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The map label for this gene is yjjG [H]

Identifier: 226948245

GI number: 226948245

Start: 1163032

End: 1163724

Strand: Reverse

Name: yjjG [H]

Synonym: CLM_1123

Alternate gene names: 226948245

Gene position: 1163724-1163032 (Counterclockwise)

Preceding gene: 226948246

Following gene: 226948243

Centisome position: 28.01

GC content: 25.69

Gene sequence:

>693_bases
ATGAAATATGAAGTTATATTATTTGATGCAGATGAAACATTATATGATTTTAAAAAATCTGAAAGAGAAGCATTTAAAAA
CACAATGCTTAAGTTTAACATAAACTATGATGAAAGTTATCATTTAAAAATTTATCAAGAAATAAATACAGTTCTATGGA
AAGAGTTTGAACAAGGACTTATCACACAAGAAAATTTAAAAGTAGAAAGATTTAAAAGATTATCAGATAGGTTAGAGGTA
AGTTTTGATGAAACTAACTTTGCAAAATTATATATGGAGTATTTAGCCGATGCATCATTCTTATATGATAATAGTATCGA
GCTTATAGAAACTCTAAACAAGTCTTACAGACTTGCTATAGTAACTAATGGTCTTACCTTAGTTCAAGATAAAAGAATCA
GAAGATCTACTATAGCAAAATTCTTTGAGACTATAGTAATATCTGAAGAAATATTAATATCAAAACCAAACCCTAAAATT
TTTGAATATGCTTTAAAAAATATAAAGCATACTGATAAAAGTAAAGTATTAATAGTAGGGGATAGCTTAACTTCTGATAT
ACAAGGTGGTATAAACTTTGGTATAGATACATGCTGGTATAACCCTAATAAAATTATAAATAAAACATCAATAAAACCTA
CCTATGAGATTTCTAATTTTGATGAGCTTAAGTCTTTGCTACTTAATCTATAA

Upstream 100 bases:

>100_bases
AGGTATTATACTTAATGCAAAATCTGATGAAAACTATAAGCAAAAGCAACTTAAATCACTTAGTAATTAAATTATTTATA
TAAATTTTGGAGGACATATT

Downstream 100 bases:

>100_bases
AAATTTTACATGAGTACTAGCACAAAAGGTATAGAATTAAATTTAGTTCTATACCTTTTTAAATATTTGTAAAAACCTCA
TTTATTTATGATACGGTTCA

Product: HAD superfamily hydrolase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKYEVILFDADETLYDFKKSEREAFKNTMLKFNINYDESYHLKIYQEINTVLWKEFEQGLITQENLKVERFKRLSDRLEV
SFDETNFAKLYMEYLADASFLYDNSIELIETLNKSYRLAIVTNGLTLVQDKRIRRSTIAKFFETIVISEEILISKPNPKI
FEYALKNIKHTDKSKVLIVGDSLTSDIQGGINFGIDTCWYNPNKIINKTSIKPTYEISNFDELKSLLLNL

Sequences:

>Translated_230_residues
MKYEVILFDADETLYDFKKSEREAFKNTMLKFNINYDESYHLKIYQEINTVLWKEFEQGLITQENLKVERFKRLSDRLEV
SFDETNFAKLYMEYLADASFLYDNSIELIETLNKSYRLAIVTNGLTLVQDKRIRRSTIAKFFETIVISEEILISKPNPKI
FEYALKNIKHTDKSKVLIVGDSLTSDIQGGINFGIDTCWYNPNKIINKTSIKPTYEISNFDELKSLLLNL
>Mature_230_residues
MKYEVILFDADETLYDFKKSEREAFKNTMLKFNINYDESYHLKIYQEINTVLWKEFEQGLITQENLKVERFKRLSDRLEV
SFDETNFAKLYMEYLADASFLYDNSIELIETLNKSYRLAIVTNGLTLVQDKRIRRSTIAKFFETIVISEEILISKPNPKI
FEYALKNIKHTDKSKVLIVGDSLTSDIQGGINFGIDTCWYNPNKIINKTSIKPTYEISNFDELKSLLLNL

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=122, Percent_Identity=36.0655737704918, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1790833, Length=228, Percent_Identity=34.6491228070175, Blast_Score=157, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 27040; Mature: 27040

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEVILFDADETLYDFKKSEREAFKNTMLKFNINYDESYHLKIYQEINTVLWKEFEQGL
CCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCC
ITQENLKVERFKRLSDRLEVSFDETNFAKLYMEYLADASFLYDNSIELIETLNKSYRLAI
CCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHCCCCEEEEE
VTNGLTLVQDKRIRRSTIAKFFETIVISEEILISKPNPKIFEYALKNIKHTDKSKVLIVG
EECCEEEEHHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCEEEEEE
DSLTSDIQGGINFGIDTCWYNPNKIINKTSIKPTYEISNFDELKSLLLNL
CCCCHHHCCCCCCCEEEEEECCCCCEECCCCCCEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MKYEVILFDADETLYDFKKSEREAFKNTMLKFNINYDESYHLKIYQEINTVLWKEFEQGL
CCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCC
ITQENLKVERFKRLSDRLEVSFDETNFAKLYMEYLADASFLYDNSIELIETLNKSYRLAI
CCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHCCCCEEEEE
VTNGLTLVQDKRIRRSTIAKFFETIVISEEILISKPNPKIFEYALKNIKHTDKSKVLIVG
EECCEEEEHHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCEEEEEE
DSLTSDIQGGINFGIDTCWYNPNKIINKTSIKPTYEISNFDELKSLLLNL
CCCCHHHCCCCCCCEEEEEECCCCCEECCCCCCEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]