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The map label for this gene is mutS [H]

Identifier: 226948841

GI number: 226948841

Start: 1779614

End: 1781527

Strand: Direct

Name: mutS [H]

Synonym: CLM_1743

Alternate gene names: 226948841

Gene position: 1779614-1781527 (Clockwise)

Preceding gene: 226948840

Following gene: 226948842

Centisome position: 42.83

GC content: 24.87

Gene sequence:

>1914_bases
ATGTTAGAGGATAAATTTTTAACTAAAATAGAAGAGCAGGAAAAAAACGTTAAAGAATATAGTAATACCTATAGTATATT
AGGGACTTTAAGATTAATAGCTATGATAAGCCTTATATATTTTATTTATAAAGCTTTAAATTCAAATTTTTATAGTAAAT
ATTTAGGTTTATCTGTATTAATGGCAGGTATATTTGTAGTATTACTAATAAAGCATAGCAATATAAAAGATAAACTTAAA
TTTTCTAAAGAAATGATAAACATAAATAAAAGATATATAGATAGAATTAATGGACAATGGACAGAATTCCAGGATAAAGG
GGAAGAATTTATTTCAGAAGATCATCCTTATTCTGGGGATTTAGATATAGTAGGAAAAGAATCACTTTTTCAACTTATAA
ATACAACTAATACCAAAGATGGTAGAGATAATTTGGCAAAATTATTATTAGAGCCAAATAAAGAGAAAGATAACATAATT
TTGAATCAAAAAGCTATAGAGGAATTAGGAGAAAGACTAGATTTTTGCCAGAATCTAGAATATACAACAGGAAAGTATAA
AGAAAAGCTAAAAAGTACAGAAAAACTTATGGGATATATAAATGAAAATGGTGTTCTAATAAAAAGTAAAATAATAAAGA
GTGTATTGTATATAATACCATTAATTACAGTGCCTGTATCATTAGGTATAATTATATTGAGGCTTAGGAATCTATATATT
TTAGTAGGGATTTTAGGTATTATACAATGTTTAATTTGGATGTTAAAAGTTTTAAAAATTAATAATATCCTACAATCTAT
AGATAAACTTAAATACAATTTTCAAACTTATAGTAAGGTGCTAAAGTTAATAGAAAGGGAAGAGGTAAAGTGTGAAAGAT
TAAAAAGTATAAAGGAATTACTTTTTAATGAAAAGGAAAATTCTATTAAAGCTATAAAAGAATTAAATATAATTTCAGAA
AAAGTTAATTTAAGGTATGGTGGTAATGGTATTTTATATATAGTTTTAAATATACTTTTCCTTTGGGATTATCAATGTGT
TTTTTCTTTAGAAACTTGGAAATTTAAATATGGCGATAAAATAGAAAAATGGCTAAATGGCATAGGAGAAGTAGAAAGTC
TTGCAAGTCTAGCTGTTTTAACTCATATAAATGACAAAATTTCTTTCCCTAATATATATGATTCTAATGAAAAAACAAGT
TTAAATAAAAATATTCAGTTTAATAGTTTAGATAAGGGGAATTTCAAATCTCAAGAAGGTAGTTATCCAAATTTAAAATC
ACAACATAGTGAAGATTTAAAGATAGAATGTAAAAACATAGGGCACCCTTTAATTAACATGAAGGATAGAGTGTGCAATG
ATTTAACTATGAAAAATAATATTCTTCTTATAACTGGATCTAATATGTCAGGAAAAACAACCTTTTTAAGAACATTAGGA
ATTAATTTAGTTTTAGCCTATAGTGGAGCACCAGTGTGTGCAAAAGAGATGAATTCTTCCCTTATGGATATATATACTTC
TATGAGGATAACAGATGATCTAAAGGGTGGTATATCTACATTTTATAGGGAACTTATAAAAATTAAATATATAATTAACC
ATTCAAAAAATAAAACCCCTATGATTTTCTTAATAGATGAAATATTTAGAGGAACAAACTCTAAGGATAGATACATAGGA
GCTAAAAATGTACTTCTTAACCTAAATAAATCTTGGATAATAGGAGCATTAACTACTCATGATTTAGAGCTTTGTGCTTT
AGATAAAGATAAAAGAATAAAAAATTATCATTTCTCAGAATACTATAAGAATAATGAAATATATTTTGACTATAAAATAA
AAGAAGGACAATCTACCACAACTAATGCTAAATATCTTATGAATATGGTAGGTATAAAGATTTTAGAAGAATAA

Upstream 100 bases:

>100_bases
TAAATGGAGTAAATAAAATAAAAAATATAAGATCAAATGTAATTTGTGATACAAGAGTTAAAAAAGATAAATAATTCGAT
AATTAAAAAGGAGGGTTTTA

Downstream 100 bases:

>100_bases
AATAAACAAATAAGGTGTTTTAAAATATATTAATATTAGATTTAATCTTAATGTAGAAAATACACTTCATAAGTTTAGCA
GTATGCTTATGAAGTGTATT

Product: mutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MLEDKFLTKIEEQEKNVKEYSNTYSILGTLRLIAMISLIYFIYKALNSNFYSKYLGLSVLMAGIFVVLLIKHSNIKDKLK
FSKEMININKRYIDRINGQWTEFQDKGEEFISEDHPYSGDLDIVGKESLFQLINTTNTKDGRDNLAKLLLEPNKEKDNII
LNQKAIEELGERLDFCQNLEYTTGKYKEKLKSTEKLMGYINENGVLIKSKIIKSVLYIIPLITVPVSLGIIILRLRNLYI
LVGILGIIQCLIWMLKVLKINNILQSIDKLKYNFQTYSKVLKLIEREEVKCERLKSIKELLFNEKENSIKAIKELNIISE
KVNLRYGGNGILYIVLNILFLWDYQCVFSLETWKFKYGDKIEKWLNGIGEVESLASLAVLTHINDKISFPNIYDSNEKTS
LNKNIQFNSLDKGNFKSQEGSYPNLKSQHSEDLKIECKNIGHPLINMKDRVCNDLTMKNNILLITGSNMSGKTTFLRTLG
INLVLAYSGAPVCAKEMNSSLMDIYTSMRITDDLKGGISTFYRELIKIKYIINHSKNKTPMIFLIDEIFRGTNSKDRYIG
AKNVLLNLNKSWIIGALTTHDLELCALDKDKRIKNYHFSEYYKNNEIYFDYKIKEGQSTTTNAKYLMNMVGIKILEE

Sequences:

>Translated_637_residues
MLEDKFLTKIEEQEKNVKEYSNTYSILGTLRLIAMISLIYFIYKALNSNFYSKYLGLSVLMAGIFVVLLIKHSNIKDKLK
FSKEMININKRYIDRINGQWTEFQDKGEEFISEDHPYSGDLDIVGKESLFQLINTTNTKDGRDNLAKLLLEPNKEKDNII
LNQKAIEELGERLDFCQNLEYTTGKYKEKLKSTEKLMGYINENGVLIKSKIIKSVLYIIPLITVPVSLGIIILRLRNLYI
LVGILGIIQCLIWMLKVLKINNILQSIDKLKYNFQTYSKVLKLIEREEVKCERLKSIKELLFNEKENSIKAIKELNIISE
KVNLRYGGNGILYIVLNILFLWDYQCVFSLETWKFKYGDKIEKWLNGIGEVESLASLAVLTHINDKISFPNIYDSNEKTS
LNKNIQFNSLDKGNFKSQEGSYPNLKSQHSEDLKIECKNIGHPLINMKDRVCNDLTMKNNILLITGSNMSGKTTFLRTLG
INLVLAYSGAPVCAKEMNSSLMDIYTSMRITDDLKGGISTFYRELIKIKYIINHSKNKTPMIFLIDEIFRGTNSKDRYIG
AKNVLLNLNKSWIIGALTTHDLELCALDKDKRIKNYHFSEYYKNNEIYFDYKIKEGQSTTTNAKYLMNMVGIKILEE
>Mature_637_residues
MLEDKFLTKIEEQEKNVKEYSNTYSILGTLRLIAMISLIYFIYKALNSNFYSKYLGLSVLMAGIFVVLLIKHSNIKDKLK
FSKEMININKRYIDRINGQWTEFQDKGEEFISEDHPYSGDLDIVGKESLFQLINTTNTKDGRDNLAKLLLEPNKEKDNII
LNQKAIEELGERLDFCQNLEYTTGKYKEKLKSTEKLMGYINENGVLIKSKIIKSVLYIIPLITVPVSLGIIILRLRNLYI
LVGILGIIQCLIWMLKVLKINNILQSIDKLKYNFQTYSKVLKLIEREEVKCERLKSIKELLFNEKENSIKAIKELNIISE
KVNLRYGGNGILYIVLNILFLWDYQCVFSLETWKFKYGDKIEKWLNGIGEVESLASLAVLTHINDKISFPNIYDSNEKTS
LNKNIQFNSLDKGNFKSQEGSYPNLKSQHSEDLKIECKNIGHPLINMKDRVCNDLTMKNNILLITGSNMSGKTTFLRTLG
INLVLAYSGAPVCAKEMNSSLMDIYTSMRITDDLKGGISTFYRELIKIKYIINHSKNKTPMIFLIDEIFRGTNSKDRYIG
AKNVLLNLNKSWIIGALTTHDLELCALDKDKRIKNYHFSEYYKNNEIYFDYKIKEGQSTTTNAKYLMNMVGIKILEE

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=192, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI284813531, Length=213, Percent_Identity=28.169014084507, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789089, Length=227, Percent_Identity=27.3127753303965, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=218, Percent_Identity=29.3577981651376, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=286, Percent_Identity=25.5244755244755, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=208, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=217, Percent_Identity=30.4147465437788, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=189, Percent_Identity=28.042328042328, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24584320, Length=203, Percent_Identity=26.6009852216749, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664545, Length=207, Percent_Identity=30.9178743961353, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 73624; Mature: 73624

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDKFLTKIEEQEKNVKEYSNTYSILGTLRLIAMISLIYFIYKALNSNFYSKYLGLSVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MAGIFVVLLIKHSNIKDKLKFSKEMININKRYIDRINGQWTEFQDKGEEFISEDHPYSGD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
LDIVGKESLFQLINTTNTKDGRDNLAKLLLEPNKEKDNIILNQKAIEELGERLDFCQNLE
EEECCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHCCC
YTTGKYKEKLKSTEKLMGYINENGVLIKSKIIKSVLYIIPLITVPVSLGIIILRLRNLYI
CCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGILGIIQCLIWMLKVLKINNILQSIDKLKYNFQTYSKVLKLIEREEVKCERLKSIKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFNEKENSIKAIKELNIISEKVNLRYGGNGILYIVLNILFLWDYQCVFSLETWKFKYGDK
HHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCHHEEEEEHEEECCCHH
IEKWLNGIGEVESLASLAVLTHINDKISFPNIYDSNEKTSLNKNIQFNSLDKGNFKSQEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCC
SYPNLKSQHSEDLKIECKNIGHPLINMKDRVCNDLTMKNNILLITGSNMSGKTTFLRTLG
CCCCCCCCCCCCCEEEHHHCCCCCCCCHHHHHCCCEECCCEEEEECCCCCCCHHHHHHHC
INLVLAYSGAPVCAKEMNSSLMDIYTSMRITDDLKGGISTFYRELIKIKYIINHSKNKTP
CEEEEEECCCCHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEECCCCCCC
MIFLIDEIFRGTNSKDRYIGAKNVLLNLNKSWIIGALTTHDLELCALDKDKRIKNYHFSE
EEEEEHHHHCCCCCCCCEECCCHHEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCHHH
YYKNNEIYFDYKIKEGQSTTTNAKYLMNMVGIKILEE
HHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEDKFLTKIEEQEKNVKEYSNTYSILGTLRLIAMISLIYFIYKALNSNFYSKYLGLSVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MAGIFVVLLIKHSNIKDKLKFSKEMININKRYIDRINGQWTEFQDKGEEFISEDHPYSGD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
LDIVGKESLFQLINTTNTKDGRDNLAKLLLEPNKEKDNIILNQKAIEELGERLDFCQNLE
EEECCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHCCC
YTTGKYKEKLKSTEKLMGYINENGVLIKSKIIKSVLYIIPLITVPVSLGIIILRLRNLYI
CCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGILGIIQCLIWMLKVLKINNILQSIDKLKYNFQTYSKVLKLIEREEVKCERLKSIKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFNEKENSIKAIKELNIISEKVNLRYGGNGILYIVLNILFLWDYQCVFSLETWKFKYGDK
HHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCHHEEEEEHEEECCCHH
IEKWLNGIGEVESLASLAVLTHINDKISFPNIYDSNEKTSLNKNIQFNSLDKGNFKSQEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCC
SYPNLKSQHSEDLKIECKNIGHPLINMKDRVCNDLTMKNNILLITGSNMSGKTTFLRTLG
CCCCCCCCCCCCCEEEHHHCCCCCCCCHHHHHCCCEECCCEEEEECCCCCCCHHHHHHHC
INLVLAYSGAPVCAKEMNSSLMDIYTSMRITDDLKGGISTFYRELIKIKYIINHSKNKTP
CEEEEEECCCCHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEECCCCCCC
MIFLIDEIFRGTNSKDRYIGAKNVLLNLNKSWIIGALTTHDLELCALDKDKRIKNYHFSE
EEEEEHHHHCCCCCCCCEECCCHHEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCHHH
YYKNNEIYFDYKIKEGQSTTTNAKYLMNMVGIKILEE
HHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]