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The map label for this gene is gap [H]

Identifier: 226948370

GI number: 226948370

Start: 1306492

End: 1307508

Strand: Direct

Name: gap [H]

Synonym: CLM_1253

Alternate gene names: 226948370

Gene position: 1306492-1307508 (Clockwise)

Preceding gene: 226948368

Following gene: 226948372

Centisome position: 31.44

GC content: 31.96

Gene sequence:

>1017_bases
ATGGGTATAAAAGTTGGACTAAATGGTTTTGGAAGAATAGGAAGAGCAGTATTAAGAATAGCACAGGACAAGTTCCCAGA
AGATGTAGAAATAGTAGCATTAAATGCGAGAGCCACTACTGAAACATTAGTACATCTATTTAAATACGACTCCTGCTACG
GAAGATTTAATGGACAAGTGGAAATAATTTCTAATGATAAAATGAGAGTAAATGGAAAAGAAATAAAAATATTTAGAGAA
AATGATCCTCAAAATTTACCGTGGAAAGAACTTGGAGTAGATATAGTTATAGAATCTACAGGAATATTTAAAGATAGAGA
AAAAGCTATGAAGCATATAGAAGCTGGAGCTAAAAAAGTTATAATAACAGCACCAGGAAAAAATGAAGATATAACTATAG
TTTTAGGAGTAAATGAAAATGAATATAATCCAGAAGAGCATAATATAATTTCAAATGCATCTTGTACTACAAATTGTTTA
GCTCCTTTTGCTAAAGTACTTGACGATAATTTTGGTATAGTTAGAGGTTTAATGACAACAGTACATTCTTATACAAATGA
CCAAAGAATATTAGATAAAACTCATAAAGATTTAAGAAGGGCAAGAGCTGCAGGAGAATCAATAATACCAACTACTACAG
GAGCTGCAAAGGCAGTAGCTAAAGTATTACCTAGTCTTAAAGGTAAATTAAATGGATTTGCTTTAAGAGTTCCGACCCCA
ACAGTATCTTTAACAGATTTAGTTTGTGAATTAAAAACTAAAGTAACTGCTGAAGAAATTAATGCAGCGTTTAAAAAAGC
AGCAGAGGGCGAAATGAATGGTGTTCTAGGATATTCAGAAGAACCACTAGTTTCAGTAGATTACAAGGGAGATCCAAGAT
CCTCTATAGTGGATGGATTATCTACTATGGTTTTAGAAGACGACATGGTTAAAGTTGTGTCTTGGTATGATAATGAATGG
GGATACTCATGTAGAACTGTAGATTTAGTTAATTATGTAGCTAAATTTATGAAATAA

Upstream 100 bases:

>100_bases
ATATAATAAGGAATCATACAACACATATATTAATTTAATGAATTATAAATAAAGTATTTTAAAGATTATTTAAATAATAT
ATTAATAGGGGGAAAAAACA

Downstream 100 bases:

>100_bases
AAATAATTAATTAGCTTATATAAATTAATTATATATGAATTAATTTTATATATAAGTACCTCTTTTATAAAATAATTATT
TATATTTATAATAACTTTAG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MGIKVGLNGFGRIGRAVLRIAQDKFPEDVEIVALNARATTETLVHLFKYDSCYGRFNGQVEIISNDKMRVNGKEIKIFRE
NDPQNLPWKELGVDIVIESTGIFKDREKAMKHIEAGAKKVIITAPGKNEDITIVLGVNENEYNPEEHNIISNASCTTNCL
APFAKVLDDNFGIVRGLMTTVHSYTNDQRILDKTHKDLRRARAAGESIIPTTTGAAKAVAKVLPSLKGKLNGFALRVPTP
TVSLTDLVCELKTKVTAEEINAAFKKAAEGEMNGVLGYSEEPLVSVDYKGDPRSSIVDGLSTMVLEDDMVKVVSWYDNEW
GYSCRTVDLVNYVAKFMK

Sequences:

>Translated_338_residues
MGIKVGLNGFGRIGRAVLRIAQDKFPEDVEIVALNARATTETLVHLFKYDSCYGRFNGQVEIISNDKMRVNGKEIKIFRE
NDPQNLPWKELGVDIVIESTGIFKDREKAMKHIEAGAKKVIITAPGKNEDITIVLGVNENEYNPEEHNIISNASCTTNCL
APFAKVLDDNFGIVRGLMTTVHSYTNDQRILDKTHKDLRRARAAGESIIPTTTGAAKAVAKVLPSLKGKLNGFALRVPTP
TVSLTDLVCELKTKVTAEEINAAFKKAAEGEMNGVLGYSEEPLVSVDYKGDPRSSIVDGLSTMVLEDDMVKVVSWYDNEW
GYSCRTVDLVNYVAKFMK
>Mature_337_residues
GIKVGLNGFGRIGRAVLRIAQDKFPEDVEIVALNARATTETLVHLFKYDSCYGRFNGQVEIISNDKMRVNGKEIKIFREN
DPQNLPWKELGVDIVIESTGIFKDREKAMKHIEAGAKKVIITAPGKNEDITIVLGVNENEYNPEEHNIISNASCTTNCLA
PFAKVLDDNFGIVRGLMTTVHSYTNDQRILDKTHKDLRRARAAGESIIPTTTGAAKAVAKVLPSLKGKLNGFALRVPTPT
VSLTDLVCELKTKVTAEEINAAFKKAAEGEMNGVLGYSEEPLVSVDYKGDPRSSIVDGLSTMVLEDDMVKVVSWYDNEWG
YSCRTVDLVNYVAKFMK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=333, Percent_Identity=50.4504504504504, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=49.1017964071856, Blast_Score=315, Evalue=3e-86,
Organism=Escherichia coli, GI1788079, Length=336, Percent_Identity=53.2738095238095, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789295, Length=330, Percent_Identity=44.2424242424242, Blast_Score=303, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17534677, Length=336, Percent_Identity=49.1071428571429, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17534679, Length=336, Percent_Identity=49.4047619047619, Blast_Score=325, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI32566163, Length=336, Percent_Identity=49.1071428571429, Blast_Score=317, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI17568413, Length=336, Percent_Identity=49.1071428571429, Blast_Score=317, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6322468, Length=336, Percent_Identity=53.5714285714286, Blast_Score=345, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6321631, Length=336, Percent_Identity=53.8690476190476, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=51.4880952380952, Blast_Score=341, Evalue=7e-95,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=49.0963855421687, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=49.0963855421687, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=48.7951807228916, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=48.7951807228916, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=46.969696969697, Blast_Score=299, Evalue=2e-81,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 37331; Mature: 37200

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKVGLNGFGRIGRAVLRIAQDKFPEDVEIVALNARATTETLVHLFKYDSCYGRFNGQV
CCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCHHCCCCCEE
EIISNDKMRVNGKEIKIFRENDPQNLPWKELGVDIVIESTGIFKDREKAMKHIEAGAKKV
EEEECCEEEECCCEEEEEECCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEE
IITAPGKNEDITIVLGVNENEYNPEEHNIISNASCTTNCLAPFAKVLDDNFGIVRGLMTT
EEECCCCCCCEEEEEECCCCCCCCHHHCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VHSYTNDQRILDKTHKDLRRARAAGESIIPTTTGAAKAVAKVLPSLKGKLNGFALRVPTP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCC
TVSLTDLVCELKTKVTAEEINAAFKKAAEGEMNGVLGYSEEPLVSVDYKGDPRSSIVDGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHH
STMVLEDDMVKVVSWYDNEWGYSCRTVDLVNYVAKFMK
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCC
>Mature Secondary Structure 
GIKVGLNGFGRIGRAVLRIAQDKFPEDVEIVALNARATTETLVHLFKYDSCYGRFNGQV
CEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCHHCCCCCEE
EIISNDKMRVNGKEIKIFRENDPQNLPWKELGVDIVIESTGIFKDREKAMKHIEAGAKKV
EEEECCEEEECCCEEEEEECCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEE
IITAPGKNEDITIVLGVNENEYNPEEHNIISNASCTTNCLAPFAKVLDDNFGIVRGLMTT
EEECCCCCCCEEEEEECCCCCCCCHHHCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VHSYTNDQRILDKTHKDLRRARAAGESIIPTTTGAAKAVAKVLPSLKGKLNGFALRVPTP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCC
TVSLTDLVCELKTKVTAEEINAAFKKAAEGEMNGVLGYSEEPLVSVDYKGDPRSSIVDGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHH
STMVLEDDMVKVVSWYDNEWGYSCRTVDLVNYVAKFMK
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2684782; 2227448; 2656407; 7408868; 193030; 3586018; 9175858 [H]