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The map label for this gene is npr [H]

Identifier: 226948705

GI number: 226948705

Start: 1671777

End: 1673495

Strand: Reverse

Name: npr [H]

Synonym: CLM_1605

Alternate gene names: 226948705

Gene position: 1673495-1671777 (Counterclockwise)

Preceding gene: 226948706

Following gene: 226948702

Centisome position: 40.27

GC content: 29.09

Gene sequence:

>1719_bases
ATGAAAAGTAAAAAATTATTAACTATACTTTTAAGTGCTATAATAACAGCTTCATCAATTTCATCAGCTTACGCTGCAGA
ACCCGTAGGAATAAAAAGTAAATACCAACCAAAAACTACCACTATATTTTGGGAAAAAGGTAAACAAAATAATAAGAAAT
CTGCCACTAATATAGCTTCAGAAAAATTCAACAATTTCGAAGAAATAAACCAGTTCTTTCAACAAAATATATCTAGGTTT
GGTTTAAAAAAAGGCTCTCTTAAAAGTACCAAAACTTTAAAGGATGAAAAAGGGAAAACCCACTATCATACAATTTATCA
AGTGGAGGGTATATCTGTATACTATGGAAGAATTGTTTTTACTACTGAAAAAGATTCCACTATAAGCTCTATAAATGGTG
GAGTAGATATTTCCTTTGAAAATGAGAATTGGAAAAACAAAATTAAACTATCAAAAAGTGATGCTATAGCAAAAGCTAAA
AATAACATCAAATATGAAGAGTTACACGATTCAAAGGCAGACTTATATTTATATAATTTTGAAGGAAAACCTTATGTTGT
CTATTTAGTAGATTTAAGCACAGATACTGGAGATTGGAATGTTTTTGTTAATGCTGAAGATGGTTCTATAGTAAATAAAT
TTAATAATACCCCTACTCTAACTAATACTAGGGATAAGAAATTCACCAGTACTAAAAAAACTAATACTAAAGTTAATAAT
GTAGTTGATGTTCAAGGTAATACCATTAAAGGAAAAGGTAAAAGCTCCTTAAATGGAATAGTAGATATTGATCTAACTTA
TAAAGATGGAAAATATTATTTAAAAAATAGCAATAAAAATATTTATGTCTATGATCTAAATAATAAATATATAAACACTT
TTACTACCCCTAAATCTTCTATATTAAAGGCTTCTAAGCTTGTAGAAAATAATAGTAACGAATTTATAGATGATAAACAT
ATAATTGCTGTAGATGCTTATATAAACTTAGAGAAGACTTATGATTATTACAAAAATAAATTTAATAGAAATAGTATTGA
TAATAAAGGTATGAACGTTGAAGCCTTTATTCATCATGGTGAGAAATATGCGGGTGCTGAGTGGAGCGAAAATCTTGGTT
CCATGCTTTTAGGGGATGGTGATGGAAGAAATAGTTCTCATATGTCAAAGGCTTTAGATGTTGTAGGTCATGAGTTTAGT
CATGGTGTAACACGTAAAGAATCTAATCTTAAATATGAAAATGAATCCGGAGCTTTAAATGAATCCTTTTCAGATATTAT
GGGAATAGCCATTAAAGGTAAAAACTTTAAATTAGGTGAAGACTGCTGGACACCAGATATTGAGGGAGATGCAATAAGAG
ATATGCAAGATCCATCTAAAGGATACCAGCCAGCTCATATGAAAGATTATAGATCTATGGATATACGCTATGACAATGGT
GGTGTTCATGTAAATTCAGGTATAATAAATCATGCAGCTTACCTAATTGCAGACGGAATAGAAAAATTAGGGGTAGAAAA
TAGTAAAGATATTATGGCAAAATTATTTTATACAGCTAATTGCTATGAATGGGATGAGACAACAAATTTCTCTAAATGTA
GAAATGACTTAATTAAAGTTACTAAAAACCTTTACGGTGAAAATAGTAAATATGTTCAAATTGTAGAAAATGCTTTTGAC
AAAGTTGGAATAACTGCTACACCTCAATTACCATTATAA

Upstream 100 bases:

>100_bases
ACTATATAAAAAGCTGAATTTAAATAAATAAGATGATTTCTACCTAAGTAAGAAATCATCTTATTTATATATAATAATTA
TATTGGGGGTTAAGATATTT

Downstream 100 bases:

>100_bases
TAAAATCCTATTAAACCTATAAATATAACTATGTAAAAAACTGAATTTAAATAAATAAGATGATTTCTTATTTGCATAGA
AATCATCTTATTTATATATA

Product: thermolysin metallopeptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKSKKLLTILLSAIITASSISSAYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKTHYHTIYQVEGISVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKSDAIAKAK
NNIKYEELHDSKADLYLYNFEGKPYVVYLVDLSTDTGDWNVFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNN
VVDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVYDLNNKYINTFTTPKSSILKASKLVENNSNEFIDDKH
IIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFIHHGEKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGHEFS
HGVTRKESNLKYENESGALNESFSDIMGIAIKGKNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSMDIRYDNG
GVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAFD
KVGITATPQLPL

Sequences:

>Translated_572_residues
MKSKKLLTILLSAIITASSISSAYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKTHYHTIYQVEGISVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKSDAIAKAK
NNIKYEELHDSKADLYLYNFEGKPYVVYLVDLSTDTGDWNVFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNN
VVDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVYDLNNKYINTFTTPKSSILKASKLVENNSNEFIDDKH
IIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFIHHGEKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGHEFS
HGVTRKESNLKYENESGALNESFSDIMGIAIKGKNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSMDIRYDNG
GVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAFD
KVGITATPQLPL
>Mature_572_residues
MKSKKLLTILLSAIITASSISSAYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSATNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKTHYHTIYQVEGISVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKSDAIAKAK
NNIKYEELHDSKADLYLYNFEGKPYVVYLVDLSTDTGDWNVFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNN
VVDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVYDLNNKYINTFTTPKSSILKASKLVENNSNEFIDDKH
IIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFIHHGEKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGHEFS
HGVTRKESNLKYENESGALNESFSDIMGIAIKGKNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSMDIRYDNG
GVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAFD
KVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 64469; Mature: 64469

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLTILLSAIITASSISSAYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSATNIAS
CCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHH
EKFNNFEEINQFFQQNISRFGLKKGSLKSTKTLKDEKGKTHYHTIYQVEGISVYYGRIVF
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECEEEEEEEEEE
TTEKDSTISSINGGVDISFENENWKNKIKLSKSDAIAKAKNNIKYEELHDSKADLYLYNF
EECCCCCHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHCCCCHHHHCCCCCCEEEEEE
EGKPYVVYLVDLSTDTGDWNVFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNN
CCCEEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVYDLNNKYINTFTTPKSS
EEEECCCEEECCCCCCCCCEEEEEEEEECCEEEEECCCCEEEEEECCCCEEEEECCCHHH
ILKASKLVENNSNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFIHHG
HHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEECC
EKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGHEFSHGVTRKESNLKYENESGALN
CCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCC
ESFSDIMGIAIKGKNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSMDIRYDNG
CCHHHHEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCCCEEEEECCC
GVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKV
CEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCEEECCCCCCHHHHHHHHHHH
TKNLYGENSKYVQIVENAFDKVGITATPQLPL
HHHHCCCCCCEEHEEHHHHHHCCCEECCCCCC
>Mature Secondary Structure
MKSKKLLTILLSAIITASSISSAYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSATNIAS
CCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHH
EKFNNFEEINQFFQQNISRFGLKKGSLKSTKTLKDEKGKTHYHTIYQVEGISVYYGRIVF
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECEEEEEEEEEE
TTEKDSTISSINGGVDISFENENWKNKIKLSKSDAIAKAKNNIKYEELHDSKADLYLYNF
EECCCCCHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHCCCCHHHHCCCCCCEEEEEE
EGKPYVVYLVDLSTDTGDWNVFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNN
CCCEEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYVYDLNNKYINTFTTPKSS
EEEECCCEEECCCCCCCCCEEEEEEEEECCEEEEECCCCEEEEEECCCCEEEEECCCHHH
ILKASKLVENNSNEFIDDKHIIAVDAYINLEKTYDYYKNKFNRNSIDNKGMNVEAFIHHG
HHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEECC
EKYAGAEWSENLGSMLLGDGDGRNSSHMSKALDVVGHEFSHGVTRKESNLKYENESGALN
CCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCC
ESFSDIMGIAIKGKNFKLGEDCWTPDIEGDAIRDMQDPSKGYQPAHMKDYRSMDIRYDNG
CCHHHHEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCCCEEEEECCC
GVHVNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKV
CEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCEEECCCCCCHHHHHHHHHHH
TKNLYGENSKYVQIVENAFDKVGITATPQLPL
HHHHCCCCCCEEHEEHHHHHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]