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The map label for this gene is botA

Identifier: 226948036

GI number: 226948036

Start: 956218

End: 960108

Strand: Direct

Name: botA

Synonym: CLM_0897

Alternate gene names: 226948036

Gene position: 956218-960108 (Clockwise)

Preceding gene: 226948035

Following gene: 226948037

Centisome position: 23.01

GC content: 26.83

Gene sequence:

>3891_bases
ATGCCATTTGTTAATAAACAATTTAATTATAAAGATCCTGTAAATGGTGTTGATATTGCTTATATAAAAATTCCAAATGC
AGGACAAATGCAACCAGTAAAAGCTTTTAAAATTCATAATAAAATATGGGTTATTCCAGAAAGAGATACCTTTACAAACC
CTGAAGAAGGAGATTTAAATCCACCACCAGAAGCAAAACAAGTTCCAGTTTCATATTATGATTCAACATATTTAAGTACA
GATAATGAAAAAGATAATTATTTAAAGGGAGTTACAAAATTATTTGAGAGAATTTATTCAACTGATCTTGGAAGAATGTT
GTTAACATCAATAGTAAGGGGAATACCATTTTGGGGTGGAAGTACAATAGATACAGAATTAAAAGTTATTGATACTAATT
GTATTAATGTGATACAGCCAGATGGTAGTTATAGATCAGAAGAGCTTAATCTAGTAATAATAGGACCCTCAGCTGATATT
ATACAGTTTGAATGTAAAAGCTTTGGACATGATGTTTTGAATCTTACGCGAAATGGTTATGGCTCTACTCAATACATTAG
ATTTAGCCCAGATTTTACATTTGGTTTTGAGGAGTCACTTGAAGTTGATACAAATCCTCTTTTAGGTGCAGGCAAATTTG
CTACAGATCCAGCAGTAACATTAGCACATGAACTTATACATGCCGAACATAGATTATATGGAATAGCAATTAATCCAAAT
AGGGTTTTTAAAGTAAATACTAATGCCTATTATGAAATGAGTGGGTTAGAAGTAAGCTTTGAGGAACTTAGAACATTTGG
GGGACATGATGCAAAGTTTATAGATAGTTTACAGGAAAACGAATTTCGTCTATATTATTATAATAAGTTTAAAGATGTAG
CAAGTACACTTAATAAAGCTAAATCAATAATAGGTACTACTGCTTCATTACAGTATATGAAAAATGTTTTTAAAGAGAAA
TATCTCCTATCTGAAGATACATCTGGAAAATTTTCGGTAGATAAATTAAAATTTGATAAGTTATACAAAATGTTAACAGA
GATTTACACAGAGGATAATTTTGTTAATTTTTTTAAAGTAATTAACAGAAAAACATATTTGAATTTTGATAAAGCCGTAT
TTAGAATAAATATAGTACCTGATGAAAATTACACAATAAAGGATGGATTTAATTTAAAAGGTGCAAATTTATCAACAAAT
TTTAATGGTCAGAATACAGAAATTAATAGTAGGAATTTTACTAGATTAAAAAATTTTACAGGATTATTTGAATTTTATAA
GCTGCTATGTGTAAGAGGGATAATACCTTTTAAAACTAAATCATTAGATGAAGGATACAATAAGGCATTAAATGATTTAT
GTATCAAAGTTAATAATTGGGACTTGTTTTTTAGTCCTTCAGAAGATAATTTTACTAATGATTTAGATAAAGTAGAAGAA
ATTACAGCTGATACCAATATAGAAGCAGCAGAAGAAAATATTAGTTTAGATTTAATACAACAATATTATTTAACTTTTGA
TTTTGATAATGAACCTGAAAATATTTCAATAGAAAATCTTTCAAGTGATATTATAGGCCAATTAGAGCCTATGCCTAATA
TAGAAAGATTTCCTAATGGAAAAAAGTATGAGTTAGATAAATATACTATGTTCCATTATCTTCGTGCTCAAGAATTTGAA
CATGGTGATTCTAGAATTATCTTAACAAATTCTGCTGAAGAAGCATTATTAAAGCCTAATGTTGCTTATACATTTTTTTC
TTCAAAATATGTAAAGAAGATTAATAAAGCCGTAGAGGCATTTATGTTTTTAAATTGGGCAGAAGAGTTAGTATATGACT
TTACCGATGAAACTAATGAAGTAACTACTATGGATAAAATTGCTGATATAACTATAATTGTTCCATATATAGGGCCTGCT
TTAAATATAGGTAATATGTTATCTAAAGGAGAGTTTGTAGAAGCTATAATATTTACGGGAGTTGTTGCTATGTTAGAATT
TATACCAGAGTATGCTCTCCCTGTATTTGGTACTTTTGCAATTGTATCATATATTGCCAATAAGGTTCTAACTGTTCAAA
CAATAAATAATGCTTTAAGTAAAAGAAATGAAAAATGGGATGAAGTCTATAAATATACAGTAACAAATTGGCTAGCAAAG
GTTAATACACAGATTGATCTAATAAGGGAAAAAATGAAAAAAGCTTTAGAAAATCAGGCAGAAGCAACAAAGGCTATAAT
AAACTATCAGTATAATCAATATACTGAGGAAGAGAAAAATAATATTAATTTTAATATTGATGATTTAAGTTCGAAACTTA
ATGAGTCTATAAATAGCGCTATGATTAACATAAATAAATTTTTGGATCAATGCTCTGTTTCATATTTAATGAATTCTATG
ATACCTTATGCTGTTAAACGGTTAAAAGATTTTGATGCTAGTGTTAGAGATGTATTATTAAAGTATATATATGATAATAG
AGGAACTTTAGTTCTTCAAGTAGATAGATTAAAAGATGAAGTTAATAATACACTTAGTGCAGATATACCTTTTCAGCTTT
CCAAATACGTAGATAATAAAAAATTATTATCTACATTTACTGAATATATTAAGAATATTGTTAATACCTCTATATTGAGT
ATAGTATATAAAAAAGATGATTTAATAGATTTATCTAGGTATGGAGCAAAAATAAATATTGGCGATAGAGTATATTATGA
TTCAATAGATAAAAATCAAATTAAATTAATTAATTTAGAAAGTAGTACAATTGAGGTAATTTTAAAAAATGCTATTGTAT
ATAATAGTATGTATGAAAATTTTAGTACTAGCTTTTGGATAAAAATTCCTAAGTATTTTAGCAAGATAAATCTAAATAAT
GAATATACAATAATAAATTGTATAGAAAATAATTCAGGATGGAAAGTATCACTTAATTATGGTGAAATAATCTGGACTTT
GCAGGATAATAAGCAAAACATACAAAGAGTAGTTTTTAAATACAGTCAAATGGTTAATATATCAGATTATATAAACAGAT
GGATTTTTGTAACTATCACTAATAATAGACTAACTAAATCTAAAATTTATATAAATGGAAGATTAATAGATCAAAAACCA
ATTTCAAATTTAGGTAATATTCATGCTAGTAATAAGATAATGTTTAAATTAGATGGCTGTAGAGATCCACGTAGATACAT
CATGATAAAATATTTCAATCTTTTCGATAAAGAATTAAATGAAAAAGAAATCAAAGATTTATATGATAGTCAATCAAATT
CAGGTATTTTAAAAGACTTTTGGGGTAATTATTTACAATATGATAAACCATACTATATGTTAAATTTATTTGATCCAAAT
AAATATGTCGATGTAAATAATATAGGTATTAGAGGTTATATGTATCTTAAAGGGCCTAGAGGTAGCGTAGTGACTACAAA
CATTTATTTAAATTCAACTTTGTATGAGGGGACAAAATTTATTATAAAAAAATATGCTTCTGGAAATGAAGATAATATTG
TTAGAAATAATGATCGTGTATATATTAATGTAGTAGTTAAAAATAAAGAATATAGGTTAGCTACTAATGCATCACAGGCA
GGCGTAGAAAAAATACTAAGTGCATTAGAAATACCTGATGTAGGAAATCTAAGTCAAGTAGTAGTAATGAAGTCAAAAGA
TGATCAAGGAATAAGAAATAAATGCAAAATGAATTTACAAGATAATAATGGGAATGATATAGGCTTTATAGGATTTCATT
TGTATGATAATATAGCTAAACTAGTAGCAAGTAATTGGTATAATAGACAAGTGGGAAAAGCTAGTAGGACTTTCGGTTGT
TCATGGGAGTTTATTCCTGTAGATGATGGATGGGGAGAAAGTTCACTGTAA

Upstream 100 bases:

>100_bases
TGGATGATATGTAATAATGATATGTCAAAATATTTGTATTTATGGTCATTTAAATAATTAATAATTTAATTAATTTTAAA
TATTATAAGAGGTGTTAAAT

Downstream 100 bases:

>100_bases
TTAATCTCAAACTATATGAACCTGTCAAGAATTTTGTATAAACATTCATAAAAATTTTTAAATTAATATGTTTAAGAATA
ACTAGATATGAGTATTGCTA

Product: bontoxilysin A

Products: NA

Alternate protein names: BoNT/A; Bontoxilysin-A; BOTOX

Number of amino acids: Translated: 1296; Mature: 1295

Protein sequence:

>1296_residues
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLST
DNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADI
IQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEK
YLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTN
FNGQNTEINSRNFTRLKNFTGLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEE
ITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFE
HGDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEAFMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPA
LNIGNMLSKGEFVEAIIFTGVVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAK
VNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSAMININKFLDQCSVSYLMNSM
IPYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDEVNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILS
IVYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNN
EYTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTITNNRLTKSKIYINGRLIDQKP
ISNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELNEKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPN
KYVDVNNIGIRGYMYLKGPRGSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQA
GVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAKLVASNWYNRQVGKASRTFGC
SWEFIPVDDGWGESSL

Sequences:

>Translated_1296_residues
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLST
DNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADI
IQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEK
YLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTN
FNGQNTEINSRNFTRLKNFTGLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEE
ITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFE
HGDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEAFMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPA
LNIGNMLSKGEFVEAIIFTGVVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAK
VNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSAMININKFLDQCSVSYLMNSM
IPYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDEVNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILS
IVYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNN
EYTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTITNNRLTKSKIYINGRLIDQKP
ISNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELNEKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPN
KYVDVNNIGIRGYMYLKGPRGSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQA
GVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAKLVASNWYNRQVGKASRTFGC
SWEFIPVDDGWGESSL
>Mature_1295_residues
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTD
NEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADII
QFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNR
VFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKY
LLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNF
NGQNTEINSRNFTRLKNFTGLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEEI
TADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFEH
GDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEAFMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPAL
NIGNMLSKGEFVEAIIFTGVVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAKV
NTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSAMININKFLDQCSVSYLMNSMI
PYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDEVNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILSI
VYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNNE
YTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTITNNRLTKSKIYINGRLIDQKPI
SNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELNEKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPNK
YVDVNNIGIRGYMYLKGPRGSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQAG
VEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAKLVASNWYNRQVGKASRTFGCS
WEFIPVDDGWGESSL

Specific function: Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of the three isoforms SV2A, SV2B and SV2C. It is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Botulinum neurotoxin A heavy chain:Secreted. Host cell junction, host synapse, host presynaptic cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M27 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BXA2_CLOBO (Q45894)

Other databases:

- EMBL:   X73423
- EMBL:   X87974
- PIR:   I40645
- RefSeq:   YP_002803127.1
- PDB:   1E1H
- PDB:   2G7K
- PDB:   2G7N
- PDB:   2G7P
- PDB:   2G7Q
- PDBsum:   1E1H
- PDBsum:   2G7K
- PDBsum:   2G7N
- PDBsum:   2G7P
- PDBsum:   2G7Q
- ProteinModelPortal:   Q45894
- SMR:   Q45894
- DIP:   DIP-437N
- GeneID:   7766540
- ProtClustDB:   CLSK912378
- BRENDA:   3.4.24.69
- BindingDB:   Q45894
- GO:   GO:0009405
- GO:   GO:0006508
- InterPro:   IPR008985
- InterPro:   IPR013320
- InterPro:   IPR011065
- InterPro:   IPR000395
- InterPro:   IPR013104
- InterPro:   IPR012928
- InterPro:   IPR012500
- Gene3D:   G3DSA:2.60.120.200
- Gene3D:   G3DSA:3.90.1240.10
- PRINTS:   PR00760

Pfam domain/function: PF01742 Peptidase_M27; PF07951 Toxin_R_bind_C; PF07953 Toxin_R_bind_N; PF07952 Toxin_trans; SSF49899 ConA_like_lec_gl; SSF50386 Kunitz_like

EC number: =3.4.24.69

Molecular weight: Translated: 149412; Mature: 149281

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 224-224

Signals:

None

Transmembrane regions:

HASH(0x127e4888)-; HASH(0x12781acc)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCC
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
CCCCCCCCCCEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGY
CCCCCEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCHHHHHHCCCC
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCC
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKA
EEEEEECCEEEEECCCEEEHHHHHHCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
KSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKV
HHHHCCHHHHHHHHHHHHHHHEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHH
INRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
HCCHHEEEECCEEEEEEEECCCCEEECCCCEECCCCEECCCCCCCCEECCCCHHHHHHHH
GLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEE
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEEECEEEEECCCCCCCCHHHHHHHH
ITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNG
HHCCCCCCHHHCCCCHHEEEEEEEEEEECCCCCCEEHHCCCHHHHHCCCCCCCHHHCCCC
KKYELDKYTMFHYLRAQEFEHGDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEA
CEEECHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEHHHHHHHHHHHHHHH
FMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPALNIGNMLSKGEFVEAIIFTG
HHHHHHHHHHHHHCCCCCCCEEEHHHHCCEEEEEECCCCCCCHHHHHCCCHHHHHHHHHH
VVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHH
VNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSA
HCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEHHHHHHHHHHHHHHH
MININKFLDQCSVSYLMNSMIPYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHH
VNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILSIVYKKDDLIDLSRYGAKINI
HCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEHHHCCCEEEC
GDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNN
CCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHEECCCC
EYTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTIT
CEEEEEEEECCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCEEEEEEE
NNRLTKSKIYINGRLIDQKPISNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELN
CCCEEEEEEEEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHCC
EKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPNKYVDVNNIGIRGYMYLKGPR
HHHHHHHHCCCCCCCCHHHHCCCCEECCCCEEEEEEECCCCEEEECCCEEEEEEEEECCC
GSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQA
CCEEEEEEEEECHHHCCHHHHHHHHCCCCCCCEEECCCEEEEEEEEECCCEEEECCCHHH
GVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAK
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHEEEEEECCCCCEEEEEHHHHHHHHHH
LVASNWYNRQVGKASRTFGCSWEFIPVDDGWGESSL
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCH
>Mature Secondary Structure 
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCC
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
CCCCCCCCCCEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGY
CCCCCEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCHHHHHHCCCC
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCC
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKA
EEEEEECCEEEEECCCEEEHHHHHHCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
KSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKV
HHHHCCHHHHHHHHHHHHHHHEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHH
INRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
HCCHHEEEECCEEEEEEEECCCCEEECCCCEECCCCEECCCCCCCCEECCCCHHHHHHHH
GLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEE
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEEECEEEEECCCCCCCCHHHHHHHH
ITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNG
HHCCCCCCHHHCCCCHHEEEEEEEEEEECCCCCCEEHHCCCHHHHHCCCCCCCHHHCCCC
KKYELDKYTMFHYLRAQEFEHGDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEA
CEEECHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEHHHHHHHHHHHHHHH
FMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPALNIGNMLSKGEFVEAIIFTG
HHHHHHHHHHHHHCCCCCCCEEEHHHHCCEEEEEECCCCCCCHHHHHCCCHHHHHHHHHH
VVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHH
VNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSA
HCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEHHHHHHHHHHHHHHH
MININKFLDQCSVSYLMNSMIPYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHH
VNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILSIVYKKDDLIDLSRYGAKINI
HCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEHHHCCCEEEC
GDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNN
CCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHEECCCC
EYTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTIT
CEEEEEEEECCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCEEEEEEE
NNRLTKSKIYINGRLIDQKPISNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELN
CCCEEEEEEEEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHCC
EKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPNKYVDVNNIGIRGYMYLKGPR
HHHHHHHHCCCCCCCCHHHHCCCCEECCCCEEEEEEECCCCEEEECCCEEEEEEEEECCC
GSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQA
CCEEEEEEEEECHHHCCHHHHHHHHCCCCCCCEEECCCEEEEEEEEECCCEEEECCCHHH
GVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAK
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHEEEEEECCCCCEEEEEHHHHHHHHHH
LVASNWYNRQVGKASRTFGCSWEFIPVDDGWGESSL
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8310180; 8863443