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The map label for this gene is cqsS [H]

Identifier: 226948273

GI number: 226948273

Start: 1194775

End: 1195158

Strand: Direct

Name: cqsS [H]

Synonym: CLM_1153

Alternate gene names: 226948273

Gene position: 1194775-1195158 (Clockwise)

Preceding gene: 226948271

Following gene: 226948274

Centisome position: 28.75

GC content: 28.91

Gene sequence:

>384_bases
ATGAGTAGCTCACAAAAGAATATATTAGTTATTGATGATTCTGCAAGTATTAGAAGCTTTGTAAGAAATATCTTAGAGAA
AGCAAATTACAAGGTTTATGAAGCTTGTGACGGTGAAGAAGGTATTGAGGTATATAAAAAATGTGGGAACATTGATTTAG
TAATGACAGATATATATATGCCTAAAAAAAGTGGTTTAGAAGTGGTAGTAGAATTACAAAACAAATATAAAGGCACTCAA
ATAATTGTTTTTTCTGATGGGGGAAAGGAGAATTTTACTAATGATTCAGGAGTATGTGAAGCTCTTGGAGCAGCTTATTT
TATTAGGAAGGATCTAATCAAAGATAAGTTACTAGATTTAGTAAATATAATATTTTCAAAATAA

Upstream 100 bases:

>100_bases
TATTAATATTTAGTACAATTTTAATCTAATATTGGTATCTTTATTTTATTAATTTGCAATGGGAGATGCTTATTAATAAG
TGAGGGGGAGGTTATAAAAA

Downstream 100 bases:

>100_bases
TTATTATTAAAGTTATAGCTAGAATTATAGTATAATAAGGTTATTTTAAGTAACCTATAATATACACCTTTCATATAATG
CTGTTAAAAGCACTATAATG

Product: response regulator

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MSSSQKNILVIDDSASIRSFVRNILEKANYKVYEACDGEEGIEVYKKCGNIDLVMTDIYMPKKSGLEVVVELQNKYKGTQ
IIVFSDGGKENFTNDSGVCEALGAAYFIRKDLIKDKLLDLVNIIFSK

Sequences:

>Translated_127_residues
MSSSQKNILVIDDSASIRSFVRNILEKANYKVYEACDGEEGIEVYKKCGNIDLVMTDIYMPKKSGLEVVVELQNKYKGTQ
IIVFSDGGKENFTNDSGVCEALGAAYFIRKDLIKDKLLDLVNIIFSK
>Mature_126_residues
SSSQKNILVIDDSASIRSFVRNILEKANYKVYEACDGEEGIEVYKKCGNIDLVMTDIYMPKKSGLEVVVELQNKYKGTQI
IVFSDGGKENFTNDSGVCEALGAAYFIRKDLIKDKLLDLVNIIFSK

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 14214; Mature: 14082

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSQKNILVIDDSASIRSFVRNILEKANYKVYEACDGEEGIEVYKKCGNIDLVMTDIYM
CCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEEC
PKKSGLEVVVELQNKYKGTQIIVFSDGGKENFTNDSGVCEALGAAYFIRKDLIKDKLLDL
CCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VNIIFSK
HHHHHCC
>Mature Secondary Structure 
SSSQKNILVIDDSASIRSFVRNILEKANYKVYEACDGEEGIEVYKKCGNIDLVMTDIYM
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEEC
PKKSGLEVVVELQNKYKGTQIIVFSDGGKENFTNDSGVCEALGAAYFIRKDLIKDKLLDL
CCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VNIIFSK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]