSEKSIAETIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNAELLKNIGIKEK
NTLENNNNFYTSKQNEICYTNKNDECLNSCNKDDYSKIEKPLQKDNKNLDALYLNEHNTNSSPINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGECTINIKEVPLILGKPNVEDLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIENMLTLNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=33.9393939393939, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4505911, Length=355, Percent_Identity=28.4507042253521, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458898, Length=355, Percent_Identity=28.4507042253521, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=26.453488372093, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=26.453488372093, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI189458896, Length=348, Percent_Identity=28.735632183908, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=24.0802675585284, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI91992160, Length=468, Percent_Identity=25.8547008547009, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI91992162, Length=468, Percent_Identity=25.8547008547009, Blast_Score=93, Evalue=8e-19,
Organism=Escherichia coli, GI1790612, Length=336, Percent_Identity=38.6904761904762, Blast_Score=235, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=32.1875, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=28.2051282051282, Blast_Score=138, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=35.7357357357357, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=376, Percent_Identity=28.7234042553192, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=761, Percent_Identity=23.6530880420499, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=194, Percent_Identity=32.9896907216495, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=33.2335329341317, Blast_Score=195, Evalue=9e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.2100840336134, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76079; Mature: 76079

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQNLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHEE
AHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
ECCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHCCEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINMYDSEKSIAETIKLEK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCH
EEVQIPIDLNSNNKIDIFGNNINKLPNNAELLKNIGIKEKNTLENNNNFYTSKQNEICYT
HHEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEE
NKNDECLNSCNKDDYSKIEKPLQKDNKNLDALYLNEHNTNSSPINIKENKPNNFYVDMKI
CCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGECTINIKEVPLILGKPNVEDLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCCEEECCCEEEEEEECEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIENMLTLNNPYTCPHGRPTMIKFTLKDLEK
EEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC
>Mature Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQNLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHEE
AHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
ECCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHCCEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINMYDSEKSIAETIKLEK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCH
EEVQIPIDLNSNNKIDIFGNNINKLPNNAELLKNIGIKEKNTLENNNNFYTSKQNEICYT
HHEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEEE
NKNDECLNSCNKDDYSKIEKPLQKDNKNLDALYLNEHNTNSSPINIKENKPNNFYVDMKI
CCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGECTINIKEVPLILGKPNVEDLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCCEEECCCEEEEEEECEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIENMLTLNNPYTCPHGRPTMIKFTLKDLEK
EEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA