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The map label for this gene is pepP [H]

Identifier: 226947793

GI number: 226947793

Start: 698169

End: 699404

Strand: Direct

Name: pepP [H]

Synonym: CLM_0643

Alternate gene names: 226947793

Gene position: 698169-699404 (Clockwise)

Preceding gene: 226947792

Following gene: 226947797

Centisome position: 16.8

GC content: 28.07

Gene sequence:

>1236_bases
GTGAATAAAGAATTTTTTATGAGAAATAGGAAAAACTTAGGGGAGAGTATAGAAGAGGGAATAATTGTTATATTTGCAGG
CAAGGCACCTTATAAATCAGCAGACGAAACCTATCCATTTACACCTAACAGAAACTTTTATTATTTAACTGGAATAGAAG
AGGAACAGATAATATTAGTCATAACTAAGAAAAATAAAAAAATAAAAGAACATTTATATATACAAAGACCAGATCCAGTA
ATGGCAAGATGGGTAGGGGCAACCATTAGCGAAGAAGAAGCTGAAGAGGTAAGTGGGATAGAAAATATAGGGTATGTAGA
TAAATTTTTTGATGATTTTCCGATCTTTATAAATAGAAATGGATTTAATAAAGTATACTTAGATTTAGAGAGGAGAGAAT
GGGAAGAAAATTTTACACCAGCTCAAATTTTTGCTAAAGAATTAAGAGAAAAATATCCTTATGTAAAAATAGAAAACATC
TATAAAGGTATAAGTGATTTAAGAACAATAAAAAGTGAAGAGGAAGTAGAATTAATCAAGAAAGCTATAGATATAACTAA
AGAAGGTATATATAACATGATGAAAAATATAAAGCCAAATATGATGGAATATGAAGTGGAAGCATATTTTGACTTTTCCT
TAAAGAAAAATGGTGTTACAGATTATGCCTTTGAAACTATAGCAGCAGCGGGAAAAAATGCTACAGTACTACATTATAGT
GAAAATAATTGTAAAATAGAAAATAACTCTTTAATCCTTTGTGATTTAGGAGCTCAATATAAATATTATAATGGTGATAT
AACAAGAACCTTTCCTGCTAATGGAAAGTTTACAGAGAGACAAAAAGAAGTATATAAAGTAGTTTTAGAAGCTAATAAAG
CTATAATTGAAAATGCAAAACCAGGAGTTACATTTAAAGAAATAGAAGATATAACTAAAAAAATATTAACAGAAGGATGC
AAAAAATTAGGAATATTGCAAGATAAAAGAGAATTAAGGAAATATTATTTCCATAGTTTTGGACATTACTTAGGCTTAGA
TACTCATGACGTAGGAAGTTATGAAGTAAAATTAAAACCAGGTATGGTTATAACCAATGAACCAGGTCTTTATATAGAAG
AAGAAAGTATTGGAATAAGAATAGAGGATGATTTATTAATAACAGAAGATGGGTGTGAAGTTTTAAGTAAGGATATAATT
AAGAGTATAGAAGAAATAGAAAACTTCATGAAATAA

Upstream 100 bases:

>100_bases
GAAAAAAATTACATTTTATGGTATTAGTATTAATATAATTATACTCAATTTTTATTCAACTTTAATGAGATATTTAAGTA
AATTAGTTAGGGGGATTTTT

Downstream 100 bases:

>100_bases
GGAAATTACAACTTAAAAGGAAGTCATACTACCCGTGGTTTAAAAAAGGGATATGTGGCGAGATCGGCAACTCACGACCA
TAAGAGATTCTAACTTGTTT

Product: Xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRNGFNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSEEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQYKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIENAKPGVTFKEIEDITKKILTEGC
KKLGILQDKRELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK

Sequences:

>Translated_411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRNGFNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSEEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQYKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIENAKPGVTFKEIEDITKKILTEGC
KKLGILQDKRELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK
>Mature_411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRNGFNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSEEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQYKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIENAKPGVTFKEIEDITKKILTEGC
KKLGILQDKRELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=424, Percent_Identity=30.6603773584906, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI149589008, Length=473, Percent_Identity=27.4841437632135, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=31.1475409836066, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI260593663, Length=468, Percent_Identity=25.8547008547009, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI264681563, Length=280, Percent_Identity=27.5, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789275, Length=440, Percent_Identity=33.1818181818182, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1788728, Length=237, Percent_Identity=31.2236286919831, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790282, Length=296, Percent_Identity=25.6756756756757, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=471, Percent_Identity=29.5116772823779, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71989583, Length=265, Percent_Identity=26.0377358490566, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321118, Length=436, Percent_Identity=28.6697247706422, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320922, Length=435, Percent_Identity=28.2758620689655, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19920384, Length=421, Percent_Identity=29.2161520190024, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21357079, Length=438, Percent_Identity=29.2237442922374, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17137632, Length=178, Percent_Identity=33.1460674157303, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47765; Mature: 47765

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILV
CCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEE
ITKKNKKIKEHLYIQRPDPVMARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRN
EECCCCCHHHCEEEECCCHHHHHHHCCCCCHHHHHHHCCCHHCCCHHHHHCCCCEEEECC
GFNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENIYKGISDLRTIKSEEEVELIK
CCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHCCHHHHHHHH
KAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
ENNCKIENNSLILCDLGAQYKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIENAK
CCCCEEECCCEEEEECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCHHHHCCCC
PGVTFKEIEDITKKILTEGCKKLGILQDKRELRKYYFHSFGHYLGLDTHDVGSYEVKLKP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDIIKSIEEIENFMK
CEEEECCCCCEEEECCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILV
CCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEE
ITKKNKKIKEHLYIQRPDPVMARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRN
EECCCCCHHHCEEEECCCHHHHHHHCCCCCHHHHHHHCCCHHCCCHHHHHCCCCEEEECC
GFNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENIYKGISDLRTIKSEEEVELIK
CCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHCCHHHHHHHH
KAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
ENNCKIENNSLILCDLGAQYKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIENAK
CCCCEEECCCEEEEECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCHHHHCCCC
PGVTFKEIEDITKKILTEGCKKLGILQDKRELRKYYFHSFGHYLGLDTHDVGSYEVKLKP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDIIKSIEEIENFMK
CEEEECCCCCEEEECCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]